JN: "Journal of pineal research [J Pineal Res] NLMUID: 8504412" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Melatonin inhibits atherosclerosis progression via galectin-3 downregulation to enhance autophagy and inhibit inflammation.
Autorzy:: Wang Z; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Gao Z; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.; Science and Research Department, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zheng Y; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Kou J; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Song D; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yu X; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Dong B; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Chen T; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yang Y; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Gao X; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Wang Q; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Ye T; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yang W; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.; School of Public Health, Qiqihar Medical University, Qiqihar, China.
Zhang X; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Li H; Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Yang L; Department of Pathophysiology, Harbin Medical University (Daqing), Daqing, China.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Apr; Vol. 74 (3), pp. e12855. Date of Electronic Publication: 2023 Feb 02.
Typ publikacji:: Journal Article
MeSH Terms:: Melatonin*/pharmacology
Atherosclerosis*/drug therapy
Atherosclerosis*/genetics
Animals ; Mice ; Galectin 3/genetics ; Galectin 3/metabolism ; Galectin 3/pharmacology ; Down-Regulation ; Signal Transduction ; Phosphatidylinositol 3-Kinases/metabolism ; Inflammation/metabolism ; NF-kappa B/metabolism ; Autophagy ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism

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Skocz do pozycji: 2.

Tytuł:: Ramelteon for delirium prevention in hospitalized patients: An updated meta-analysis and trial sequential analysis of randomized controlled trials.
Autorzy:: Yu CL; Department of Pharmacy, Chang-Gung Memorial Hospital, Linkou, Taiwan.
Carvalho AF; IMPACT (Innovation in Mental and Physical Health and Clinical Treatment) Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, Australia.
Thompson T; Centre for Chronic Illness and Ageing, University of Greenwich, London, UK.
Tsai TC; Department of Pharmacy, Chang-Gung Memorial Hospital, Linkou, Taiwan.
Tseng PT; Prospect Clinic for Otorhinolaryngology & Neurology, Kaohsiung City, Taiwan.; Department of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan.; Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
Tu YK; Institute of Epidemiology & Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.
Yang SN; Department of Psychiatry, National Defense Medical Centre Beitou Branch, Tri-Service General Hospital, Taipei, Taiwan.; Department of Psychiatry, Armed Forces Taoyuan General Hospital, Taoyuan, Taiwan.; Graduate Institute of Health and Welfare Policy, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yang FC; Department of Neurology, National Defense Medical Centre, Tri-Service General Hospital, Taipei, Taiwan.
Chang CH; Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Hsu CW; Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Hsu TW; Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Liang CS; Department of Psychiatry, National Defense Medical Centre Beitou Branch, Tri-Service General Hospital, Taipei, Taiwan.; Department of Psychiatry, National Defense Medical Centre, Taipei, Taiwan.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Apr; Vol. 74 (3), pp. e12857. Date of Electronic Publication: 2023 Feb 08.
Typ publikacji:: Journal Article; Meta-Analysis; Review
MeSH Terms:: Delirium*/prevention & control
Delirium*/drug therapy
Delirium*/epidemiology
Melatonin*/therapeutic use
Humans ; Middle Aged ; Randomized Controlled Trials as Topic ; Reproducibility of Results

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Skocz do pozycji: 3.

Tytuł:: Histone deacetylase 9 regulates disease resistance through fine-tuning histone deacetylation of melatonin biosynthetic genes and melatonin accumulation in cassava.
Autorzy:: Zhao H; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.
Ge Z; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.
Zhou M; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.
Zeng H; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.; Hainan Yazhou Bay Seed Laboratory, Sanya, Hainan Province, China.
Wei Y; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.; Hainan Yazhou Bay Seed Laboratory, Sanya, Hainan Province, China.
Liu G; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.; Hainan Yazhou Bay Seed Laboratory, Sanya, Hainan Province, China.
Yan Y; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.; Hainan Yazhou Bay Seed Laboratory, Sanya, Hainan Province, China.
Reiter RJ; Department of Cellular and Structural Biology, UT Health San Antonio, Long School of Medicine, San Antonio, Texas, USA.
He C; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.; Hainan Yazhou Bay Seed Laboratory, Sanya, Hainan Province, China.
Shi H; Key Laboratory of Biotechnology of Salt Tolerant Crops of Hainan Province, Sanya Nanfan Research Institute-College of Tropical Crops, Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture, Hainan University, Sanya and Haikou, Hainan Province, China.; Hainan Yazhou Bay Seed Laboratory, Sanya, Hainan Province, China.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Apr; Vol. 74 (3), pp. e12861. Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:: Journal Article
MeSH Terms:: Melatonin*/metabolism
Manihot*/genetics
Manihot*/metabolism
Histones/genetics ; Histones/metabolism ; Disease Resistance/genetics ; Epigenesis, Genetic ; Plants/metabolism ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Gene Expression Regulation, Plant

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Skocz do pozycji: 4.

Tytuł:: Melatonin mediates elevated carbon dioxide-induced photosynthesis and thermotolerance in tomato.
Autorzy:: Hasan MK; Hainan Institute, Zhejiang University, Sanya, China.; Department of Horticulture, Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zijingang Campus, Zhejiang University, Hangzhou, China.
Xing QF; Department of Horticulture, Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zijingang Campus, Zhejiang University, Hangzhou, China.
Zhou CY; Department of Horticulture, Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zijingang Campus, Zhejiang University, Hangzhou, China.
Wang KX; Department of Horticulture, Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zijingang Campus, Zhejiang University, Hangzhou, China.
Xu T; Hainan Institute, Zhejiang University, Sanya, China.; Department of Horticulture, Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zijingang Campus, Zhejiang University, Hangzhou, China.
Yang P; Agricultural Experiment Station, Zhejiang University, Hangzhou, China.
Qi ZY; Hainan Institute, Zhejiang University, Sanya, China.; Agricultural Experiment Station, Zhejiang University, Hangzhou, China.
Shao SJ; Department of Horticulture, Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zijingang Campus, Zhejiang University, Hangzhou, China.
Ahammed GJ; College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang, China.; Henan International Joint Laboratory of Stress Resistance Regulation and Safe Production of Protected Vegetables, Henan University of Science and Technology, Luoyang, China.
Zhou J; Hainan Institute, Zhejiang University, Sanya, China.; Department of Horticulture, Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zijingang Campus, Zhejiang University, Hangzhou, China.; Key Laboratory of Horticultural Plants Growth, Development and Quality Improvement, Ministry of Agriculture of China, Hangzhou, China.; Shandong (Linyi) Institute of Modern Agriculture, Zhejiang University, Linyi, China.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Apr; Vol. 74 (3), pp. e12858. Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:: Journal Article
MeSH Terms:: Thermotolerance*
Melatonin*
Solanum lycopersicum*
Carbon Dioxide/metabolism ; Photosynthesis

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Skocz do pozycji: 5.

Tytuł:: Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland.
Autorzy:: Elazary Y; School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel.
Cheow K; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Cheng RK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Molecular and Cell Biology, Singapore.
Ghosh R; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Shainer I; School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel.
Wexler Y; School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel.
Crasta K; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Gothilf Y; School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel.
Jesuthasan SJ; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Institute of Molecular and Cell Biology, Singapore.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Apr; Vol. 74 (3), pp. e12854. Date of Electronic Publication: 2023 Feb 04.
Typ publikacji:: Journal Article
MeSH Terms:: Neuroglia*/cytology
Neuroglia*/metabolism
Photoreceptor Cells, Vertebrate*/metabolism
Photoreceptor Cells, Vertebrate*/physiology
Pineal Gland*/cytology
Pineal Gland*/metabolism
Visual Perception*/genetics
Visual Perception*/physiology
Animals ; Extracellular Vesicles/genetics ; Extracellular Vesicles/metabolism ; Gene Expression ; Melatonin ; Meninges/cytology ; Meninges/physiology ; Photoreceptor Cells/cytology ; Photoreceptor Cells/metabolism ; Rhodopsin/metabolism ; Tetraspanin 30/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism

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Skocz do pozycji: 6.

Tytuł:: Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload.
Autorzy:: Qin X; Xi'an Key Laboratory of Special Medicine and Health Engineering, School of Life Sciences, Northwestern Polytechnical University, Beilin District, Xi'an, Shaanxi, China.
Fu Y; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xincheng District, Xi'an, Shaanxi, China.
Fan J; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xincheng District, Xi'an, Shaanxi, China.
Liu B; Xi'an Key Laboratory of Special Medicine and Health Engineering, School of Life Sciences, Northwestern Polytechnical University, Beilin District, Xi'an, Shaanxi, China.
Liu P; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xincheng District, Xi'an, Shaanxi, China.
Zhang Y; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xincheng District, Xi'an, Shaanxi, China.
Jiang T; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Zheng Q; Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xincheng District, Xi'an, Shaanxi, China.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Apr; Vol. 74 (3), pp. e12851. Date of Electronic Publication: 2023 Jan 23.
Typ publikacji:: Journal Article
MeSH Terms:: Atrial Fibrillation*/genetics
Atrial Fibrillation*/metabolism
Melatonin*/pharmacology
Insulin Resistance*
Mice ; Rats ; Animals ; Proto-Oncogene Proteins c-akt ; Mice, Obese ; Obesity/metabolism ; Lipids

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Skocz do pozycji: 7.

Tytuł:: Daytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students.
Autorzy:: Dunster GP; Department of Biology, University of Washington, Seattle, Washington, USA.
Hua I; Department of Biology, University of Washington, Seattle, Washington, USA.
Grahe A; Department of Biology, University of Washington, Seattle, Washington, USA.
Fleischer JG; Regulatory Biology Laboratory, Salk Institute, La Jolla, California, USA.
Panda S; Regulatory Biology Laboratory, Salk Institute, La Jolla, California, USA.
Wright KP Jr; Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Vetter C; Circadian and Sleep Epidemiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Doherty JH; Department of Biology, University of Washington, Seattle, Washington, USA.
de la Iglesia HO; Department of Biology, University of Washington, Seattle, Washington, USA.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Mar; Vol. 74 (2), pp. e12843. Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:: Journal Article
MeSH Terms:: Circadian Rhythm*
Melatonin*
Humans ; Seasons ; Universities ; Sleep ; Photoperiod ; Students

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Skocz do pozycji: 8.

Tytuł:: Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Autorzy:: Barrea L; Dipartimento di Scienze Umanistiche, Università Telematica Pegaso, Via Porzio, Centro Direzionale, isola F2, Napoli, Italy.; Department of Clinical Medicine and Surgery, Endocrinology Unit, Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), University Medical School of Naples, Naples, Italy.
Verde L; Department of Clinical Medicine and Surgery, Endocrinology Unit, Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), University Medical School of Naples, Naples, Italy.
Vetrani C; Department of Clinical Medicine and Surgery, Endocrinology Unit, Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), University Medical School of Naples, Naples, Italy.; Department of Clinical Medicine and Surgery, Unit of Endocrinology, Federico II University Medical School of Naples, Naples, Italy.
Docimo A; Department of Clinical Medicine and Surgery, Unit of Endocrinology, Federico II University Medical School of Naples, Naples, Italy.
de Alteriis G; Department of Clinical Medicine and Surgery, Unit of Endocrinology, Federico II University Medical School of Naples, Naples, Italy.
Savastano S; Department of Clinical Medicine and Surgery, Endocrinology Unit, Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), University Medical School of Naples, Naples, Italy.; Department of Clinical Medicine and Surgery, Unit of Endocrinology, Federico II University Medical School of Naples, Naples, Italy.
Colao A; Department of Clinical Medicine and Surgery, Endocrinology Unit, Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), University Medical School of Naples, Naples, Italy.; Department of Clinical Medicine and Surgery, Unit of Endocrinology, Federico II University Medical School of Naples, Naples, Italy.; Cattedra Unesco 'Educazione alla salute e allo sviluppo sostenibile', Federico II University, Naples, Italy.
Muscogiuri G; Department of Clinical Medicine and Surgery, Endocrinology Unit, Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), University Medical School of Naples, Naples, Italy.; Department of Clinical Medicine and Surgery, Unit of Endocrinology, Federico II University Medical School of Naples, Naples, Italy.; Cattedra Unesco 'Educazione alla salute e allo sviluppo sostenibile', Federico II University, Naples, Italy.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Mar; Vol. 74 (2), pp. e12844. Date of Electronic Publication: 2022 Dec 05.
Typ publikacji:: Observational Study; Journal Article
MeSH Terms:: Polycystic Ovary Syndrome*/epidemiology
Polycystic Ovary Syndrome*/complications
Melatonin*
Insulin Resistance*
Female ; Humans ; Insulin/metabolism ; Case-Control Studies ; Chronotype ; Obesity/complications ; Testosterone

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Skocz do pozycji: 9.

Tytuł:: A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit.
Autorzy:: Mansilla-Roselló A; General and Digestive Surgery Department, Virgen de las Nieves University Hospital, Granada, Spain.
Hernández-Magdalena J; Department of Pharmacy, Virgen de las Nieves University Hospital, Granada, Spain.
Domínguez-Bastante M; General and Digestive Surgery Department, Virgen de las Nieves University Hospital, Granada, Spain.
Olmedo-Martín C; Experimental Surgery Unit, Virgen de las Nieves University Hospital, Granada, Spain.
Comino-Pardo A; Experimental Surgery Unit, Virgen de las Nieves University Hospital, Granada, Spain.
Escames G; Departamento de Fisiología, Centro de Investigación Biomédica, Instituto de Biotecnología, Facultad de Medicina, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERfes, ISCIII), Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.; Instituto Biosanitario de Granada (Ibs.Granada), Hospital Universitario San Cecilio, Granada, Spain.
Acuña-Castroviejo D; Departamento de Fisiología, Centro de Investigación Biomédica, Instituto de Biotecnología, Facultad de Medicina, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERfes, ISCIII), Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.; Instituto Biosanitario de Granada (Ibs.Granada), Hospital Universitario San Cecilio, Granada, Spain.; UGC de Laboratorios Clínicos, Hospital Universitario San Cecilio, Granada, Spain.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Mar; Vol. 74 (2), pp. e12845. Date of Electronic Publication: 2022 Dec 02.
Typ publikacji:: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article
MeSH Terms:: Melatonin*/therapeutic use
Sepsis*/drug therapy
Humans ; Intensive Care Units ; Double-Blind Method

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Skocz do pozycji: 10.

Tytuł:: The pathway of melatonin biosynthesis in common wheat (Triticum aestivum).
Autorzy:: Chen J; National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, China.; Hubei Hongshan Laboratory, Wuhan, China.
Zhang Y; National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, China.; Hubei Hongshan Laboratory, Wuhan, China.
Yin H; National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, China.; Hubei Hongshan Laboratory, Wuhan, China.
Liu W; National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, China.; Hubei Hongshan Laboratory, Wuhan, China.
Hu X; National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, China.; Hubei Hongshan Laboratory, Wuhan, China.
Li D; National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, China.
Lan C; Hubei Hongshan Laboratory, Wuhan, China.
Gao L; Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
He Z; Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Cui F; Wheat Molecular Breeding Innovation Research Group, Key Laboratory of Molecular Module-Based Breeding of High Yield and Abiotic Resistant Plants in Universities of Shandong, School of Agriculture, Ludong University, Yantai, China.
Fernie AR; Max-Planck-Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
Chen W; National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, China.; Hubei Hongshan Laboratory, Wuhan, China.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Mar; Vol. 74 (2), pp. e12841. Date of Electronic Publication: 2022 Dec 12.
Typ publikacji:: Journal Article
MeSH Terms:: Melatonin*/metabolism
Animals ; Triticum/genetics ; Triticum/metabolism ; Serotonin/metabolism ; Genome-Wide Association Study ; Tryptamines ; Plants/metabolism ; Tryptophan/metabolism

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Skocz do pozycji: 11.

Tytuł:: Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors.
Autorzy:: Maity J; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, Kolkata, India.
Dey T; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, Kolkata, India.
Banerjee A; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, Kolkata, India.
Chattopadhyay A; Department of Physiology, Vidyasagar College, Kolkata, India.
Das AR; Department of Chemistry, University of Calcutta, Kolkata, India.
Bandyopadhyay D; Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, Kolkata, India.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Mar; Vol. 74 (2), pp. e12847. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Melatonin*/pharmacology
Melatonin*/therapeutic use
Plaque, Atherosclerotic*/drug therapy
Diabetes Mellitus, Type 2*/drug therapy
Myocardial Infarction*/drug therapy
Humans ; Obesity/complications ; Obesity/drug therapy ; Antioxidants/pharmacology ; Oxidative Stress ; Apoptosis ; Cholesterol/metabolism ; Cholesterol/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Macrophages/metabolism

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Skocz do pozycji: 12.

Tytuł:: Continuous light exposure influences luteinization and luteal function of ovary in ICR mice.
Autorzy:: Li XL; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Zhu HJ; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Zhang Q; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Li YS; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Li YC; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Feng X; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Yuan RY; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Sha QQ; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.; Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Guangdong Second Provincial General Hospital, Guangzhou, China.; Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Ma JY; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.; Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Guangdong Second Provincial General Hospital, Guangzhou, China.; Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Luo SM; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.; Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Guangdong Second Provincial General Hospital, Guangzhou, China.; Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Sun QY; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.; Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Guangdong Second Provincial General Hospital, Guangzhou, China.; Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Chen LN; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.; Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Guangdong Second Provincial General Hospital, Guangzhou, China.; Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Ou XH; Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.; Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Guangdong Second Provincial General Hospital, Guangzhou, China.; Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Mar; Vol. 74 (2), pp. e12846. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:: Journal Article
MeSH Terms:: Ovary*/metabolism
Melatonin*/pharmacology
Melatonin*/metabolism
Female ; Pregnancy ; Mice ; Animals ; Mice, Inbred ICR ; Corpus Luteum/metabolism ; Progesterone/metabolism ; Luteinization

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Skocz do pozycji: 13.

Tytuł:: ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites.
Autorzy:: Álvarez-Fernández L; Department of Biomedical Sciences-Physiology, Animal Health Institute (INDEGSAL), Faculty of Veterinary Medicine, Universidad de León, León, Spain.
Gomez-Gomez A; Applied Metabolomics Research Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
Haro N; Applied Metabolomics Research Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
García-Lino AM; Department of Biomedical Sciences-Physiology, Animal Health Institute (INDEGSAL), Faculty of Veterinary Medicine, Universidad de León, León, Spain.
Álvarez AI; Department of Biomedical Sciences-Physiology, Animal Health Institute (INDEGSAL), Faculty of Veterinary Medicine, Universidad de León, León, Spain.
Pozo OJ; Applied Metabolomics Research Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
Merino G; Department of Biomedical Sciences-Physiology, Animal Health Institute (INDEGSAL), Faculty of Veterinary Medicine, Universidad de León, León, Spain.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Mar; Vol. 74 (2), pp. e12849. Date of Electronic Publication: 2022 Dec 31.
Typ publikacji:: Journal Article
MeSH Terms:: Lactation*/metabolism
Melatonin*
Female ; Mice ; Animals ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Tissue Distribution ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Mice, Knockout

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Skocz do pozycji: 14.

Tytuł:: Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses.
Autorzy:: Gao Y; National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, P. R. China.
Chen H; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China.
Chen D; National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, P. R. China.
Hao G; National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, P. R. China.; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Mar; Vol. 74 (2), pp. e12850. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Melatonin*/metabolism
Phylogeny ; Plant Development ; Plants/metabolism ; Signal Transduction/genetics ; Gene Expression Regulation, Plant ; Stress, Physiological

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Skocz do pozycji: 15.

Tytuł:: Melatonin functions as a broad-spectrum antifungal by targeting a conserved pathogen protein kinase.
Autorzy:: Li R; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.
Bi R; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.
Cai H; College of Science, Huazhong Agricultural University, Wuhan, China.
Zhao J; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.
Sun P; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.
Xu W; College of Science, Huazhong Agricultural University, Wuhan, China.
Zhou Y; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.
Yang W; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.
Zheng L; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.
Chen XL; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.
Wang G; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, China.
Wang D; Ministry of Agriculture Key Laboratory for Crop Pest Monitoring and Green Control, China Agricultural University, Beijing, China.; State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Liu J; Ministry of Agriculture Key Laboratory for Crop Pest Monitoring and Green Control, China Agricultural University, Beijing, China.; State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Teng H; College of Science, Huazhong Agricultural University, Wuhan, China.
Li G; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, The Center of Crop Nanobiotechnology, The Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Jan; Vol. 74 (1), pp. e12839. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:: Journal Article
MeSH Terms:: Melatonin*
Oryza*
Antifungal Agents/pharmacology ; Protein Kinases ; Phosphorylation ; Plants ; Plant Diseases/microbiology

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Skocz do pozycji: 16.

Tytuł:: Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs.
Autorzy:: Park S; Department of Plant and Biomaterials Science, Gyeongsang National University, Jinju, Republic of Korea.
Ham J; Institute of Animal Molecular Biotechnology and Department of Biotechnology, Korea University, Seoul, Republic of Korea.
Yang C; Institute of Animal Molecular Biotechnology and Department of Biotechnology, Korea University, Seoul, Republic of Korea.
Park W; Institute of Animal Molecular Biotechnology and Department of Biotechnology, Korea University, Seoul, Republic of Korea.
Park H; Institute of Animal Molecular Biotechnology and Department of Biotechnology, Korea University, Seoul, Republic of Korea.
An G; Institute of Animal Molecular Biotechnology and Department of Biotechnology, Korea University, Seoul, Republic of Korea.
Song J; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, Republic of Korea.
Hong T; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, Republic of Korea.
Park SJ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kim HS; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Song G; Institute of Animal Molecular Biotechnology and Department of Biotechnology, Korea University, Seoul, Republic of Korea.
Lim W; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, Republic of Korea.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Jan; Vol. 74 (1), pp. e12842. Date of Electronic Publication: 2022 Nov 27.
Typ publikacji:: Journal Article
MeSH Terms:: Endometriosis*/drug therapy
Endometriosis*/metabolism
Endometriosis*/pathology
Melatonin*/metabolism
Animals ; Female ; Mice ; Cell Proliferation ; Endometrium/metabolism ; Endometrium/pathology ; Mitochondria/metabolism ; Phosphatidylinositol 3-Kinases/metabolism

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Skocz do pozycji: 17.

Tytuł:: Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure.
Autorzy:: Hirayama J; Department of Clinical Engineering, Faculty of Health Sciences & Division of Health Sciences, Graduate School of Sustainable Systems Science, Komatsu University, Komatsu, Japan.
Hattori A; Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan.
Takahashi A; Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Furusawa Y; Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan.
Tabuchi Y; Life Science Research Center, University of Toyama, Toyama, Japan.
Shibata M; Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan.
Nagamatsu A; Japan Aerospace Exploration Agency, Tsukuba, Japan.
Yano S; Japan Aerospace Exploration Agency, Tsukuba, Japan.
Maruyama Y; Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan.
Matsubara H; Noto Center for Fisheries Science and Technology, Kanazawa University, Noto-cho, Ishikawa, Japan.
Sekiguchi T; Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan.
Suzuki N; Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Jan; Vol. 74 (1), pp. e12834. Date of Electronic Publication: 2022 Oct 17.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Melatonin*/pharmacology
Melatonin*/physiology
Circadian Clocks*
Space Flight*
Chronobiology Disorders*
Radiation Injuries*
Humans ; Circadian Rhythm/physiology

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Skocz do pozycji: 18.

Tytuł:: N-Acetylserotonin is an oxidation-responsive activator of Nrf2 ameliorating colitis in rats.
Autorzy:: Kang C; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Jeong S; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Kim J; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Ju S; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Im E; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Heo G; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Park S; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Yoo JW; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Lee J; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Yoon IS; College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Jung Y; College of Pharmacy, Pusan National University, Busan, Republic of Korea.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Jan; Vol. 74 (1), pp. e12835. Date of Electronic Publication: 2022 Oct 17.
Typ publikacji:: Journal Article
MeSH Terms:: Melatonin*/pharmacology
Melatonin*/therapeutic use
Colitis*/chemically induced
Colitis*/drug therapy
Colitis*/metabolism
Rats ; Animals ; NF-E2-Related Factor 2/metabolism ; Heme Oxygenase-1/metabolism ; Anti-Inflammatory Agents/therapeutic use

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Skocz do pozycji: 19.

Tytuł:: Quality-of-life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double-blind, randomized, placebo-controlled trial.
Autorzy:: Zetner D; Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.; Department of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen Ø, Denmark.
Kamby C; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen Ø, Denmark.
Gülen S; Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Christophersen C; Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Paulsen CB; Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Piga E; Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Hoffmeyer B; Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Mahmood F; Department of Oncology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Rosenberg J; Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Jan; Vol. 74 (1), pp. e12840. Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:: Randomized Controlled Trial; Journal Article
MeSH Terms:: Melatonin*/therapeutic use
Breast Neoplasms*/radiotherapy
Dermatitis*
Humans ; Female ; Quality of Life ; Double-Blind Method

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Skocz do pozycji: 20.

Tytuł:: Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV).
Autorzy:: Redman KN; Wits Sleep Laboratory, Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
O'Brien KE; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK.
Ruiz FS; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK.
Rae DE; Department of Human Biology, Health through Physical Activity, Lifestyle and Sport Research Centre & Division of Physiological Science, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Gómez-Olivé FX; Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
von Schantz M; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK.; Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UK.
Scheuermaier K; Wits Sleep Laboratory, Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Pokaż więcej
Źródło:: Journal of pineal research [J Pineal Res] 2023 Jan; Vol. 74 (1), pp. e12838. Date of Electronic Publication: 2022 Nov 06.
Typ publikacji:: Journal Article
MeSH Terms:: Melatonin*
HIV Infections*/epidemiology
Humans ; Aged ; Middle Aged ; Aged, 80 and over ; Longitudinal Studies ; HIV ; African People ; Circadian Rhythm

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