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Tytuł:: Synergism between Angiotensin receptors ligands: Role of Angiotensin-(1-7) in modulating AT 2 R agonist response on nitric oxide in kidney cells.
Autorzy:: Patel S; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.
Hussain T; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Dec; Vol. 8 (6), pp. e00667.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Angiotensin I/*administration & dosage
Kidney/*cytology
Kidney/*metabolism
Nitric Oxide/*metabolism
Peptide Fragments/*administration & dosage
Proto-Oncogene Proteins/*metabolism
Receptor, Angiotensin, Type 2/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Angiotensin II/administration & dosage ; Cell Line ; Dose-Response Relationship, Drug ; Drug Synergism ; Humans ; Kidney/drug effects ; Ligands ; Proto-Oncogene Mas ; Proto-Oncogene Proteins/agonists ; Receptor, Angiotensin, Type 2/agonists ; Receptors, G-Protein-Coupled/agonists

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Skocz do pozycji: 2.

Tytuł:: Diversity of molecular targets and signaling pathways for CBD.
Autorzy:: de Almeida DL; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.; Department of Pharmacology, Institute of Biological Sciences, UFMG, Av. Antônio Carlos, Belo Horizonte, Brazil.
Devi LA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Dec; Vol. 8 (6), pp. e00682.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Cannabidiol/*administration & dosage
Cannabidiol/*metabolism
Molecular Targeted Therapy/*methods
Receptors, G-Protein-Coupled/*metabolism
Signal Transduction/*drug effects
Animals ; Humans ; Molecular Targeted Therapy/trends ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/metabolism ; Receptor, Serotonin, 5-HT1A/metabolism ; Receptors, Dopamine/metabolism ; Receptors, G-Protein-Coupled/agonists ; Signal Transduction/physiology

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Skocz do pozycji: 3.

Tytuł:: A simple open source bioinformatic methodology for initial exploration of GPCR ligands' agonistic/antagonistic properties.
Autorzy:: Panagiotopoulos AA; Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece.
Papachristofi C; Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece.
Kalyvianaki K; Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece.
Malamos P; Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece.
Theodoropoulos PA; Laboratory of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece.
Notas G; Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece.
Calogeropoulou T; Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece.
Castanas E; Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece.
Kampa M; Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Aug; Vol. 8 (4), pp. e00600.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Development/*methods
Receptors, G-Protein-Coupled/*agonists
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Computational Biology/methods ; Crystallography ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/metabolism ; Humans ; Ligands ; Molecular Docking Simulation ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction

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Skocz do pozycji: 4.

Tytuł:: MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo-allergic and anaphylactoid reactions.
Autorzy:: Grimes J; Medicines Research Centre GlaxoSmithKline R&D Ltd Stevenage United Kingdom.; Present address: Centre of Membrane Proteins and Receptors (COMPARE) University of Birmingham Edgbaston UK.
Desai S; Medicines Research Centre GlaxoSmithKline R&D Ltd Stevenage United Kingdom.
Charter NW; Eurofins Pharma Discovery Services Fremont CA USA.
Lodge J; Medicines Research Centre GlaxoSmithKline R&D Ltd Stevenage United Kingdom.
Moita Santos R; Medicines Research Centre GlaxoSmithKline R&D Ltd Stevenage United Kingdom.
Isidro-Llobet A; Medicines Research Centre GlaxoSmithKline R&D Ltd Stevenage United Kingdom.
Mason AM; Medicines Research Centre GlaxoSmithKline R&D Ltd Stevenage United Kingdom.
Wu Z; GlaxoSmithKline Collegeville PA USA.
Wolfe LA 3rd; GlaxoSmithKline Collegeville PA USA.
Anantharaman L; Eurofins Pharma Discovery Services Fremont CA USA.
Green A; Eurofins Pharma Discovery Services Fremont CA USA.
Bridges AM; Medicines Research Centre GlaxoSmithKline R&D Ltd Stevenage United Kingdom.
Dalmas Wilk DA; GlaxoSmithKline Collegeville PA USA.
Brown AJ; Medicines Research Centre GlaxoSmithKline R&D Ltd Stevenage United Kingdom.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2019 Dec 02; Vol. 7 (6), pp. e00547. Date of Electronic Publication: 2019 Dec 02 (Print Publication: 2019).
Typ publikacji:: Journal Article
MeSH Terms:: Anaphylaxis/*chemically induced
Mast Cells/*drug effects
Nerve Tissue Proteins/*agonists
Peptide Fragments/*adverse effects
Receptors, G-Protein-Coupled/*agonists
Receptors, Neuropeptide/*agonists
Vancomycin/*adverse effects
Anaphylaxis/immunology ; Animals ; Cell Degranulation/drug effects ; Cell Degranulation/immunology ; Cell Line, Tumor ; Cell-Penetrating Peptides/administration & dosage ; Cell-Penetrating Peptides/adverse effects ; Disease Models, Animal ; Drug Evaluation, Preclinical/adverse effects ; HEK293 Cells ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Humans ; Mast Cells/immunology ; Mast Cells/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/immunology ; Nerve Tissue Proteins/metabolism ; Peptide Fragments/administration & dosage ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/immunology ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Neuropeptide/genetics ; Receptors, Neuropeptide/immunology ; Receptors, Neuropeptide/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Recombinant Proteins/metabolism ; Syndrome ; Vancomycin/administration & dosage ; p-Methoxy-N-methylphenethylamine/pharmacology

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Skocz do pozycji: 5.

Tytuł:: N -Palmitoylglycine and other N -acylamides activate the lipid receptor G2A/GPR132.
Autorzy:: Foster JR; GlaxoSmithKline R&D Ltd, Medicines Research Centre Stevenage UK.; School of Medicine Ninewells Hospital and Medical School Dundee University Dundee UK.
Ueno S; GlaxoSmithKline R&D Ltd, Medicines Research Centre Stevenage UK.; Present address: Regeneron Uxbridge UK.
Chen MX; GlaxoSmithKline R&D Ltd, Medicines Research Centre Stevenage UK.
Harvey J; School of Medicine Ninewells Hospital and Medical School Dundee University Dundee UK.
Dowell SJ; GlaxoSmithKline R&D Ltd, Medicines Research Centre Stevenage UK.
Irving AJ; School of Biomolecular and Biomedical Science The Conway Institute University College Dublin Dublin Ireland.
Brown AJ; GlaxoSmithKline R&D Ltd, Medicines Research Centre Stevenage UK.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2019 Nov 21; Vol. 7 (6), pp. e00542. Date of Electronic Publication: 2019 Nov 21 (Print Publication: 2019).
Typ publikacji:: Journal Article
MeSH Terms:: Cell Cycle Proteins/*agonists
Glycine/*analogs & derivatives
Palmitic Acids/*pharmacology
Peptidomimetics/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Animals ; CHO Cells ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cricetulus ; Cyclohexanols/pharmacology ; Drug Antagonism ; Fatty Acids, Unsaturated/pharmacology ; Glycine/pharmacology ; Hydrophobic and Hydrophilic Interactions ; Molecular Docking Simulation ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Signal Transduction ; Structural Homology, Protein ; Telmisartan/analogs & derivatives ; Telmisartan/pharmacology

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Skocz do pozycji: 6.

Tytuł:: Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis.
Autorzy:: Hoare BL; Florey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health Parkville Victoria Australia.
Kocan M; Florey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health Parkville Victoria Australia.
Bruell S; Florey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health Parkville Victoria Australia.; Department of Biochemistry and Molecular Biology The University of Melbourne Parkville Victoria Australia.
Scott DJ; Florey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health Parkville Victoria Australia.; Department of Biochemistry and Molecular Biology The University of Melbourne Parkville Victoria Australia.
Bathgate RAD; Florey Institute of Neuroscience and Mental Health and Florey Department of Neuroscience and Mental Health Parkville Victoria Australia.; Department of Biochemistry and Molecular Biology The University of Melbourne Parkville Victoria Australia.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2019 Jul 30; Vol. 7 (4), pp. e00513. Date of Electronic Publication: 2019 Jul 30 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Luciferases/*metabolism
Receptors, G-Protein-Coupled/*chemistry
Receptors, G-Protein-Coupled/*metabolism
Receptors, Peptide/*chemistry
Receptors, Peptide/*metabolism
Bioluminescence Resonance Energy Transfer Techniques ; HEK293 Cells ; Humans ; Protein Multimerization ; Relaxin/metabolism ; Staining and Labeling

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Skocz do pozycji: 7.

Tytuł:: Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors.
Autorzy:: Wang L; Janssen Research & Development, LLC San Diego California.
Lee G; Janssen Research & Development, LLC San Diego California.
Shih A; Janssen Research & Development, LLC San Diego California.
Kuei C; Janssen Research & Development, LLC San Diego California.
Nepomuceno D; Janssen Research & Development, LLC San Diego California.
Wennerholm M; Janssen Research & Development, LLC San Diego California.
Fan F; Janssen Research & Development, LLC San Diego California.; Present address: UCSF Helen Diller Family Comprehensive Cancer Center San Francisco California.
Wu J; Janssen Research & Development, LLC San Diego California.
Bonaventure P; Janssen Research & Development, LLC San Diego California.
Lovenberg TW; Janssen Research & Development, LLC San Diego California.
Liu C; Janssen Research & Development, LLC San Diego California.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2019 Feb 07; Vol. 7 (1), pp. e00466. Date of Electronic Publication: 2019 Feb 07 (Print Publication: 2019).
Typ publikacji:: Journal Article
MeSH Terms:: Gain of Function Mutation*
Loss of Function Mutation*
Nerve Tissue Proteins/*genetics
Receptors, G-Protein-Coupled/*genetics
Binding Sites ; Calcium/metabolism ; Drug Design ; High-Throughput Nucleotide Sequencing ; Humans ; Ligands ; Mutagenesis ; Mutagenesis, Site-Directed ; Nerve Tissue Proteins/agonists ; Receptors, G-Protein-Coupled/agonists

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Skocz do pozycji: 8.

Tytuł:: Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases.
Autorzy:: Wannick M; Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.
Bezdek S; Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.
Guillen N; Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.
Thieme M; Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.
Meshrkey F; Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.
Mousavi S; Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.
Seeling M; Chair of Genetics Department of Biology University of Erlangen-Nuremberg Erlangen Germany.
Nimmerjahn F; Chair of Genetics Department of Biology University of Erlangen-Nuremberg Erlangen Germany.
Mócsai A; Department of Physiology Semmelweis University School of Medicine MTA-SE 'Lendület' Inflammation Physiology Research Group of the Hungarian Academy of Sciences Semmelweis University Budapest Hungary.
Zillikens D; Center for Research on Inflammation of the Skin (CRIS) University of Lübeck Lübeck Germany.
Sezin T; Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.
Sadik CD; Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.; Center for Research on Inflammation of the Skin (CRIS) University of Lübeck Lübeck Germany.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2018 Nov 08; Vol. 6 (6), pp. e00438. Date of Electronic Publication: 2018 Nov 08 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Acetic Acid/*administration & dosage
Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage
Arthritis, Rheumatoid/*drug therapy
Aza Compounds/*administration & dosage
Pemphigoid, Bullous/*drug therapy
Psoriasis/*drug therapy
Receptors, G-Protein-Coupled/*agonists
Acetic Acid/therapeutic use ; Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Arthritis, Rheumatoid/immunology ; Aza Compounds/therapeutic use ; Disease Models, Animal ; Fatty Acids, Omega-3/metabolism ; Humans ; Imiquimod/immunology ; Mice ; Mice, Inbred C57BL ; Pemphigoid, Bullous/immunology ; Psoriasis/immunology ; Receptors, G-Protein-Coupled/immunology ; Receptors, G-Protein-Coupled/metabolism ; Treatment Outcome

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Skocz do pozycji: 9.

Tytuł:: Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor.
Autorzy:: Valkovic AL; Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Leckey MB; Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Whitehead AR; Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Hossain MA; Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Inoue A; Graduate School of Pharmaceutical Sciences Tohoku University Aoba Miyagi Japan.
Kocan M; Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.
Bathgate RAD; Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia.; Department of Biochemistry and Molecular Biology The University of Melbourne Parkville Victoria Australia.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2018 Sep 24; Vol. 6 (5), pp. e00432. Date of Electronic Publication: 2018 Sep 24 (Print Publication: 2018).
Typ publikacji:: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Energy Transfer*
Bioluminescence Resonance Energy Transfer Techniques/*methods
Biosensing Techniques/*methods
Cyclic AMP/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Receptors, Peptide/*metabolism
Cell Line ; Cell Line, Tumor ; Cytoplasm/metabolism ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Luminescent Proteins/chemistry ; Receptors, G-Protein-Coupled/genetics ; Receptors, Peptide/genetics ; Relaxin/metabolism ; Signal Transduction ; Time Factors

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Skocz do pozycji: 10.

Tytuł:: The G protein-coupled estrogen receptor agonist, G-1, attenuates BK channel activation in cerebral arterial smooth muscle cells.
Autorzy:: Evanson KW; Department of Nutrition, Food, and Exercise Sciences Florida State University Tallahassee Florida.
Goldsmith JA; Department of Nutrition, Food, and Exercise Sciences Florida State University Tallahassee Florida.
Ghosh P; Department of Nutrition, Food, and Exercise Sciences Florida State University Tallahassee Florida.
Delp MD; Department of Nutrition, Food, and Exercise Sciences Florida State University Tallahassee Florida.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2018 Jun 21; Vol. 6 (4), pp. e00409. Date of Electronic Publication: 2018 Jun 21 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cyclopentanes/*pharmacology
Estrogens/*pharmacology
Large-Conductance Calcium-Activated Potassium Channels/*physiology
Myocytes, Smooth Muscle/*drug effects
Quinolines/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Animals ; Cerebral Arteries/cytology ; Female ; Myocytes, Smooth Muscle/physiology ; Rats, Sprague-Dawley ; Receptors, Estrogen/physiology ; Receptors, G-Protein-Coupled/physiology

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