- Tytuł :
-
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue
macrophages . - Autorzy :
- Źródło :
- Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 102. Date of Electronic Publication: 2021 Jan 04.
- Typ publikacji :
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms :
-
Drug Delivery Systems*
Adipose Tissue/*metabolismMacrophages /*metabolism
Mitochondria/*metabolism
Obesity/*drug therapy
Small Molecule Libraries/*therapeutic use
Animals ; Body Weight/drug effects ; Fatty Liver/genetics ; Fatty Liver/pathology ; Inflammation/genetics ; Inflammation/pathology ; Insulin Resistance ; Liver/metabolism ; Liver/pathology ; Macrophage Activation/drug effects ;Macrophages /drug effects ;Macrophages /pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Obesity/genetics ; Obesity/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; RAW 264.7 Cells ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Weight Loss/drug effects -
Czasopismo naukowe