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Wyszukujesz frazę ""KCNQ1"" wg kryterium: Temat


Tytuł :
[Association of polymorphisms of genes TCF7L2, FABP2, KCNQ1, ADIPOQ with the prognosis of the development of type 2 diabetes mellitus].
Autorzy :
Mel'nikova ES; Research Institute of Internal and Preventive Medicine.
Rymar OD; Research Institute of Internal and Preventive Medicine.
Ivanova AA; Research Institute of Internal and Preventive Medicine.
Mustafina SV; Research Institute of Internal and Preventive Medicine.
Shapkina MJ; Research Institute of Internal and Preventive Medicine.
Bobak M; Department of Epidemiology & Public Health, University College London.
Maljutina SK; Research Institute of Internal and Preventive Medicine.
Voevoda MI; Research Institute of Internal and Preventive Medicine.
Maksimov VN; Research Institute of Internal and Preventive Medicine.
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Źródło :
Terapevticheskii arkhiv [Ter Arkh] 2020 Nov 24; Vol. 92 (10), pp. 40-47. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2*/diagnosis
Diabetes Mellitus, Type 2*/epidemiology
Diabetes Mellitus, Type 2*/genetics
KCNQ1 Potassium Channel*/genetics
Adiponectin ; Case-Control Studies ; Fatty Acid-Binding Proteins ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prognosis ; Prospective Studies ; Transcription Factor 7-Like 2 Protein
Czasopismo naukowe
Tytuł :
The auxiliary subunit KCNE1 regulates KCNQ1 channel response to sustained calcium-dependent PKC activation.
Autorzy :
Xu Parks X; Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States of America.
Qudsi H; Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States of America.
Braun C; Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States of America.
Lopes CMB; Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Aug 24; Vol. 15 (8), pp. e0237591. Date of Electronic Publication: 2020 Aug 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
KCNQ1 Potassium Channel/*metabolism
Myocytes, Cardiac/*metabolism
Potassium Channels, Voltage-Gated/*metabolism
Protein Kinase C/*metabolism
Animals ; Female ; HEK293 Cells ; Humans ; KCNQ1 Potassium Channel/genetics ; Mutation ; Myocytes, Cardiac/cytology ; Potassium Channels, Voltage-Gated/genetics ; Protein Kinase C/genetics ; Rats
Czasopismo naukowe
Tytuł :
KCNQ1 Antibodies for Immunotherapy of Long QT Syndrome Type 2.
Autorzy :
Maguy A; Department of Physiology, University of Bern, Bern, Switzerland.
Kucera JP; Department of Physiology, University of Bern, Bern, Switzerland.
Wepfer JP; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Forest V; l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.
Charpentier F; l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, Nantes, France; l'Institut du Thorax, CHU Nantes, Nantes, France.
Li J; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland; Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: .
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Źródło :
Journal of the American College of Cardiology [J Am Coll Cardiol] 2020 May 05; Vol. 75 (17), pp. 2140-2152.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoantibodies/*blood
Immunotherapy/*methods
KCNQ1 Potassium Channel/*blood
Long QT Syndrome/*blood
Long QT Syndrome/*therapy
Animals ; CHO Cells ; Cells, Cultured ; Cricetinae ; Cricetulus ; HEK293 Cells ; Humans ; KCNQ1 Potassium Channel/chemistry ; KCNQ1 Potassium Channel/immunology ; Long QT Syndrome/immunology ; Membrane Potentials/physiology ; Myocytes, Cardiac/immunology ; Myocytes, Cardiac/metabolism ; Proof of Concept Study ; Protein Structure, Secondary ; Rabbits
Czasopismo naukowe
Tytuł :
4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region.
Autorzy :
Bollmann E; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
Schreiber JA; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany.
Ritter N; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.; DFG Graduate School Chembion, Münster, Germany.
Peischard S; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
Ho HT; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
Wünsch B; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany.; DFG Graduate School Chembion, Münster, Germany.
Strünker T; DFG Graduate School Chembion, Münster, Germany.; Center of Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany.
Meuth S; DFG Graduate School Chembion, Münster, Germany.; Clinic of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Budde T; DFG Graduate School Chembion, Münster, Germany.; Institute of Physiology I, Westfälische Wilhelms-University, Münster, Germany.
Strutz-Seebohm N; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
Seebohm G; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany, .
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2020 Apr 08; Vol. 54 (2), pp. 321-332.
Typ publikacji :
Journal Article
MeSH Terms :
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid/*pharmacology
Action Potentials/*drug effects
KCNQ1 Potassium Channel/*metabolism
Myocytes, Cardiac/*metabolism
Potassium Channels, Voltage-Gated/*metabolism
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid/chemistry ; Allosteric Regulation ; Animals ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Ion Channel Gating/drug effects ; KCNQ1 Potassium Channel/chemistry ; KCNQ1 Potassium Channel/genetics ; Models, Molecular ; Mutation ; Oocytes/metabolism ; Potassium Channels, Voltage-Gated/chemistry ; Potassium Channels, Voltage-Gated/genetics ; Protein Domains ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Structure-function relationship of the slow delayed rectifier channel: impactful questions in 2020 and beyond.
Autorzy :
Tseng GN; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia.
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2020 Feb 01; Vol. 318 (2), pp. H329-H331. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
KCNQ1 Potassium Channel*
Potassium Channels, Voltage-Gated*
Ion Channel Gating ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Decoding KCNH2 variants of unknown significance.
Autorzy :
Vanoye CG; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
George AL Jr; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address: .
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Źródło :
Heart rhythm [Heart Rhythm] 2020 Mar; Vol. 17 (3), pp. 501-502. Date of Electronic Publication: 2019 Oct 05.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
KCNQ1 Potassium Channel*
Potassium Channels*
ERG1 Potassium Channel ; Ethers ; Humans
Raport
Tytuł :
Structural Basis of Human KCNQ1 Modulation and Gating.
Autorzy :
Sun J; Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
MacKinnon R; Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: .
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Źródło :
Cell [Cell] 2020 Jan 23; Vol. 180 (2), pp. 340-347.e9. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
KCNQ1 Potassium Channel/*metabolism
KCNQ1 Potassium Channel/*ultrastructure
Cryoelectron Microscopy ; Humans ; Ion Channel Gating/physiology ; KCNQ1 Potassium Channel/chemistry ; Membrane Potentials/physiology ; Patch-Clamp Techniques ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Potassium Channels, Voltage-Gated/chemistry ; Potassium Channels, Voltage-Gated/metabolism ; Potassium Channels, Voltage-Gated/ultrastructure
Czasopismo naukowe
Tytuł :
A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.
Autorzy :
Hu B; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zeng WP; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.; School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.
Li X; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Al-Sheikh U; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Chen SY; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.; CAS Key Laboratory of Microscale Magnetic Resonance and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui, China.
Ding J; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Źródło :
Channels (Austin, Tex.) [Channels (Austin)] 2019 Dec; Vol. 13 (1), pp. 483-497.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum/*metabolism
KCNQ1 Potassium Channel/*metabolism
Potassium Channels, Voltage-Gated/*chemistry
Potassium Channels, Voltage-Gated/*metabolism
Amino Acid Motifs ; Arginine/metabolism ; Endoplasmic Reticulum/chemistry ; Endoplasmic Reticulum/genetics ; HEK293 Cells ; Humans ; KCNQ1 Potassium Channel/chemistry ; KCNQ1 Potassium Channel/genetics ; Lysine/metabolism ; Potassium Channels, Voltage-Gated/genetics ; Protein Transport
Czasopismo naukowe
Tytuł :
Dexamethasone reduces airway epithelial Cl channels.
Autorzy :
Hynes D; Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.
Harvey BJ; Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland; Centro di Estudios Cientificos CECs, Valdivia, Chile. Electronic address: .
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Źródło :
Steroids [Steroids] 2019 Nov; Vol. 151, pp. 108459. Date of Electronic Publication: 2019 Jul 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chlorides/*metabolism
Dexamethasone/*pharmacology
Epithelial Cells/*drug effects
Epithelial Cells/*metabolism
Intermediate-Conductance Calcium-Activated Potassium Channels/*antagonists & inhibitors
KATP Channels/*antagonists & inhibitors
KCNQ1 Potassium Channel/*antagonists & inhibitors
Bronchi/cytology ; Cell Line ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Colforsin/pharmacology ; Cyclic AMP/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Intermediate-Conductance Calcium-Activated Potassium Channels/metabolism ; KATP Channels/metabolism ; KCNQ1 Potassium Channel/metabolism ; Potassium/metabolism ; Potassium Channel Blockers/pharmacology ; Time Factors
Czasopismo naukowe
Tytuł :
APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival.
Autorzy :
Lee SH; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kang J; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ho A; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Watanabe H; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Bolshakov VY; Department of Psychiatry, McLean Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
Shen J; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Nov 25; Vol. 108 (4), pp. 676-690.e8. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*physiology
Amyloid beta-Protein Precursor/*physiology
Cerebral Cortex/*physiology
Hippocampus/*physiology
Neuronal Plasticity/*physiology
Neurons/*physiology
Animals ; Anthracenes/pharmacology ; Apoptosis/physiology ; Behavior, Animal/physiology ; Cell Survival ; Excitatory Postsynaptic Potentials/physiology ; KCNQ1 Potassium Channel/antagonists & inhibitors ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Upgraded molecular models of the human KCNQ1 potassium channel.
Autorzy :
Kuenze G; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.
Duran AM; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.
Woods H; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.
Brewer KR; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, United States of America.
McDonald EF; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.
Vanoye CG; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
George AL Jr; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Sanders CR; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, United States of America.
Meiler J; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America.
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Źródło :
PloS one [PLoS One] 2019 Sep 13; Vol. 14 (9), pp. e0220415. Date of Electronic Publication: 2019 Sep 13 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
KCNQ1 Potassium Channel/*chemistry
Humans ; Hydrogen Bonding ; KCNQ1 Potassium Channel/genetics ; KCNQ1 Potassium Channel/metabolism ; Lipids/chemistry ; Loss of Function Mutation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity.
Autorzy :
Harkcom WT; Pharmacology Department, Weill Medical College of Cornell University, New York, New York.
Papanikolaou M; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, California.
Kanda V; Pharmacology Department, Weill Medical College of Cornell University, New York, New York.
Crump SM; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, California.
Abbott GW; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, California.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2019 Aug; Vol. 234 (8), pp. 13361-13369. Date of Electronic Publication: 2019 Jan 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
KCNQ1 Potassium Channel/*metabolism
Membrane Proteins/*metabolism
Amino Acid Motifs ; Animals ; CHO Cells ; COS Cells ; Cell Membrane/metabolism ; Chlorocebus aethiops ; Cricetulus ; Female ; Hair Cells, Auditory, Inner/metabolism ; Humans ; KCNQ1 Potassium Channel/chemistry ; KCNQ1 Potassium Channel/genetics ; Mechanotransduction, Cellular/genetics ; Mechanotransduction, Cellular/physiology ; Membrane Potentials ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Mice ; Mutagenesis, Site-Directed ; Oocytes/metabolism ; Patch-Clamp Techniques ; Potassium Channels, Voltage-Gated/chemistry ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Generation of eight human induced pluripotent stem cell (iPSC) lines from familial Long QT Syndrome type 1 (LQT1) patients carrying KCNQ1 c.1697C>A mutation (NUIGi005-A, NUIGi005-B, NUIGi005-C, NUIGi006-A, NUIGi006-B, NUIGi006-C, NUIGi007-A, and NUIGi007-B).
Autorzy :
Ge N; Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI), Galway, Ireland.
Liu M; Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI), Galway, Ireland; Department of Physiology, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Krawczyk J; Department of Haematology, Galway University Hospital, Ireland.
McInerney V; HRB Clinical Research Facility, National University of Ireland (NUI) Galway, Ireland.
Galvin J; Mater Misericordiae University Hospital, Eccles st., Dublin 7, Ireland.
Shen S; Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI), Galway, Ireland. Electronic address: .
O'Brien T; Regenerative Medicine Institute, School of Medicine, National University of Ireland (NUI), Galway, Ireland. Electronic address: .
Prendiville T; National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland. Electronic address: .
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Źródło :
Stem cell research [Stem Cell Res] 2019 Aug; Vol. 39, pp. 101502. Date of Electronic Publication: 2019 Jul 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Induced Pluripotent Stem Cells/*cytology
Induced Pluripotent Stem Cells/*metabolism
KCNQ1 Potassium Channel/*metabolism
Cell Line ; Humans ; KCNQ1 Potassium Channel/genetics ; Long QT Syndrome/genetics ; Long QT Syndrome/metabolism ; Mutation/genetics ; Romano-Ward Syndrome/genetics
Czasopismo naukowe
Tytuł :
Pathogenic mechanism and gene correction for LQTS-causing double mutations in KCNQ1 using a pluripotent stem cell model.
Autorzy :
Wang Z; Heart Center, Peking University People's Hospital, Beijing, China.
Wang L; State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, China.
Liu W; Heart Center, Peking University People's Hospital, Beijing, China.
Hu D; Heart Center, Peking University People's Hospital, Beijing, China.
Gao Y; Heart Center, Peking University People's Hospital, Beijing, China.
Ge Q; Heart Center, Peking University People's Hospital, Beijing, China.
Liu X; Heart Center, Peking University People's Hospital, Beijing, China.
Li L; Heart Center, Peking University People's Hospital, Beijing, China.
Wang Y; Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China. Electronic address: .
Wang S; State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, China. Electronic address: .
Li C; Heart Center, Peking University People's Hospital, Beijing, China. Electronic address: .
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Źródło :
Stem cell research [Stem Cell Res] 2019 Jul; Vol. 38, pp. 101483. Date of Electronic Publication: 2019 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Gene Editing*
Induced Pluripotent Stem Cells*/metabolism
Induced Pluripotent Stem Cells*/pathology
KCNQ1 Potassium Channel*
Long QT Syndrome*/genetics
Long QT Syndrome*/metabolism
Long QT Syndrome*/pathology
Long QT Syndrome*/therapy
Models, Cardiovascular*
Mutation*
Humans ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology
Czasopismo naukowe
Tytuł :
A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants.
Autorzy :
Kernik DC; Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California, Davis, Davis, California, United States of America.
Yang PC; Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California, Davis, Davis, California, United States of America.
Kurokawa J; Department of Bio-Informational Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Wu JC; Stanford Cardiovascular Institute, Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Clancy CE; Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California, Davis, Davis, California, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Aug 14; Vol. 16 (8), pp. e1008109. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Cardiovascular*
Myocytes, Cardiac*/classification
Myocytes, Cardiac*/cytology
KCNQ1 Potassium Channel/*genetics
Mutation/*genetics
Arrhythmias, Cardiac/genetics ; Computational Biology ; Genetic Predisposition to Disease/genetics ; Humans ; Induced Pluripotent Stem Cells/cytology
Czasopismo naukowe
Tytuł :
The membrane protein KCNQ1 potassium ion channel: Functional diversity and current structural insights.
Autorzy :
Dixit G; Cell, Molecular, and Structural Biology Program, Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056, USA; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Dabney-Smith C; Cell, Molecular, and Structural Biology Program, Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056, USA; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Lorigan GA; Cell, Molecular, and Structural Biology Program, Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056, USA; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 May 01; Vol. 1862 (5), pp. 183148. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
KCNQ1 Potassium Channel/*chemistry
KCNQ1 Potassium Channel/*metabolism
Humans ; Ion Channel Gating/physiology ; Ion Channels/metabolism ; Ion Transport ; Long QT Syndrome/metabolism ; Membranes/metabolism ; Potassium/metabolism ; Potassium Channels/metabolism ; Potassium Channels, Voltage-Gated/metabolism
Czasopismo naukowe
Tytuł :
Repurposing Approved Drugs as Inhibitors of K v 7.1 and Na v 1.8 to Treat Pitt Hopkins Syndrome.
Autorzy :
Ekins S; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina, 27606, USA. .
Gerlach J; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina, 27606, USA.
Zorn KM; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina, 27606, USA.
Antonio BM; Icagen, Inc., 4222 Emperor Blvd, Durham, North Carolina, 27703, USA.
Lin Z; Icagen, Inc., 4222 Emperor Blvd, Durham, North Carolina, 27703, USA.
Gerlach A; Icagen, Inc., 4222 Emperor Blvd, Durham, North Carolina, 27703, USA.
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Źródło :
Pharmaceutical research [Pharm Res] 2019 Jul 22; Vol. 36 (9), pp. 137. Date of Electronic Publication: 2019 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Dihydropyridines/*pharmacology
Drug Repositioning/*methods
Hyperventilation/*drug therapy
Intellectual Disability/*drug therapy
KCNQ1 Potassium Channel/*antagonists & inhibitors
NAV1.8 Voltage-Gated Sodium Channel/*metabolism
Potassium Channel Blockers/*pharmacology
Sodium Channel Blockers/*pharmacology
Voltage-Gated Sodium Channel Blockers/*pharmacology
Animals ; Bayes Theorem ; CHO Cells ; Cricetulus ; Dihydropyridines/chemistry ; Facies ; HEK293 Cells ; Humans ; KCNQ1 Potassium Channel/metabolism ; Machine Learning ; Potassium Channel Blockers/chemistry ; Small Molecule Libraries/chemistry ; Sodium Channel Blockers/chemistry ; Structure-Activity Relationship ; Voltage-Gated Sodium Channel Blockers/chemistry
SCR Disease Name :
Pitt-Hopkins syndrome
Czasopismo naukowe
Tytuł :
Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine.
Autorzy :
Feng M; Department of Biology, Pennsylvania State University, University Park, PA 16802; Center for Molecular Investigation of Neurological Disorders (CMIND), The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802.
Crowley NA; Department of Biology, Pennsylvania State University, University Park, PA 16802; Center for Molecular Investigation of Neurological Disorders (CMIND), The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802.
Patel A; Department of Biology, Pennsylvania State University, University Park, PA 16802; Center for Molecular Investigation of Neurological Disorders (CMIND), The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802.
Guo Y; Department of Biology, Pennsylvania State University, University Park, PA 16802; Center for Molecular Investigation of Neurological Disorders (CMIND), The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802.
Bugni SE; Department of Biology, Pennsylvania State University, University Park, PA 16802; Center for Molecular Investigation of Neurological Disorders (CMIND), The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802.
Luscher B; Department of Biology, Pennsylvania State University, University Park, PA 16802; Department of Biochemistry & Molecular Biology, Pennsylvania State University, University Park, PA 16802; Center for Molecular Investigation of Neurological Disorders (CMIND), The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2019 May 15; Vol. 406, pp. 109-125. Date of Electronic Publication: 2019 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*drug effects
Carbamates/*therapeutic use
Depressive Disorder, Treatment-Resistant/*drug therapy
Diet, High-Fat/*adverse effects
KCNQ1 Potassium Channel/*physiology
Phenylenediamines/*therapeutic use
Animals ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Brain/metabolism ; Carbamates/pharmacology ; Depressive Disorder, Treatment-Resistant/etiology ; Depressive Disorder, Treatment-Resistant/metabolism ; Female ; KCNQ1 Potassium Channel/agonists ; Male ; Mice ; Mice, Inbred C57BL ; Organ Culture Techniques ; Phenylenediamines/pharmacology
Czasopismo naukowe
Tytuł :
A trafficking-deficient KCNQ1 mutation, T587M, causes a severe phenotype of long QT syndrome by interfering with intracellular hERG transport.
Autorzy :
Wu J; Department of Pharmacology, School of Basic Medical Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan; Department of Physiology, Shiga University of Medical Science, Otsu, Japan.
Sakaguchi T; Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.
Takenaka K; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Toyoda F; Department of Physiology, Shiga University of Medical Science, Otsu, Japan.
Tsuji K; Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.
Matsuura H; Department of Physiology, Shiga University of Medical Science, Otsu, Japan.
Horie M; Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan. Electronic address: .
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Źródło :
Journal of cardiology [J Cardiol] 2019 May; Vol. 73 (5), pp. 343-350. Date of Electronic Publication: 2018 Dec 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ether-A-Go-Go Potassium Channels/*physiology
KCNQ1 Potassium Channel/*genetics
Long QT Syndrome/*genetics
Ether-A-Go-Go Potassium Channels/genetics ; HEK293 Cells ; Humans ; KCNQ1 Potassium Channel/physiology ; Long QT Syndrome/physiopathology ; Mutation ; Patch-Clamp Techniques ; Phenotype ; Protein Transport ; Transfection
Czasopismo naukowe
Tytuł :
Investigation of KCNQ1 polymorphisms as biomarkers for cardiovascular diseases in the Turkish Cypriots for establishing preventative medical measures.
Autorzy :
Tulay P; Near East University, Faculty of Medicine, Department of Medical Genetics, Nicosia, North Cyprus Mersin 10, Turkey. Electronic address: .
Temel SG; Uludag University, Faculty of Medicine, Department of Medical Genetics, Bursa, 16059, Turkey; Uludag University, Faculty of Medicine, Department of Histology and Embryology, Bursa, 16059, Turkey.
Ergoren MC; Near East University, Faculty of Medicine, Department of Medical Biology, Nicosia, 99138, Cyprus.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2019 Mar 01; Vol. 124, pp. 537-540. Date of Electronic Publication: 2018 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Cardiovascular Diseases/*genetics
KCNQ1 Potassium Channel/*genetics
Alleles ; Asymptomatic Diseases ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/ethnology ; Cyprus/epidemiology ; Female ; Gene Expression ; Gene Frequency ; Haplotypes ; Heterozygote ; Humans ; KCNQ1 Potassium Channel/blood ; Lipids/blood ; Male ; Molecular Epidemiology ; Prognosis ; Turkey/ethnology
Czasopismo naukowe

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