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Wyszukujesz frazę ""Kümler, I."" wg kryterium: Autor


Tytuł :
Oral administration of irinotecan in patients with solid tumors: an open-label, phase I, dose escalating study evaluating safety, tolerability and pharmacokinetics
Autorzy :
Kümler, I.
Sørensen, P. Grundtvig
Palshof, J.
Høgdall, E.
Skovrider-Ruminski, W.
Theile, S.
Fullerton, A.
Nielsen, P. G.
Jensen, B. Vittrup
Nielsen, D. L.
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Temat :
Dose finding
Original Article
Oral irinotecan
Clinical Trial, Phase I
Phase I
Journal Article
Research Support, Non-U.S. Gov't
Źródło :
Kümler, I, Sørensen, P G, Palshof, J, Høgdall, E, Skovrider-Ruminski, W, Theile, S, Fullerton, A, Nielsen, P G, Jensen, B V & Nielsen, D L 2019, ' Oral administration of irinotecan in patients with solid tumors : an open-label, phase I, dose escalating study evaluating safety, tolerability and pharmacokinetics ', Cancer Chemotherapy and Pharmacology, vol. 83, no. 1, pp. 169-178 . https://doi.org/10.1007/s00280-018-3720-7
Cancer Chemotherapy and Pharmacology
Opis pliku :
application/pdf
Tytuł :
Prognostic and Clinicopathologic Associations of LAG-3 Expression in Triple-negative Breast Cancer.
Autorzy :
Stovgaard ES; Departments of Pathology Oncology, Herlev and Gentofte Hospital, Herlev Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
Kümler I
List-Jensen K
Roslind A
Christensen IJ
Høgdall E
Nielsen D
Balslev E
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Źródło :
Applied immunohistochemistry & molecular morphology : AIMM [Appl Immunohistochem Mol Morphol] 2021 Jun 03. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase I gene.
Autorzy :
Kümler I; Department of Oncology, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark. .
Balslev E; Department of Pathology, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark.
Stenvang J; Institut for Lægemiddeldesign og Farmakologi, Jagtvej 160, 2100, København Ø, Denmark.
Brünner N; Institut for Lægemiddeldesign og Farmakologi, Jagtvej 160, 2100, København Ø, Denmark.
Ejlertsen B; Department of Oncology, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Jakobsen EH; Department of Oncology, Vejle Sygehus, Beriderbakken 4, DK-7100, Vejle, Denmark.
Nielsen DL; Department of Oncology, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark.
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Źródło :
BMC cancer [BMC Cancer] 2019 Jun 13; Vol. 19 (1), pp. 573. Date of Electronic Publication: 2019 Jun 13.
Typ publikacji :
Clinical Trial, Phase II; Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Breast Neoplasms/*drug therapy
DNA Topoisomerases, Type I/*genetics
Irinotecan/*therapeutic use
Topoisomerase I Inhibitors/*therapeutic use
Trastuzumab/*therapeutic use
Aged ; Biomarkers, Pharmacological ; Breast Neoplasms/diagnosis ; Drug Therapy, Combination ; Female ; Gene Dosage ; Humans ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Receptor, ErbB-2/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Expression Patterns of Biomarkers in Primary Tumors and Corresponding Metastases in Breast Cancer.
Autorzy :
Kümler I; Department of Oncology, Herlev Hospital, Herlev Ringvej, Herlev, Denmark.
Balslev E
Knop AS
Brünner N
Klausen TW
Jespersen SS
Nielsen SL
Nielsen DL
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Źródło :
Applied immunohistochemistry & molecular morphology : AIMM [Appl Immunohistochem Mol Morphol] 2018 Jan; Vol. 26 (1), pp. 13-19.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Profiling*
Biomarkers, Tumor/*genetics
Breast Neoplasms/*genetics
Anthracyclines/pharmacology ; Anthracyclines/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/physiopathology ; Endocrine Gland Neoplasms/drug therapy ; Endocrine Gland Neoplasms/genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans
Czasopismo naukowe
Tytuł :
Specific CDK4/6 inhibition in breast cancer: a systematic review of current clinical evidence.
Autorzy :
Polk A; Department of Oncology, Herlev and Gentofte Hospital, Herlev Denmark. Electronic address: .
Kolmos IL; Department of Oncology, Herlev and Gentofte Hospital, Herlev Denmark.
Kümler I; Department of Oncology, Herlev and Gentofte Hospital, Herlev Denmark.
Nielsen DL; Department of Oncology, Herlev and Gentofte Hospital, Herlev Denmark.
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Źródło :
ESMO open [ESMO Open] 2017 Jan 23; Vol. 1 (6), pp. e000093. Date of Electronic Publication: 2017 Jan 23 (Print Publication: 2016).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Review of hormone-based treatments in postmenopausal patients with advanced breast cancer focusing on aromatase inhibitors and fulvestrant.
Autorzy :
Kümler I; Department of Oncology , Herlev Hospital, University of Copenhagen , Herlev , Denmark.
Knoop AS; Department of Oncology , Finsen Centre, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.
Jessing CA; Department of Oncology , Herlev Hospital, University of Copenhagen , Herlev , Denmark.
Ejlertsen B; Department of Oncology , Finsen Centre, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.
Nielsen DL; Department of Oncology , Herlev Hospital, University of Copenhagen , Herlev , Denmark.
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Źródło :
ESMO open [ESMO Open] 2016 Aug 16; Vol. 1 (4), pp. e000062. Date of Electronic Publication: 2016 Aug 16 (Print Publication: 2016).
Typ publikacji :
Review; Journal Article
Czasopismo naukowe
Tytuł :
Topoisomerase-1 gene copy aberrations are frequent in patients with breast cancer.
Autorzy :
Kümler I; Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Balslev E; Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Poulsen TS; Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Nielsen SL; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Nygård SB; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Rømer MU; Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.
Christensen IJ; The Finsen Laboratory, Rigshospitalet and Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark.
Høgdall E; Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Moreira J; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Nielsen DL; Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Brünner N; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Stenvang J; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
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Źródło :
International journal of cancer [Int J Cancer] 2015 Oct 15; Vol. 137 (8), pp. 2000-6. Date of Electronic Publication: 2015 Apr 27.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*enzymology
Breast Neoplasms/*genetics
Chromosomes, Human, Pair 20/*genetics
DNA Topoisomerases, Type I/*genetics
Breast Neoplasms/pathology ; Centromere/genetics ; Cohort Studies ; Female ; Gene Amplification ; Gene Dosage ; Humans ; In Situ Hybridization, Fluorescence ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer.
Autorzy :
Kümler I; Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730, Herlev, Denmark, Iben.Kumler@regionh.dk.
Parner VK
Tuxen MK
Skjoldbye B
Bergenfeldt M
Nelausen KM
Nielsen DL
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Źródło :
La Radiologia medica [Radiol Med] 2015 Jun; Vol. 120 (6), pp. 536-41. Date of Electronic Publication: 2015 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Catheter Ablation*
Breast Neoplasms/*pathology
Liver Neoplasms/*secondary
Liver Neoplasms/*therapy
Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol.
Autorzy :
Kümler I; Department of Oncology, Herlev University Hospital, Copenhagen, Denmark. iben.kumler@regionh.dk.
Balslev E; Department of Pathology, Herlev University Hospital, Copenhagen, Denmark. .
Stenvang J; Department of Veterinary Disease Biology, University of Copenhagen, Copenhagen, Denmark. .
Brünner N; Department of Veterinary Disease Biology, University of Copenhagen, Copenhagen, Denmark. .
Nielsen D; Department of Oncology, Herlev University Hospital, Copenhagen, Denmark. .
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Źródło :
BMC cancer [BMC Cancer] 2015 Feb 21; Vol. 15, pp. 78. Date of Electronic Publication: 2015 Feb 21.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Breast Neoplasms/*drug therapy
Camptothecin/*analogs & derivatives
DNA Topoisomerases, Type I/*genetics
Topoisomerase I Inhibitors/*administration & dosage
Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Camptothecin/administration & dosage ; Camptothecin/therapeutic use ; Drug Administration Schedule ; Female ; Genetic Markers/genetics ; Humans ; Irinotecan ; Neoplasm Metastasis ; Prospective Studies ; Receptor, ErbB-2/genetics ; Topoisomerase I Inhibitors/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Drug transporters in breast cancer: response to anthracyclines and taxanes.
Autorzy :
Kümler I; a ¹ Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
Stenvang J
Moreira J
Brünner N
Nielsen DL
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Źródło :
Expert review of anticancer therapy [Expert Rev Anticancer Ther] 2015; Vol. 15 (9), pp. 1075-92.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anthracyclines/*pharmacology
Breast Neoplasms/*drug therapy
Taxoids/*pharmacology
ATP-Binding Cassette Transporters/metabolism ; Anthracyclines/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/pathology ; Drug Resistance, Neoplasm ; Female ; Humans ; Molecular Targeted Therapy ; Taxoids/therapeutic use
Czasopismo naukowe
Tytuł :
A systematic review of bevacizumab efficacy in breast cancer.
Autorzy :
Kümler I; Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark. Electronic address: iben.kumler@regionh.dk.
Christiansen OG; Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark. Electronic address: .
Nielsen DL; Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark. Electronic address: .
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Źródło :
Cancer treatment reviews [Cancer Treat Rev] 2014 Sep; Vol. 40 (8), pp. 960-73. Date of Electronic Publication: 2014 May 22.
Typ publikacji :
Journal Article; Review; Systematic Review
MeSH Terms :
Angiogenesis Inhibitors/*therapeutic use
Antibodies, Monoclonal, Humanized/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Breast Neoplasms/*blood supply
Breast Neoplasms/*drug therapy
Angiogenesis Inhibitors/administration & dosage ; Antibodies, Monoclonal, Humanized/administration & dosage ; Bevacizumab ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Female ; Humans ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
A systematic review of dual targeting in HER2-positive breast cancer.
Autorzy :
Kümler I; Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark. Electronic address: Iben.Kumler@regionh.dk.
Tuxen MK
Nielsen DL
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Źródło :
Cancer treatment reviews [Cancer Treat Rev] 2014 Mar; Vol. 40 (2), pp. 259-70. Date of Electronic Publication: 2013 Sep 11.
Typ publikacji :
Journal Article; Review; Systematic Review
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Breast Neoplasms/*drug therapy
Breast Neoplasms/*metabolism
Molecular Targeted Therapy/*methods
Receptor, ErbB-2/*antagonists & inhibitors
Receptor, ErbB-2/*metabolism
Ado-Trastuzumab Emtansine ; Afatinib ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/pathology ; Clinical Trials as Topic ; Disease-Free Survival ; Everolimus ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lapatinib ; Maytansine/administration & dosage ; Maytansine/analogs & derivatives ; Neoadjuvant Therapy/methods ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Quinazolines/administration & dosage ; Quinolines/administration & dosage ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Trastuzumab ; Treatment Outcome ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy: a novel strategy in drug development.
Autorzy :
Stenvang J; Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Section for Molecular Disease Biology and Sino-Danish Breast Cancer Research Centre, University of Copenhagen , Copenhagen , Denmark ; Danish Centre for Translational Breast Cancer Research , Copenhagen , Denmark.
Kümler I; Department of Oncology, Center for Cancer Research, Herlev Hospital, University of Copenhagen , Copenhagen , Denmark.
Nygård SB; Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Section for Molecular Disease Biology and Sino-Danish Breast Cancer Research Centre, University of Copenhagen , Copenhagen , Denmark.
Smith DH; Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Section for Molecular Disease Biology and Sino-Danish Breast Cancer Research Centre, University of Copenhagen , Copenhagen , Denmark ; DAKO A/S , Glostrup , Denmark.
Nielsen D; Department of Oncology, Center for Cancer Research, Herlev Hospital, University of Copenhagen , Copenhagen , Denmark.
Brünner N; Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Section for Molecular Disease Biology and Sino-Danish Breast Cancer Research Centre, University of Copenhagen , Copenhagen , Denmark ; Danish Centre for Translational Breast Cancer Research , Copenhagen , Denmark.
Moreira JM; Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Section for Molecular Disease Biology and Sino-Danish Breast Cancer Research Centre, University of Copenhagen , Copenhagen , Denmark ; Danish Centre for Translational Breast Cancer Research , Copenhagen , Denmark.
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Źródło :
Frontiers in oncology [Front Oncol] 2013 Dec 25; Vol. 3, pp. 313. Date of Electronic Publication: 2013 Dec 25.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe

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