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Wyszukujesz frazę ""KIDNEY tubules"" wg kryterium: Temat


Tytuł :
Activation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats.
Autorzy :
Gohar EY; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Almutlaq RN; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Daugherty EM; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Butt MK; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Jin C; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Pollock JS; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Pollock DM; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
De Miguel C; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2021 Mar 01; Vol. 320 (3), pp. R297-R306. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Albuminuria/*prevention & control
Cyclopentanes/*pharmacology
Kidney Diseases/*prevention & control
Kidney Glomerulus/*drug effects
Kidney Tubules, Proximal/*drug effects
Quinolines/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Albuminuria/etiology ; Albuminuria/metabolism ; Albuminuria/pathology ; Animals ; Arterial Pressure ; Cell Adhesion Molecules/metabolism ; Disease Models, Animal ; Female ; Hypertension/etiology ; Hypertension/physiopathology ; Kidney Diseases/etiology ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/pathology ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Rats, Inbred Dahl ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Sodium Chloride, Dietary
Czasopismo naukowe
Tytuł :
Salt intake and the dance of the macula densa cells.
Autorzy :
Cowley AW; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Mar 01; Vol. 320 (3), pp. F375-F377. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Kidney Tubules*
Sodium Chloride, Dietary*/adverse effects
Juxtaglomerular Apparatus
Raport
Tytuł :
Effect of forkhead box O1 in renal tubular epithelial cells on endotoxin-induced acute kidney injury.
Autorzy :
Zhang M; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Dong W; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Li Z; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xiao Z; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Xie Z; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Ye Z; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Liu S; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Li R; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chen Y; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhang L; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Wang M; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Liang H; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Baihetiyaer R; Division of Nephrology, First People's Hospital of Kasha, Foshan, China.
Apaer R; Division of Nephrology, First People's Hospital of Kasha, Foshan, China.
Dong Z; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.; Department of Medical Research, Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
Liang X; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Mar 01; Vol. 320 (3), pp. F262-F272. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Kidney Injury/*metabolism
Endotoxemia/*complications
Epithelial Cells/*metabolism
Forkhead Box Protein O1/*metabolism
Kidney Tubules/*metabolism
Acute Kidney Injury/etiology ; Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Animals ; Cell Line ; Disease Models, Animal ; Endotoxemia/chemically induced ; Epithelial Cells/ultrastructure ; Forkhead Box Protein O1/genetics ; Humans ; Kidney Tubules/ultrastructure ; Lipopolysaccharides ; Male ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Putting the pressure on endocytosis in the kidney.
Autorzy :
Van Giel D; Laboratory of Ion Channel Research, TRP Research Platform Leuven, VIB Center for Brain and Disease Research, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium.
Vennekens R; Laboratory of Ion Channel Research, TRP Research Platform Leuven, VIB Center for Brain and Disease Research, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2021 Mar; Vol. 94, pp. 102338. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Kidney Tubules, Proximal*
TRPV Cation Channels*
Albumins ; Endocytosis
Czasopismo naukowe
Tytuł :
Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
Autorzy :
Geng H; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Lan R; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Liu Y; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Chen W; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Wu M; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Saikumar P; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Weinberg JM; Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Venkatachalam MA; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Mar 01; Vol. 320 (3), pp. F359-F374. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acute Kidney Injury/*metabolism
Cytokines/*metabolism
Kidney Tubules, Proximal/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Reperfusion Injury/*metabolism
Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Animals ; Cell Line ; Connective Tissue Growth Factor/metabolism ; Disease Models, Animal ; ErbB Receptors/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fibrosis ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Kidney Tubules, Proximal/pathology ; Lymphokines/metabolism ; Male ; Mice ; Phosphorylation ; Platelet-Derived Growth Factor/metabolism ; Rats, Sprague-Dawley ; Receptors, Lysophosphatidic Acid/genetics ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology ; Signal Transduction ; Transcription Factor AP-1/metabolism ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells.
Autorzy :
Wang S; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China; Institute of Poisonous Plants in Western China, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Guo R; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China; Institute of Poisonous Plants in Western China, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Su Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China; Institute of Poisonous Plants in Western China, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Yang C; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China; Institute of Poisonous Plants in Western China, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Guo Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China; Institute of Poisonous Plants in Western China, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Tan C; Department of Biotechnology, Guizhou Medical University, Guiyang, Guizhou, 550004, China.
Zhao B; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China; Institute of Poisonous Plants in Western China, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Feb 25; Vol. 336, pp. 109319. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*drug effects
Epithelial Cells/*drug effects
Kidney Tubules/*drug effects
Lysosomes/*drug effects
Swainsonine/*pharmacology
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Epithelial Cells/metabolism ; Kidney Tubules/metabolism ; Lysosomes/metabolism ; Molecular Conformation ; Rats ; Structure-Activity Relationship ; Swainsonine/chemistry
Czasopismo naukowe
Tytuł :
Potential Protection Effect of ER Homeostasis of N -(2-Hydroxyethyl)adenosine Isolated from Cordyceps cicadae in Nonsteroidal Anti-Inflammatory Drug-Stimulated Human Proximal Tubular Cells.
Autorzy :
Chyau CC; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Wu HL; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Peng CC; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Huang SH; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Chen CC; Grape King Biotechnology Center, Chung-Li City 320054, Taiwan.
Chen CH; Department of Nephrology, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Peng RY; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 04; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Homeostasis*
Adenosine/*analogs & derivatives
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cordyceps/*chemistry
Endoplasmic Reticulum Stress/*drug effects
Kidney Tubules, Proximal/*drug effects
Protective Agents/*pharmacology
Adenosine/pharmacology ; Gene Expression Regulation ; Humans ; Kidney Tubules, Proximal/metabolism ; Oxidative Stress
SCR Organism :
Cordyceps cicadae
Czasopismo naukowe
Tytuł :
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation.
Autorzy :
Lawlor KT; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Vanslambrouck JM; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Higgins JW; Organovo, San Diego, CA, USA.
Chambon A; Organovo, San Diego, CA, USA.
Bishard K; Organovo, San Diego, CA, USA.
Arndt D; Organovo, San Diego, CA, USA.
Er PX; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Wilson SB; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Howden SE; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Tan KS; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Li F; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Hale LJ; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Shepherd B; Organovo, San Diego, CA, USA.
Pentoney S; Organovo, San Diego, CA, USA.
Presnell SC; Organovo, San Diego, CA, USA.
Chen AE; Organovo, San Diego, CA, USA.
Little MH; Murdoch Children's Research Institute, Melbourne, Victoria, Australia. .; Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia. .; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia. .
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Źródło :
Nature materials [Nat Mater] 2021 Feb; Vol. 20 (2), pp. 260-271. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bioprinting*
Kidney Tubules, Proximal/*metabolism
Organoids/*metabolism
Pluripotent Stem Cells/*metabolism
Humans ; Kidney Tubules, Proximal/cytology ; Organoids/cytology ; Pluripotent Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Renal ischemia-reperfusion leads to hypertension and changes in proximal tubule Na transport and renin-angiotensin-aldosterone system: Role of NADPH oxidase.
Autorzy :
Lima NKS; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
Farias WRA; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
Cirilo MAS; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
Oliveira AG; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
Farias JS; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
Aires RS; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil.
Muzi-Filho H; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; National Center for Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Paixão ADO; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil; National Center for Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Vieira LD; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil; National Center for Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118879. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Renin-Angiotensin System*
Acute Kidney Injury/*complications
Hypertension/*pathology
Kidney Tubules, Proximal/*pathology
NADPH Oxidases/*metabolism
Reperfusion Injury/*complications
Sodium/*metabolism
Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Aldosterone/metabolism ; Animals ; Hypertension/enzymology ; Hypertension/etiology ; Kidney Tubules, Proximal/metabolism ; Male ; Oxidative Stress ; Rats ; Rats, Wistar ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
Czasopismo naukowe
Tytuł :
Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction.
Autorzy :
Sotokawauchi A; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan.
Nakamura N; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan.
Matsui T; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan.
Higashimoto Y; Department of Chemistry, Kurume University School of Medicine, Kurume 830-0011, Japan.
Yamagishi SI; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 09; Vol. 21 (7). Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial Cells/*drug effects
Epithelial Cells/*metabolism
Glycation End Products, Advanced/*metabolism
Glyceraldehyde/*pharmacology
Kidney Tubules/*drug effects
Kidney Tubules/*metabolism
Pyridinium Compounds/*pharmacology
Biomarkers ; Cells, Cultured ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Glycation End Products, Advanced/pharmacology ; Glyceraldehyde/analogs & derivatives ; Humans ; Kidney Tubules/pathology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Oxidative Stress/drug effects ; Pyridinium Compounds/chemistry ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Autorzy :
Unterschemmann K; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
Ehrmann A; Drug Discovery Sciences, Bayer Pharmaceuticals, Wuppertal, Germany.
Herzig I; Drug Discovery Sciences, Bayer Pharmaceuticals, Wuppertal, Germany.
Andreevski AL; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
Lustig K; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
Schmeck C; Drug Discovery Sciences, Bayer Pharmaceuticals, Wuppertal, Germany.
Eitner F; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
Grundmann M; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Jan 01; Vol. 320 (1), pp. F61-F73. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*prevention & control
Amidohydrolases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Kidney Tubules, Proximal/*drug effects
Nephritis, Hereditary/*prevention & control
Oxidative Stress/*drug effects
Renal Insufficiency, Chronic/*prevention & control
Reperfusion Injury/*prevention & control
Acute Kidney Injury/enzymology ; Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Amidohydrolases/genetics ; Amidohydrolases/metabolism ; Animals ; Apoptosis/drug effects ; Autoantigens/genetics ; Autoantigens/metabolism ; Cell Line ; Collagen Type IV/genetics ; Collagen Type IV/metabolism ; Disease Models, Animal ; Enzyme Inhibitors/pharmacokinetics ; Fibrosis ; GPI-Linked Proteins/antagonists & inhibitors ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Humans ; Kidney Tubules, Proximal/enzymology ; Kidney Tubules, Proximal/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Nephritis, Hereditary/enzymology ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/pathology ; Renal Insufficiency, Chronic/enzymology ; Renal Insufficiency, Chronic/genetics ; Renal Insufficiency, Chronic/pathology ; Reperfusion Injury/enzymology ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology
Czasopismo naukowe
Tytuł :
Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells.
Autorzy :
Lee HY; Department of Anesthesiology and Pain Medicine, South Korea.
Oh SH; School of Medicine, Chosun University, 309 Pilmundaero, Dong-gu, Gwangju, 61452, South Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 01; Vol. 534, pp. 128-133. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Cadmium/*toxicity
Kidney Tubules, Proximal/*cytology
Tumor Suppressor Protein p53/*metabolism
Apoptosis/physiology ; Autophagy/physiology ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Cell Line ; Epithelial Cells ; Humans ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Membrane Proteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; RNA Interference ; Tumor Suppressor Protein p53/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease.
Autorzy :
Yuan H; School of Pharmaceutical, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zheng C; Department of Cardiology, the Second Clinical Medical College and Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhu L; School of Pharmaceutical, Guangzhou University of Chinese Medicine, Guangzhou, China.
Song Z; School of Pharmaceutical, Guangzhou University of Chinese Medicine, Guangzhou, China.
Dai L; School of Pharmaceutical, Guangzhou University of Chinese Medicine, Guangzhou, China.
Hu Q; School of Pharmaceutical, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wang L; School of Pharmaceutical, Guangzhou University of Chinese Medicine, Guangzhou, China.
Chen Y; School of Pharmaceutical, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: .
Xiong J; Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 110949. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*/drug effects
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
Epithelial Cells/*metabolism
Kidney Tubules/*metabolism
Nephritis, Interstitial/*metabolism
Renal Insufficiency, Chronic/*metabolism
Adenine ; Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/agonists ; Cell Line ; Disease Models, Animal ; Epithelial Cells/drug effects ; Epithelial Cells/ultrastructure ; Fibrosis ; Humans ; Inflammation Mediators/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Kidney Tubules/drug effects ; Kidney Tubules/ultrastructure ; Male ; Mice, Inbred C57BL ; Nephritis, Interstitial/chemically induced ; Nephritis, Interstitial/pathology ; Rats ; Renal Insufficiency, Chronic/chemically induced ; Renal Insufficiency, Chronic/pathology ; Signal Transduction ; Trehalose/pharmacology
Czasopismo naukowe
Tytuł :
Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6.
Autorzy :
Wang SZ; Department of Nephrology, Suizhou Central Hospital, Hubei University of Medicine, Suizhou, Hubei, P.R. China.
Zhang YL; Department of Endocrinology, The First People's Hospital of Lanzhou City, Lanzhou, Gansu, P.R. China.
Shi HB; Department of Nephrology, Weifang People's Hospital, Weifang, Shandong, P.R. China. Electronic address: .
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Źródło :
Archives of medical research [Arch Med Res] 2021 Jan; Vol. 52 (1), pp. 58-68. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Chemokine CXCL6/*genetics
Diabetic Nephropathies/*genetics
Kidney Tubules/*pathology
MicroRNAs/*physiology
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Chemokine CXCL6/metabolism ; Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/pathology ; Diabetic Nephropathies/pathology ; Dose-Response Relationship, Drug ; Gene Expression Regulation/drug effects ; Glucose/pharmacology ; Humans ; Kidney Tubules/drug effects ; Kidney Tubules/physiology ; Transcriptome
Czasopismo naukowe
Tytuł :
PEGylated and Acylated Elabela Analogues Show Enhanced Receptor Binding, Prolonged Stability, and Remedy of Acute Kidney Injury.
Autorzy :
Wang C; School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Xiong M; School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Yang C; School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Yang D; School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Zheng J; School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Fan Y; College of Life Sciences, Wuhan University, Wuhan 430072, China.
Wang S; Department of Blood Transfusion, Wuhan Hospital of Traditional and Western Medicine, Wuhan 430022, China.
Gai Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China.
Lan X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, China.; Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China.
Chen H; School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Zheng L; College of Life Sciences, Wuhan University, Wuhan 430072, China.
Huang K; School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 24; Vol. 63 (24), pp. 16028-16042. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Kidney Injury/*drug therapy
Apelin Receptors/*metabolism
Kidney Tubules/*drug effects
Peptide Fragments/*pharmacology
Peptide Hormones/*chemistry
Polyethylene Glycols/*chemistry
Reperfusion Injury/*complications
Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Acylation ; Animals ; Antineoplastic Agents/toxicity ; Cisplatin/toxicity ; Disease Models, Animal ; Kidney Tubules/injuries ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Peptide Fragments/chemistry
Czasopismo naukowe
Tytuł :
PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells.
Autorzy :
Zhu H; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Jiang W; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Zhao H; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
He C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Tang X; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Xu S; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Xu C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Feng R; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Li J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Ma T; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China. .
Huang C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2020 Dec 12; Vol. 11 (12), pp. 1057. Date of Electronic Publication: 2020 Dec 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Acute Kidney Injury/*chemically induced
Acute Kidney Injury/*pathology
Adaptor Proteins, Signal Transducing/*metabolism
Cisplatin/*adverse effects
Cytoskeletal Proteins/*metabolism
Epithelial Cells/*pathology
Kidney Tubules/*pathology
Acute Kidney Injury/genetics ; Acute Kidney Injury/physiopathology ; Animals ; Cell Line ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Histone Deacetylase Inhibitors/pharmacology ; Kidney Tubules/drug effects ; Kidney Tubules/physiopathology ; Male ; Mice, Inbred C57BL ; Up-Regulation/drug effects ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.
Autorzy :
Jin X; Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.; Department of Anesthesiology, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
An C; Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.; Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
Jiao B; Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
Safirstein RL; Renal Section, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.
Wang Y; Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.; Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.; Renal Section, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.; Department of Cell Biology, University of Connecticut School of Medicine, Farmington, Connecticut.; Institute for Systems Genomics, University of Connecticut School of Medicine, Farmington, Connecticut.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Dec 01; Vol. 319 (6), pp. F1073-F1080. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Acute Kidney Injury/*chemically induced
Apoptosis/*drug effects
Cisplatin/*toxicity
Epithelial Cells/*drug effects
Kidney Tubules/*drug effects
AMP-Activated Protein Kinases/genetics ; Acute Kidney Injury/enzymology ; Acute Kidney Injury/pathology ; Animals ; Caspase 3/metabolism ; Cell Line ; Epithelial Cells/enzymology ; Epithelial Cells/pathology ; Kidney Tubules/enzymology ; Kidney Tubules/pathology ; Mice ; Phosphorylation ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of autophagy enhances cadmium-induced apoptosis in duck renal tubular epithelial cells.
Autorzy :
Wang C; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Nie G; School of Information Technology, Jiangxi University of Finance and Economics, No. 665 Yuping West Street, Economic and Technological Development District, Nanchang, 330032, Jiangxi, PR China.
Zhuang Y; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Hu R; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Wu H; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Xing C; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Li G; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Hu G; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China.
Yang F; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China. Electronic address: .
Zhang C; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang, 330045, Jiangxi, PR China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111188. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Ducks*
Apoptosis/*drug effects
Autophagosomes/*drug effects
Autophagy/*drug effects
Cadmium/*toxicity
Epithelial Cells/*drug effects
Kidney Tubules/*drug effects
Animals ; Autophagosomes/metabolism ; Autophagosomes/pathology ; Cells, Cultured ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Humans ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Membrane Potential, Mitochondrial/drug effects
Czasopismo naukowe
Tytuł :
Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?
Autorzy :
Obeidat M; Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.
Isaacson AL; Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.
Chen SJ; Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.
Ivanovic M; Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.
Holanda D; Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.
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Źródło :
Ultrastructural pathology [Ultrastruct Pathol] 2020 Nov 20; Vol. 44 (4-6), pp. 519-523. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Case Reports
MeSH Terms :
Acute Kidney Injury/*chemically induced
Antiviral Agents/*adverse effects
COVID-19/*drug therapy
Hydroxychloroquine/*adverse effects
Kidney Tubules/*drug effects
Organelles/*drug effects
Phospholipids/*metabolism
Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Aged ; Autopsy ; Fatal Outcome ; Humans ; Kidney Tubules/metabolism ; Kidney Tubules/ultrastructure ; Male ; Organelles/metabolism ; Organelles/ultrastructure
SCR Protocol :
COVID-19 drug treatment
Raport
Tytuł :
Rhabdomyolysis-Induced AKI Was Ameliorated in NLRP3 KO Mice via Alleviation of Mitochondrial Lipid Peroxidation in Renal Tubular Cells.
Autorzy :
Song SJ; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
Kim SM; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
Lee SH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
Moon JY; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
Hwang HS; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
Kim JS; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
Park SH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
Jeong KH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
Kim YG; Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul 05278, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 13; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury*/etiology
Acute Kidney Injury*/genetics
Acute Kidney Injury*/metabolism
Acute Kidney Injury*/pathology
Kidney Tubules*/metabolism
Kidney Tubules*/pathology
Lipid Peroxidation*
Mitochondria*/genetics
Mitochondria*/metabolism
Mitochondria*/pathology
Rhabdomyolysis*/complications
Rhabdomyolysis*/genetics
Rhabdomyolysis*/metabolism
Rhabdomyolysis*/pathology
NLR Family, Pyrin Domain-Containing 3 Protein/*deficiency
Animals ; Mice ; Mice, Knockout ; Mitochondrial Dynamics/genetics ; Myoglobin/genetics ; Myoglobin/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe

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