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Tytuł :
Heterotrimeric Kinesin II is required for flagellar assembly and elongation of nuclear morphology during spermiogenesis in Schmidtea mediterranea.
Autorzy :
Christman DA; Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH, 45435-0001, USA.
Curry HN; Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH, 45435-0001, USA.
Rouhana L; Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH, 45435-0001, USA. Electronic address: .
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Źródło :
Developmental biology [Dev Biol] 2021 Sep; Vol. 477, pp. 191-204. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Kinesin/*physiology
Planarians/*cytology
Sperm Tail/*physiology
Spermatogenesis/*physiology
Animals ; Cell Nucleus/ultrastructure ; Cytoskeletal Proteins/physiology ; Gene Knockdown Techniques ; Kinesin/chemistry ; Kinesin/genetics ; Male ; RNA Interference ; Sperm Head/ultrastructure ; Sperm Tail/ultrastructure
Czasopismo naukowe
Tytuł :
Molecular characterization, dynamic transcription, and potential function of KIF3A/KIF3B during spermiogenesis in Opsariichthys bidens.
Autorzy :
Lin C; Key Laboratory of Applied Marine Biotechnology by the Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211, People's Republic of China.
Tang D; Key Laboratory of Applied Marine Biotechnology by the Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211, People's Republic of China.
Gao X; Key Laboratory of Applied Marine Biotechnology by the Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211, People's Republic of China.
Jiang H; Key Laboratory of Applied Marine Biotechnology by the Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211, People's Republic of China.
Du C; Key Laboratory of Applied Marine Biotechnology by the Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211, People's Republic of China.
Zhu J; Key Laboratory of Applied Marine Biotechnology by the Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211, People's Republic of China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Sep 25; Vol. 798, pp. 145795. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cyprinidae/*physiology
Kinesin/*physiology
Spermatogenesis/*physiology
Animals ; Cyprinidae/genetics ; Kinesin/chemistry ; Kinesin/genetics ; Male ; Microtubules/metabolism ; Mitochondria/metabolism ; Phylogeny ; Protein Conformation ; RNA, Messenger/metabolism ; Sequence Alignment ; Sequence Analysis, DNA ; Sperm Tail/physiology ; Spermatids/physiology ; Spermatids/ultrastructure ; Spermatogenesis/genetics ; Testis/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Differential regulation of single microtubules and bundles by a three-protein module.
Autorzy :
Mani N; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Jiang S; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Neary AE; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Wijeratne SS; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Subramanian R; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Sep; Vol. 17 (9), pp. 964-974. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
Kinesin/*metabolism
Microtubule-Associated Proteins/*metabolism
Microtubules/*metabolism
Cell Cycle Proteins/genetics ; Cell Cycle Proteins/isolation & purification ; Humans ; Kinesin/genetics ; Kinesin/isolation & purification ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
Kinesin Nanomotors Mediated Trafficking of NMDA-Loaded Cargo as A Novel Target in Chronic Pain.
Autorzy :
Uniyal A; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
Thakur V; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
Rani M; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
Tiwari V; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
Akhilesh; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
Gadepalli A; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
Ummadisetty O; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
Modi A; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
Tiwari V; Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology B.H.U., Varanasi 221005, India.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Aug 18; Vol. 12 (16), pp. 2956-2963. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chronic Pain*/drug therapy
Kinesin*/metabolism
Humans ; Neurons/metabolism ; Protein Transport ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Tytuł :
Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking.
Autorzy :
Goldstein-Levitin A; Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Pandey H; Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Allhuzaeel K; Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Kass I; Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; InterX LTD, Ramat-Gan, Israel.
Gheber L; Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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Źródło :
ELife [Elife] 2021 Aug 13; Vol. 10. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
Kinesin/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae/*physiology
Saccharomyces cerevisiae Proteins/*metabolism
Hydrogen Bonding ; Kinesin/chemistry ; Kinesin/classification ; Kinesin/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Spindle Apparatus/metabolism
Czasopismo naukowe
Tytuł :
Multiscale Coarse-Grained Model for the Stepping of Molecular Motors with Application to Kinesin.
Autorzy :
Goldtzvik Y; Department of Chemistry, University of Texas at Austin, Austin, Texas 78705, United States.
Thirumalai D; Department of Chemistry, University of Texas at Austin, Austin, Texas 78705, United States.
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Źródło :
Journal of chemical theory and computation [J Chem Theory Comput] 2021 Aug 10; Vol. 17 (8), pp. 5358-5368. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Kinesin/*chemistry
Kinesin/metabolism ; Microtubules/chemistry ; Microtubules/metabolism
Czasopismo naukowe
Tytuł :
KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma.
Autorzy :
Qiu MJ; Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, China.
Zhang L; Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, China.
Chen YB; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhu LS; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhang B; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li QT; Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, China.
Yang SL; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xiong ZF; Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, China. Electronic address: .
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2021 Aug; Vol. 137, pp. 106037. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial-Mesenchymal Transition*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Carcinoma, Hepatocellular/*pathology
Kinesin/*metabolism
Liver Neoplasms/*pathology
Tumor Microenvironment/*genetics
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/metabolism ; Cell Movement ; Cell Proliferation ; Humans ; Kinesin/genetics ; Liver Neoplasms/genetics ; Liver Neoplasms/immunology ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prognosis ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Characterization of the motility of monomeric kinesin-5/Cin8.
Autorzy :
Yamagishi M; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Maruyama Y; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Sugawa M; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan; Komaba Institute for Science, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Yajima J; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan; Komaba Institute for Science, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan; Research Center for Complex Systems Biology, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 28; Vol. 555, pp. 115-120. Date of Electronic Publication: 2021 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Kinesin/*chemistry
Kinesin/*metabolism
Microtubules/*metabolism
Saccharomyces cerevisiae Proteins/*chemistry
Saccharomyces cerevisiae Proteins/*metabolism
Kinesin/genetics ; Mutation ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
A minus-end directed kinesin motor directs gravitropism in Physcomitrella patens.
Autorzy :
Li Y; State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences and School of Life Sciences, Peking University, Beijing, China.
Deng Z; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, China.
Kamisugi Y; Centre for Plant Sciences, University of Leeds, Leeds, UK.
Chen Z; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, China.; Tsinghua-Peking Center for Life Sciences, Beijing, China.
Wang J; State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences and School of Life Sciences, Peking University, Beijing, China.
Han X; State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences and School of Life Sciences, Peking University, Beijing, China.
Wei Y; State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences and School of Life Sciences, Peking University, Beijing, China.; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, China.
He H; State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences and School of Life Sciences, Peking University, Beijing, China.
Terzaghi W; Department of Biology, Wilkes University, Wilkes-Barre, PA, USA.
Cove DJ; Centre for Plant Sciences, University of Leeds, Leeds, UK.
Cuming AC; Centre for Plant Sciences, University of Leeds, Leeds, UK.
Chen H; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, China. .; Tsinghua-Peking Center for Life Sciences, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 22; Vol. 12 (1), pp. 4470. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bryopsida/*physiology
Gravitropism/*physiology
Kinesin/*physiology
Plant Proteins/*physiology
Actin Cytoskeleton/chemistry ; Actin Cytoskeleton/physiology ; Base Sequence ; Bryopsida/genetics ; Chromosome Mapping ; Cytoskeleton/chemistry ; Cytoskeleton/physiology ; DNA, Plant/genetics ; Genes, Plant ; Gravitropism/genetics ; Kinesin/chemistry ; Kinesin/genetics ; Microtubules/chemistry ; Microtubules/physiology ; Mutagenesis ; Mutation ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Plants, Genetically Modified ; Protein Domains
Czasopismo naukowe
Tytuł :
Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7.
Autorzy :
Blasius TL; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yue Y; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Prasad R; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Liu X; Department of Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, New York, NY 10461, USA.
Gennerich A; Department of Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, New York, NY 10461, USA.
Verhey KJ; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
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Źródło :
Journal of cell science [J Cell Sci] 2021 Jul 01; Vol. 134 (13). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cilia*
Kinesin*/genetics
Axoneme ; Hedgehog Proteins ; Humans ; Microtubules
Czasopismo naukowe
Tytuł :
Studies of Conformational Changes of Tubulin Induced by Interaction with Kinesin Using Atomistic Molecular Dynamics Simulations.
Autorzy :
Shi XX; School of Material Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
Wang PY; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
Chen H; School of Material Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Xie P; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 23; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Kinesin/*chemistry
Tubulin/*chemistry
Adenosine Diphosphate/chemistry ; Adenosine Diphosphate/metabolism ; Kinesin/metabolism ; Molecular Dynamics Simulation ; Protein Conformation ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14.
Autorzy :
Benoit MPMH; Department Physiology and Biophysics, Albert Einstein College of Medicine, New York, NY, USA.
Asenjo AB; Department Physiology and Biophysics, Albert Einstein College of Medicine, New York, NY, USA.
Paydar M; Department of Medicine, Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.
Dhakal S; Department of Medicine, Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.
Kwok BH; Department of Medicine, Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada. .
Sosa H; Department Physiology and Biophysics, Albert Einstein College of Medicine, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 15; Vol. 12 (1), pp. 3637. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Kinesin/*chemistry
Kinesin/*metabolism
Oncogene Proteins/*chemistry
Oncogene Proteins/*metabolism
Adenosine Diphosphate/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Binding Sites ; Cryoelectron Microscopy ; Kinesin/genetics ; Ligands ; Mice ; Microtubules/chemistry ; Microtubules/genetics ; Microtubules/metabolism ; Molecular Docking Simulation ; Oncogene Proteins/genetics ; Protein Binding ; Protein Conformation ; Protein Domains
Czasopismo naukowe
Tytuł :
Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions.
Autorzy :
Pandey H; Department of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel.
Popov M; Department of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel.
Goldstein-Levitin A; Department of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel.
Gheber L; Department of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 15; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Intracellular Space/*metabolism
Kinesin/*metabolism
Animals ; Humans ; Kinesin/chemistry ; Microtubules/metabolism ; Models, Biological ; Protein Processing, Post-Translational ; Spindle Apparatus/metabolism
Czasopismo naukowe
Tytuł :
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Autorzy :
Qiu R; Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Wu J; Division of Comparative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Gudenas B; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Northcott PA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Lu Q; Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA. .
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Źródło :
Communications biology [Commun Biol] 2021 May 11; Vol. 4 (1), pp. 552. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Kinesin/*metabolism
Medulloblastoma/*metabolism
Neural Stem Cells/*metabolism
Animals ; Cell Cycle/genetics ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/pathology ; Hedgehog Proteins/metabolism ; Kinesin/genetics ; Kinesin/physiology ; Medulloblastoma/physiopathology ; Mice ; Mice, Knockout ; Neural Stem Cells/physiology ; Neurons/metabolism ; Signal Transduction/physiology ; Stem Cells/metabolism
Czasopismo naukowe
Tytuł :
Highly-Parallel Microfluidics-Based Force Spectroscopy on Single Cytoskeletal Motors.
Autorzy :
Urbanska M; B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden, 01069, Dresden, Germany.
Lüdecke A; B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden, 01069, Dresden, Germany.
Walter WJ; B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden, 01069, Dresden, Germany.
van Oijen AM; Zernike Institute for Advanced Materials, University of Groningen, Groningen, AE, 9700, Netherlands.; Molecular Horizons, University of Wollongong, Illawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia.
Duderstadt KE; Zernike Institute for Advanced Materials, University of Groningen, Groningen, AE, 9700, Netherlands.; Structure and Dynamics of Molecular Machines, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.; Physics Department, Technische Universität München, 85748, Garching, Germany.
Diez S; B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden, 01069, Dresden, Germany.; Cluster of Excellence Physics of Life, Technische Universität Dresden, 01062, Dresden, Germany.; Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
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Źródło :
Small (Weinheim an der Bergstrasse, Germany) [Small] 2021 May; Vol. 17 (18), pp. e2007388. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Kinesin*
Microfluidics*
Cytoskeleton ; Microtubules ; Spectrum Analysis
Czasopismo naukowe
Tytuł :
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.
Autorzy :
Hou W; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
Kang W; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
Li Y; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
Shan Y; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
Wang S; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.; Computational Optics Laboratory, Jiangnan University , Wuxi, Jiangsu, China.
Liu F; Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University , Nanjing, Jiangsu, China.
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Źródło :
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 615-629.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dyneins/*metabolism
Kinesin/*metabolism
Microtubules/*metabolism
Porcine epidemic diarrhea virus/*physiology
Animals ; Biological Transport ; Chlorocebus aethiops ; Cytoplasm/metabolism ; Dyneins/antagonists & inhibitors ; Kinesin/genetics ; Membrane Fusion ; Microscopy, Fluorescence ; RNA, Small Interfering ; Vero Cells
Czasopismo naukowe
Tytuł :
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer.
Autorzy :
Das R; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Sjöström M; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Shrestha R; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Yogodzinski C; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
Egusa EA; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Chesner LN; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Chen WS; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Chou J; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Dang DK; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Swinderman JT; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
Ge A; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
Hua JT; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Kabir S; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
Quigley DA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Small EJ; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ashworth A; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Feng FY; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA. .; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. .; Department of Urology, University of California, San Francisco, San Francisco, CA, USA. .; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. .
Gilbert LA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. .; Department of Urology, University of California, San Francisco, San Francisco, CA, USA. .; Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 29; Vol. 12 (1), pp. 4601. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Cycle Proteins/*genetics
Kinesin/*genetics
Nerve Tissue Proteins/*genetics
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*pathology
Animals ; CRISPR-Cas Systems ; Cell Cycle/physiology ; Cell Cycle Proteins/metabolism ; Cell Movement/physiology ; Cells, Cultured ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; Heterografts ; Humans ; Kinesin/metabolism ; Male ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Metastasis ; Neoplasm Staging ; Nerve Tissue Proteins/metabolism ; Prostatic Neoplasms/metabolism ; Survival Rate
Czasopismo naukowe
Tytuł :
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
Autorzy :
Li Y; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Zhu X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences , East China Normal University, Shanghai, China.
Yang M; Department of Orthopedic Oncology, Changzheng Hospital, The Second Military Medical University, Shanghai, China.
Wang Y; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Li J; Department of Pathology, Xuchang Central Hospital Affiliated to Henan University of Science and Technology, Xuchang, China.
Fang J; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Guo W; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Ma S; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Guan F; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2021 Jul; Vol. 60 (7), pp. 440-454. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
DNA-Binding Proteins/*metabolism
Esophageal Neoplasms/*pathology
Esophageal Squamous Cell Carcinoma/*pathology
Kinesin/*genetics
Muscle Proteins/*metabolism
Transcription Factors/*genetics
Transcription Factors/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Aged ; Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; DNA-Binding Proteins/genetics ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/mortality ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/mortality ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Kinesin/metabolism ; Male ; Mice, Nude ; Middle Aged ; Muscle Proteins/genetics ; Prognosis ; Verteporfin/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
Autorzy :
Qian LX; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China.
Cao X; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China.
Du MY; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China.
Ma CX; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China.
Zhu HM; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China.
Peng Y; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China.
Hu XY; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China.
He X; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, 210000, Jiangsu, China. Electronic address: .
Yin L; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210000, Jiangsu, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jun 11; Vol. 557, pp. 192-198. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement/*genetics
Cell Proliferation/*genetics
Esophageal Neoplasms/*metabolism
Kinesin/*metabolism
Neoplasm Invasiveness/*genetics
Radiation Tolerance/*genetics
Cell Line, Tumor ; Cell Movement/radiation effects ; Cell Proliferation/radiation effects ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Gene Knockdown Techniques ; Humans ; Kinesin/genetics ; Prognosis ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Real-Time Polymerase Chain Reaction ; Up-Regulation
Czasopismo naukowe
Tytuł :
USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3.
Autorzy :
Chen W; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Song J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Liu S; Clinical Laboratory, Lishui Central Hospital, Lishui, 323000, China.
Tang B; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Shen L; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Zhu J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Fang S; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Wu F; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Zheng L; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Qiu R; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Chen C; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Gao Y; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Tu J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China.
Zhao Z; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China. .
Ji J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/Clinical College of The Affiliated Central Hospital of Lishui University, Lishui, 323000, China. .
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Źródło :
Journal of biomedical science [J Biomed Sci] 2021 Jun 10; Vol. 28 (1), pp. 44. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Apoptosis/*genetics
Cholangiocarcinoma/*physiopathology
Hypoxia-Inducible Factor-Proline Dioxygenases/*genetics
Kinesin/*genetics
Ubiquitin Thiolesterase/*genetics
Animals ; Cholangiocarcinoma/genetics ; Female ; Humans ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Kinesin/metabolism ; Mice ; Mice, Inbred BALB C ; Ubiquitin Thiolesterase/metabolism ; Ubiquitination
Czasopismo naukowe

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