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Tytuł:
Cervicovaginal Human Papillomavirus Genomes, Microbiota Composition and Cytokine Concentrations in South African Adolescents.
Autorzy:
Happel AU; Department of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Balle C; Department of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Havyarimana E; Department of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Brown B; Seattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.; Department of Pediatrics, University of Washington, 1510 San Juan Road NE, Seattle, WA 98195, USA.
Maust BS; Seattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.; Department of Pediatrics, University of Washington, 1510 San Juan Road NE, Seattle, WA 98195, USA.
Feng C; Seattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.
Yi BH; Seattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.
Gill K; Desmond Tutu Health Foundation, 3 Woodlands Rd, Woodstock, Cape Town 7915, South Africa.
Bekker LG; Desmond Tutu Health Foundation, 3 Woodlands Rd, Woodstock, Cape Town 7915, South Africa.
Passmore JS; Department of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.; National Health Laboratory Service, Observatory, Cape Town 7925, South Africa.; NRF-DST Center of Excellence in HIV Prevention, Centre for the AIDS Programme of Research in South Africa, 719 Umbilo Road, Congella, Durban 4013, South Africa.
Jaspan HB; Department of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.; Seattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.; Department of Pediatrics, University of Washington, 1510 San Juan Road NE, Seattle, WA 98195, USA.; Department of Global Health, University of Washington, 1959 NE Pacific St., Seattle, WA 98195, USA.
Varsani A; The Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine and School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.; Structural Biology Research Unit, Department of Integrative Biomedical Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa.
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Źródło:
Viruses [Viruses] 2023 Mar 15; Vol. 15 (3). Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Vaginosis, Bacterial*/microbiology
Papillomavirus Infections*
Microbiota*/genetics
Herpesviridae*/genetics
Female ; Adolescent ; Humans ; Young Adult ; Adult ; Human Papillomavirus Viruses ; Cytokines ; RNA, Ribosomal, 16S/genetics ; South Africa ; Vagina ; Papillomaviridae/genetics ; Bacteria/genetics ; Inflammation/complications
SCR Organism:
human papillomavirus 35
Czasopismo naukowe
Tytuł:
Genital microbiota of women using a 90 day tenofovir or tenofovir and levonorgestrel intravaginal ring in a placebo controlled randomized safety trial in Kenya.
Autorzy:
Dabee S; Seattle Children's Research Institute, 307 Westlake Ave N, Seattle, WA, USA. .
Mugo N; University of Washington Global Health, 325 Ninth Ave, Box 359927, Seattle, WA, USA. .; Center for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. .
Mudhune V; Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
McLellan-Lemal E; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Peacock S; University of Washington Global Health, 325 Ninth Ave, Box 359927, Seattle, WA, USA.
O'Connor S; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Njoroge B; Center for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya.
Nyagol B; Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Thurman AR; CONRAD, Eastern Virginia Medical School, Norfolk, VA, USA.
Ouma E; Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Ridzon R; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.; US National Institutes of Health, Bethesda, MD, USA.
Wiener J; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Haugen HS; University of Washington Global Health, 325 Ninth Ave, Box 359927, Seattle, WA, USA.
Gasper M; Seattle Children's Research Institute, 307 Westlake Ave N, Seattle, WA, USA.
Feng C; Seattle Children's Research Institute, 307 Westlake Ave N, Seattle, WA, USA.
Allen SA; United States Agency for International Development, Washington, DC, USA.
Doncel GF; CONRAD, Eastern Virginia Medical School, Norfolk, VA, USA.
Jaspan HB; Seattle Children's Research Institute, 307 Westlake Ave N, Seattle, WA, USA.; University of Washington Global Health, 325 Ninth Ave, Box 359927, Seattle, WA, USA.; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Heffron R; University of Washington Global Health, 325 Ninth Ave, Box 359927, Seattle, WA, USA. .
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Corporate Authors:
Kisumu Combined Ring Study Team
Źródło:
Scientific reports [Sci Rep] 2022 Jul 14; Vol. 12 (1), pp. 12040. Date of Electronic Publication: 2022 Jul 14.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
HIV Infections*/drug therapy
HIV Infections*/prevention & control
Microbiota*
Administration, Intravaginal ; Female ; Humans ; Kenya/epidemiology ; Levonorgestrel/adverse effects ; RNA, Ribosomal, 16S ; Tenofovir/adverse effects ; Vagina
Czasopismo naukowe
Tytuł:
Presence and Persistence of Putative Lytic and Temperate Bacteriophages in Vaginal Metagenomes from South African Adolescents.
Autorzy:
Happel AU; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.
Balle C; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.
Maust BS; Seattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.; Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA 98195, USA.
Konstantinus IN; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.; Namibia Institute of Pathology, Hosea Kutako, Windhoek 10005, Namibia.
Gill K; Desmond Tutu HIV Centre, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.; NRF-DST CAPRISA Centre of Excellence in HIV Prevention, 719 Umbilo Road, Congella, Durban 4013, South Africa.
Bekker LG; Desmond Tutu HIV Centre, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.; NRF-DST CAPRISA Centre of Excellence in HIV Prevention, 719 Umbilo Road, Congella, Durban 4013, South Africa.
Froissart R; CNRS, IRD, Université Montpellier, UMR 5290, MIVEGEC, 34394 Montpellier, France.
Passmore JA; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.; Desmond Tutu HIV Centre, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.; NRF-DST CAPRISA Centre of Excellence in HIV Prevention, 719 Umbilo Road, Congella, Durban 4013, South Africa.; National Health Laboratory Service, Anzio Road, Cape Town 7925, South Africa.
Karaoz U; Earth and Environmental Science, Lawrence Berkeley National Laboratories, 1 Cyclotron Rd., Berkeley, CA 94720, USA.
Varsani A; The Biodesign Center of Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, 1001 S. McAllister Ave., Tempe, AZ 85281, USA.; Structural Biology Research Unit, Department of Integrative Biomedical Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.
Jaspan H; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Cape Town 7925, South Africa.; Seattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.; Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA 98195, USA.; Department of Global Health, University of Washington School of Public Health, 1510 San Juan Road NE, Seattle, WA 98195, USA.
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Źródło:
Viruses [Viruses] 2021 Nov 23; Vol. 13 (12). Date of Electronic Publication: 2021 Nov 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Metagenome*
Microbiota*
Vagina*/microbiology
Vagina*/virology
Bacteriophages/*isolation & purification
Adolescent ; Cohort Studies ; Female ; Humans ; South Africa/epidemiology
Czasopismo naukowe
Tytuł:
An open-label, randomized crossover study to evaluate the acceptability and preference for contraceptive options in female adolescents, 15 to 19 years of age in Cape Town, as a proxy for HIV prevention methods (UChoose).
Autorzy:
Gill K; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Happel AU; Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Pidwell T; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Mendelsohn A; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Duyver M; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Johnson L; Centre for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Meyer L; Centre for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.; Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Slack C; HIV AIDS Vaccines Ethics Group, University of KwaZulu-Natal, Durban, South Africa.
Strode A; HIV AIDS Vaccines Ethics Group, University of KwaZulu-Natal, Durban, South Africa.
Mendel E; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Fynn L; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Wallace M; Cancer Association of South Africa, Johannesburg, South Africa.
Spiegel H; Department of Health and Human Services, Kelly Government Solutions, Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Jaspan H; Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Departments of Pediatrics and Global Health, University of Washington, Seattle, WA, USA.; Centre for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Passmore JA; Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; National Health Laboratory Service (NHLS), Cape Town, South Africa.
Hosek S; Stroger Hospital of Cook County, Chicago, IL, USA.
Smit D; MSD (Pty) Ltd, Halfway House, South Africa.
Rinehart A; ViiV Healthcare, Research Triangle Park, NC, USA.
Bekker LG; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
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Źródło:
Journal of the International AIDS Society [J Int AIDS Soc] 2020 Oct; Vol. 23 (10), pp. e25626.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Contraceptive Devices, Female*
Ethinyl Estradiol*
Contraceptive Agents, Hormonal/*administration & dosage
Contraceptives, Oral, Combined/*administration & dosage
Desogestrel/*analogs & derivatives
HIV Infections/*prevention & control
Administration, Intravaginal ; Adolescent ; Africa, Southern ; Cross-Over Studies ; Drug Combinations ; Female ; Humans ; Injections, Intramuscular ; Patient Preference ; Patient Satisfaction ; South Africa ; Young Adult
Czasopismo naukowe
Tytuł:
Preconception helminth infection alters offspring microbiota and immune subsets in a mouse model.
Autorzy:
Nyangahu DD; Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Darby M; Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Havyarimana E; Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Brown BP; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Horsnell W; Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
Jaspan HB; Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.; Departments of Pediatrics and Global Health, University of Washington, Seattle, WA, USA.
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Źródło:
Parasite immunology [Parasite Immunol] 2020 Sep; Vol. 42 (9), pp. e12721. Date of Electronic Publication: 2020 May 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunity, Maternally-Acquired*
Gastrointestinal Microbiome/*immunology
Nippostrongylus/*immunology
Strongylida Infections/*immunology
Animals ; Animals, Newborn/immunology ; Animals, Newborn/microbiology ; Feces ; Female ; Lymphocyte Subsets/immunology ; Mice ; Mice, Inbred BALB C ; Pregnancy
Czasopismo naukowe
Tytuł:
The Vaginal Virome-Balancing Female Genital Tract Bacteriome, Mucosal Immunity, and Sexual and Reproductive Health Outcomes?
Autorzy:
Happel AU; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Varsani A; The Biodesign Center of Fundamental and Applied Microbiomics, School of Life Sciences, Center for Evolution and Medicine, Arizona State University, 1001 S. McAllister Ave, Tempe, AZ 85287-5001, USA.; Structural Biology Research Unit, Department of Integrative Biomedical Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Balle C; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Passmore JA; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.; NRF-DST CAPRISA Centre of Excellence in HIV Prevention, 719 Umbilo Road, Congella, Durban 4013, South Africa.; National Health Laboratory Service, Anzio Road, Observatory, Cape Town 7925, South Africa.
Jaspan H; Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.; Department of Pediatrics and Global Health, University of Washington, 1510 San Juan Road NE, Seattle, WA 98195, USA.; Seattle Children's Research Institute, 307 Westlake Ave N, Seattle, WA 98109, USA.
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Źródło:
Viruses [Viruses] 2020 Jul 30; Vol. 12 (8). Date of Electronic Publication: 2020 Jul 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Immunity, Mucosal*
Reproductive Health*
Microbiota/*immunology
Vagina/*microbiology
Vagina/*virology
Virome/*immunology
Animals ; Female ; Host Microbial Interactions/immunology ; Humans ; Mice ; Sexual Health
Czasopismo naukowe
Tytuł:
Testing the regulatory framework in South Africa - a single-blind randomized pilot trial of commercial probiotic supplementation to standard therapy in women with bacterial vaginosis.
Autorzy:
Happel AU; Division of Medical Virology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa. .; NRF-DST CAPRISA Centre of Excellence in HIV Prevention, Cape Town, South Africa. .
Singh R; School of Laboratory Medicine and Medical Sciences, University of Kwa-Zulu Natal, Durban, South Africa.; National Health Laboratory Service, Durban, South Africa.
Mitchev N; School of Laboratory Medicine and Medical Sciences, University of Kwa-Zulu Natal, Durban, South Africa.
Mlisana K; School of Laboratory Medicine and Medical Sciences, University of Kwa-Zulu Natal, Durban, South Africa.; National Health Laboratory Service, Durban, South Africa.
Jaspan HB; Division of Medical Virology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa.; Seattle Children's Hospital, Seattle, USA.
Barnabas SL; Division of Medical Virology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa.; Family Centre for Research with Ubuntu, Stellenbosch University, Tygerberg, South Africa.
Passmore JS; Division of Medical Virology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa.; NRF-DST CAPRISA Centre of Excellence in HIV Prevention, Cape Town, South Africa.; National Health Laboratory Service, Durban, South Africa.
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Źródło:
BMC infectious diseases [BMC Infect Dis] 2020 Jul 10; Vol. 20 (1), pp. 491. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Probiotics/*therapeutic use
Vaginosis, Bacterial/*microbiology
Vaginosis, Bacterial/*therapy
Administration, Intravaginal ; Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Dietary Supplements ; Drug Approval ; Female ; Humans ; Interleukin-1alpha/metabolism ; Medication Adherence ; Metronidazole/administration & dosage ; Metronidazole/therapeutic use ; Microbiota ; Pilot Projects ; Recurrence ; Single-Blind Method ; South Africa ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł:
Exploring potential of vaginal Lactobacillus isolates from South African women for enhancing treatment for bacterial vaginosis.
Autorzy:
Happel AU; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Kullin B; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Gamieldien H; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Wentzel N; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Zauchenberger CZ; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Jaspan HB; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Seattle Children's Hospital, Seattle, United States of America.
Dabee S; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Seattle Children's Hospital, Seattle, United States of America.
Barnabas SL; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Family Centre for Research with Ubuntu (FAMCRU), Stellenbosch University, Tygerberg, South Africa.
Jaumdally SZ; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Dietrich J; Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa.
Gray G; Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa.
Bekker LG; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Desmond Tutu HIV Foundation, University of Cape Town, Cape Town, South Africa.
Froissart R; UMR MIVEGEC CNRS-IRD-UM, University Montpellier, Montpellier, France.
Passmore JS; Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; NRF-DST CAPRISA Centre of Excellence in HIV Prevention, Cape Town, South Africa.; National Health Laboratory Service (NHLS), Cape Town, South Africa.
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Źródło:
PLoS pathogens [PLoS Pathog] 2020 Jun 04; Vol. 16 (6), pp. e1008559. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2020).
Typ publikacji:
Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gardnerella vaginalis*
Lactobacillus*/genetics
Lactobacillus*/isolation & purification
Lactobacillus*/metabolism
Prevotella*
Bacteroidaceae Infections/*microbiology
Gram-Positive Bacterial Infections/*microbiology
Vaginosis, Bacterial/*microbiology
Adolescent ; Adult ; Bacteroidaceae Infections/drug therapy ; Bacteroidaceae Infections/genetics ; Bacteroidaceae Infections/metabolism ; Clindamycin/pharmacology ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/genetics ; Female ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/genetics ; Gram-Positive Bacterial Infections/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Lactic Acid/metabolism ; Metronidazole/pharmacology ; South Africa ; Species Specificity ; Vaginosis, Bacterial/drug therapy ; Vaginosis, Bacterial/genetics
SCR Organism:
Prevotella bivia
Czasopismo naukowe
Tytuł:
Inflammatory and antimicrobial properties differ between vaginal Lactobacillus isolates from South African women with non-optimal versus optimal microbiota.
Autorzy:
Manhanzva MT; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Abrahams AG; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Gamieldien H; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Froissart R; UMR 5290 MIVEGEC, French National Centre for Scientific Research (CNRS), Montpellier, France.
Jaspan H; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Seattle Children's Research Institute, University of Washington, Seattle, Washington, USA.
Jaumdally SZ; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Barnabas SL; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Dabee S; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Bekker LG; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Gray G; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.; South African Medical Research Council, Cape Town, South Africa.
Passmore JS; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; National Health Laboratory Service, Cape Town, South Africa.
Masson L; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa. .; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. .; Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2020 Apr 10; Vol. 10 (1), pp. 6196. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gardnerella vaginalis/*immunology
Gram-Positive Bacterial Infections/*microbiology
Inflammation/*microbiology
Lactobacillus/*immunology
Vagina/*microbiology
Vaginosis, Bacterial/*microbiology
Adolescent ; Adult ; Cytokines/immunology ; Female ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/immunology ; Humans ; Inflammation/epidemiology ; Inflammation/immunology ; Lactobacillus/isolation & purification ; South Africa/epidemiology ; Vagina/immunology ; Vaginosis, Bacterial/epidemiology ; Vaginosis, Bacterial/immunology ; Young Adult
Czasopismo naukowe
Tytuł:
Natural compulsive-like behaviour in the deer mouse (Peromyscus maniculatus bairdii) is associated with altered gut microbiota composition.
Autorzy:
Scheepers IM; Centre of Excellence for Pharmaceutical Sciences, North West-University, Potchefstroom, South Africa.
Cryan JF; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Bastiaanssen TFS; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Rea K; APC Microbiome Ireland, University College Cork, Cork, Ireland.
Clarke G; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
Jaspan HB; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Seattle Children's Research Institute, University of Washington, Seattle, WA, USA.
Harvey BH; Centre of Excellence for Pharmaceutical Sciences, North West-University, Potchefstroom, South Africa.; MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.
Hemmings SMJ; Department of Psychiatry, Stellenbosch University, Tygerberg, South Africa.
Santana L; Unit for Business Mathematics and Informatics, North-West University, Potchefstroom, South Africa.
van der Sluis R; Focus area for Human Metabolomics, North-West University, Potchefstroom, South Africa.
Malan-Müller S; Department of Psychiatry, Stellenbosch University, Tygerberg, South Africa.
Wolmarans W; Centre of Excellence for Pharmaceutical Sciences, North West-University, Potchefstroom, South Africa.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2020 Mar; Vol. 51 (6), pp. 1419-1427. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gastrointestinal Microbiome*
Obsessive-Compulsive Disorder*
Animals ; Brain ; Disease Models, Animal ; Female ; Humans ; Male ; Peromyscus
Czasopismo naukowe
Tytuł:
Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.
Autorzy:
Dabee S; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; DST-NRF CAPRISA Centre of Excellence in HIV Prevention, Durban, South Africa.
Barnabas SL; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Desmond Tutu HIV Foundation (DTHF), University of Cape Town, Cape Town, South Africa.
Lennard KS; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Jaumdally SZ; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; DST-NRF CAPRISA Centre of Excellence in HIV Prevention, Durban, South Africa.
Gamieldien H; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Balle C; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Happel AU; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; DST-NRF CAPRISA Centre of Excellence in HIV Prevention, Durban, South Africa.
Murugan BD; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Williamson AL; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; SAMRC-UCT Gynaecological Cancer Research Center (GCRC), University of Cape Town, Cape Town, South Africa.; National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa.
Mkhize N; Centre for HIV and STIs, National Institute for Communicable Disease (NICD), National Health Laboratory Service, Johannesburg, South Africa.
Dietrich J; Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Diepkloof, Johannesburg, South Africa.
Lewis DA; Western Sydney Sexual Health Centre, Western Sydney Local Health District, Parramatta, Australia.; Marie Bashir Institute for Infectious Diseases and Biosecurity & Sydney Medical School-Westmead, University of Sydney, Sydney, Australia.
Chiodi F; Karolinska Institute, Stockholm, Sweden.
Hope TJ; Northwestern University, Chicago, IL, United States of America.
Shattock R; Imperial College London, London, United Kingdom.
Gray G; Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Diepkloof, Johannesburg, South Africa.; South African Medical Research Council, Cape Town, South Africa.
Bekker LG; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Desmond Tutu HIV Foundation (DTHF), University of Cape Town, Cape Town, South Africa.
Jaspan HB; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Seattle Children's Research Institute, University of Washington, Seattle, Washington, United States of America.
Passmore JS; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; DST-NRF CAPRISA Centre of Excellence in HIV Prevention, Durban, South Africa.; SAMRC-UCT Gynaecological Cancer Research Center (GCRC), University of Cape Town, Cape Town, South Africa.; National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa.
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Źródło:
PloS one [PLoS One] 2019 Apr 04; Vol. 14 (4), pp. e0213975. Date of Electronic Publication: 2019 Apr 04 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections/*immunology
Microbiota/*immunology
Vagina/*microbiology
Vaginosis, Bacterial/*epidemiology
Women's Health/*statistics & numerical data
Adolescent ; CD4-Positive T-Lymphocytes/immunology ; Cervix Uteri/cytology ; Cervix Uteri/immunology ; Cervix Uteri/microbiology ; Cohort Studies ; Cytokines/immunology ; Cytokines/metabolism ; Estrogens/blood ; Estrogens/immunology ; Female ; HIV Infections/prevention & control ; Humans ; Hydrogen-Ion Concentration ; Lactobacillus crispatus/immunology ; Lactobacillus crispatus/isolation & purification ; Progesterone/blood ; Progesterone/immunology ; Risk Factors ; South Africa/epidemiology ; Vagina/cytology ; Vagina/immunology ; Vaginosis, Bacterial/blood ; Vaginosis, Bacterial/immunology ; Young Adult
Czasopismo naukowe
Tytuł:
Antimicrobial and inflammatory properties of South African clinical Lactobacillus isolates and vaginal probiotics.
Autorzy:
Chetwin E; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Manhanzva MT; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Abrahams AG; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Froissart R; UMR 5290 MIVEGEC, French National Centre for Scientific Research (CNRS), Montpellier, France.
Gamieldien H; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Jaspan H; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Seattle Children's Research Institute, University of Washington, Seattle, Washington, USA.
Jaumdally SZ; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Barnabas SL; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Dabee S; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Happel AU; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Bowers D; Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Davids L; Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Passmore JS; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA) Centre of Excellence in HIV Prevention, Durban, South Africa.; National Health Laboratory Service, Cape Town, South Africa.
Masson L; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa. .; Centre for the AIDS Programme of Research in South Africa (CAPRISA) Centre of Excellence in HIV Prevention, Durban, South Africa. .
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Źródło:
Scientific reports [Sci Rep] 2019 Feb 13; Vol. 9 (1), pp. 1917. Date of Electronic Publication: 2019 Feb 13.
Typ publikacji:
Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Probiotics*/isolation & purification
Probiotics*/therapeutic use
Vaginosis, Bacterial*/microbiology
Vaginosis, Bacterial*/prevention & control
Gardnerella vaginalis/*growth & development
Gram-Positive Bacterial Infections/*prevention & control
Lactobacillus acidophilus/*isolation & purification
Lacticaseibacillus rhamnosus/*isolation & purification
Vagina/*microbiology
Adolescent ; Adult ; Female ; Humans
Czasopismo naukowe
Tytuł:
Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection.
Autorzy:
Balle C; Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Lennard K; Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Computational Biology Division, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.
Dabee S; Institute of Institute of Infectious Disease and Molecular Medicine & Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Barnabas SL; Institute of Institute of Infectious Disease and Molecular Medicine & Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Jaumdally SZ; Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Gasper MA; Seattle Children's Research Institute, Seattle, WA, USA.
Maseko V; National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa.
Mbulawa ZZA; Institute of Institute of Infectious Disease and Molecular Medicine & Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Center for HIV and STIs, National Institute for Communicable Disease, National Health Laboratory Service, Johannesburg, South Africa.; SAMRC-UCT Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa.
Williamson AL; Institute of Institute of Infectious Disease and Molecular Medicine & Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Bekker LG; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Lewis DA; National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa.; Western Sydney Sexual Health Centre, Parramatta, Australia.; Marie Bashir Institute for Infectious Diseases and Biosecurity & Sydney Medical School-Westmead, University of Sydney, Sydney, Australia.
Passmore JS; Institute of Institute of Infectious Disease and Molecular Medicine & Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; DST-NRF CAPRISA Centre of Excellence in HIV Prevention, Durban, South Africa.; National Health Laboratory Service Cape Town, Cape Town, South Africa.
Jaspan HB; Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. .; Seattle Children's Research Institute, Seattle, WA, USA. .; University of Washington Department of Pediatrics and Global Health, Seattle, WA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2018 Jul 23; Vol. 8 (1), pp. 11109. Date of Electronic Publication: 2018 Jul 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Microbiota*
Cervix Uteri/*microbiology
Chlamydia Infections/*microbiology
Chlamydia trachomatis/*physiology
Vagina/*microbiology
Adolescent ; Chlamydia trachomatis/genetics ; Female ; Humans ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; South Africa ; Young Adult
Czasopismo naukowe
Tytuł:
High human papillomavirus (HPV) prevalence in South African adolescents and young women encourages expanded HPV vaccination campaigns.
Autorzy:
Mbulawa ZZA; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Center for HIV and STIs, National Institute for Communicable Disease, National Health Laboratory Service, Johannesburg, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.; UCT-MRC Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa.
van Schalkwyk C; The South African Department of Science and Technology/National Research Foundation Centre of Excellence in Epidemiological Modelling and Analysis, Stellenbosch University, Stellenbosch, South Africa.
Hu NC; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.
Meiring TL; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.
Barnabas S; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.; The Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Dabee S; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.
Jaspan H; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Seattle Children's Research Institute, University of Washington, Seattle, United States.
Kriek JM; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.
Jaumdally SZ; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.
Muller E; Center for HIV and STIs, National Institute for Communicable Disease, National Health Laboratory Service, Johannesburg, South Africa.
Bekker LG; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; The Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Lewis DA; Western Sydney Sexual Health Centre, Western Sydney Local Health District, Parramatta, Australia.; Marie Bashir Institute for Infectious Diseases and Biosecurity & Sydney Medical School-Westmead, University of Sydney, Sydney, Australia.
Dietrich J; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Diepkloof, Johannesburg, South Africa.; Canada-African Prevention Trials Network, The Ottawa Hospital General Campus, Ottawa, Canada.
Gray G; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Diepkloof, Johannesburg, South Africa.; South African Medical Research Council, Cape Town, South Africa.
Passmore JS; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.; DST-NRF CAPRISA Centre of Excellence in HIV Prevention, University of Cape Town, Cape Town, South Africa.; National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town, South Africa.
Williamson AL; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa.; UCT-MRC Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa.; National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town, South Africa.
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Źródło:
PloS one [PLoS One] 2018 Jan 02; Vol. 13 (1), pp. e0190166. Date of Electronic Publication: 2018 Jan 02 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alphapapillomavirus/*isolation & purification
Papillomavirus Infections/*epidemiology
Papillomavirus Vaccines/*administration & dosage
Adolescent ; Adult ; Female ; Humans ; Papillomavirus Infections/prevention & control ; Papillomavirus Infections/virology ; Prevalence ; South Africa/epidemiology ; Young Adult
Czasopismo naukowe
Tytuł:
CCR5 expression, haplotype and immune activation in protection from infection in HIV-exposed uninfected individuals in HIV-serodiscordant relationships.
Autorzy:
Jaumdally SZ; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; NRF-DST Centre of Excellence in HIV Prevention, CAPRISA, Durban, South Africa.
Picton A; Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tiemessen CT; Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Paximadis M; Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Jaspan HB; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Gamieldien H; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Masson L; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; NRF-DST Centre of Excellence in HIV Prevention, CAPRISA, Durban, South Africa.
Coetzee D; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Williamson AL; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; National Health Laboratory Service, Cape Town, South Africa.
Little F; Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa.
Gumbi PP; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; NRF-DST Centre of Excellence in HIV Prevention, CAPRISA, Durban, South Africa.
Passmore JS; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; NRF-DST Centre of Excellence in HIV Prevention, CAPRISA, Durban, South Africa.; National Health Laboratory Service, Cape Town, South Africa.
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Źródło:
Immunology [Immunology] 2017 Aug; Vol. 151 (4), pp. 464-473. Date of Electronic Publication: 2017 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Marriage*
HIV Infections/*immunology
HIV-1/*immunology
Receptors, CCR5/*metabolism
T-Lymphocytes/*immunology
Adult ; Environmental Exposure/adverse effects ; Female ; Gene Expression Regulation ; Granulocyte-Macrophage Colony-Stimulating Factor/blood ; HIV Infections/epidemiology ; HIV Seropositivity ; Haplotypes ; Humans ; Interferon-gamma/blood ; Interleukin-2/blood ; Lymphocyte Activation ; Male ; Middle Aged ; Polymorphism, Genetic ; Receptors, CCR5/genetics ; South Africa
Czasopismo naukowe
Tytuł:
Probiotics for vaginal health in South Africa: what is on retailers' shelves?
Autorzy:
Happel AU; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.; UMR 5290 MIVEGEC, CNRS IRD Université Montpellier, Montpellier, France.
Jaumdally SZ; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.; CAPRISA DST-NRF Centre of Excellence in HIV Prevention, Cape Town, South Africa.
Pidwell T; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.; Desmond Tutu HIV Foundation, Cape Town, South Africa.
Cornelius T; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.
Jaspan HB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.; Seattle Children's Research Institute, University of Washington, Seattle, WA, USA.
Froissart R; UMR 5290 MIVEGEC, CNRS IRD Université Montpellier, Montpellier, France.
Barnabas SL; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.; Desmond Tutu HIV Foundation, Cape Town, South Africa.
Passmore JS; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa. .; CAPRISA DST-NRF Centre of Excellence in HIV Prevention, Cape Town, South Africa. .; National Health Laboratory Service, Cape Town, South Africa. .
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Źródło:
BMC women's health [BMC Womens Health] 2017 Jan 19; Vol. 17 (1), pp. 7. Date of Electronic Publication: 2017 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Consumer Behavior*
Probiotics/*pharmacology
Vagina/*microbiology
Bifidobacterium animalis/metabolism ; Bifidobacterium longum/metabolism ; Candidiasis/diet therapy ; Candidiasis/prevention & control ; Commerce/methods ; Cross-Sectional Studies ; Female ; Health Status ; Humans ; Lactobacillus acidophilus/metabolism ; Lacticaseibacillus rhamnosus/metabolism ; Probiotics/economics ; Probiotics/therapeutic use ; South Africa ; Surveys and Questionnaires ; Vaginosis, Bacterial/diet therapy ; Vaginosis, Bacterial/prevention & control
Czasopismo naukowe
Tytuł:
Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells.
Autorzy:
Masson L; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa.
Salkinder AL; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa.
Olivier AJ; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa.
McKinnon LR; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa.
Gamieldien H; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa.
Mlisana K; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; National Health Laboratory Services, Cape Town, South Africa.
Scriba TJ; South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa.
Lewis DA; Western Sydney Sexual Health Centre, Parramatta, Sydney, NSW, Australia.; Centre for Infectious Diseases and Microbiology & Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.; National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa.
Little F; Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa.
Jaspan HB; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa.; Seattle Children's Research Institute, Seattle, WA, USA.
Ronacher K; SA MRC Centre for TB Research, NRF/DST Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
Denny L; Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa.
Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa.; Columbia University, New York, NY, USA.
Passmore JA; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Medical School, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa.; National Health Laboratory Services, Cape Town, South Africa.
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Źródło:
Immunology [Immunology] 2015 Dec; Vol. 146 (4), pp. 557-67. Date of Electronic Publication: 2015 Oct 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-17/*biosynthesis
Mucous Membrane/*immunology
Mucous Membrane/*metabolism
Reproductive Tract Infections/*immunology
Reproductive Tract Infections/*metabolism
Th17 Cells/*immunology
Th17 Cells/*metabolism
Adult ; Bacterial Infections/immunology ; Bacterial Infections/metabolism ; Bacterial Infections/microbiology ; CD4 Lymphocyte Count ; Candidiasis/immunology ; Candidiasis/metabolism ; Candidiasis/microbiology ; Cervix Uteri ; Cytokines/biosynthesis ; Female ; Humans ; Interleukin-17/blood ; Mucous Membrane/microbiology ; Reproductive Tract Infections/microbiology ; Sexually Transmitted Diseases/immunology ; Sexually Transmitted Diseases/metabolism ; Sexually Transmitted Diseases/microbiology ; Sexually Transmitted Diseases/virology ; Vagina ; Young Adult
Czasopismo naukowe
Tytuł:
Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses.
Autorzy:
Gervassi A; Seattle Biomedical Research Institute, Seattle, Washington, United States of America.
Lejarcegui N; Seattle Biomedical Research Institute, Seattle, Washington, United States of America.
Dross S; Seattle Biomedical Research Institute, Seattle, Washington, United States of America; University of Washington Department of Global Health, Seattle, Washington, United States of America.
Jacobson A; Seattle Biomedical Research Institute, Seattle, Washington, United States of America.
Itaya G; Seattle Biomedical Research Institute, Seattle, Washington, United States of America.
Kidzeru E; Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Gantt S; University of British Columbia Department of Pediatrics and Child and Family Research Institute, Vancouver, Canada.
Jaspan H; University of Washington Seattle Children's Hospital, Seattle, Washington, United States of America; Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Horton H; Seattle Biomedical Research Institute, Seattle, Washington, United States of America; University of Washington Department of Global Health, Seattle, Washington, United States of America; University of Washington Department of Medicine, Seattle, Washington, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Sep 23; Vol. 9 (9), pp. e107816. Date of Electronic Publication: 2014 Sep 23 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Granulocytes/*cytology
Myeloid Cells/*metabolism
Adult ; Cells, Cultured ; Fetal Blood/cytology ; Humans ; In Vitro Techniques ; Infant ; Infant, Newborn ; Interferon-gamma/metabolism ; Myeloid Cells/cytology
Czasopismo naukowe
Tytuł:
The oral mucosa immune environment and oral transmission of HIV/SIV.
Autorzy:
Wood LF; Seattle Biomedical Research Institute, Seattle, WA, USA.
Chahroudi A
Chen HL
Jaspan HB
Sodora DL
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Źródło:
Immunological reviews [Immunol Rev] 2013 Jul; Vol. 254 (1), pp. 34-53.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
HIV/*immunology
HIV Infections/*immunology
HIV Infections/*transmission
Mouth Mucosa/*immunology
Mouth Mucosa/*virology
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Acquired Immunodeficiency Syndrome/*transmission
Simian Immunodeficiency Virus/*immunology
Adaptive Immunity ; Adult ; Age Factors ; Animals ; Disease Models, Animal ; Disease Susceptibility/immunology ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Infant ; Infant, Newborn ; Inflammation/immunology
Czasopismo naukowe
Tytuł:
Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa.
Autorzy:
Nglazi MD; The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925 Cape Town, South Africa. />Kranzer K
Holele P
Kaplan R
Mark D
Jaspan H
Lawn SD
Wood R
Bekker LG
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Źródło:
BMC infectious diseases [BMC Infect Dis] 2012 Jan 25; Vol. 12, pp. 21. Date of Electronic Publication: 2012 Jan 25.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-HIV Agents/*administration & dosage
Antiretroviral Therapy, Highly Active/*methods
HIV Infections/*drug therapy
Adolescent ; Adult ; Ambulatory Care Facilities ; CD4 Lymphocyte Count ; Child ; Female ; HIV Infections/immunology ; HIV Infections/mortality ; HIV Infections/virology ; Humans ; Male ; South Africa ; Survival Analysis ; Treatment Outcome ; Viral Load ; Young Adult
Czasopismo naukowe

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