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    Wyświetlanie 1-4 z 4
    Tytuł:
    Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.
    Autorzy:
    Tubío-Santamaría N; Innere Medizin C, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.; Leibniz Institute On Aging, Fritz-Lipmann Institute, 07745, Jena, Germany.
    Jayavelu AK; Max-Planck-Institute of Biochemistry, Munich, Germany.; Proteomics and Cancer Cell Signaling Group, DKFZ, Heidelberg, Germany.
    Schnoeder TM; Innere Medizin C, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.; Leibniz Institute On Aging, Fritz-Lipmann Institute, 07745, Jena, Germany.
    Eifert T; Innere Medizin C, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.; Leibniz Institute On Aging, Fritz-Lipmann Institute, 07745, Jena, Germany.
    Hsu CJ; Innere Medizin C, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.; Leibniz Institute On Aging, Fritz-Lipmann Institute, 07745, Jena, Germany.
    Perner F; Innere Medizin C, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.
    Zhang Q; Innere Medizin C, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.
    Wenge DV; Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard University, Boston, MA, 02215, USA.
    Hansen FM; Max-Planck-Institute of Biochemistry, Munich, Germany.
    Kirkpatrick JM; Independent consultant, London, UK.
    Jyotsana N; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
    Lane SW; Queensland Institute for Medical Research (QIMR), Brisbane, Australia.
    von Eyss B; Leibniz Institute On Aging, Fritz-Lipmann Institute, 07745, Jena, Germany.
    Deshpande AJ; Sanford Burnham Research Institute, San Diego, USA.
    Kühn MWM; Medizinische Klinik 3, Hämatologie, Onkologie und Pneumologie, Universitätsmedizin Mainz, Mainz, Germany.
    Schwaller J; Department of Biomedicine, University Children's Hospital of Basel, Basel, Switzerland.
    Cammann C; Friedrich Loeffler-Institut für Medizinische Mikrobiologie - Virologie, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.
    Seifert U; Friedrich Loeffler-Institut für Medizinische Mikrobiologie - Virologie, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.
    Ebstein F; Department of Biochemistry, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.
    Krüger E; Department of Biochemistry, Universitätsmedizin Greifswald, 17475, Greifswald, Germany.
    Hochhaus A; Innere Medizin 2, Universitätsklinikum Jena, Jena, Germany.
    Heuser M; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany.
    Ori A; Leibniz Institute On Aging, Fritz-Lipmann Institute, 07745, Jena, Germany.
    Mann M; Max-Planck-Institute of Biochemistry, Munich, Germany.
    Armstrong SA; Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard University, Boston, MA, 02215, USA.
    Heidel FH; Innere Medizin C, Universitätsmedizin Greifswald, 17475, Greifswald, Germany. .; Leibniz Institute On Aging, Fritz-Lipmann Institute, 07745, Jena, Germany. .; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany. .
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    Źródło:
    Molecular cancer [Mol Cancer] 2023 Dec 04; Vol. 22 (1), pp. 196. Date of Electronic Publication: 2023 Dec 04.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
    MeSH Terms:
    Proteomics*
    Leukemia, Myeloid, Acute*/metabolism
    Humans ; Mice ; Animals ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Transcription Factors/genetics ; Mutation ; Gene Expression
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.
    Autorzy:
    Bahrami E; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.
    Schmid JP; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.
    Jurinovic V; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.
    Becker M; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.
    Wirth AK; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.
    Ludwig R; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.
    Kreissig S; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany.
    Duque Angel TV; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.
    Amend D; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.
    Hunt K; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.
    Öllinger R; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, and Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, Technische Universität München, Munich, Germany.
    Rad R; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, and Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Institute of Molecular Oncology and Functional Genomics, Technische Universität München, Munich, Germany.
    Frenz JM; Proteomics and Cancer Cell Signaling Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg and Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
    Solovey M; Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; Chair of Physiological Chemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.
    Ziemann F; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.
    Mann M; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Munich, Germany.
    Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.
    Wichmann C; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, LMU University Hospital, LMU Munich, Munich, Germany.
    Herold T; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.
    Jayavelu AK; Proteomics and Cancer Cell Signaling Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg and Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Munich, Germany.
    Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany. .; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany. .; Department of Pediatrics, Dr. Von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany. .
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    Źródło:
    Molecular cancer [Mol Cancer] 2023 Jul 08; Vol. 22 (1), pp. 107. Date of Electronic Publication: 2023 Jul 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Proteomics*
    Leukemia*/genetics
    Humans ; Mice ; Animals ; ADAM10 Protein/genetics ; ADAM10 Protein/metabolism ; CRISPR-Cas Systems ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Disease Models, Animal ; Tumor Microenvironment ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Adverse stem cell clones within a single patient's tumor predict clinical outcome in AML patients.
    Autorzy:
    Zeller C; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.
    Richter D; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University (LMU), Munich, Germany.
    Jurinovic V; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, LMU, Munich, Germany.
    Valtierra-Gutiérrez IA; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University (LMU), Munich, Germany.
    Jayavelu AK; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
    Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
    Bagnoli JW; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University (LMU), Munich, Germany.
    Hellmann I; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University (LMU), Munich, Germany.
    Herold T; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
    Enard W; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University (LMU), Munich, Germany.
    Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
    Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany. .; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. .; Department of Pediatrics, Dr. von Hauner Children´s Hospital, University Hospital, LMU, Munich, Germany. .
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    Źródło:
    Journal of hematology & oncology [J Hematol Oncol] 2022 Mar 12; Vol. 15 (1), pp. 25. Date of Electronic Publication: 2022 Mar 12.
    Typ publikacji:
    Letter; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Leukemia, Myeloid, Acute*/drug therapy
    Leukemia, Myeloid, Acute*/genetics
    Leukemia, Myeloid, Acute*/pathology
    Proteomics*
    Clone Cells ; Cytarabine/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Humans ; Recurrence ; Stem Cells/pathology
    Raport
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Novel NPM1 mutation in the 3'-untranslated region identified in two patients with acute myeloid leukemia.
    Autorzy:
    Abraham A; Department of Haematology.
    Karathedath S
    Kumaraswamy V
    Jayavelu AK
    Mani S
    Srivastava VM
    Zhang W
    Zhou T
    George B
    Srivastava A
    Mathews V
    Balasubramanian P
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    Źródło:
    Leukemia & lymphoma [Leuk Lymphoma] 2014 Jun; Vol. 55 (6), pp. 1421-4. Date of Electronic Publication: 2013 Oct 09.
    Typ publikacji:
    Case Reports; Letter
    MeSH Terms:
    3' Untranslated Regions*
    Mutation*
    Leukemia, Myeloid, Acute/*genetics
    Nuclear Proteins/*genetics
    Adult ; DNA Mutational Analysis ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Male ; Nuclear Proteins/chemistry ; Nucleic Acid Conformation ; Nucleophosmin ; Treatment Outcome
    Raport
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-4 z 4

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