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Tytuł :
Sortilin regulates keratinocyte proliferation and apoptosis through the PI3K-AKT signaling pathway.
Autorzy :
Zhang R; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Wang YH; Department of Cell Biology, School of Biology and Basic Medical, Soochow University, No. 199 Renai Road, Suzhou 215123, China.
Shi X; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Ji J; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Zhan FQ; Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, 215004, China.
Leng H; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119630. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Proliferation*
Adaptor Proteins, Vesicular Transport/*pharmacology
Keratinocytes/*pathology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Psoriasis/*pathology
Adolescent ; Adult ; Aged ; Animals ; Case-Control Studies ; Female ; Gene Expression Regulation ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Psoriasis/drug therapy ; Psoriasis/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Inhibition of desmoglein-1 by aspirin leads to synthetic lethality of keratinocytes in Shuanghuanglian-induced cutaneous eruption response.
Autorzy :
Zhuang P; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Xie L; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Zhang Y; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Yuan Y; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Liu H; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Bi C; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Zhao H; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Li Y; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: .
Zhang Y; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 01; Vol. 349, pp. 145-154. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Aspirin/*toxicity
Desmoglein 1/*antagonists & inhibitors
Drug Eruptions/*etiology
Drugs, Chinese Herbal/*toxicity
Keratinocytes/*drug effects
Animals ; Chlorogenic Acid/analogs & derivatives ; Chlorogenic Acid/toxicity ; Desmoglein 1/metabolism ; Drug Eruptions/metabolism ; Drug Eruptions/pathology ; Female ; HaCaT Cells ; Humans ; Inflammation Mediators/metabolism ; Interleukin-4/metabolism ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Mice, Inbred ICR ; Quinic Acid/analogs & derivatives ; Quinic Acid/toxicity ; Rutin/toxicity ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
NRF2 deficiency sensitizes human keratinocytes to zinc oxide nanoparticles-induced autophagy and cytotoxicity.
Autorzy :
Yin Y; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China; School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.
Peng H; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China.
Shao J; School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.
Zhang J; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No.23 Back District, Dongcheng Area, Beijing, 100010, China.
Li Y; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China.
Pi J; School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China. Electronic address: .
Guo J; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China; School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China. Electronic address: .
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Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2021 Oct; Vol. 87, pp. 103721. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Keratinocytes/*drug effects
NF-E2-Related Factor 2/*genetics
Nanoparticles/*toxicity
Zinc Oxide/*toxicity
Autophagy/drug effects ; Cell Line ; Cell Survival/drug effects ; Humans ; Kelch-Like ECH-Associated Protein 1/metabolism ; Keratinocytes/metabolism ; Membrane Potential, Mitochondrial/drug effects ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
The effect of biodegradable silk fibroin-based scaffolds containing glial cell line-derived neurotrophic factor (GDNF) on the corneal regeneration process.
Autorzy :
Gavrilova NA; The A.I. Evdokimov Моscow State University of Medicine and Dentistry of the Ministry of Healthcare the Russian Federation, Moscow, Russian Federation.
Borzenok SA; The A.I. Evdokimov Моscow State University of Medicine and Dentistry of the Ministry of Healthcare the Russian Federation, Moscow, Russian Federation; The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation.
Revishchin AV; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russian Federation.
Tishchenko OE; The A.I. Evdokimov Моscow State University of Medicine and Dentistry of the Ministry of Healthcare the Russian Federation, Moscow, Russian Federation.
Ostrovkiy DS; The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation.
Bobrova MM; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Safonova LA; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Efimov AE; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Agapova OI; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Agammedov MB; The A.I. Evdokimov Моscow State University of Medicine and Dentistry of the Ministry of Healthcare the Russian Federation, Moscow, Russian Federation.
Pavlova GV; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russian Federation.
Agapov II; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 264-276. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Corneal Injuries/*therapy
Fibroins/*chemistry
Glial Cell Line-Derived Neurotrophic Factor/*metabolism
Keratinocytes/*transplantation
Animals ; Biomarkers/metabolism ; Cell Proliferation ; Corneal Injuries/metabolism ; Humans ; Keratinocytes/cytology ; Keratinocytes/metabolism ; Male ; Mice ; Primary Cell Culture ; Tissue Scaffolds
Czasopismo naukowe
Tytuł :
Oat β-glucan ameliorates epidermal barrier disruption by upregulating the expression of CaSR through dectin-1-mediated ERK and p38 signaling pathways.
Autorzy :
Gao S; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Chen Y; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Zhao J; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Jing R; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Guo K; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Wang L; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Li X; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Li C; LB Cosmeceutical Technology Co., Ltd., Shanghai 200233, China.
Hu Z; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China; School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address: .
Xu N; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 876-889. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article
MeSH Terms :
Avena/*chemistry
Keratinocytes/*cytology
Lectins, C-Type/*metabolism
Receptors, Calcium-Sensing/*metabolism
beta-Glucans/*adverse effects
Animals ; Calcium/metabolism ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Gene Expression Regulation/drug effects ; HaCaT Cells ; Humans ; Hyperplasia ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Lectins, C-Type/genetics ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Receptors, Calcium-Sensing/genetics ; Up-Regulation ; beta-Glucans/pharmacology
Czasopismo naukowe
Tytuł :
Kahweol Exerts Skin Moisturizing Activities by Upregulating STAT1 Activity.
Autorzy :
Chen H; Department of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea.
Hossain MA; Department of Veterinary Physiology, College of Medicine, Chonbuk National University, Iksan 54596, Korea.
Kim JH; Department of Veterinary Physiology, College of Medicine, Chonbuk National University, Iksan 54596, Korea.
Cho JY; Department of Veterinary Physiology, College of Medicine, Chonbuk National University, Iksan 54596, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Diterpenes/*pharmacology
Gene Expression Regulation/*drug effects
Keratinocytes/*physiology
STAT1 Transcription Factor/*metabolism
Skin/*drug effects
Apoptosis ; Cell Proliferation ; Cells, Cultured ; Humans ; Keratinocytes/cytology ; Keratinocytes/drug effects ; STAT1 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
A Michael Acceptor Analogue, SKSI-0412, Down-Regulates Inflammation and Proliferation Factors through Suppressing Signal Transducer and Activator of Transcription 3 Signaling in IL-17A-Induced Human Keratinocyte.
Autorzy :
Kim AR; Department of Dermatology, School of Medicine, CHA University, 120 Haeryong-ro, Pocheon 11160, Gyeonggi-do, Korea.
Lee S; Department of Pharmacy, College of Pharmacy, CHA University, 120 Haeryong-ro, Pocheon 11160, Gyeonggi-do, Korea.
Shin JU; Department of Dermatology, CHA Bundang Mediacal Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Gyeonggi-do, Korea.
Seok SH; Department of Dermatology, CHA Bundang Mediacal Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Gyeonggi-do, Korea.
Suh YG; Department of Pharmacy, College of Pharmacy, CHA University, 120 Haeryong-ro, Pocheon 11160, Gyeonggi-do, Korea.
Kim DH; Department of Dermatology, CHA Bundang Mediacal Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Gyeonggi-do, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 16; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Interleukin-17/*adverse effects
Keratinocytes/*cytology
STAT3 Transcription Factor/*metabolism
Small Molecule Libraries/*pharmacology
Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Cell Proliferation/drug effects ; Cells, Cultured ; Down-Regulation ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Phosphorylation/drug effects ; Primary Cell Culture ; STAT3 Transcription Factor/chemistry ; Signal Transduction/drug effects ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation.
Autorzy :
Shin KO; Convergence Program of Material Science for Medicine and Pharmaceutics, Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea.; The Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea.; LaSS Lipid Institute (LLI), LaSS Inc., Chuncheon 24252, Korea.
Kim S; Convergence Program of Material Science for Medicine and Pharmaceutics, Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea.; The Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea.
Park BD; Dr. Raymond Laboratories Inc., Englewood Cliffs, NJ 07632, USA.
Uchida Y; Veterans Affairs Medical Center, Department of Dermatology, School of Medicine, Northern California Institute for Research and Education, University of California, San Francisco, CA 94143, USA.
Park K; Convergence Program of Material Science for Medicine and Pharmaceutics, Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea.; The Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 02; Vol. 22 (15). Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Ceramides/*metabolism
Inflammation/*metabolism
Keratinocytes/*metabolism
Propanolamines/*pharmacology
Propylene Glycols/*pharmacology
Receptor, Cannabinoid, CB1/*metabolism
Skin/*metabolism
Cells, Cultured ; Humans ; In Vitro Techniques ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/pathology ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Propanolamines/chemistry ; Propylene Glycols/chemistry ; Skin/cytology ; Skin/drug effects
Czasopismo naukowe
Tytuł :
Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes.
Autorzy :
Saitoh Y; Laboratory of Bioscience & Biotechnology for Cell Function Control, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka, Shobara, Hiroshima, 727-0023, Japan. .
Yamaguchi Y; Laboratory of Bioscience & Biotechnology for Cell Function Control, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka, Shobara, Hiroshima, 727-0023, Japan.
Okada Y; Laboratory of Bioscience & Biotechnology for Cell Function Control, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka, Shobara, Hiroshima, 727-0023, Japan.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3613-3622. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Dermis/*injuries
Glyoxal/*toxicity
Hydrogen/*pharmacology
Hydrogen Peroxide/*toxicity
Keratinocytes/*metabolism
Cell Line ; Dermis/metabolism ; Dermis/pathology ; Humans ; Keratinocytes/pathology
Czasopismo naukowe
Tytuł :
Possible role of epiregulin from dermal fibroblasts in the keratinocyte hyperproliferation of psoriasis.
Autorzy :
Iwata H; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Haga N; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Ujiie H; Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
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Źródło :
The Journal of dermatology [J Dermatol] 2021 Sep; Vol. 48 (9), pp. 1433-1438. Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Epiregulin*/genetics
Keratinocytes*
Psoriasis*/genetics
Cell Proliferation ; Fibroblasts ; Humans ; Skin
Czasopismo naukowe
Tytuł :
Woodsmoke Extracts Cross-Link Proteins and Induce Cornified Envelope Formation without Stimulating Keratinocyte Terminal Differentiation.
Autorzy :
Lin LW; Department of Environmental Toxicology, University of California, Davis, CA 95616-8588, USA.
Denison MS
Rice RH; Department of Environmental Toxicology, University of California, Davis, CA 95616-8588, USA.
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Źródło :
Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2021 Aug 30; Vol. 183 (1), pp. 128-138.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Keratinocytes*
Transglutaminases*/genetics
Cell Differentiation ; Cells, Cultured ; Epidermis ; Humans ; Skin
Czasopismo naukowe
Tytuł :
Guardians of the barrier: Microbiota engage AHR in keratinocytes to mantain skin homeostasis.
Autorzy :
Alwan W; Guy's and St Thomas' NHS Foundation Trust, London, UK; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK.
Di Meglio P; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2021 Aug 11; Vol. 29 (8), pp. 1213-1216.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Keratinocytes*
Microbiota*
Homeostasis ; Humans ; Signal Transduction ; Skin
Czasopismo naukowe
Tytuł :
Q-switched Nd-YAG laser alone and in combination with innovative hyaluronic acid gels improve keratinocytes wound healing in vitro.
Autorzy :
de Filippis A; Department of Experimental Medicine, Section of Microbiology and Clinical Microbioloy, University of Campania 'Luigi Vanvitelli', Naples, Italy.
D'Agostino A; Department of Mental Health and Physics and Preventive Medicine, Section of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.; Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania Luigi Vanvitelli, via De Crecchio n°7, 80138, Naples, Italy.
Pirozzi AVA; Department of Mental Health and Physics and Preventive Medicine, Section of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.; Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania Luigi Vanvitelli, via De Crecchio n°7, 80138, Naples, Italy.
Tufano MA; Department of Experimental Medicine, Section of Microbiology and Clinical Microbioloy, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Schiraldi C; Department of Mental Health and Physics and Preventive Medicine, Section of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy. .; Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania Luigi Vanvitelli, via De Crecchio n°7, 80138, Naples, Italy. .
Baroni A; Department of Experimental Medicine, Section of Microbiology and Clinical Microbioloy, University of Campania 'Luigi Vanvitelli', Naples, Italy.; Department of Mental Health and Physics and Preventive Medicine, Section of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.
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Źródło :
Lasers in medical science [Lasers Med Sci] 2021 Jul; Vol. 36 (5), pp. 1047-1057. Date of Electronic Publication: 2020 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Hyaluronic Acid/*pharmacology
Keratinocytes/*drug effects
Keratinocytes/*radiation effects
Lasers, Solid-State/*therapeutic use
Wound Healing/*drug effects
Biomarkers/metabolism ; Gels ; Humans ; Keratinocytes/cytology ; Keratinocytes/metabolism
Czasopismo naukowe
Tytuł :
Nabumetone induced photogenotoxicity mechanism mediated by ROS generation under environmental UV radiation in human keratinocytes (HaCaT) cell line.
Autorzy :
Qureshi S; Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India; Academy of Scientific and Innovative Research, AcSIR Headquarters, CSIR-HRDC Campus, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh-, 201 002, India.
Chandra S; Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India; Academy of Scientific and Innovative Research, AcSIR Headquarters, CSIR-HRDC Campus, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh-, 201 002, India.
Chopra D; Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.
Dubey D; Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.
Jain V; Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226001, India; Academy of Scientific and Innovative Research, AcSIR Headquarters, CSIR-HRDC Campus, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh-, 201 002, India.
Roy SK; Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226001, India; Academy of Scientific and Innovative Research, AcSIR Headquarters, CSIR-HRDC Campus, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh-, 201 002, India.
Ray RS; Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India; Academy of Scientific and Innovative Research, AcSIR Headquarters, CSIR-HRDC Campus, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh-, 201 002, India. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jun 01; Vol. 420, pp. 115516. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Ultraviolet Rays*
Anti-Inflammatory Agents, Non-Steroidal/*toxicity
Keratinocytes/*drug effects
Micronuclei, Chromosome-Defective/*chemically induced
Nabumetone/*toxicity
Oxidative Stress/*drug effects
Reactive Oxygen Species/*metabolism
Anti-Inflammatory Agents, Non-Steroidal/radiation effects ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Drug Stability ; HaCaT Cells ; Histones/metabolism ; Humans ; Keratinocytes/metabolism ; Keratinocytes/ultrastructure ; Nabumetone/radiation effects ; Photolysis ; Time Factors ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing.
Autorzy :
Malinowska MA; Organic Chemistry and Technology Department, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Cracow, Poland.
Sikora E; Organic Chemistry and Technology Department, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Cracow, Poland.
Stalińska J; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Cracow, Poland.
Ogonowski J; Organic Chemistry and Technology Department, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Cracow, Poland.
Drukała J; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Cracow, Poland.
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Źródło :
Biomolecules [Biomolecules] 2021 May 21; Vol. 11 (6). Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants*/chemical synthesis
Antioxidants*/chemistry
Antioxidants*/pharmacology
Keratinocytes*/metabolism
Keratinocytes*/pathology
Pentacyclic Triterpenes*/chemical synthesis
Pentacyclic Triterpenes*/chemistry
Pentacyclic Triterpenes*/pharmacology
Skin*/injuries
Skin*/metabolism
Skin*/pathology
Wounds and Injuries*/drug therapy
Wounds and Injuries*/metabolism
Wounds and Injuries*/pathology
Wound Healing/*drug effects
Humans
Czasopismo naukowe
Tytuł :
Immortalization of Human Keratinocytes Using the Catalytic Subunit of Telomerase.
Autorzy :
Beilin AK; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.; Pirogov Russian National Research Medical University, Moscow, Russia.
Gurskaya NG; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.; Pirogov Russian National Research Medical University, Moscow, Russia.
Evtushenko NA; Pirogov Russian National Research Medical University, Moscow, Russia.
Alpeeva EV; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
Kosykh AV; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.; Pirogov Russian National Research Medical University, Moscow, Russia.
Terskikh VV; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
Vasiliev AV; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.; Moscow State University, Moscow, Russia.
Vorotelyak EA; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. .; Pirogov Russian National Research Medical University, Moscow, Russia. .; Moscow State University, Moscow, Russia. .
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Źródło :
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2021 May; Vol. 496 (1), pp. 5-9. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Transformation, Neoplastic/*metabolism
Keratinocytes/*cytology
Keratinocytes/*metabolism
Telomerase/*metabolism
Animals ; Catalytic Domain ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Chromosome Aberrations ; Heterografts ; Humans ; Keratinocytes/enzymology ; Male ; Mice ; Mice, Nude ; Primary Cell Culture ; Telomerase/genetics
Czasopismo naukowe
Tytuł :
Intracellular oxidative stress induced by calcium influx initiates the activation of phagocytosis in keratinocytes accumulating at S-phase of the cell cycle after UVB irradiation.
Autorzy :
Katsuyama Y; CIEL CO., LTD, Kanagawa, Japan. Electronic address: .
Sato Y; CIEL CO., LTD, Kanagawa, Japan.
Okano Y; CIEL CO., LTD, Kanagawa, Japan.
Masaki H; School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan.
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Źródło :
Journal of dermatological science [J Dermatol Sci] 2021 Jul; Vol. 103 (1), pp. 41-48. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium/*metabolism
Keratinocytes/*radiation effects
Phagocytosis/*radiation effects
S Phase Cell Cycle Checkpoints/*radiation effects
Ultraviolet Rays/*adverse effects
Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Cell Line ; Chelating Agents/pharmacology ; DNA Damage/drug effects ; DNA Damage/radiation effects ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Humans ; Keratinocytes/cytology ; Keratinocytes/metabolism ; Melanins/biosynthesis ; Melanosomes/metabolism ; Oxidative Stress/drug effects ; Oxidative Stress/genetics ; Oxidative Stress/radiation effects ; Phagocytosis/drug effects ; Phagocytosis/genetics ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Anoctamin1 Induces Hyperproliferation of HaCaT Keratinocytes and Triggers Imiquimod-Induced Psoriasis-Like Skin Injury in Mice.
Autorzy :
Choi MR; Laboratory Animal Research Center, Ajou University School of Medicine 164, Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea.
Kim HD; Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Cho S; Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Jeon SH; Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
Kim DH; Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Seongnam-si 13488, Korea.
Wee J; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Gyunggy 16229, Korea.
Yang YD; Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon 11160, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 01; Vol. 22 (13). Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Anoctamin-1/*pharmacology
Keratinocytes/*drug effects
Psoriasis/*chemically induced
Acetamides/pharmacology ; Animals ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Disease Models, Animal ; Female ; HaCaT Cells ; Humans ; Hydrazones/pharmacology ; Imiquimod/adverse effects ; Imiquimod/pharmacology ; Inflammation/metabolism ; Inflammation/pathology ; Interleukins/metabolism ; Keratinocytes/metabolism ; Keratinocytes/pathology ; MAP Kinase Signaling System ; Mice ; Mice, Inbred BALB C ; Psoriasis/metabolism ; Psoriasis/pathology ; Pyrimidines/pharmacology ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł :
Overexpression of D-dopachrome tautomerase increases ultraviolet B irradiation-induced skin tumorigenesis in mice.
Autorzy :
Yoshihisa Y; Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Rehman MU; Department of Radiology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Andoh T; Department of Pharmacology and Pathophysiology, College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan.
Tabuchi Y; Division of Molecular Genetics Research, Life Science Research Center, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Makino T; Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Shimizu T; Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Jul; Vol. 35 (7), pp. e21671.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis/*pathology
Intramolecular Oxidoreductases/*metabolism
Keratinocytes/*pathology
Skin Neoplasms/*pathology
Ultraviolet Rays/*adverse effects
Animals ; Apoptosis ; Carcinogenesis/metabolism ; Carcinogenesis/radiation effects ; Cell Proliferation ; Female ; Intramolecular Oxidoreductases/genetics ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Mice ; Mice, Transgenic ; Skin Neoplasms/etiology ; Skin Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct.
Autorzy :
Wattanapitayakula SK; Department of Pharmacology Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.
Chularojmontri L; Department of Preclinical Sciences Faculty of Medicine, Thammasat University, Klongluang, Pathumthani 12120, Thailand.
Schäfer-Korting M; Institute for Pharmacy, Freie Universität Berlin, 14195 Berlin Germany.
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Źródło :
Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2021 Jun 01; Vol. 71 (2), pp. 293-303.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence/*radiation effects
Keratinocytes/*radiation effects
Skin Aging/*radiation effects
Ultraviolet Rays/*adverse effects
Cells, Cultured ; Epidermal Cells/cytology ; Epidermal Cells/radiation effects ; Foreskin/cytology ; Humans ; Keratinocytes/cytology ; Male ; Models, Biological ; Reactive Oxygen Species/metabolism
Czasopismo naukowe

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