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Tytuł :
Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma
Autorzy :
Abe, Namiko
Abecasis, Goncalo
Albert, Christine
Palmer Allred, Nicholette (Nichole)
Almasy, Laura
Alonso, Alvaro
Ament, Seth
Anderson, Peter
Anugu, Pramod
Applebaum-Bowden, Deborah
Arking, Dan
Arnett, Donna K.
Ashley-Koch, Allison
Aslibekyan, Stella
Assimes, Tim
Auer, Paul
Avramopoulos, Dimitrios
Barnard, John
Barnes, Kathleen
Barr, R. Graham
Barron-Casella, Emily
Beaty, Terri
Becker, Diane
Becker, Lewis
Beer, Rebecca
Begum, Ferdouse
Beitelshees, Amber
Benjamin, Emelia
Bezerra, Marcos
Bielak, Larry
Bis, Joshua
Blackwell, Thomas
Blangero, John
Boerwinkle, Eric
Borecki, Ingrid
Bowler, Russell
Brody, Jennifer
Broeckel, Ulrich
Broome, Jai
Bunting, Karen
Burchard, Esteban
Cardwell, Jonathan
Carty, Cara
Casaburi, Richard
Casella, James
Chaffin, Mark
Chang, Christy
Chasman, Daniel
Chavan, Sameer
Chen, Bo-Juen
Chen, Wei-Min
Chen, Yii-Der Ida
Cho, Michael H.
Choi, Seung Hoan
Chuang, Lee-Ming
Chung, Mina
Cornell, Elaine
Correa, Adolfo
Crandall, Carolyn
Crapo, James
Cupples, L. Adrienne
Curran, Joanne
Curtis, Jeffrey
Custer, Brian
Damcott, Coleen
Darbar, Dawood
Das, Sayantan
David, Sean
Davis, Colleen
Daya, Michelle
de Andrade, Mariza
DeBaun, Michael
Deka, Ranjan
DeMeo, Dawn
Devine, Scott
Do, Ron
Duan, Qing
Duggirala, Ravi
Durda, Peter
Dutcher, Susan
Eaton, Charles
Ekunwe, Lynette
Ellinor, Patrick
Emery, Leslie
Farber, Charles
Farnam, Leanna
Fingerlin, Tasha
Flickinger, Matthew
Fornage, Myriam
Franceschini, Nora
Fu, Mao
Fullerton, Stephanie M.
Fulton, Lucinda
Gabriel, Stacey
Gan, Weiniu
Gao, Yan
Gass, Margery
Gelb, Bruce
Geng, Xiaoqi (Priscilla)
Germer, Soren
Gignoux, Chris
Gladwin, Mark
Glahn, David
Gogarten, Stephanie
Gong, Da-Wei
Goring, Harald
Gu, C. Charles
Guan, Yue
Guo, Xiuqing
Haessler, Jeff
Hall, Michael
Harris, Daniel
Hawley, Nicola
He, Jiang
Heavner, Ben
Heckbert, Susan
Hernandez, Ryan
Herrington, David
Hersh, Craig
Hidalgo, Bertha
Hixson, James
Hokanson, John
Holly, Kramer
Hong, Elliott
Hoth, Karin
(Agnes) Hsiung, Chao
Huston, Haley
Hwu, Chii Min
Irvin, Marguerite Ryan
Jackson, Rebecca
Jain, Deepti
Jaquish, Cashell
Jhun, Min A.
Johnsen, Jill
Johnson, Andrew
Johnson, Craig
Johnston, Rich
Jones, Kimberly
Kachroo, Priyadarshini
Kang, Hyun Min
Kaplan, Robert
Kardia, Sharon
Kathiresan, Sekar
Kaufman, Laura
Kelly, Shannon
Kenny, Eimear
Kessler, Michael
Khan, Alyna
Kinney, Greg
Konkle, Barbara
Kooperberg, Charles
Krauter, Stephanie
Lange, Christoph
Lange, Ethan
Lange, Leslie
Laurie, Cathy
Laurie, Cecelia
LeBoff, Meryl
Lee, Seunggeun Shawn
Lee, Wen-Jane
LeFaive, Jonathon
Levine, David
Levy, Dan
Lewis, Joshua
Li, Yun
Lin, Honghuang
Lin, Keng Han
Liu, Simin
Liu, Yongmei
Loos, Ruth
Lubitz, Steven
Lunetta, Kathryn
Luo, James
Mahaney, Michael
Make, Barry
Manichaikul, Ani
Manson, JoAnn
Margolin, Lauren
Martin, Lisa
Mathai, Susan
Mathias, Rasika
McArdle, Patrick
McDonald, Merry-Lynn
McFarland, Sean
McGarvey, Stephen
Mei, Hao
Meyers, Deborah A.
Mikulla, Julie
Min, Nancy
Minear, Mollie
Minster, Ryan L.
Mitchell, Braxton
Montasser, May E.
Musani, Solomon
Mwasongwe, Stanford
Mychaleckyj, Josyf C.
Nadkarni, Girish
Naik, Rakhi
Natarajan, Pradeep
Nekhai, Sergei
Nickerson, Deborah
North, Kari
O'Connell, Jeff
O'Connor, Tim
Ochs-Balcom, Heather
Pankow, James
Papanicolaou, George
Parker, Margaret
Parsa, Afshin
Penchev, Sara
Peralta, Juan Manuel
Perez, Marco
Perry, James
Peters, Ulrike
Peyser, Patricia
Phillips, Lawrence S.
Phillips, Sam
Pollin, Toni
Post, Wendy
Becker, Julia Powers
Boorgula, Meher Preethi
Preuss, Michael
Prokopenko, Dmitry
Psaty, Bruce
Qasba, Pankaj
Qiao, Dandi
Qin, Zhaohui
Rafaels, Nicholas
Raffield, Laura
Ramachandran, Vasan
Rao, D.C.
Rasmussen-Torvik, Laura
Ratan, Aakrosh
Redline, Susan
Reed, Robert
Regan, Elizabeth
Reiner, Alex
Rice, Ken
Rich, Stephen
Roden, Dan
Roselli, Carolina
Rotter, Jerome
Ruczinski, Ingo
Russell, Pamela
Ruuska, Sarah
Ryan, Kathleen
Sakornsakolpat, Phuwanat
Salimi, Shabnam
Salzberg, Steven
Sandow, Kevin
Sankaran, Vijay
Scheller, Christopher
Schmidt, Ellen
Schwander, Karen
Schwartz, David
Sciurba, Frank
Seidman, Christine
Seidman, Jonathan
Sheehan, Vivien
Shetty, Amol
Shetty, Aniket
Sheu, Wayne Hui-Heng
Shoemaker, M. Benjamin
Silver, Brian
Silverman, Edwin
Smith, Jennifer
Smith, Josh
Smith, Nicholas
Smith, Tanja
Smoller, Sylvia
Snively, Beverly
Sofer, Tamar
Sotoodehnia, Nona
Stilp, Adrienne
Streeten, Elizabeth
Sung, Yun Ju
Su-Lasky, Jessica
Sylvia, Jody
Szpiro, Adam
Sztalryd, Carole
Taliun, Daniel
Tang, Hua
Taub, Margaret
Taylor, Kent
Taylor, Simeon
Telen, Marilyn
Thornton, Timothy A.
Tinker, Lesley
Tirschwell, David
Tiwari, Hemant
Tracy, Russell
Tsai, Michael
Vaidya, Dhananjay
VandeHaar, Peter
Vrieze, Scott
Walker, Tarik
Wallace, Robert
Walts, Avram
Wan, Emily
Wang, Fei Fei
Watson, Karol
Weeks, Daniel E.
Weir, Bruce
Weiss, Scott
Weng, Lu-Chen
Willer, Cristen
Williams, Kayleen
Williams, L. Keoki
Wilson, Carla
Wilson, James
Wong, Quenna
Xu, Huichun
Yanek, Lisa
Yang, Ivana
Yang, Rongze
Zaghloul, Norann
Zekavat, Maryam
Zhang, Yingze
Zhao, Snow Xueyan
Zhao, Wei
Zheng, Xiuwen
Zhi, Degui
Zhou, Xiang
Zody, Michael
Zoellner, Sebastian
Kachroo, Priyadarshini
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Źródło :
In Chest December 2019 156(6):1068-1079
Czasopismo naukowe
Tytuł :
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Autorzy :
Merid, Simon KebedeAff1, Aff2
Novoloaca, Alexei
Sharp, Gemma C.Aff4, Aff5
Küpers, Leanne K.Aff5, Aff6, Aff7
Kho, Alvin T.
Roy, RituAff9, Aff10
Gao, Lu
Annesi-Maesano, Isabella
Jain, PoojaAff13, Aff14
Plusquin, MichelleAff13, Aff15
Kogevinas, ManolisAff16, Aff17, Aff18, Aff19
Allard, Catherine
Vehmeijer, Florianne O.Aff21, Aff22
Kazmi, NabilaAff4, Aff5
Salas, Lucas A.
Rezwan, Faisal I.
Zhang, Hongmei
Sebert, SylvainAff26, Aff27, Aff28
Czamara, Darina
Rifas-Shiman, Sheryl L.
Melton, Phillip E.Aff31, Aff32
Lawlor, Debbie A.Aff4, Aff5, Aff33
Pershagen, GöranAff1, Aff34
Breton, Carrie V.
Huen, Karen
Baiz, Nour
Gagliardi, Luigi
Nawrot, Tim S.Aff13, Aff37
Corpeleijn, Eva
Perron, PatriceAff20, Aff38
Duijts, LiesbethAff21, Aff22
Nohr, Ellen Aagaard
Bustamante, MarionaAff16, Aff17, Aff18
Ewart, Susan L.
Karmaus, Wilfried
Zhao, Shanshan
Page, Christian M.
Herceg, Zdenko
Jarvelin, Marjo-RiittaAff26, Aff27, Aff43, Aff44
Lahti, JariAff45, Aff46
Baccarelli, Andrea A.
Anderson, Denise
Kachroo, Priyadarshini
Relton, Caroline L.Aff4, Aff5, Aff33
Bergström, AnnaAff1, Aff34
Eskenazi, Brenda
Soomro, Munawar Hussain
Vineis, Paolo
Snieder, Harold
Bouchard, LuigiAff20, Aff52, Aff53
Jaddoe, Vincent W.Aff21, Aff22
Sørensen, Thorkild I. A.Aff4, Aff54, Aff55
Vrijheid, MartineAff16, Aff17, Aff18
Arshad, S. HasanAff56, Aff57
Holloway, John W.
Håberg, Siri E.
Magnus, Per
Dwyer, TerenceAff59, Aff60
Binder, Elisabeth B.Aff29, Aff61
DeMeo, Dawn L.
Vonk, Judith M.Aff7, Aff62
Newnham, John
Tantisira, Kelan G.
Kull, IngerAff2, Aff64
Wiemels, Joseph L.
Heude, Barbara
Sunyer, JordiAff16, Aff17, Aff18, Aff19
Nystad, Wenche
Munthe-Kaas, Monica C.Aff42, Aff67
Räikkönen, Katri
Oken, Emily
Huang, Rae-Chi
Weiss, Scott T.
Antó, Josep MariaAff16, Aff17, Aff18, Aff19
Bousquet, JeanAff68, Aff69
Kumar, AshishAff1, Aff70, Aff71
Söderhäll, Cilla
Almqvist, CatarinaAff73, Aff74
Cardenas, Andres
Gruzieva, OlenaAff1, Aff34
Xu, Cheng-Jian
Reese, Sarah E.
Kere, JuhaAff77, Aff78
Brodin, PetterAff72, Aff79, Aff80
Solomon, Olivia
Wielscher, Matthias
Holland, Nina
Ghantous, Akram
Hivert, Marie-FranceAff20, Aff30, Aff81
Felix, Janine F.Aff21, Aff22
Koppelman, Gerard H.
London, Stephanie J.
Melén, ErikAff1, Aff2, Aff82
Pokaż więcej
Źródło :
Genome Medicine. 12(1)
Czasopismo naukowe
Tytuł :
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Autorzy :
Pan, Wei-Hung
Sommer, FelixAff1, Aff2
Falk-Paulsen, Maren
Ulas, Thomas
Best, Philipp
Fazio, Antonella
Kachroo, Priyadarshini
Luzius, Anne
Jentzsch, Marlene
Rehman, Ateequr
Müller, Fabian
Lengauer, ThomasAff4, Aff5
Walter, Jörn
Künzel, Sven
Baines, John F.Aff7, Aff8
Schreiber, StefanAff1, Aff9
Franke, Andre
Schultze, Joachim L.Aff3, Aff10
Bäckhed, FredrikAff2, Aff11
Rosenstiel, Philip
Pokaż więcej
Źródło :
Genome Medicine. 10(1)
Czasopismo naukowe
Tytuł :
Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial.
Autorzy :
Huang, Mengna
Kelly, Rachel S.
Kachroo, Priyadarshini
Chu, Su H.
Lee-Sarwar, Kathleen
Chawes, Bo L.
Bisgaard, Hans
Litonjua, Augusto A.
Weiss, Scott T.
Lasky-Su, Jessica
Pokaż więcej
Temat :
VITAMIN D
OMEGA-6 fatty acids
METABOLITES
VITAMIN D deficiency
ASTHMA in children
DOCOSAHEXAENOIC acid
UNSATURATED fatty acids
Źródło :
Metabolites (2218-1989); Apr2020, Vol. 10 Issue 4, p151, 1p
Czasopismo naukowe
Tytuł :
DNA methylation perturbations may link altered development and aging in the lung.
Autorzy :
Kachroo P; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Morrow JD; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Vyhlidal CA; Children's Mercy Hospital and Clinics, Kansas City, MO 64108, USA.
Gaedigk R; Children's Mercy Hospital and Clinics, Kansas City, MO 64108, USA.
Silverman EK; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Weiss ST; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Tantisira KG; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
DeMeo DL; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Pokaż więcej
Źródło :
Aging [Aging (Albany NY)] 2021 Jan 19; Vol. 13. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests.
Autorzy :
Hecker J; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
William Townes F; Department of Computer Science, Princeton University, Princeton, New Jersey, USA.
Kachroo P; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Laurie C; Department of Biostatistics, University of Washington, Seattle, Washington, USA.
Lasky-Su J; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ziniti J; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Laird NM; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Lange C; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2020 Dec 26. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD.
Autorzy :
Kachroo P; Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Morrow JD; Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kho AT; Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Vyhlidal CA; Children's Mercy Hospital and Clinics, Kansas City, MO, USA.
Silverman EK; Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Weiss ST; Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Tantisira KG; Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
DeMeo DL; Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA .; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Pokaż więcej
Źródło :
The European respiratory journal [Eur Respir J] 2020 Oct 29; Vol. 56 (4). Date of Electronic Publication: 2020 Oct 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
Autorzy :
Bick AG; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Weinstock JS; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Nandakumar SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Bao EL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA.
Zekavat SM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Yale School of Medicine, New Haven, CT, USA.
Szeto MD; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Liao X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Leventhal MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Chang K; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Laurie C; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Burugula BB; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Gibson CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Lin AE; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Taub MA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ardlie K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
Barnes KC; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
Moscati A; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Redline S; Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Silverman EK; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Weiss ST; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Vasan RS; Departments of Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA.
Burchard EG; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, USA.
Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.; Tulane University Translational Science Institute, New Orleans, LA, USA.
Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Seattle Epidemiologic Information and Research Center, Department of Veterans Affairs, Office of Research and Development, Seattle, WA, USA.
Arnett DK; College of Public Health, University of Kentucky, Lexington, KY, USA.
Schwartz DA; Department of Medicine, University of Colorado, Aurora, CO, USA.
Correa A; Departments of Medicine and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
de Andrade M; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Konkle BA; Bloodworks Northwest, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.
Custer B; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Peralta JM; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Gui H; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
Meyers DA; Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.
McGarvey ST; Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA.
Chen IY; Medical Genetics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA.
Shoemaker MB; Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Broome JG; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Wang FF; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Wong Q; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Montasser ME; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Daya M; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kenny EE; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Launer LJ; Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA.
Cade BE; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA.
Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Cho MH; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Lasky-Su J; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Cupples LA; Departments of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Mak ACY; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Becker LC; GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.; Tulane University Translational Science Institute, New Orleans, LA, USA.
Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Heckbert SR; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Tiwari HK; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Yang IV; Department of Medicine, University of Colorado, Aurora, CO, USA.
Heit JA; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Lubitz SA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Johnsen JM; Bloodworks Northwest, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.
Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Wenzel SE; Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Weeks DE; Departments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Rao DC; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.
Darbar D; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
Moon JY; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.
Tracy RP; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Buth EJ; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Rafaels N; Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Durda P; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Liu Y; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Hou L; Department of Preventive Medicine, Northwestern Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lee J; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Kachroo P; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Levy D; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Hixson JE; Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.
Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Ellinor PT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Fingerlin TE; Center for Genes Environment and Health, National Jewish Health, Denver, CO, USA.
Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Armasu SM; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Wheeler MM; Department of Genome Science, University of Washington, Seattle, WA, USA.
Sabino EC; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Williams LK; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
Levy BD; Harvard Medical School, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Boerwinkle E; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Manson JE; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Mathias RA; GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Desai P; Department of Medicine, Weill Cornell Medical School, New York, NY, USA.
Taylor KD; Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Johnson AD; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Auer PL; Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Blackwell TW; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Smith AV; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Zhao H; Department of Biostatistics, School of Public Health, Yale University, New Haven, CT, USA.; Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.
Lange E; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Lange L; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Rotter JI; Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Scheet P; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kitzman JO; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.
Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Society of Fellows, Harvard University, Cambridge, MA, USA.
Ebert BL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.
Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jaiswal S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Abecasis G; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Sankaran VG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Kathiresan S; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Harvard Medical School, Boston, MA, USA. .; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. .; Verve Therapeutics, Cambridge, MA, USA. .
Natarajan P; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Harvard Medical School, Boston, MA, USA. .; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. .
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Corporate Authors :
NHLBI Trans-Omics for Precision Medicine Consortium
Źródło :
Nature [Nature] 2020 Oct; Vol. 586 (7831), pp. 763-768. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.
Autorzy :
Pan WH; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Sommer F; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345, Gothenburg, Sweden.
Falk-Paulsen M; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Ulas T; Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany.
Best P; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Fazio A; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Kachroo P; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Luzius A; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Jentzsch M; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Rehman A; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Müller F; Max Planck Institute for Informatics, 66123, Saarbrücken, Germany.
Lengauer T; Max Planck Institute for Informatics, 66123, Saarbrücken, Germany.; Graduate School of Computer Science, Saarland University, 66123, Saarbrücken, Germany.
Walter J; Department of Genetics, University of Saarland, 66123, Saarbrücken, Germany.
Künzel S; Institute for Experimental Medicine, Christian Albrechts University of Kiel, Kiel, Germany.
Baines JF; Institute for Experimental Medicine, Christian Albrechts University of Kiel, Kiel, Germany.; Max Planck Institute for Evolutionary Biology, Evolutionary Genomics, August-Thienemann-Str. 2, 24306, Plön, Germany.
Schreiber S; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.; Department of Internal Medicine I, University Hospital Schleswig Holstein, 24105, Kiel, Germany.
Franke A; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany.
Schultze JL; Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany.; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
Bäckhed F; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345, Gothenburg, Sweden.; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Rosenstiel P; Institute for Clinical Molecular Biology, University of Kiel, Rosalind-Franklin-Straße 12, 24105, Kiel, Germany. .
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Źródło :
Genome medicine [Genome Med] 2018 Apr 13; Vol. 10 (1), pp. 27. Date of Electronic Publication: 2018 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Developmental*
DNA Methylation/*genetics
Epithelial Cells/*metabolism
Gastrointestinal Microbiome/*genetics
Intestines/*cytology
Transcriptome/*genetics
Animals ; Female ; Genetic Loci ; Growth and Development/genetics ; Mice, Inbred C57BL ; RNA/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia.
Autorzy :
Kachroo P; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel 24105, Germany.; Channing Laboratory, Department of Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, MA 02115, USA.
Szymczak S; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel 24105, Germany.; Institute of Medical Informatics & Statistics, Christian Albrechts University of Kiel, Kiel 24105, Germany.
Heinsen FA; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel 24105, Germany.
Forster M; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel 24105, Germany.
Bethune J; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel 24105, Germany.
Hemmrich-Stanisak G; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel 24105, Germany.
Baker L; Department of Applied Mathematics, University of Colorado, Boulder, CO 80309, USA.
Schrappe M; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
Stanulla M; Pediatric Hematology & Oncology, Hannover Medical School, Hannover 30625, Germany.
Franke A; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel 24105, Germany.
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Źródło :
Epigenomics [Epigenomics] 2018 Feb; Vol. 10 (2), pp. 133-147. Date of Electronic Publication: 2018 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CpG Islands*
DNA Methylation*
Epigenesis, Genetic*
Oncogene Proteins, Fusion/*genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Adolescent ; B-Lymphocytes/metabolism ; Child ; Gene Expression ; Humans ; Oncogene Proteins, Fusion/biosynthesis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
Czasopismo naukowe

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