NO Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis.
Autorzy:
Mikulska-Ruminska K; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Grudziadzka 5, 87-100 Toruń, Poland. Anthonymuthu TS; Department of Critical Care Medicine, Safar Center for Resuscitation Research, Children's Neuroscience Institute, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15260, USA. Levkina A; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Institute of Translational Medicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia. Shrivastava IH; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260, USA. KapralovAA; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260, USA. Bayır H; Department of Critical Care Medicine, Safar Center for Resuscitation Research, Children's Neuroscience Institute, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260, USA. Kagan VE; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Institute of Regenerative Medicine, IM Sechenov Moscow State Medical University, 119048 Moscow, Russia. Bahar I; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
A mitochondrial pathway for biosynthesis of lipid mediators.
Autorzy:
Tyurina YY; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Poloyac SM; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Tyurin VA; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. KapralovAA; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Jiang J; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Anthonymuthu TS; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Departments of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Kapralova VI; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Vikulina AS; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [3] Department of Biophysics, MV Lomonosov Moscow State University, Moscow 117192, Russia. Jung MY; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Epperly MW; Radiation Oncology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Mohammadyani D; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Klein-Seetharaman J; Division of Metabolic and Vascular Health, University of Warwick, Coventry CV4 7AL, UK. Jackson TC; Departments of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Kochanek PM; Departments of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Pitt BR; 1] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Greenberger JS; Radiation Oncology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Vladimirov YA; Department of Biophysics, MV Lomonosov Moscow State University, Moscow 117192, Russia. Bayır H; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Departments of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Kagan VE; 1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
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Źródło:
Nature chemistry [Nat Chem] 2014 Jun; Vol. 6 (6), pp. 542-52. Date of Electronic Publication: 2014 Apr 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2.
Autorzy:
Tyurin VA; 1] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA. Balasubramanian K; 1] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA. Winnica D; 1] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA. Tyurina YY; 1] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA. Vikulina AS; 1] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA [3] Department of Biophysics, MV Lomonosov Moscow State University, Moscow, Russia. He RR; 1] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA [3] Pharmacy College, Jinan University, Guangzhou, China. KapralovAA; 1] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA. Macphee CH; GlaxoSmithKline, King of Prussia, PA, USA. Kagan VE; 1] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
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Źródło:
Cell death and differentiation [Cell Death Differ] 2014 May; Vol. 21 (5), pp. 825-35. Date of Electronic Publication: 2014 Jan 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells.
Autorzy:
Chu CT; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213. Ji J; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213.; Department of Critical Care Medicine and Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213. Dagda RK; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213. Jiang JF; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. Tyurina YY; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. KapralovAA; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. Tyurin VA; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. Yanamala N; Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15213. Shrivastava IH; Department of Computational and Systems Biology, University of Pittsburgh, PA 15213. Mohammadyani D; Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15213. Wang KZQ; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213. Zhu J; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213. Klein-Seetharaman J; Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15213. Balasubramanian K; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. Amoscato AA; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. Borisenko G; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. Huang Z; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. Gusdon AM; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213. Cheikhi A; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213. Steer EK; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213. Wang R; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213. Baty C; Department of Cell Biology and Physiology and Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213. Watkins S; Department of Cell Biology and Physiology and Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213. Bahar I; Department of Computational and Systems Biology, University of Pittsburgh, PA 15213. Bayir H; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213.; Department of Critical Care Medicine and Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213. Kagan VE; Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213.
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Źródło:
Nature cell biology [Nat Cell Biol] 2013 Oct; Vol. 15 (10), pp. 1197-1205. Date of Electronic Publication: 2013 Sep 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
PloS one [PLoS One] 2012; Vol. 7 (3), pp. e30923. Date of Electronic Publication: 2012 Mar 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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