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Tytuł :
Ras/Raf/MEK/ERK pathway axis mediated neurotoxicity induced by high-risk pesticide residue-Avermectin.
Autorzy :
Zhu T; Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou, China.; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, China.; Xiangyang Central Hospital, Xiangyang, China.
Liu X; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, China.
Song J; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, China.
Li D; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, China.
Pang XJ; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, China.
Wang SH; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.; Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li QR; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Fu DJ; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, China.
Zhang SY; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.; Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, China.; Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, China.
Xie HZ; Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou, China.; Key Laboratory of Fruit Breeding Technology,Ministry of Agriculture and Rural Affairs, Zhengzhou, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 May; Vol. 36 (5), pp. 984-993. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Pesticide Residues*
raf Kinases*/metabolism
China ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Ivermectin/analogs & derivatives ; MAP Kinase Kinase Kinases ; MAP Kinase Signaling System ; Mitogen-Activated Protein Kinase Kinases/metabolism
Czasopismo naukowe
Tytuł :
Noncanonical Gene Fusions Detected at the DNA Level Necessitate Orthogonal Diagnosis Methods Before Targeted Therapy.
Autorzy :
Song Z; Department of Clinical Trial, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, People's Republic of China; Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, People's Republic of China.
Lu C; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, People's Republic of China; Biotechnology and Health Centre, City University of Hong Kong Shenzhen Research Institute, Shenzhen, People's Republic of China.
Xu CW; Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Zheng Z; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, People's Republic of China; Biotechnology and Health Centre, City University of Hong Kong Shenzhen Research Institute, Shenzhen, People's Republic of China; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, People's Republic of China. Electronic address: .
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Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2021 Mar; Vol. 16 (3), pp. 344-348.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Lung Neoplasms*/diagnosis
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Protein-Tyrosine Kinases*
DNA/genetics ; Gene Fusion ; Genomics ; Humans ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-ret ; Receptor Protein-Tyrosine Kinases
Raport
Tytuł :
Bacterial Protein Kinases.
Autorzy :
Engin ED; Ankara University, Biotechnology Institute, Gümüşdere Campus, Keçiören, Ankara, Turkey. .
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1275, pp. 323-338.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Protein Kinases*/genetics
Protein Kinases*/metabolism
Bacteria/genetics ; Bacteria/metabolism ; Phosphorylation ; Protein Processing, Post-Translational ; Protein-Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Protein Kinases in Hematological Disorders.
Autorzy :
Okay M; Hacettepe University, Medical School, Department of Hematology, Ankara, Turkey.
Haznedaroglu IC; Hacettepe University, Medical School, Department of Hematology, Ankara, Turkey. .
Pokaż więcej
Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1275, pp. 383-393.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Janus Kinases*/metabolism
Signal Transduction*
Hematopoietic Stem Cells/metabolism ; Phosphorylation ; Renin-Angiotensin System ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK/mTOR/ULK1 signalling pathway.
Autorzy :
Lin M; Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
Hua R; Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Ma J; Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhou Y; Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li P; Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
Xu X; Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yu Z; State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. Electronic address: .
Quan S; Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: .
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Źródło :
Environment international [Environ Int] 2021 Feb; Vol. 147, pp. 106298. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AMP-Activated Protein Kinases*
Infertility, Female*
Signal Transduction*
Animals ; Autophagy ; Autophagy-Related Protein-1 Homolog ; Benzhydryl Compounds ; Female ; Granulosa Cells ; Humans ; Intracellular Signaling Peptides and Proteins ; Mice ; Phenols ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma.
Autorzy :
Lamberti G; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Andrini E; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Sisi M; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Rizzo A; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Parisi C; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Di Federico A; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Gelsomino F; Oncologia Medica, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni - 15, Bologna, Italy. Electronic address: .
Ardizzoni A; Department of Specialized, Experimental and Diagnostic Medicine, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; Oncologia Medica, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni - 15, Bologna, Italy.
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Źródło :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2020 Dec; Vol. 156, pp. 103119. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Protein-Tyrosine Kinases*
Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Anaplastic Lymphoma Kinase ; ErbB Receptors/genetics ; Humans ; Mutation ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Tytuł :
Dysregulation of Wnt/β-catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application.
Autorzy :
Li Q; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Sun M; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Wang M; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Feng M; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Yang F; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Li L; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Zhao J; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Chang C; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Dong H; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Xie T; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.
Chen J; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Department of Hepatology, Institute of Hepatology and Metabolic Diseases, Institute of Integrated Chinese and Western Medicine for Oncology, The Affiliated Hospital of Hangzhou Normal University, College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China.; Division of Cellular and Molecular Research, Laboratory of Cancer Genomics, National Cancer Centre, Singapore City, Singapore.
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Źródło :
Cancer science [Cancer Sci] 2021 May; Vol. 112 (5), pp. 1695-1706. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
Protein Kinases/*metabolism
Wnt Signaling Pathway/*physiology
beta Catenin/*antagonists & inhibitors
Axin Signaling Complex/metabolism ; CDC2 Protein Kinase/metabolism ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/therapy ; Combined Modality Therapy/methods ; Creatine Kinase/metabolism ; Cyclin-Dependent Kinases/metabolism ; ErbB Receptors/metabolism ; Focal Adhesion Kinase 1/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Liver Neoplasms/etiology ; Liver Neoplasms/therapy ; Low Density Lipoprotein Receptor-Related Protein-5/metabolism ; Low Density Lipoprotein Receptor-Related Protein-6/metabolism ; MAP Kinase Kinase Kinases/metabolism ; NIMA-Related Kinases/metabolism ; Precision Medicine ; Protein Kinase Inhibitors/therapeutic use ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-met/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor Tyrosine Kinase-like Orphan Receptors/metabolism ; Wnt Proteins/antagonists & inhibitors ; Wnt Proteins/metabolism ; beta Catenin/metabolism ; p21-Activated Kinases/metabolism ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
Recent advances in development of hetero-bivalent kinase inhibitors.
Autorzy :
Lee S; College of Pharmacy, CHA University, Pocheon-si, Gyeonggi-do, 11160, Republic of Korea.
Kim J; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Jo J; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Chang JW; Department of Pharmacology & Chemical Biology, School of Medicine, Emory University, Atlanta, GA, USA; Department of Hematology & Medical Oncology, School of Medicine, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Sim J; College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea. Electronic address: .
Yun H; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113318. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Protein Kinase Inhibitors/*chemistry
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/metabolism ; Receptor, EphA1/antagonists & inhibitors ; Receptor, EphA1/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism ; src-Family Kinases/antagonists & inhibitors ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
PINK1-mediated mitophagy maintains pluripotency through optineurin.
Autorzy :
Wang C; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; School of Life Sciences, Qufu Normal University, Qufu, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Liu K; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Cao J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Wang L; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Zhao Q; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Li Z; Department of Digestive System, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhang H; School of Life Sciences, Qufu Normal University, Qufu, China.
Chen Q; College of Life Sciences, Nankai University, Tianjin, China.
Zhao T; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; School of Life Sciences, Qufu Normal University, Qufu, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 May; Vol. 54 (5), pp. e13034.
Typ publikacji :
Journal Article
MeSH Terms :
Mitophagy*
Cell Cycle Proteins/*metabolism
Membrane Transport Proteins/*metabolism
Protein Kinases/*metabolism
Animals ; CRISPR-Cas Systems/genetics ; Cell Cycle Proteins/deficiency ; Cell Cycle Proteins/genetics ; Cellular Reprogramming ; Gene Editing ; Membrane Transport Proteins/deficiency ; Membrane Transport Proteins/genetics ; Mice ; Mice, Knockout ; Mitochondria/metabolism ; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/metabolism ; Mutagenesis, Site-Directed ; Phosphorylation ; Protein Kinases/chemistry ; Protein Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways.
Autorzy :
Zhang Y; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
Li Y; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, PR China.
Zhang J; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
Qi X; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
Cui Y; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
Yin K; College of Wildlife Resources, Northeast Forestry University, Harbin 150040, PR China.
Lin H; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Mar 15; Vol. 415, pp. 115449. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Extracellular Signal-Regulated MAP Kinases*
Apoptosis/*drug effects
Cadmium Chloride/*toxicity
Epididymis/*drug effects
Inflammation/*chemically induced
Mitochondria/*drug effects
Mitogen-Activated Protein Kinase Kinases/*metabolism
NF-kappa B/*metabolism
Proto-Oncogene Proteins c-raf/*metabolism
Animals ; Apoptosis Regulatory Proteins/metabolism ; Epididymis/enzymology ; Epididymis/pathology ; Heat-Shock Proteins/metabolism ; Inflammation/enzymology ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Male ; Mitochondria/enzymology ; Mitochondria/pathology ; Signal Transduction ; Sus scrofa
Czasopismo naukowe
Tytuł :
[shRNA-Mediated Suppression of γ-Synuclein Leading to Downregulation of p38/ERK/JNK Phosphorylation and Cell Cycle Arrest in Endometrial Cancer Cells].
Autorzy :
Sun D; Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 People's Republic of China.
Li WY; Department of Gynaecology and Obstetrics, Liuzhou General Hospital, Liuzhou, 545006 People's Republic of China.
Chen SH; Department of Gynaecology, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, 545001 People's Republic of China.
Zhi ZF; Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 People's Republic of China.
Lin HS; Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 People's Republic of China.
Fan JT; Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 People's Republic of China.; .
Fan YJ; Department of Gynaecology and Obstetrics, University of Chinese Academy of Sciences, Shenzhen Hospital, Shenzhen, 518106 People's Republic of China.; .
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Źródło :
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2020 Nov-Dec; Vol. 54 (6), pp. 1006-1017.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle Checkpoints*
Endometrial Neoplasms*/genetics
Endometrial Neoplasms*/pathology
Extracellular Signal-Regulated MAP Kinases*/metabolism
Neoplasm Proteins/*genetics
RNA, Small Interfering/*genetics
gamma-Synuclein/*genetics
Cell Line, Tumor ; Cell Proliferation/genetics ; Down-Regulation ; Female ; Humans ; Phosphorylation ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
PINK1-Parkin signaling in Parkinson's disease: Lessons from Drosophila.
Autorzy :
Imai Y; Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan. Electronic address: .
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Źródło :
Neuroscience research [Neurosci Res] 2020 Oct; Vol. 159, pp. 40-46. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drosophila Proteins*
Mitochondria*/genetics
Mitochondria*/pathology
Parkinson Disease*/enzymology
Parkinson Disease*/genetics
Parkinson Disease*/physiopathology
Protein-Serine-Threonine Kinases*
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Animals ; DNA-Binding Proteins/metabolism ; Disease Models, Animal ; Drosophila ; Humans ; Protein Kinases/genetics ; Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
mTORC1 silencing during intestinal epithelial Caco-2 cell differentiation is mediated by the activation of the AMPK/TSC2 pathway.
Autorzy :
Kaur H; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Moreau R; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Mar 19; Vol. 545, pp. 183-188. Date of Electronic Publication: 2021 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Intestinal Mucosa/*metabolism
Mechanistic Target of Rapamycin Complex 1/*antagonists & inhibitors
Mechanistic Target of Rapamycin Complex 1/*metabolism
Tuberous Sclerosis Complex 2 Protein/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/metabolism ; Caco-2 Cells ; Cell Differentiation ; Down-Regulation ; Humans ; Intestinal Mucosa/cytology ; MAP Kinase Signaling System ; Models, Biological ; Phosphorylation ; Regulatory-Associated Protein of mTOR/chemistry ; Regulatory-Associated Protein of mTOR/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Clash of the cascades: Release the inhibition.
Autorzy :
Currier BS; Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
Joanisse S; Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
McKendry J; Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
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Źródło :
The Journal of physiology [J Physiol] 2020 Oct; Vol. 598 (19), pp. 4153-4154. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
AMP-Activated Protein Kinases*
Glycogen*
Mechanistic Target of Rapamycin Complex 1 ; Muscle, Skeletal ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
p38 MAPK reins in right ventricular growth.
Autorzy :
Wu T
Chen J
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Oct 01; Vol. 130 (10), pp. 5109-5111.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Heart Ventricles*
p38 Mitogen-Activated Protein Kinases*/genetics
Animals ; Endoribonucleases ; Female ; Heart ; Pregnancy ; Protein-Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
An International Real-World Analysis of the Efficacy and Safety of Lorlatinib Through Early or Expanded Access Programs in Patients With Tyrosine Kinase Inhibitor-Refractory ALK-Positive or ROS1-Positive NSCLC.
Autorzy :
Zhu VW; Chao Family Comprehensive Cancer Center, University of California, Irvine School of Medicine, Orange, California.
Lin YT; Department of Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University Cancer Center, National Taiwan University, Taipei, Taiwan, Republic of China; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China.
Kim DW; Department of Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Loong HH; Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Nagasaka M; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
To H; University of Nevada School of Medicine, Reno, Nevada.
Ang YL; Department of Hematology-Oncology, National University Cancer Institute, Singapore.
Ock CY; Department of Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Tchekmedyian N; Pacific Shores Medical Group, Long Beach, California.
Ou SI; Chao Family Comprehensive Cancer Center, University of California, Irvine School of Medicine, Orange, California. Electronic address: .
Syn NL; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Reungwetwattana T; Division of Medical Oncology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Lin CC; Department of Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University Cancer Center, National Taiwan University, Taipei, Taiwan, Republic of China; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China.
Soo RA; Department of Hematology-Oncology, National University Cancer Institute, Singapore.
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Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2020 Sep; Vol. 15 (9), pp. 1484-1496. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms*/drug therapy
Protein-Tyrosine Kinases*
Hong Kong ; Humans ; Lactams, Macrocyclic ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases ; Republic of Korea ; Taiwan
Czasopismo naukowe
Tytuł :
Potential for Protein Kinase Pharmacological Regulation in Flaviviridae Infections.
Autorzy :
Blázquez AB; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain.
Saiz JC; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 15; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Flaviviridae Infections/*drug therapy
Hepacivirus/*drug effects
Hepatitis C, Chronic/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Protein Kinases/*metabolism
Antiviral Agents/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Casein Kinase I/antagonists & inhibitors ; Casein Kinase I/metabolism ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cyclin-Dependent Kinases/metabolism ; Flaviviridae/drug effects ; Flaviviridae/enzymology ; Flaviviridae Infections/enzymology ; Hepacivirus/enzymology ; Hepacivirus/metabolism ; Hepatitis C, Chronic/metabolism ; Humans ; Phosphorylation ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Structural basis for the action of the drug trametinib at KSR-bound MEK.
Autorzy :
Khan ZM; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Real AM; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marsiglia WM; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chow A; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Duffy ME; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yerabolu JR; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Scopton AP; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dar AC; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature [Nature] 2020 Dec; Vol. 588 (7838), pp. 509-514. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitogen-Activated Protein Kinase Kinases/*chemistry
Mitogen-Activated Protein Kinase Kinases/*metabolism
Protein Kinases/*chemistry
Protein Kinases/*metabolism
Pyridones/*chemistry
Pyridones/*pharmacology
Pyrimidinones/*chemistry
Pyrimidinones/*pharmacology
Amino Acid Sequence ; Animals ; Binding Sites/drug effects ; Humans ; Mice ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Models, Molecular ; Protein Binding/drug effects ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Substrate Specificity ; raf Kinases/chemistry ; raf Kinases/metabolism
Czasopismo naukowe
Tytuł :
C5aR deficiency attenuates the breast cancer development via the p38/p21 axis.
Autorzy :
Chen J; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Sun ZH; Breast Disease Center, Guiqian International General Hospital, Guiyang 550000, China.
Chen LY; Institute of Cancer, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Xu F; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Zhao YP; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Li GQ; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Tang M; Urinary Nephropathy Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400065, China.
Li Y; Department of ICU, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Zheng QY; Department of Urology, 958 Hospital, Army Medical University (Third Military Medical University), Chongqing 400020, China.
Wang SF; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Yang XH; Breast Disease Center, Guiqian International General Hospital, Guiyang 550000, China.
Wu YZ; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Xu GL; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Jul 15; Vol. 12 (14), pp. 14285-14299. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
p21-Activated Kinases*
p38 Mitogen-Activated Protein Kinases*
Breast Neoplasms/*genetics
Receptor, Anaphylatoxin C5a/*genetics
Signal Transduction/*genetics
Adult ; Animals ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cellular Senescence ; Complement C5a ; Female ; Humans ; MAP Kinase Signaling System ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Middle Aged ; Mitogen-Activated Protein Kinases/genetics ; Receptor, Anaphylatoxin C5a/antagonists & inhibitors ; Recombinant Proteins/pharmacology
Czasopismo naukowe

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