Temat: "KINASES" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Effect of High-Fat Food on the Pharmacokinetic Profile and Safety of SAF-189s, an ALK/ROS1 Inhibitor, in Healthy Chinese Adults.
Autorzy:: Qin H; Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Tan Y; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Diao L; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Hui AM; EnCureGen Pharma, 9 Yayingshi Road, Huangpu District, Guangzhou, 510700, China.
Wu Z; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Zhou Y; Wanbang Biopharmaceuticals, 6 Yangshan Road, Economic Zone, Xuzhou, 221004, Jiangsu, China.
Sun J; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Xiang X; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Qiu J; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Hu W; Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. .; Pokaż więcej
Źródło:: Drugs in R&D [Drugs R D] 2023 Dec; Vol. 23 (4), pp. 465-473. Date of Electronic Publication: 2023 Nov 07.
Typ publikacji:: Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article
MeSH Terms:: East Asian People*
Protein-Tyrosine Kinases*/pharmacokinetics
Diet, High-Fat*
Adult ; Humans ; Administration, Oral ; Area Under Curve ; Biological Availability ; Cross-Over Studies ; Fasting ; Food-Drug Interactions ; Healthy Volunteers ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases

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Skocz do pozycji: 2.

Tytuł:: Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Autorzy:: Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Katis VL; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Du Y; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Sikdar A; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Wang D; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Bradshaw WJ; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Rygiel KA; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Leisner TM; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Chalk R; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Mishra S; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Williams CA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Gileadi O; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Brennan PE; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Wiley JC; Sage Bionetworks, Seattle, WA, United States of America.
Gockley J; Sage Bionetworks, Seattle, WA, United States of America.
Cary GA; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America.
Carter GW; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America.
Young JE; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Pearce KH; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Fu H; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.; Pokaż więcej
Corporate Authors:: Emory-Sage-SGC TREAT-AD Center
Źródło:: PloS one [PLoS One] 2024 Feb 15; Vol. 19 (2), pp. e0293548. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: src Homology Domains*
Protein-Tyrosine Kinases*/metabolism
Humans ; Immunoreceptor Tyrosine-Based Activation Motif ; Intracellular Signaling Peptides and Proteins/metabolism ; Syk Kinase/metabolism ; Phosphorylation ; Receptors, Fc/metabolism ; Enzyme Precursors/metabolism

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Skocz do pozycji: 3.

Tytuł:: Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract.
Autorzy:: Kiyozumi D; Japan Science and Technology Agency, 7, Gobancho, Chiyoda-ku, Tokyo, 102-0076, Japan. .; Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. .; Pokaż więcej
Źródło:: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2024 Jan 02; Vol. 22 (1), pp. 3. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:: Journal Article
MeSH Terms:: Protein-Tyrosine Kinases*
Proto-Oncogene Proteins*/metabolism
Humans ; Male ; Mice ; Animals ; Ligands ; Semen ; Testis/metabolism ; Epididymis/metabolism ; Spermatozoa/metabolism ; Nerve Tissue Proteins

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Skocz do pozycji: 4.

Tytuł:: A Comprehensive Review of Small-Molecule Inhibitors Targeting Bruton Tyrosine Kinase: Synthetic Approaches and Clinical Applications.
Autorzy:: Zhang Q; Nanyang Central Hospital, Nanyang 473000, China.
Wen C; Nanyang Central Hospital, Nanyang 473000, China.
Zhao L; The Rogel Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Wang Y; First People's Hospital of Shangqiu, Shangqiu 476100, China.; Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 11; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 11.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Protein-Tyrosine Kinases*
Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Humans ; Adult ; Agammaglobulinaemia Tyrosine Kinase/metabolism ; B-Lymphocytes/metabolism ; Signal Transduction

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Skocz do pozycji: 5.

Tytuł:: Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1 .
Autorzy:: Liu S; Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medicinal University (Foshan Maternity & Child Healthcare Hospital), Foshan, China.; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Huang C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Huang C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Huang Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Yu Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Wu G; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Guo F; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Jiang Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Wan S; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Zhu Z; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Tian Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Zhu J; Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medicinal University (Foshan Maternity & Child Healthcare Hospital), Foshan, China.
Zhang J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2227779.
Typ publikacji:: Journal Article
MeSH Terms:: Protein-Tyrosine Kinases*
Lung Neoplasms*
Humans ; Anaplastic Lymphoma Kinase ; Drug Resistance, Neoplasm ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/chemistry ; Crizotinib/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Mutation ; Cell Line, Tumor

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Skocz do pozycji: 6.

Tytuł:: Preventive Effect of Pharmaceutical Phytochemicals Targeting the Src Family of Protein Tyrosine Kinases and Aryl Hydrocarbon Receptor on Environmental Stress-Induced Skin Disease.
Autorzy:: Paik SJ; School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea.
Kim DJ; Department of Microbiology, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Jung SK; School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea.; Research Institute of Tailored Food Technology, Kyungpook National University, Daegu 41566, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 21; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 21.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Protein-Tyrosine Kinases*
Skin Diseases*
Humans ; Particulate Matter ; Receptors, Aryl Hydrocarbon/metabolism ; src-Family Kinases/metabolism

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Skocz do pozycji: 7.

Tytuł:: Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
Autorzy:: Kan Y; Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Paung Y; Department of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Seeliger MA; Department of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Miller WT; Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.; Department of Veterans Affairs Medical Center, Northport, NY 11768-2200, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Mar 15; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:: Journal Article; Review; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:: ErbB Receptors*/metabolism
Protein-Tyrosine Kinases*/chemistry
Protein-Tyrosine Kinases*/metabolism
Protein-Tyrosine Kinases*/physiology
Protein Domains ; Receptor Protein-Tyrosine Kinases/metabolism ; src Homology Domains

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Skocz do pozycji: 8.

Tytuł:: Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR.
Autorzy:: Chien W; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. .
Tyner JW; Knight Cancer Institute, Oregon Health & Science University, Oregon Health and Science University, 2720 S.W. Moody Avenue, Portland, OR, 97201, USA.
Gery S; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA.
Zheng Y; Clinical Big Data Research Center, Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, P. R. China.
Li LY; The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guandong Province, P. R. China.
Gopinatha Pillai MS; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA.
Nam C; Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90089, USA.
Bhowmick NA; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA.
Lin DC; Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90089, USA.
Koeffler HP; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA.; Department of Hematology-Oncology, National University Cancer Institute of Singapore, National University Hospital, Singapore, 119074, Singapore.; Pokaż więcej
Źródło:: Journal of ovarian research [J Ovarian Res] 2023 Apr 22; Vol. 16 (1), pp. 80. Date of Electronic Publication: 2023 Apr 22.
Typ publikacji:: Journal Article
MeSH Terms:: Adenocarcinoma, Clear Cell*/drug therapy
Adenocarcinoma, Clear Cell*/pathology
Ataxia Telangiectasia Mutated Proteins*/antagonists & inhibitors
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/pathology
Protein-Tyrosine Kinases*/antagonists & inhibitors
Female ; Humans ; Carcinoma, Ovarian Epithelial ; Cell Cycle Proteins/metabolism ; China ; TOR Serine-Threonine Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use

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Skocz do pozycji: 9.

Tytuł:: Luxeptinib interferes with LYN-mediated activation of SYK and modulates BCR signaling in lymphoma.
Autorzy:: Sonowal H; Moores Cancer Center, Division of Hematology, Department of Medicine, University of California, San Diego, San Diego, California, United States of America.
Rice WG; Aptose Biosciences, Inc., San Diego, California, United States of America.
Howell SB; Moores Cancer Center, Division of Hematology, Department of Medicine, University of California, San Diego, San Diego, California, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Mar 08; Vol. 18 (3), pp. e0277003. Date of Electronic Publication: 2023 Mar 08 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein-Tyrosine Kinases*/metabolism
Lymphoma*/drug therapy
Humans ; src-Family Kinases/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Receptors, Antigen, B-Cell/metabolism ; Syk Kinase/metabolism ; Cell Line ; Phosphorylation

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Skocz do pozycji: 10.

Tytuł:: A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review.
Autorzy:: Liu X; Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Duan Y; Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Department of Pathology, School of Basic Medical Science, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China.
Wang G; Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Department of Pathology, School of Basic Medical Science, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China.
Zhu P; Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. .; Department of Pathology, School of Basic Medical Science, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China. .; Pokaż więcej
Źródło:: Diagnostic pathology [Diagn Pathol] 2023 Sep 21; Vol. 18 (1), pp. 105. Date of Electronic Publication: 2023 Sep 21.
Typ publikacji:: Review; Case Reports; Journal Article
MeSH Terms:: Protein-Tyrosine Kinases*/genetics
Proto-Oncogene Proteins*/genetics
Female ; Humans ; Young Adult ; Antibodies, Monoclonal ; Exons ; Gene Fusion

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Skocz do pozycji: 11.

Tytuł:: DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity.
Autorzy:: Zhu B; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Science, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
Parsons T; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Science, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
Foley C; Department of Chemistry and Biochemistry, University of Arizona, Tucson, USA.
Shaw Y; Division of Drug Discovery and Development, Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, 85721, USA.
Dunckley T; Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ, 85281, USA.
Hulme C; Department of Chemistry and Biochemistry, University of Arizona, Tucson, USA.; Division of Drug Discovery and Development, Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, 85721, USA.
Hodge JJL; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Science, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Sep 23; Vol. 12 (1), pp. 15847. Date of Electronic Publication: 2022 Sep 23.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease*/metabolism
Down Syndrome*/drug therapy
Down Syndrome*/genetics
Down Syndrome*/metabolism
Neurotoxicity Syndromes*
Protein Serine-Threonine Kinases*/antagonists & inhibitors
Protein-Tyrosine Kinases*/antagonists & inhibitors
Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Disease Models, Animal ; Drosophila ; Humans ; Phosphorylation ; Tyrosine/metabolism ; tau Proteins/metabolism ; Dyrk Kinases

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Skocz do pozycji: 12.

Tytuł:: The Omnipresence of DYRK1A in Human Diseases.
Autorzy:: Deboever E; ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
Fistrovich A; Department of Chemistry and Biochemistry, College of Science, The University of Arizona, Tucson, AZ 85721, USA.; Division of Drug Discovery and Development, Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.
Hulme C; Department of Chemistry and Biochemistry, College of Science, The University of Arizona, Tucson, AZ 85721, USA.; Division of Drug Discovery and Development, Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.
Dunckley T; ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Aug 19; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Protein Serine-Threonine Kinases*/genetics
Protein-Tyrosine Kinases*/genetics
Protein-Tyrosine Kinases*/metabolism
Disease ; Humans ; Dyrk Kinases

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Skocz do pozycji: 13.

Tytuł:: Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition.
Autorzy:: Daly RJ; Cancer Program, Monash Biomedicine Discovery Institute, Monash University, 23 Innovation Walk, Clayton, VIC, 3800, Australia. .; Department of Biochemistry & Molecular Biology, Monash University, 23 Innovation Walk, Clayton, VIC, 3800, Australia. .
Scott AM; Department of Biochemistry & Molecular Biology, Monash University, 23 Innovation Walk, Clayton, VIC, 3800, Australia.; Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, 145 Studley Rd, Melbourne-Heidelberg, VIC, 3084, Australia.; Department of Molecular Imaging & Therapy, Austin Health, and Faculty of Medicine, University of Melbourne, 145 Studley Rd, Melbourne-Heidelberg, VIC, 3084, Australia.
Klein O; Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, 145 Studley Rd, Melbourne-Heidelberg, VIC, 3084, Australia.
Ernst M; Department of Biochemistry & Molecular Biology, Monash University, 23 Innovation Walk, Clayton, VIC, 3800, Australia. .; Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, 145 Studley Rd, Melbourne-Heidelberg, VIC, 3084, Australia. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2022 Sep 29; Vol. 21 (1), pp. 189. Date of Electronic Publication: 2022 Sep 29.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Neoplasms*/therapy
Protein-Tyrosine Kinases*
Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Receptor Protein-Tyrosine Kinases ; Tumor Microenvironment ; Tyrosine/therapeutic use

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Skocz do pozycji: 14.

Tytuł:: A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors.
Autorzy:: Qiu X; Cancer Research Center Nantong, Affiliated Tumor Hospital of Nantong University, 30 Tongyang North Road, Nantong, 226361, China.
Shen C; Department of Computer Science and Engineering, Tandon School of Engineering, New York University, Brooklyn, NY 11201, US.
Zhao W; Cancer Research Center Nantong, Affiliated Tumor Hospital of Nantong University, 30 Tongyang North Road, Nantong, 226361, China.
Zhang X; Department of Oncology, Affiliated Tumor Hospital of Nantong University, 30 Tongyang North Road, Nantong, 226361, China.
Zhao D; Cancer Research Center Nantong, Affiliated Tumor Hospital of Nantong University, 30 Tongyang North Road, Nantong, 226361, China.
Wu X; Affiliated Mental Health Center of Nantong University, 37 Chenggang Road, Gangzha District, Nantong, 226005, China. .
Yang L; Department of Oncology, Affiliated Tumor Hospital of Nantong University, 30 Tongyang North Road, Nantong, 226361, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Sep 14; Vol. 12 (1), pp. 15419. Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Neoplasms*/genetics
Protein-Tyrosine Kinases*/metabolism
Carcinogenesis ; Humans ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; Tumor Microenvironment ; Tyrosine/metabolism

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Skocz do pozycji: 15.

Tytuł:: Fer and FerT: A New Regulatory Link between Sperm and Cancer Cells.
Autorzy:: Nir U; The Mina & Everard Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Grinshtain E; The Mina & Everard Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Breitbart H; The Mina & Everard Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 09; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Protein-Tyrosine Kinases*/metabolism
Neoplasms*/metabolism
Male ; Humans ; Semen/metabolism ; Spermatozoa/metabolism ; Phosphorylation

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Skocz do pozycji: 16.

Tytuł:: Combination of EphA2- and Wee1-Targeted Therapies in Endometrial Cancer.
Autorzy:: Dasari SK; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; National Institute of Animal Biotechnology, Hyderabad 500029, India.
Joseph R; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Umamaheswaran S; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mangala LS; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Bayraktar E; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rodriguez-Aguayo C; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Wu Y; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Nguyen N; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Powell RT; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Sobieski M; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Liu Y; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Chowdhury MA; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Amero P; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Stephan C; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Lopez-Berestein G; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Westin SN; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sood AK; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 15; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/therapeutic use
Endometrial Neoplasms*/drug therapy
Protein Kinase Inhibitors*/therapeutic use
Protein-Tyrosine Kinases*/antagonists & inhibitors
Receptor, EphA2*/antagonists & inhibitors
Molecular Targeted Therapy*
Animals ; Female ; Humans ; Mice ; Apoptosis ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation

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Skocz do pozycji: 17.

Tytuł:: Infant-Type Hemispheric Glioma in a Chinese Girl: A Newly Defined Entity.
Autorzy:: Fang Y; Department of Pathology, Anhui Provincial Children's Hospital, Hefei, China.
Wang YZ; Department of Pathology, Anhui Provincial Children's Hospital, Hefei, China.
Wei X; Department of Pathology, Anhui Provincial Children's Hospital, Hefei, China.
Li SM; Department of Pathology, Anhui Provincial Children's Hospital, Hefei, China.
Chen L; Department of Pathology, Children's Hospital of Fudan University, Shanghai, China.; Pokaż więcej
Źródło:: Fetal and pediatric pathology [Fetal Pediatr Pathol] 2023 Feb; Vol. 42 (1), pp. 114-122. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Glioma*/genetics
Protein-Tyrosine Kinases*/genetics
Female ; Humans ; Infant ; Infant, Newborn ; Homozygote ; Proto-Oncogene Proteins/genetics ; Sequence Deletion ; China

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Skocz do pozycji: 18.

Tytuł:: Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.
Autorzy:: Papenfuss M; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Lützow S; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Wilms G; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Babendreyer A; Institute of Molecular Pharmacology, RWTH Aachen University, 52074, Aachen, Germany.
Flaßhoff M; Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, 38106, Braunschweig, Germany.
Kunick C; Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, 38106, Braunschweig, Germany.
Becker W; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Feb 14; Vol. 12 (1), pp. 2393. Date of Electronic Publication: 2022 Feb 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Cycle Proteins/*metabolism
Chaperonins/*metabolism
HSP90 Heat-Shock Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Protein-Tyrosine Kinases/*metabolism
Animals ; Catalytic Domain ; Cell Cycle Proteins/genetics ; Chaperonins/genetics ; HSP90 Heat-Shock Proteins/genetics ; Humans ; Phosphorylation ; Protein Domains ; Protein Folding ; Protein Kinases/chemistry ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/chemistry ; Protein-Tyrosine Kinases/genetics ; Xenopus/genetics ; Xenopus/metabolism ; Xenopus Proteins/chemistry ; Xenopus Proteins/genetics ; Xenopus Proteins/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/chemistry ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Dyrk Kinases

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Skocz do pozycji: 19.

Tytuł:: Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models.
Autorzy:: Jamal R; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
LaCombe J; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Patel R; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Blackwell M; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Thomas JR; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Sloan K; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Wallace JM; Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Roper RJ; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Feb 23; Vol. 17 (2), pp. e0264254. Date of Electronic Publication: 2022 Feb 23 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Catechin/*analogs & derivatives
Down Syndrome/*drug therapy
Muscle, Skeletal/*drug effects
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Protein-Tyrosine Kinases/*antagonists & inhibitors
Animals ; Catechin/administration & dosage ; Catechin/adverse effects ; Catechin/therapeutic use ; Down Syndrome/metabolism ; Drug Administration Schedule ; Female ; Male ; Mice ; Muscle, Skeletal/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Dyrk Kinases

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Skocz do pozycji: 20.

Tytuł:: Novel and Potential Small Molecule Scaffolds as DYRK1A Inhibitors by Integrated Molecular Docking-Based Virtual Screening and Dynamics Simulation Study.
Autorzy:: Shahroz MM; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore 466001, Madhya Pradesh, India.
Sharma HK; Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore 466001, Madhya Pradesh, India.
Altamimi ASA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia.
Alamri MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia.
Ali A; Department of Pharmacognosy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Ali A; Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Alqahtani S; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia.
Altharawi A; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia.
Alabbas AB; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia.
Alossaimi MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia.
Riadi Y; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia.
Firoz A; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia.
Afzal O; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al Kharj 11942, Saudi Arabia.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Feb 09; Vol. 27 (4). Date of Electronic Publication: 2022 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Molecular Docking Simulation*
Molecular Dynamics Simulation*
Protein Kinase Inhibitors*/chemical synthesis
Protein Kinase Inhibitors*/chemistry
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Protein Serine-Threonine Kinases/*chemistry
Protein-Tyrosine Kinases/*antagonists & inhibitors
Protein-Tyrosine Kinases/*chemistry
Catalytic Domain ; Humans ; Molecular Structure ; Dyrk Kinases

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