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Wyszukujesz frazę ""Janus Kinase 2"" wg kryterium: Temat


Tytuł:
Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.
Autorzy:
Abraham BG; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Haikarainen T; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland.
Vuorio J; Department of Physics, University of Helsinki, Helsinki, Finland.
Girych M; Department of Physics, University of Helsinki, Helsinki, Finland.
Virtanen AT; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Kurttila A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Karathanasis C; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany.
Heilemann M; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany.
Sharma V; Department of Physics, University of Helsinki, Helsinki, Finland.; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Vattulainen I; Department of Physics, University of Helsinki, Helsinki, Finland.
Silvennoinen O; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland.; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
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Źródło:
Science advances [Sci Adv] 2024 Mar 08; Vol. 10 (10), pp. eadl2097. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Erythropoietin*/genetics
Janus Kinase 2*/genetics
Janus Kinase 2*/metabolism
Artificial Intelligence ; Mutation ; Receptors, Erythropoietin/genetics ; Signal Transduction/genetics ; Humans
Czasopismo naukowe
Tytuł:
Identification and validation of the association of Janus kinase 2 mutations with the response to immune checkpoint inhibitor therapy.
Autorzy:
Chen P; Department of Clinical Nutrition & Health Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Long J; Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhang J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
Xie F; Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Wu W; Department of Cardiology, Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Tian Z; Department of Cardiology, Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Zhang S; Department of Cardiology, Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. .
Yu K; Department of Clinical Nutrition & Health Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .
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Źródło:
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2024 Feb; Vol. 73 (2), pp. 263-276. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Janus Kinase 2*/genetics
Immune Checkpoint Inhibitors*/therapeutic use
Humans ; Immunotherapy ; Mutation ; Biomarkers, Tumor
Czasopismo naukowe
Tytuł:
Anti-inflammatory effects of reticuline on the JAK2/STAT3/SOCS3 and p38 MAPK/NF-κB signaling pathway in a mouse model of obesity-associated asthma.
Autorzy:
Lyu X; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Liu J; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Liu Z; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Wu Y; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Zhu P; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Liu C; Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
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Źródło:
The clinical respiratory journal [Clin Respir J] 2024 Jan; Vol. 18 (1), pp. e13729.
Typ publikacji:
Journal Article
MeSH Terms:
Asthma*/drug therapy
Asthma*/metabolism
Benzylisoquinolines*/pharmacology
Benzylisoquinolines*/therapeutic use
Janus Kinase 2*/drug effects
Janus Kinase 2*/metabolism
NF-kappa B*/drug effects
NF-kappa B*/metabolism
STAT3 Transcription Factor*/drug effects
STAT3 Transcription Factor*/metabolism
Animals ; Mice ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Bronchoalveolar Lavage Fluid ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/metabolism ; Lung/pathology ; Mice, Inbred BALB C ; Obesity/complications ; Obesity/drug therapy ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/pharmacology ; p38 Mitogen-Activated Protein Kinases/therapeutic use ; Signal Transduction ; Suppressor of Cytokine Signaling 3 Protein/drug effects ; Suppressor of Cytokine Signaling 3 Protein/metabolism
Czasopismo naukowe
Tytuł:
Discovery of furopyridine-based compounds as novel inhibitors of Janus kinase 2: In silico and in vitro studies.
Autorzy:
Suriya U; Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Mahalapbutr P; Department of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khan Kaen 40002, Thailand. Electronic address: .
Geronikaki A; Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124, Greece.
Kartsev V; InterBioScreen, 85355 Moscow, Russia.
Zubenko A; North-Caucasian Zonal Research Veterinary Institute, 346406 Novocherkassk, Russia.
Divaeva L; Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, 344090, Russia.
Chekrisheva V; North-Caucasian Zonal Research Veterinary Institute, 346406 Novocherkassk, Russia.
Petrou A; Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124, Greece.
Oopkaew L; Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Chulalongkorn University, Bangkok 10330, Thailand.
Somngam P; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Choowongkomon K; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand. Electronic address: .
Rungrotmongkol T; Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Chulalongkorn University, Bangkok 10330, Thailand; Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 260 (Pt 2), pp. 129308. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Janus Kinase 2*/metabolism
Signal Transduction*
Humans ; Janus Kinases/metabolism ; STAT Transcription Factors/metabolism ; Cell Line ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry
Czasopismo naukowe
Tytuł:
TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma.
Autorzy:
Yin YT; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Shi L; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Wu C; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Zhang MY; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Li JX; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Zhou YF; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Wang SC; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Wang HY; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China. .
Mai SJ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China. .
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Źródło:
Medical oncology (Northwood, London, England) [Med Oncol] 2024 Feb 23; Vol. 41 (3), pp. 79. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
STAT3 Transcription Factor*
Janus Kinase 2*
Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Cell Line, Tumor ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Cell Proliferation/genetics ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; DNA-Binding Proteins/metabolism ; Transcription Factors/genetics ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism
Czasopismo naukowe
Tytuł:
Deciphering the molecular choreography of Janus kinase 2 inhibition via Gaussian accelerated molecular dynamics simulations: a dynamic odyssey.
Autorzy:
Sk MF; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, MP, 453552, India.; Theoretical and Computational Biophysics Group, Beckman Institute for Advanced Science and Technology, NIH Resource for Macromolecular Modeling and Visualization, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Samanta S; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, MP, 453552, India.
Poddar S; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, MP, 453552, India.
Kar P; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, MP, 453552, India. .
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Źródło:
Journal of computer-aided molecular design [J Comput Aided Mol Des] 2024 Feb 07; Vol. 38 (1), pp. 8. Date of Electronic Publication: 2024 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Janus Kinase 2*
Molecular Dynamics Simulation*
Catalytic Domain ; Drug Development
Czasopismo naukowe
Tytuł:
Targeting the JAK2/STAT3 signaling pathway for chronic pain.
Autorzy:
Dai XY; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Liu L; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Song FH; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Gao SJ; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Wu JY; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Li DY; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Zhang LQ; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Liu DQ; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Zhou YQ; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
Mei W; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan, China.; Wuhan Clinical Research Center for Geriatric Anesthesia, Wuhan, China.
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Źródło:
Aging and disease [Aging Dis] 2024 Feb 01; Vol. 15 (1), pp. 186-200. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Janus Kinase 2*
Chronic Pain*/drug therapy
Animals ; STAT3 Transcription Factor/genetics ; Retrospective Studies ; Signal Transduction ; Cytokines/metabolism
Czasopismo naukowe
Tytuł:
Case report: Refractory Evans syndrome in two patients with spondyloenchondrodysplasia with immune dysregulation treated successfully with JAK1/JAK2 inhibition.
Autorzy:
Gernez Y; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Narula M; Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Cepika AM; Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Valdes Camacho J; Division of Allergy and Immunology, Department of Pediatrics, Louisiana State University (LSU) Health, Shreveport, LA, United States.
Hoyte EG; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Mouradian K; Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Glader B; Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Singh D; Division of Rheumatology, Department of Pediatrics, Valley Children Hospital, Madera, CA, United States.
Sathi B; Division of Hematology, Department of Pediatrics, Valley Children Hospital, Madera, CA, United States.
Rao L; Division of Hematology, Department of Pediatrics, Valley Children Hospital, Madera, CA, United States.
Tolin AL; Division of Immunology, Department of Pediatrics, Hospital Pediatrico Dr. Humberto Notti, Mendoza, Argentina.
Weinberg KI; Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Lewis DB; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Bacchetta R; Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
Weinacht KG; Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.
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Źródło:
Frontiers in immunology [Front Immunol] 2024 Jan 29; Vol. 14, pp. 1328005. Date of Electronic Publication: 2024 Jan 29 (Print Publication: 2023).
Typ publikacji:
Review; Case Reports
MeSH Terms:
Immunoglobulin G*
Janus Kinase 2*
Autoimmune Diseases*
Anemia, Hemolytic, Autoimmune*
Osteochondrodysplasias*
Immunologic Deficiency Syndromes*
Thrombocytopenia*
Humans ; Tartrate-Resistant Acid Phosphatase/genetics ; Janus Kinase 1
SCR Disease Name:
Combined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia; Evans Syndrome; Spondyloenchondrodysplasia
Recenzja
Tytuł:
ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1.
Autorzy:
Li YK; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Gao AB; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.; Clinical Research Institute, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zeng T; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Liu D; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Zhang QF; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Ran XM; Department of Gynecologic Oncology, School of Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya, Central South University, Changsha, Hunan, China.
Tang ZZ; Department of Gynecologic Oncology, School of Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya, Central South University, Changsha, Hunan, China.
Li Y; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Liu J; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zhang T; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shi GQ; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zhou WC; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zou WD; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Peng J; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
Zhang J; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. .
Li H; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. lihui_.
Zou J; Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China. .; The Second Affiliated Hospital, Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Jan 11; Vol. 22 (1), pp. 46. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Cystadenocarcinoma, Serous*
Ovarian Neoplasms*/genetics
STAT3 Transcription Factor*
Janus Kinase 2*
Animals ; Female ; Humans ; Tumor Microenvironment ; Molecular Docking Simulation ; Angiogenesis ; Zebrafish/metabolism ; Carcinogenesis ; Cell Proliferation ; Carcinoma, Ovarian Epithelial ; Cell Line, Tumor ; Angiopoietin-Like Protein 4/genetics ; Neoplasm Proteins ; Proteoglycans
Czasopismo naukowe
Tytuł:
Genetic evidence supporting a causal role of Janus kinase 2 in prostate cancer: a Mendelian randomization study.
Autorzy:
Xi Y; Department of Urology, The Second Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, China.; Shanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, PR China.; Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, PR China.
Wen R; Shanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, PR China.; Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, PR China.
Zhang R; Shanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, PR China.; Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, PR China.
Dong Q; Shanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, PR China.; Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, PR China.
Hou S; Shanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, PR China.; Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, PR China.; Department of Neurology, The First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, China.
Zhang S; Shanxi Provincial Key Laboratory of Rheumatism Immune Microecology, Taiyuan, PR China.; Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, PR China.; Department of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, China.
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Źródło:
The aging male : the official journal of the International Society for the Study of the Aging Male [Aging Male] 2023 Dec; Vol. 26 (1), pp. 2257300.
Typ publikacji:
Journal Article
MeSH Terms:
Janus Kinase 2*/genetics
Prostatic Neoplasms*/genetics
Humans ; Male ; Mendelian Randomization Analysis ; Risk Factors
Czasopismo naukowe
Tytuł:
Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria.
Autorzy:
Bohlen J; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg University, 69120 Heidelberg, Germany. Electronic address: .
Zhou Q; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA; Children's Hospital of Fudan University, 201102 Shanghai, China.
Philippot Q; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Ogishi M; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Rinchai D; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Nieminen T; New Children's Hospital, 00290 Helsinki, Finland.
Seyedpour S; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, P94V+8MF Tehran, Iran; Nanomedicine Research Association (NRA), P94V+8MF Tehran, Iran.
Parvaneh N; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, P94V+8MF Tehran, Iran; Department of Pediatrics, Tehran University of Medical Sciences, P94V+8MF Tehran, Iran; Children's Medical Center, P94V+8MF Tehran, Iran.
Rezaei N; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, P94V+8MF Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), 1419733151 Tehran, Iran.
Yazdanpanah N; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, P94V+8MF Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), 1419733151 Tehran, Iran.
Momenilandi M; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Conil C; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Neehus AL; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Schmidt C; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA; Faculty of Medicine, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Arango-Franco CA; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
Voyer TL; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Khan T; College of Health and Life Sciences, Hamad Bin Khalifa University, 8C8M+6Q Doha, Qatar; Department of Immunology, Sidra Medicine, 8C8M+6Q Doha, Qatar; The Jackson Laboratory, Farmington, CT, USA.
Yang R; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Puchan J; Institute of Microbiology, ETH Zürich, 8049 Zürich, Switzerland.
Erazo L; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Roiuk M; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg University, 69120 Heidelberg, Germany.
Vatovec T; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; Heidelberg University, 69120 Heidelberg, Germany.
Janda Z; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; Heidelberg University, 69120 Heidelberg, Germany.
Bagarić I; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; Heidelberg University, 69120 Heidelberg, Germany.
Materna M; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Gervais A; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Li H; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Rosain J; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Peel JN; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Seeleuthner Y; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Han JE; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
L'Honneur AS; Department of Virology, Cochin Hospital, AP-HP, 75015 Paris, France.
Moncada-Vélez M; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Martin-Fernandez M; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School, New York, NY 10029, USA; Department of Pediatrics, Icahn School, New York, NY 10029, USA; Department of Microbiology, Icahn School, New York, NY 10029, USA.
Horesh ME; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School, New York, NY 10029, USA; Department of Pediatrics, Icahn School, New York, NY 10029, USA; Department of Microbiology, Icahn School, New York, NY 10029, USA.
Kochetkov T; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Schmidt M; University Hospital Erlangen, Institute of Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
AlShehri MA; King Fahad Medical City, Children's Specialized Hospital, 12231 Riyadh, Saudi Arabia.
Salo E; New Children's Hospital, 00290 Helsinki, Finland.
Saxen H; New Children's Hospital, 00290 Helsinki, Finland.
ElGhazali G; Sheikh Khalifa Medical City- Union71, Purehealth, Abu Dhabi, United Arab Emirates, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Yatim A; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Soudée C; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Sallusto F; Institute of Microbiology, ETH Zürich, 8049 Zürich, Switzerland; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.
Ensser A; University Hospital Erlangen, Institute of Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Marr N; College of Health and Life Sciences, Hamad Bin Khalifa University, 8C8M+6Q Doha, Qatar; Department of Immunology, Sidra Medicine, 8C8M+6Q Doha, Qatar.
Zhang P; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Bogunovic D; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School, New York, NY 10029, USA; Department of Pediatrics, Icahn School, New York, NY 10029, USA; Department of Microbiology, Icahn School, New York, NY 10029, USA.
Cobat A; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France.
Shahrooei M; Clinical and Diagnostic Immunology, KU Leuven, 3000 Leuven, Belgium; Dr. Shahrooei Laboratory, 22 Bahman St., Ashrafi Esfahani Blvd, Tehran, Iran.
Béziat V; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Abel L; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Wang X; Children's Hospital of Fudan University, 201102 Shanghai, China.
Boisson-Dupuis S; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Teleman AA; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg University, 69120 Heidelberg, Germany.
Bustamante J; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA; Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, 75015 Paris, France. Electronic address: .
Zhang Q; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA.
Casanova JL; Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, 75015 Paris, France; Paris Cité University, Imagine Institute, 75015 Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10032, USA; Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France. Electronic address: .
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Źródło:
Cell [Cell] 2023 Nov 09; Vol. 186 (23), pp. 5114-5134.e27. Date of Electronic Publication: 2023 Oct 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Interferon-gamma*/immunology
Janus Kinase 2*/metabolism
Mycobacterium Infections*/immunology
Mycobacterium Infections*/metabolism
Humans ; Male ; Cell Cycle Proteins/metabolism ; Interleukin-12 ; Interleukin-23 ; Mycobacterium/physiology ; Oncogene Proteins/metabolism
Czasopismo naukowe
Tytuł:
JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms.
Autorzy:
Giraldo-Rincón AI; Universidad de Antioquia, Facultad de Medicina, Unidad de Genética Médica, Medellín, Colombia.
Naranjo Molina S; Universidad de Antioquia, Facultad de Medicina, Unidad de Genética Médica, Medellín, Colombia.
Gomez-Lopera N; Universidad de Antioquia, Facultad de Medicina, Unidad de Genética Médica, Medellín, Colombia.
Aguirre Acevedo D; Universidad de Antioquia, Grupo Académico de Epidemiología Clinica, Medellin, Colombia.
Ucroz Benavidez A; Universidad de Antioquia, Facultad de Medicina, Unidad de Genética Médica, Medellín, Colombia.
Gálvez Cárdenas K; Hospital Pablo Tobón Uribe, Medellín, Colombia.
Cuellar Ambrosí F; Hospital Alma Mater, Medellín, Colombia.
Torres JD; Hospital Universitario San Vicente Fundación, Medellín, Colombia.
Ospina S; Hospital Universitario San Vicente Fundación, Medellín, Colombia.
Palacio K; Universidad de Antioquia, Facultad de Medicina, Unidad de Genética Médica, Medellín, Colombia.
Gaviria Jaramillo L; Hospital Universitario San Vicente Fundación, Medellín, Colombia.
Muñeton CM; Universidad de Antioquia, Facultad de Medicina, Unidad de Genética Médica, Medellín, Colombia.
Vasquez Palacio G; Universidad de Antioquia, Facultad de Medicina, Unidad de Genética Médica, Medellín, Colombia.
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Źródło:
Colombia medica (Cali, Colombia) [Colomb Med (Cali)] 2023 Sep 30; Vol. 54 (3), pp. e2035353. Date of Electronic Publication: 2023 Sep 30 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Janus Kinase 2*/genetics
Myeloproliferative Disorders*/genetics
Myeloproliferative Disorders*/metabolism
Receptors, Thrombopoietin*/genetics
Calreticulin*/genetics
Humans ; Colombia ; Mutation ; Polycythemia Vera/genetics ; Primary Myelofibrosis/genetics ; Thrombocythemia, Essential/genetics
Czasopismo naukowe
Tytuł:
Increased circulating exosomal Janus kinase 2 messenger RNA levels in psoriasis.
Autorzy:
Shimada S; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Myangat TM; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kajihara I; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Sawamura S; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Makino K; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Aoi J; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Masuguchi S; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Fukushima S; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
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Źródło:
The Journal of dermatology [J Dermatol] 2023 Sep; Vol. 50 (9), pp. e301-e302. Date of Electronic Publication: 2023 Apr 18.
Typ publikacji:
Letter
MeSH Terms:
Janus Kinase 2*
Psoriasis*/diagnosis
Psoriasis*/genetics
Humans ; RNA, Messenger/genetics
Opinia redakcyjna
Tytuł:
Progress on the Pharmacological Targeting of Janus Pseudokinases.
Autorzy:
Henry SP; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.
Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Aug 24; Vol. 66 (16), pp. 10959-10990. Date of Electronic Publication: 2023 Aug 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Janus Kinase 2*/metabolism
Janus Kinases*/metabolism
Phosphorylation ; TYK2 Kinase/metabolism ; Psoriasis/drug therapy
Czasopismo naukowe
Tytuł:
Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.
Autorzy:
Yue P; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China.
Lv X; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
You J; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China.
Zou Y; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China.
Luo J; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China.
Lu Z; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China.
Cao H; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China.
Liu Z; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China.
Fan X; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China. fanxl_.
Ye Q; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, 430071, Wuhan, China. yqf_.; The Third Xiangya Hospital of Central South University, Research Center of National Health Ministry On Transplantation Medicine Engineering and Technology, Changsha, 410013, China. yqf_.
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Źródło:
Cellular & molecular biology letters [Cell Mol Biol Lett] 2023 Jul 12; Vol. 28 (1), pp. 55. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Janus Kinase 2*
STAT3 Transcription Factor*
Animals ; Rats ; Liver ; Endoplasmic Reticulum Stress ; Perfusion
Czasopismo naukowe
Tytuł:
Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening.
Autorzy:
Pölläniemi A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Virtanen A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Silvennoinen O; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland; Fimlab Laboratories, Tampere, Finland.
Haikarainen T; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Fimlab Laboratories, Tampere, Finland. Electronic address: .
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Źródło:
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2023 Jun; Vol. 28 (4), pp. 180-187. Date of Electronic Publication: 2023 May 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Janus Kinase 2*/genetics
Janus Kinase 2*/metabolism
Myeloproliferative Disorders*/drug therapy
Myeloproliferative Disorders*/genetics
Myeloproliferative Disorders*/metabolism
Humans ; Protein Kinase Inhibitors/chemistry ; Quality of Life ; Cytokines
Czasopismo naukowe
Tytuł:
Development of machine learning models based on molecular fingerprints for selection of small molecule inhibitors against JAK2 protein.
Autorzy:
Belenahalli Shekarappa S; School of Systems Biomedical Science and Department of Bioinformatics and Life Science, Soongsil University, Seoul, South Korea.
Kandagalla S; Laboratory of Computational Modeling of Drugs, Higher Medical & Biological School, South Ural State University, Chelyabinsk, Russia.
Lee J; School of Systems Biomedical Science and Department of Bioinformatics and Life Science, Soongsil University, Seoul, South Korea.
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Źródło:
Journal of computational chemistry [J Comput Chem] 2023 Jun 15; Vol. 44 (16), pp. 1493-1504. Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Janus Kinase 2*
Machine Learning*
Molecular Docking Simulation ; Algorithms
Czasopismo naukowe
Tytuł:
The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate.
Autorzy:
Araya-Secchi R; Structural Biophysics, Section for Neutron and X-ray Science, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.; Facultad de Ingenieria Arquitectura y Diseño, Universidad San Sebastian, Santiago, Chile.
Bugge K; Structural Biology and NMR Laboratory (SBiNLab), Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Seiffert P; Structural Biology and NMR Laboratory (SBiNLab), Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Petry A; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Haxholm GW; Structural Biology and NMR Laboratory (SBiNLab), Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Lindorff-Larsen K; Structural Biology and NMR Laboratory (SBiNLab), Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Pedersen SF; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Arleth L; Structural Biophysics, Section for Neutron and X-ray Science, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.
Kragelund BB; Structural Biology and NMR Laboratory (SBiNLab), Department of Biology, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
ELife [Elife] 2023 May 26; Vol. 12. Date of Electronic Publication: 2023 May 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Janus Kinase 2*/metabolism
Receptors, Prolactin*/metabolism
Humans ; Carrier Proteins/metabolism ; Phosphorylation ; Prolactin/metabolism ; Signal Transduction ; STAT5 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł:
Compound in-cis JAK2 mutant polycythemia vera manifesting as first-onset transient ischemic attack with erythrocytosis and an attenuated JAK2 V617F mutant signal on a quantitative DD-PCR assay.
Autorzy:
Ng IKS; Department of Medicine, National University Hospital, Singapore, Singapore.
Lee PL; Molecular Diagnosis Center, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
Ng LJ; Molecular Diagnosis Center, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
Chua RP; Molecular Diagnosis Center, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
Ng YA; Molecular Diagnosis Center, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
Lee CK; Molecular Diagnosis Center, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
Tan JG; Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.
Chan THM; Molecular Diagnosis Center, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
Yan B; Molecular Diagnosis Center, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore.
Prasad V; Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.
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Źródło:
International journal of laboratory hematology [Int J Lab Hematol] 2023 Apr; Vol. 45 (2), pp. e28-e31. Date of Electronic Publication: 2022 Oct 07.
Typ publikacji:
Letter
MeSH Terms:
Ischemic Attack, Transient*/etiology
Ischemic Attack, Transient*/genetics
Janus Kinase 2*/genetics
Polycythemia*/diagnosis
Polycythemia*/etiology
Polycythemia*/genetics
Polycythemia Vera*/complications
Polycythemia Vera*/diagnosis
Polycythemia Vera*/genetics
Humans ; Mutation ; Polymerase Chain Reaction
Opinia redakcyjna
Tytuł:
Hypoxia Potentiated Lung Cancer Cell Migration and Invasion by up-regulating HIF1α/JAK2/STAT3 Axis and Activating MMP13 Transcription.
Autorzy:
Cheng X; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China.
Liang D; Department of Medical Technology, Zunyi Medical College, Zunyi, 563003, China.
Li X; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China.
Deng C; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China.
Ye M; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China.
Yang J; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China.
Liu Y; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China.
Wu K; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China.
Wu J; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China. .
Tian P; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China. .; Department of Pathology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563003, China. .
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Źródło:
Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Mar; Vol. 82 (1), pp. 259-270. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Neoplasms*/metabolism
Adenocarcinoma of Lung*
Humans ; Matrix Metalloproteinase 13/genetics ; Matrix Metalloproteinase 13/metabolism ; Hypoxia/metabolism ; Cell Movement ; STAT3 Transcription Factor/metabolism ; Cell Line, Tumor ; Janus Kinase 2/metabolism ; Janus Kinase 2/pharmacology ; Cell Proliferation
Czasopismo naukowe

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