Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Autorzy :
Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Boddapati AK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Viox EG; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Starke CE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA. Upadhyay AA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Nekorchuk M; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA. Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA. Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Tharp GK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Pellegrini KL; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Kirejczyk S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Zandi K; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA. Tao S; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA. Horton TR; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Beagle EN; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Mahar EA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Lee MYH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. JeanSM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Delmas OM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Cooney KA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Sayegh MN; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Wang L; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Filev PD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA 30322, USA. Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA. Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Waggoner J; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Piantadosi A; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Al-Shakhshir H; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Schinazi RF; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: . Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: . Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Jan 21; Vol. 184 (2), pp. 460-475.e21. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Autorzy :
Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Boddapati AK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Viox EG; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Starke CE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA. Upadhyay AA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA. Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Tharp GK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Pellegrini KL; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Kirejczyk S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Zandi K; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Tao S; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Horton TR; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Beagle EN; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Mahar EA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Lee MY; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. JeanSM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Delmas OM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Cooney KA; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Sayegh MN; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Wang L; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA. Filev PD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia, USA. Waggoner J; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Piantadosi A; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Al-Shakhshir H; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA. Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Schinazi RF; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.
Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques.
Autorzy :
Raper J; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. Kovacs-Balint Z; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Mavigner M; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA. Gumber S; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Burke MW; Department of Physiology and Biophysics, Howard University, Washington, DC, USA. Habib J; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. Mattingly C; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. Fair D; Oregon Health and Science University, Portland, OR, USA. Earl E; Oregon Health and Science University, Portland, OR, USA. Feczko E; Oregon Health and Science University, Portland, OR, USA. Styner M; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. JeanSM; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Cohen JK; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Suthar MS; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, 30329, USA. Sanchez MM; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Alvarado MC; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Chahroudi A; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. .; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. .; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 May 21; Vol. 11 (1), pp. 2534. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence.
Autorzy :
Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Paganini S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America. Padhan K; Tissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America. Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. King CT; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Micci L; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Cervasi B; Flow Cytometry Core, Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America. Mudd JC; Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland Medical Center, Cleveland, Ohio, United States of America. Gill KP; Flow Cytometry Core, Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America. JeanSM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. Easley K; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America. Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America. Estes JD; Vaccine and Gene Therapy Institute at Oregon Health Science Center, Portland, Oregon, United States of America. Petrovas C; Tissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America. Lederman MM; Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland Medical Center, Cleveland, Ohio, United States of America. Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2019 Oct 18; Vol. 15 (10), pp. e1008081. Date of Electronic Publication: 2019 Oct 18 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques.
Autorzy :
Mavigner M; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. Raper J; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Kovacs-Balint Z; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Gumber S; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. O'Neal JT; Emory Vaccine Center, Atlanta, GA 30329, USA. Bhaumik SK; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. Zhang X; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Habib J; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. Mattingly C; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. McDonald CE; Emory Vaccine Center, Atlanta, GA 30329, USA. Avanzato V; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. Burke MW; Department of Physiology and Biophysics, Howard University, Washington, DC 20060, USA. Magnani DM; Department of Pathology, University of Miami, Miami, FL 33146, USA. Bailey VK; Department of Pathology, University of Miami, Miami, FL 33146, USA. Watkins DI; Department of Pathology, University of Miami, Miami, FL 33146, USA. Vanderford TH; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Fair D; Oregon Health and Science University, Portland, OR 97239, USA. Earl E; Oregon Health and Science University, Portland, OR 97239, USA. Feczko E; Oregon Health and Science University, Portland, OR 97239, USA. Styner M; Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA. JeanSM; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Cohen JK; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Silvestri G; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Johnson RP; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. O'Connor DH; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA. Wrammert J; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. Suthar MS; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Emory Vaccine Center, Atlanta, GA 30329, USA. Sanchez MM; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. Alvarado MC; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. .; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Self-Injurious Behavior Secondary to Cytomegalovirus-Induced Neuropathy in an SIV-Infected Rhesus Macaque (Macaca mulatta).
Autorzy :
Clemmons EA; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Gumber S; Division of Pathology, Yerkes National Primate Research Center, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. Strobert E; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Bloomsmith MA; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. JeanSM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. sherrie.jean@emory.edu.
Extraintestinal campylobacteriosis in rhesus macaques (Macaca mulatta).
Autorzy :
Clemmons EA; Division of Animal Resources, School of Medicine, Emory University, Atlanta, Georgia, USA. JeanSM; Division of Animal Resources, School of Medicine, Emory University, Atlanta, Georgia, USA. Machiah DK; Division of Pathology, Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia, USA. Breding E; Division of Pathology, Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia, USA. Sharma P; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA; Division of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. .
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