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Tytuł :
Copper(I)-Catalyzed Nitrile-Addition/ N -Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6 H -indolo[3,2- c ]quinolin-6-ones as Potent Topoisomerase-I Inhibitors.
Autorzy :
Hsueh WY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Lee YE; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Huang MS; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Lai CH; Department of Applied Chemistry, Chung Shan Medical University, Taichung 40201, Taiwan.
Gao YS; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Lin JC; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Chen YF; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Chang CL; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Chou SY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chen SF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Lu YY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chang LH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Lin SF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Lin YH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Hsu PC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Wei WY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Huang YC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Kao YF; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Teng LW; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Liu HH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chen YC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Yuan TT; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chan YW; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Huang PH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Chao YT; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Huang SY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Jian BH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Huang HY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Yang SC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Lo TH; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Huang GR; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Wang SY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.
Lin HS; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Chuang SH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Huang JJ; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi City 60004, Taiwan.; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City 11571, Taiwan.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Feb 11; Vol. 64 (3), pp. 1435-1453. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Copper/*chemistry
Nitriles/*chemistry
Quinolones/*chemical synthesis
Quinolones/*pharmacology
Topoisomerase I Inhibitors/*chemical synthesis
Topoisomerase I Inhibitors/*pharmacology
Animals ; Catalysis ; DNA Topoisomerases, Type I/chemistry ; Drug Design ; Drug Screening Assays, Antitumor ; Female ; Humans ; Male ; Mice ; Mice, Nude ; Models, Molecular ; Molecular Docking Simulation ; Quinolones/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Topoisomerase I Inhibitors/pharmacokinetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
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