- Tytuł:
- A novel germline mutation of PTEN associated with brain tumours of multiple lineages.
- Autorzy:
- Źródło:
- British journal of cancer [Br J Cancer] 2002 May 20; Vol. 86 (10), pp. 1586-91.
- Typ publikacji:
- Case Reports; Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Amino Acid Substitution*
Frontal Lobe*/pathology
Germ-Line Mutation*
Mutation, Missense*
Point Mutation*
Protein Serine-Threonine Kinases*Brain Neoplasms /*genetics
Meningeal Neoplasms/*genetics
Meningioma/*genetics
Neoplasm Proteins/*genetics
Neoplasms, Multiple Primary/*genetics
Oligodendroglioma/*genetics
Phosphoric Monoester Hydrolases/*genetics
Tumor Suppressor Proteins/*genetics
Adult ; Apoptosis/genetics ;Brain Neoplasms /pathology ; Cell Division ; Cell Lineage ; DNA Mutational Analysis ; DNA, Neoplasm/genetics ; Enzyme Activation/drug effects ; Genetic Predisposition to Disease ; Humans ; Insulin/pharmacology ; Loss of Heterozygosity ; Male ; Meningeal Neoplasms/pathology ; Meningioma/pathology ; Models, Molecular ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/physiology ; Neoplasms, Multiple Primary/pathology ; Oligodendroglioma/pathology ; PTEN Phosphohydrolase ; Phosphoric Monoester Hydrolases/chemistry ; Phosphoric Monoester Hydrolases/physiology ; Protein Conformation ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-akt ; Transfection ; Tumor Suppressor Proteins/chemistry ; Tumor Suppressor Proteins/physiology ; U937 Cells/drug effects ; U937 Cells/enzymology
Czasopismo naukowe