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Tytuł :
Altered NK-cell compartment and dysfunctional NKG2D/NKG2D-ligand axis in patients with ataxia-telangiectasia.
Autorzy :
Desimio MG; Research Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Finocchi A; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Di Matteo G; Research Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Di Cesare S; Research Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Giancotta C; Research Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Conti F; Research Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Chessa L; Fondazione Università La Sapienza, Rome, Italy.
Piane M; Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Montin D; Pediatric Immunology and Rheumatology, Regina Margherita Children's Hospital, Turin, Italy.
Dellepiane M; Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Rossi P; Research Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Cancrini C; Research Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Doria M; Research Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2021 Sep; Vol. 230, pp. 108802. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ataxia Telangiectasia/*immunology
Killer Cells, Natural/*immunology
NK Cell Lectin-Like Receptor Subfamily K/*immunology
Adolescent ; Ataxia Telangiectasia/genetics ; Ataxia Telangiectasia/metabolism ; Case-Control Studies ; Cell Line ; Child ; Cytotoxicity, Immunologic ; Down-Regulation ; Female ; Flow Cytometry ; GPI-Linked Proteins/blood ; Histocompatibility Antigens Class I/blood ; Humans ; Intercellular Signaling Peptides and Proteins/blood ; Intracellular Signaling Peptides and Proteins/blood ; K562 Cells ; Killer Cells, Natural/metabolism ; Ligands ; Male ; NK Cell Lectin-Like Receptor Subfamily K/genetics ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Phenotype ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Novel germline mutation KMT2A G3131S confers genetic susceptibility to familial myeloproliferative neoplasms.
Autorzy :
Yin L; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Xie S; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Chen Y; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Li W; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Jiang X; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Li H; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Li J; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Wu Z; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Xiao X; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Zhang G; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Cheng Z; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China. .; Institute of Molecular Hematology, Central South University, Changsha, People's Republic of China. .
Peng H; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China. .; Institute of Molecular Hematology, Central South University, Changsha, People's Republic of China. .; Hunan Key Laboratory of Tumor Models and Individualized Medicine, Changsha, Hunan, 410011, People's Republic of China. .
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Źródło :
Annals of hematology [Ann Hematol] 2021 Sep; Vol. 100 (9), pp. 2229-2240. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article
MeSH Terms :
Germ-Line Mutation*
Histone-Lysine N-Methyltransferase/*genetics
Myeloid-Lymphoid Leukemia Protein/*genetics
Myeloproliferative Disorders/*genetics
Apoptosis ; Cell Proliferation ; Female ; Genetic Predisposition to Disease ; Humans ; K562 Cells ; Male ; Middle Aged ; Myeloproliferative Disorders/congenital ; Pedigree ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Direct Synthesis of Polyaromatic Cyclophanes Containing Bis-Methylene-Interrupted Z -Double Bonds and Study of Their Antitumor Activity In Vitro.
Autorzy :
D'yakonov VA; Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Pr. Oktyabrya 141, 450075 Ufa, Russia.
Islamov II; Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Pr. Oktyabrya 141, 450075 Ufa, Russia.
Dzhemileva LU; Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Pr. Oktyabrya 141, 450075 Ufa, Russia.
Makarova EK; Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Pr. Oktyabrya 141, 450075 Ufa, Russia.
Dzhemilev UM; Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Pr. Oktyabrya 141, 450075 Ufa, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 16; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Ethers, Cyclic/*chemical synthesis
Organometallic Compounds/*chemistry
Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cycloaddition Reaction ; Ethers, Cyclic/chemistry ; Ethers, Cyclic/pharmacology ; Flow Cytometry ; HL-60 Cells ; Humans ; Jurkat Cells ; K562 Cells ; Molecular Structure
Czasopismo naukowe
Tytuł :
Identification of the transcription factor MAZ as a regulator of erythropoiesis.
Autorzy :
Deen D; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom.
Butter F; Institute of Molecular Biology, Mainz, Germany.
Daniels DE; School of Biochemistry, University of Bristol, Bristol, United Kingdom.
Ferrer-Vicens I; School of Biochemistry, University of Bristol, Bristol, United Kingdom.
Ferguson DCJ; School of Biochemistry, University of Bristol, Bristol, United Kingdom.
Holland ML; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom.
Samara V; MRC Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; and.
Sloane-Stanley JA; MRC Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; and.
Ayyub H; MRC Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; and.
Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Frayne J; School of Biochemistry, University of Bristol, Bristol, United Kingdom.
Garrick D; MRC Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; and.
Vernimmen D; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom.
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Źródło :
Blood advances [Blood Adv] 2021 Aug 10; Vol. 5 (15), pp. 3002-3015.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Erythropoiesis*/genetics
Transcription Factors*/genetics
Transcription Factors*/metabolism
Erythroid Cells/metabolism ; Gene Expression Regulation ; Humans ; K562 Cells ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin.
Autorzy :
Abdelrahman S; Laboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
Alghrably M; Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Campagna M; Department of Medical Sciences and Public Health, University of Cagliari, Policlinico Universitario, 09124 Cagliari, Italy.
Hauser CAE; Laboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
Jaremko M; Laboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
Lachowicz JI; Department of Medical Sciences and Public Health, University of Cagliari, Policlinico Universitario, 09124 Cagliari, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 05; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Coordination Complexes/*chemistry
Copper/*chemistry
Metformin/*chemistry
Cell Survival/drug effects ; Glutathione/chemistry ; Humans ; K562 Cells ; Metformin/pharmacology
Czasopismo naukowe
Tytuł :
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo.
Autorzy :
Žumer K; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Faßberg 11, 37077 Göttingen, Germany.
Maier KC; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Faßberg 11, 37077 Göttingen, Germany.
Farnung L; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Faßberg 11, 37077 Göttingen, Germany.
Jaeger MG; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT 25.3, 1090 Vienna, Austria.
Rus P; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Faßberg 11, 37077 Göttingen, Germany.
Winter G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT 25.3, 1090 Vienna, Austria.
Cramer P; Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Faßberg 11, 37077 Göttingen, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Aug 05; Vol. 81 (15), pp. 3096-3109.e8. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA/*biosynthesis
RNA Polymerase II/*metabolism
Transcription Factors/*metabolism
Humans ; K562 Cells ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; RNA Polymerase II/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
[Effect of Petroleum Ether Extract of Rhizoma Amorphophalli on Biological Characteristics of K562 Cells and Its Mechanism].
Autorzy :
Yu XL; Institute of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006,Zhejiang Province, China.
Zhao YN; Institute of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006,Zhejiang Province, China.
Yin LM; Institute of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006,Zhejiang Province, China.
Gao RL; Institute of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006,Zhejiang Province, China.
Pan L; Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006,Zhejiang Province, China.
DU WX; Key Laboratory of Bone Arthromyodynia, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006,Zhejiang Province, China,Email: .
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Aug; Vol. 29 (4), pp. 1028-1033.
Typ publikacji :
Journal Article
MeSH Terms :
Petroleum*
Alkanes ; Apoptosis ; Cell Proliferation ; Humans ; K562 Cells ; Plant Extracts/pharmacology
Czasopismo naukowe
Tytuł :
Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR-FlowFISH.
Autorzy :
Reilly SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Center for System Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. .
Gosai SJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for System Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Harvard Graduate Program in Biological and Biomedical Science, Boston, MA, USA.
Gutierrez A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mackay-Smith A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Graduate Program in Biological and Biomedical Science, Boston, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Kanai M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.
Mouri K; The Jackson Laboratory, Bar Harbor, ME, USA.
Berenzy D; The Jackson Laboratory, Bar Harbor, ME, USA.
Kales S; The Jackson Laboratory, Bar Harbor, ME, USA.
Butler GM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Gladden-Young A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bhuiyan RM; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, University of Connecticut, Farmington, CT, USA.
Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, University of Connecticut, Farmington, CT, USA.; Institute of Systems Genomics, University of Connecticut, Farmington, CT, USA.
Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Center for System Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD, USA. .; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, MA, USA. .
Tewhey R; The Jackson Laboratory, Bar Harbor, ME, USA. .; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA. .; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA. .
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Źródło :
Nature genetics [Nat Genet] 2021 Aug; Vol. 53 (8), pp. 1166-1176. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Regulatory Sequences, Nucleic Acid*
In Situ Hybridization, Fluorescence/*methods
Adaptor Proteins, Signal Transducing/genetics ; Bayes Theorem ; Clustered Regularly Interspaced Short Palindromic Repeats ; Deoxyribonuclease I/genetics ; Deoxyribonuclease I/metabolism ; Fatty Acid Desaturases/genetics ; Flow Cytometry ; GATA1 Transcription Factor/genetics ; Humans ; K562 Cells ; LIM Domain Proteins/genetics ; Models, Genetic ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins/genetics ; Quantitative Trait Loci ; RNA, Guide
Czasopismo naukowe
Tytuł :
Histone H3K4me1 and H3K27ac play roles in nucleosome eviction and eRNA transcription, respectively, at enhancers.
Autorzy :
Kang Y; Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Korea.
Kim YW; Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Korea.
Kang J; Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Korea.
Kim A; Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Korea.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Aug; Vol. 35 (8), pp. e21781.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*metabolism
Histones/*physiology
Nucleosomes/*metabolism
RNA/*metabolism
Enhancer Elements, Genetic ; Histone Code ; Humans ; K562 Cells ; Methylation ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Missense RHD single nucleotide variants induce weakened D antigen expression by altering splicing and/or protein expression.
Autorzy :
Raud L; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.; Laboratory of Excellence GR-Ex, Paris, France.
Le Tertre M; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.; Laboratory of Excellence GR-Ex, Paris, France.; Service de Génétique Médicale, CHRU Brest, Brest, France.
Vigneron L; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.
Ka C; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.; Laboratory of Excellence GR-Ex, Paris, France.; Service de Génétique Médicale, CHRU Brest, Brest, France.
Richard G; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.; Laboratory of Excellence GR-Ex, Paris, France.
Callebaut I; Sorbonne Université, Muséum National d'Histoire Naturelle, UMR CNRS 7590, Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie (IMPMC), Paris, France.
Chen JM; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.; Laboratory of Excellence GR-Ex, Paris, France.
Férec C; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.; Laboratory of Excellence GR-Ex, Paris, France.; Service de Génétique Médicale, CHRU Brest, Brest, France.
Le Gac G; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.; Laboratory of Excellence GR-Ex, Paris, France.; Service de Génétique Médicale, CHRU Brest, Brest, France.
Fichou Y; Univ Brest, Inserm, EFS, UMR1078, GGB, Brest, France.; Laboratory of Excellence GR-Ex, Paris, France.
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Źródło :
Transfusion [Transfusion] 2021 Aug; Vol. 61 (8), pp. 2468-2476. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation, Missense*
Polymorphism, Single Nucleotide*
Rh-Hr Blood-Group System/*genetics
Gene Expression ; Humans ; K562 Cells ; Models, Molecular ; RNA Splicing ; Rh-Hr Blood-Group System/chemistry
Czasopismo naukowe
Tytuł :
The CD226-ERK1/2-LAMP1 pathway is an important mechanism for Vγ9Vδ2 T cell cytotoxicity against chemotherapy-resistant acute myeloid leukemia blasts and leukemia stem cells.
Autorzy :
Wu K; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, Medical College of Xiamen University, Xiamen, China.
Wang LM; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liu M; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiu Y; Eye Institute and Xiamen Eye Center Affiliated to Xiamen University, Xiamen, China.
Hu Y; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Fu S; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Huang H; Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xu B; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, Medical College of Xiamen University, Xiamen, China.
Xiao H; Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Aug; Vol. 112 (8), pp. 3233-3242. Date of Electronic Publication: 2021 Jul 04.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Antigens, Differentiation, T-Lymphocyte/*metabolism
Leukemia, Myeloid, Acute/*therapy
Lysosome-Associated Membrane Glycoproteins/*metabolism
T-Lymphocytes, Cytotoxic/*transplantation
Animals ; Cytotoxicity, Immunologic ; Female ; HL-60 Cells ; Humans ; Immunotherapy, Adoptive ; K562 Cells ; Leukemia, Myeloid, Acute/immunology ; MAP Kinase Signaling System ; Mice ; T-Lymphocytes, Cytotoxic/immunology ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
VLX1570 induces apoptosis through the generation of ROS and induction of ER stress on leukemia cell lines.
Autorzy :
Kurozumi N; Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan.; Field of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, Japan.
Tsujioka T; Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan.
Ouchida M; Department of Molecular Oncology, Graduate School of Medical, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Sakakibara K; Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan.
Nakahara T; Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan.
Suemori SI; Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan.
Takeuchi M; Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan.
Kitanaka A; Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan.; Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan.
Shibakura M; Field of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, Japan.
Tohyama K; Division of Medical Technology, Kawasaki University of Medical Welfare, Okayama, Japan.; Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Aug; Vol. 112 (8), pp. 3302-3313. Date of Electronic Publication: 2021 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Azepines/*pharmacology
Benzylidene Compounds/*pharmacology
Leukemia, Lymphoid/*metabolism
Leukemia, Myeloid, Acute/*metabolism
Reactive Oxygen Species/*metabolism
Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Endoplasmic Reticulum Stress/drug effects ; Gene Expression Profiling ; Gene Expression Regulation, Leukemic/drug effects ; Gene Regulatory Networks/drug effects ; HL-60 Cells ; Humans ; K562 Cells ; Leukemia, Lymphoid/drug therapy ; Leukemia, Lymphoid/genetics ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics
Czasopismo naukowe
Tytuł :
Identification of Spiro-Fused [3-azabicyclo[3.1.0]hexane]oxindoles as Potential Antitumor Agents: Initial In Vitro Evaluation of Anti-Proliferative Effect and Actin Cytoskeleton Transformation in 3T3 and 3T3-SV40 Fibroblast.
Autorzy :
Knyazev NA; Saint-Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological), 197758 Saint Petersburg, Russia.; Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.
Shmakov SV; Saint Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint Petersburg, Russia.
Pechkovskaya SA; Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.
Filatov AS; Department of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
Stepakov AV; Department of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
Boitsov VM; Saint Petersburg National Research Academic University of the Russian Academy of Sciences, 194021 Saint Petersburg, Russia.; Scientific and Research Centre, Pavlov First Saint Petersburg State Medical University, 197022 Saint Petersburg, Russia.
Filatova NA; Institute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 31; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Journal Article
MeSH Terms :
Actin Cytoskeleton/*drug effects
Antineoplastic Agents/*pharmacology
Cell Proliferation/*drug effects
Oxindoles/*pharmacology
3T3 Cells ; Animals ; Humans ; K562 Cells ; Mice ; Oxindoles/chemistry ; Pyrrolidines/chemistry
Czasopismo naukowe
Tytuł :
The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin.
Autorzy :
Pashkina E; Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya St, 630099 Novosibirsk, Russia.; Department of Clinical Immunology, Novosibirsk State Medical University, 52 Krasny Prospect, 630091 Novosibirsk, Russia.
Aktanova A; Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya St, 630099 Novosibirsk, Russia.
Mirzaeva I; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Lavrentiev Ave, 630090 Novosibirsk, Russia.
Kovalenko E; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Lavrentiev Ave, 630090 Novosibirsk, Russia.
Andrienko I; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Lavrentiev Ave, 630090 Novosibirsk, Russia.
Knauer N; Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya St, 630099 Novosibirsk, Russia.
Pronkina N; Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya St, 630099 Novosibirsk, Russia.
Kozlov V; Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya St, 630099 Novosibirsk, Russia.; Department of Clinical Immunology, Novosibirsk State Medical University, 52 Krasny Prospect, 630091 Novosibirsk, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 08; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Bridged-Ring Compounds/*pharmacology
Carboplatin/*pharmacology
Imidazoles/*pharmacology
Immunologic Factors/*pharmacology
Melanoma, Experimental/*drug therapy
Organoplatinum Compounds/*pharmacology
Pyridines/*pharmacology
Animals ; Female ; Humans ; K562 Cells ; Melanoma, Experimental/immunology ; Melanoma, Experimental/pathology ; Mice
Czasopismo naukowe
Tytuł :
[Autophagy Does Not Contribute to TKI Response in a Imatinib-resistant Chronic Myeloid Leukemia Cell Line].
Autorzy :
Baykal-Köse S; Izmir Biomedicine and Genome Center (IB G), Dokuz Eylul University Health Campus, Inciralti-Balcova, Izmir, 35340 Turkey.; .
Efe H; Dokuz Eylul University, Medical School, Medical Biology Department, Izmir, 35330 Turkey.
Yüce Z; Dokuz Eylul University, Medical School, Medical Biology Department, Izmir, 35330 Turkey.
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Źródło :
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2021 Jul-Aug; Vol. 55 (4), pp. 626-633.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Autophagy ; Humans ; Imatinib Mesylate/pharmacology ; K562 Cells
Czasopismo naukowe
Tytuł :
α-amyrin-loaded nanocapsules produce selective cytotoxic activity in leukemic cells.
Autorzy :
Neto SF; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Prada AL; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Achod LDR; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Torquato HFV; Biochemistry Department, Universidade Federal de São Paulo, Rua Três de Maio 100, São Paulo, SP, CEP 04044-020, Brazil.
Lima CS; Biochemistry Department, Universidade Federal de São Paulo, Rua Três de Maio 100, São Paulo, SP, CEP 04044-020, Brazil.
Paredes-Gamero EJ; Biochemistry Department, Universidade Federal de São Paulo, Rua Três de Maio 100, São Paulo, SP, CEP 04044-020, Brazil; Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Food and Nutrition, Universidade Federal do Mato Grosso do Sul, Av. Costa e Silva, Pioneiros, Campo Grande, MS CEP 79070-900, Brazil.
Silva de Moraes MO; Thematic Microscopy and Nanotechnology Laboratory (LTMN), Instituto Nacional de Pesquisas da Amazônia (INPA), Av. Bem Te ví, 8-406. Petrópolis, Manaus, AM 69067-001, Brazil.
Lima ES; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Sosa EH; Department of Biochemistry & Molecular Biology, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia B3H 4R2, Canada.
de Souza TP; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Amado JRR; Laboratory of Pharmaceutical Technology (LTF), Faculty of Pharmacy, Food and Nutrition, Universidade Federal do Mato Grosso do Sul, Av. Costa e Silva, Pioneiros, Campo Grande, MS CEP 79070-900, Brazil. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jul; Vol. 139, pp. 111656. Date of Electronic Publication: 2021 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia/*drug therapy
Nanocapsules/*chemistry
Pentacyclic Triterpenes/*pharmacology
Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Caproates/pharmacology ; Cell Line, Tumor ; Cells, Cultured ; Humans ; Jurkat Cells ; K562 Cells ; Lactones/pharmacology ; Leukocytes, Mononuclear/drug effects ; Particle Size ; Polymethacrylic Acids/chemistry
Czasopismo naukowe
Tytuł :
Human IL-15 Inhibits NK Cells Specific for Human NK-92 Cells.
Autorzy :
Bergman H; Cell Biology Unit, Faculty of Natural Sciences and Engineering, Åbo Akademi University, Turku, Finland.
Lindqvist C; Cell Biology Unit, Faculty of Natural Sciences and Engineering, Åbo Akademi University, Turku, Finland .
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Źródło :
Anticancer research [Anticancer Res] 2021 Jul; Vol. 41 (7), pp. 3281-3285.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-15/*immunology
Killer Cells, Natural/*immunology
Leukemia/*immunology
Lymphoma/*immunology
CD4-Positive T-Lymphocytes/immunology ; Cell Line ; Cell Line, Tumor ; Cytotoxicity, Immunologic/immunology ; Humans ; Immunotherapy, Adoptive/methods ; Interleukin-2/immunology ; Interleukins/immunology ; K562 Cells ; Leukocytes, Mononuclear/immunology ; Receptors, Chimeric Antigen/immunology
Czasopismo naukowe
Tytuł :
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Autorzy :
Shukla S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Ying W; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Gray F; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Yao Y; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Simes ML; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Zhao Q; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Miao H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Cho HJ; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
González-Alonso P; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Winkler A; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Lund G; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Purohit T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Kim E; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Zhang X; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Ray JM; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
He S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Nikolaidis C; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Ndoj J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Wang J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; MedImmune, LLC, Gaithersburg, MD, USA.
Jaremko Ł; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Jaremko M; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Ryan RJH; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Guzman ML; Division of Hematology and Medical Oncology, Leukemia Program, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, NY, USA.
Grembecka J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. .
Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Jul; Vol. 17 (7), pp. 784-793. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Polycomb Repressive Complex 1/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Cell Differentiation/drug effects ; Dose-Response Relationship, Drug ; Humans ; K562 Cells ; Models, Molecular ; Molecular Structure ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Ubiquitination/drug effects
Czasopismo naukowe
Tytuł :
Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.
Autorzy :
Hübschmann D; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.; Heidelberg Institute of Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.; Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Kleinheinz K; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.
Wagener R; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Düsseldorf, Germany.
Bernhart SH; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
López C; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.
Toprak UH; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sungalee S; EMBL Heidelberg, Genome Biology, Heidelberg, Germany.
Ishaque N; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ-HIPO, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kretzmer H; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Kreuz M; Institute for Medical Informatics Statistics and Epidemiology, Leipzig, Germany.
Waszak SM; EMBL Heidelberg, Genome Biology, Heidelberg, Germany.
Paramasivam N; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
Ammerpohl O; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.
Aukema SM; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany.
Beekman R; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Bergmann AK; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Bieg M; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ-HIPO, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Binder H; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.
Borkhardt A; University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Düsseldorf, Germany.
Borst C; Department of Internal Medicine/Hematology, Friedrich-Ebert-Hospital, Neumünster, Neumünster, Germany.
Brors B; Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bruns P; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carrillo de Santa Pau E; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, Madrid, Spain.
Claviez A; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Doose G; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Haake A; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.
Karsch D; Department for Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Haas S; Department of Internal Medicine/Hematology, Friedrich-Ebert-Hospital, Neumünster, Neumünster, Germany.
Hansmann ML; Senckenberg Institute of Pathology, University of Frankfurt Medical School, Frankfurt am Main, Germany.
Hoell JI; University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Düsseldorf, Germany.
Hovestadt V; Division of Molecular Genetics, German Cancer Consortium (DKFK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Huang B; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; College of Big Data and Internet, Shenzhen Technology University, Shenzhen, China.
Hummel M; Institute of Pathology, Charité - University Medicine Berlin, Berlin, Germany.
Jäger-Schmidt C; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kerssemakers JNA; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Korbel JO; EMBL Heidelberg, Genome Biology, Heidelberg, Germany.
Kube D; Department of Hematology and Oncology, Georg-Augusts-University of Göttingen, Göttingen, Germany.
Lawerenz C; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lenze D; Institute of Pathology, Charité - University Medicine Berlin, Berlin, Germany.
Martens JHA; Department of Molecular Biology, Radboud University, Faculty of Science, Nijmegen, The Netherlands.
Ott G; Department of Clinical Pathology, Robert-Bosch-Hospital and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, Germany.
Radlwimmer B; Division of Molecular Genetics, German Cancer Consortium (DKFK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Reisinger E; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Richter J; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany.
Rico D; Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Rosenstiel P; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Rosenwald A; Institute of Pathology, University of Wuerzburg and Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany.
Schillhabel M; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
Stilgenbauer S; Department for Internal Medicine III, Ulm University, Ulm, Germany.
Stadler PF; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.
Martín-Subero JI; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Szczepanowski M; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany.
Warsow G; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Weniger MA; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School, Essen, Germany.; German Cancer Consortium (DKTK), Essen, Germany.
Zapatka M; Division of Molecular Genetics, German Cancer Consortium (DKFK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Valencia A; Barcelona Supercomputing Centre (BSC), Barcelona, Spain.; ICREA, Barcelona, Spain.
Stunnenberg HG; Department of Molecular Biology, Radboud University, Faculty of Science, Nijmegen, The Netherlands.
Lichter P; Division of Molecular Genetics, German Cancer Consortium (DKFK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Möller P; Institute of Pathology, Medical Faculty of the Ulm University, Ulm, Germany.
Loeffler M; Institute for Medical Informatics Statistics and Epidemiology, Leipzig, Germany.
Eils R; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.
Klapper W; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany.
Hoffmann S; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany.; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Trümper L; Department of Hematology and Oncology, Georg-Augusts-University of Göttingen, Göttingen, Germany.
Küppers R; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School, Essen, Germany. .; German Cancer Consortium (DKTK), Essen, Germany. .
Schlesner M; Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Institute for Informatics, Faculty of Computer Science and Medical Faculty, University of Augsburg, Augsburg, Germany. .
Siebert R; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany. .; Intitute of Human Genetics, Christian-Albrechts-University, Kiel, Germany. .
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Corporate Authors :
ICGC MMML-Seq consortium
ICGC DE-Mining consortium
BLUEPRINT consortium
Źródło :
Leukemia [Leukemia] 2021 Jul; Vol. 35 (7), pp. 2002-2016. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome/*genetics
Germinal Center/*metabolism
Lymphoma, B-Cell/*genetics
Mutation/*genetics
Adult ; B-Lymphocytes/metabolism ; Cell Line ; Cell Line, Tumor ; Genes, Immunoglobulin/genetics ; HeLa Cells ; Hep G2 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunoglobulin Class Switching/genetics ; K562 Cells ; MCF-7 Cells ; Somatic Hypermutation, Immunoglobulin/genetics ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia.
Autorzy :
Emadi A; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA. .; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. .; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA. .
Kapadia B; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, USA.
Bollino D; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Bhandary B; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Baer MR; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Niyongere S; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Strovel ET; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.
Kaizer H; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Chang E; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Choi EY; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Ma X; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Tighe KM; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Carter-Cooper B; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Moses BS; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.; University of Maryland Center for Stem Cell Biology & Regenerative Medicine, Baltimore, MD, USA.
Civin CI; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.; University of Maryland Center for Stem Cell Biology & Regenerative Medicine, Baltimore, MD, USA.; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Mahurkar A; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Institute of Genome Sciences, University of Maryland, Baltimore, MD, USA.
Shetty AC; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Institute of Genome Sciences, University of Maryland, Baltimore, MD, USA.
Gartenhaus RB; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, USA.
Kamangar F; Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, USA.
Lapidus RG; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
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Źródło :
Leukemia [Leukemia] 2021 Jul; Vol. 35 (7), pp. 1907-1924. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antineoplastic Agents/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Leukemia, Myeloid, Acute/*drug therapy
Sulfonamides/*pharmacology
Animals ; Cell Line, Tumor ; Female ; HL-60 Cells ; Humans ; K562 Cells ; Leukemia, Myeloid, Acute/metabolism ; Male ; Mice ; Mice, Inbred NOD ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; U937 Cells
Czasopismo naukowe

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