Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""Karch CM"" wg kryterium: Autor


Tytuł:
RAB10: an Alzheimer’s disease resilience locus and potential drug target
Autorzy:
Tavana JP
Rosene M
Jensen NO
Ridge PG
Kauwe JSK
Karch CM
Pokaż więcej
Temat:
Alzheimer disease
RAB10
Retromer
APP
resilience
GTPase
Geriatrics
RC952-954.6
Źródło:
Clinical Interventions in Aging, Vol Volume 14, Pp 73-79 (2018)
Opis pliku:
electronic resource
Relacje:
https://www.dovepress.com/rab10-an-alzheimers-disease-resilience-locus-and-potential-drug-target-peer-reviewed-article-CIA; https://doaj.org/toc/1178-1998
Dostęp URL:
https://doaj.org/article/eb7048d406034231a0061c376e346c0a  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice.
Autorzy:
Iyer AK; Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Schoch KM; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Verbeck A; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Galasso G; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Chen H; Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Smith S; Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Oldenborg A; Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Miller TM; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Karch CM; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Bonni A; Neuroscience and Rare Diseases, Roche Pharma Research and Early Development (pRED), Roche Innovation Centre Basel, Basel, Switzerland.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2023 Nov 28; Vol. 18 (11), pp. e0294731. Date of Electronic Publication: 2023 Nov 28 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/pathology
Animals ; Mice ; Astrocytes/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Motor Neurons/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Spinal Cord/metabolism ; Superoxide Dismutase/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism
Czasopismo naukowe
Tytuł:
Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease.
Autorzy:
Schultz SA; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Shirzadi Z; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Schultz AP; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Liu L; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Ann Romney Center for Neurologic Diseases, Boston, Massachusetts, USA.
Fitzpatrick CD; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
McDade E; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Barthelemy NR; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Renton A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Esposito B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Joseph-Mathurin N; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Cruchaga C; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Chen CD; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Goate A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Allegri RF; INEBA, Buenos Aires, Argentina.
Benzinger TLS; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Berman S; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chui HC; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Fagan AM; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Farlow MR; Indiana Alzheimer's Disease Research Center, Indianapolis, Indiana, USA.
Fox NC; Dementia Research Centre & UK Dementia Research Institute, UCL Institute of Neurology, London, UK.
Gordon BA; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Day GS; Mayo Clinic, Jacksonville, Florida, USA.
Graff-Radford NR; Mayo Clinic, Jacksonville, Florida, USA.
Hassenstab JJ; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Hanseeuw BJ; Institute of Neuroscience, UCLouvain, Brussels, Belgium.; Gordon Center for Medical Imaging in the Radiology Department of MGH, Boston, Massachusetts, USA.
Hofmann A; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.
Jack CR Jr; Mayo Clinic, Rochester, Minnesota, USA.
Jucker M; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.
Karch CM; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Koeppe RA; University of Michigan, Ann Arbor, Michigan, USA.
Lee JH; Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Levey AI; Emory Goizueta Alzheimer's Disease Research Center, Atlanta, Georgia, USA.
Levin J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Martins RN; Edith Cowan University, Joondalup, Western Australia, Australia.
Mori H; Osaka City University Medical School, Osaka, Japan.
Morris JC; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Noble J; Columbia University, New York, New York, USA.
Perrin RJ; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Rosa-Neto P; Translational Neuroimaging Laboratory, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Salloway SP; Butler Hospital, Providence, Rhode Island, USA.
Sanchez-Valle R; Alzheimer's disease and other cognitive disorders Unit, Neurology Department, Hospital Clínic de Barcelona, Institut d'Investigacions Biomediques, Barcelona, Spain.
Schofield PR; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Xiong C; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Johnson KA; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.
Bateman RJ; Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Sperling RA; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.
Chhatwal JP; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.
Pokaż więcej
Corporate Authors:
Dominantly Inherited Alzheimer Network Investigators
Źródło:
Aging cell [Aging Cell] 2023 Aug; Vol. 22 (8), pp. e13871. Date of Electronic Publication: 2023 Jun 08.
Typ publikacji:
Observational Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Presenilin-1*/chemistry
Presenilin-1*/genetics
Presenilin-1*/metabolism
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Humans ; Male ; Female ; Adult ; Brain/metabolism ; Brain/pathology ; Positron-Emission Tomography ; Magnetic Resonance Imaging ; Mutation ; Cognition ; Amyloid beta-Peptides/metabolism ; tau Proteins/metabolism ; Longitudinal Studies ; Cross-Sectional Studies ; Biomarkers
Czasopismo naukowe
Tytuł:
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.
Autorzy:
Ali M; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA.
Archer DB; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Gorijala P; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA.
Western D; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA.
Timsina J; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA.
Fernández MV; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA.
Wang TC; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Satizabal CL; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health, San Antonio, TX, 78229, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.
Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Beiser AS; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.
Wang R; Boston University, Boston, MA, USA.
Chen G; Knight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA.
Gordon B; Knight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA.
Benzinger TLS; Knight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA.
Xiong C; Knight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.
Morris JC; Knight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.; Department of Neurology, Washington University, St Louis, MO, USA.
Bateman RJ; Knight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.; Department of Neurology, Washington University, St Louis, MO, USA.; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Karch CM; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
McDade E; Department of Neurology, Washington University, St Louis, MO, USA.
Goate A; Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Boston University School of Medicine, Boston, MA, USA.
Mayeux RP; The Department of Neurology, Columbia University, New York, NY, USA.
Sperling RA; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Brigham and Women's Hospital and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Buckley RF; Brigham and Women's Hospital and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.
Johnson KA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Won HH; Department of Digital Health, Samsung Medical Center, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.
Jung SH; Department of Digital Health, Samsung Medical Center, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.
Kim HR; Department of Neurology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Republic of Korea.
Seo SW; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Kim HJ; Department of Digital Health, Samsung Medical Center, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Mormino E; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Laws SM; Centre for Precision Health, Edith Cowan University, 270 Joondalup Dr, Joondalup, WA, 6027, Australia.
Fan KH; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Kamboh MI; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Vemuri P; Department of Radiology, Mayo Clinic-Minnesota, Rochester, MN, 55905, USA.
Ramanan VK; Department of Neurology, Mayo Clinic-Minnesota, Rochester, MN, 55905, USA.
Yang HS; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, USA.
Wenzel A; Wisconsin Alzheimer's Institute, Madison, WI, USA.
Rajula HSR; UMR 1219, University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, 33000, Bordeaux, France.
Mishra A; UMR 1219, University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, 33000, Bordeaux, France.
Dufouil C; UMR 1219, University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, 33000, Bordeaux, France.
Debette S; UMR 1219, University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, 33000, Bordeaux, France.; Department of Neurology, Boston University School of Medicine, Boston, MA, 2115, USA.; Department of Neurology, CHU de Bordeaux, 33000, Bordeaux, France.
Lopez OL; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
DeKosky ST; Department of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Tao F; Neurogenomics, Genetics-Guided Dementia Discovery, Eisai, Inc, Cambridge, MA, USA.
Nagle MW; Neurogenomics, Genetics-Guided Dementia Discovery, Eisai, Inc, Cambridge, MA, USA.
Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Sung YJ; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA.
Dumitrescu L; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Cruchaga C; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA. .; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA. .; Knight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA. .; Hope Center for Neurologic Diseases, Washington University, St. Louis, MO, 63110, USA. .; Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA. .
Pokaż więcej
Corporate Authors:
Knight Alzheimer Disease Research Center (Knight ADRC)
Dominantly Inherited Alzheimer Network (DIAN)
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
ADNI-DOD, A4 Study Team
Australian Imaging Biomarkers, Lifestyle (AIBL) Study
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Apr 26; Vol. 11 (1), pp. 68. Date of Electronic Publication: 2023 Apr 26.
Typ publikacji:
Multicenter Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Alzheimer Disease*/complications
Amyloidosis*/diagnostic imaging
Amyloidosis*/genetics
Humans ; Female ; Amyloid beta-Peptides/genetics ; Genome-Wide Association Study ; Amyloid ; Apolipoproteins E/genetics
Czasopismo naukowe
Tytuł:
Discovery and validation of dominantly inherited Alzheimer's disease mutations in populations from Latin America.
Autorzy:
Takada LT; Department of Neurology, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.
Aláez-Verson C; Laboratorio de Diagnóstico Genómico, Instituto Nacional de Medicina Genómica, Ciudad de México, México.
Burgute BD; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Nitrini R; Department of Neurology, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.
Sosa AL; Instituto Nacional de Neurología y Neurocirugía, Ciudad de Mexico, Mexico.
Castilhos RM; Neurology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Chaves MF; Neurology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Department of Internal Medicine, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Longoria EM; Instituto Nacional de Neurología y Neurocirugía, Ciudad de Mexico, Mexico.
Carrillo-Sánchez K; Laboratorio de Diagnóstico Genómico, Instituto Nacional de Medicina Genómica, Ciudad de México, México.
Brucki SMD; Department of Neurology, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.
Flores-Lagunes LL; Laboratorio de Diagnóstico Genómico, Instituto Nacional de Medicina Genómica, Ciudad de México, México.
Molina C; Laboratorio de Diagnóstico Genómico, Instituto Nacional de Medicina Genómica, Ciudad de México, México.
Olivares MJ; Laboratorio de Diagnóstico Genómico, Instituto Nacional de Medicina Genómica, Ciudad de México, México.
Ziegemeier E; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Petranek J; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Goate AM; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Renton AE; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fernández MV; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Day GS; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA.
McDade E; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Bateman RJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Karch CM; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Llibre-Guerra JJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA. .
Pokaż więcej
Corporate Authors:
Dominantly Inherited Alzheimer Network
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Aug 05; Vol. 14 (1), pp. 108. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/genetics
Adult ; Amyloid beta-Protein Precursor/genetics ; Humans ; Latin America ; Middle Aged ; Mutation/genetics ; Presenilin-1/genetics
SCR Disease Name:
Alzheimer disease, familial, type 3
Czasopismo naukowe
Tytuł:
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.
Autorzy:
Bowles KR; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pugh DA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Liu Y; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Patel T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Renton AE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bandres-Ciga S; Laboratory of Neurogenetics, National Institute On Aging, National Institutes of Health, Bethesda, MD, USA.
Gan-Or Z; Department of Human Genetics, McGill University, Montréal, Québec, Canada.; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
Heutink P; Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Siitonen A; Institute of Clinical Medicine, Department of Neurology, University of Oulu, Oulu, Finland.; Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland.
Bertelsen S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cherry JD; Alzheimer's Disease and CTE Center, Boston University, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, USA.; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
Karch CM; Department of Psychiatry, Washington University in St Louis, St. Louis, MO, USA.
Frucht SJ; Department of Neurology, Fresco Institute for Parkinson's and Movement Disorders, New York University Langone, New York, NY, USA.
Kopell BH; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Neuromodulation, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peter I; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Park YJ; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Charney A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Raj T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Crary JF; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
Pokaż więcej
Corporate Authors:
International Parkinson’s Disease Genomics Consortium (IPDGC)
Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2022 Jul 15; Vol. 17 (1), pp. 48. Date of Electronic Publication: 2022 Jul 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/genetics
Parkinson Disease*/pathology
Astrocytes/pathology ; DNA Copy Number Variations/genetics ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Polymorphism, Single Nucleotide ; alpha-Synuclein/genetics ; tau Proteins/genetics
Czasopismo naukowe
Tytuł:
Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models.
Autorzy:
Gregory JA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA.
Hoelzli E; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA.
Abdelaal R; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA.
Braine C; Department of Neurology, Columbia University Medical Center, New York, NY 10068, USA.
Cuevas M; Department of Neurology, Columbia University Medical Center, New York, NY 10068, USA.
Halpern M; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Barretto N; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Schrode N; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Akbalik G; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA.
Kang K; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA.
Cheng E; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bowles K; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lotz S; Neural Stem Cell Institute, One Discovery Drive, Rensselaer, NY 12144, USA.
Goderie S; Neural Stem Cell Institute, One Discovery Drive, Rensselaer, NY 12144, USA.
Karch CM; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
Temple S; Neural Stem Cell Institute, One Discovery Drive, Rensselaer, NY 12144, USA.
Goate A; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Brennand KJ; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Phatnani H; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA.; Department of Neurology, Columbia University Medical Center, New York, NY 10068, USA.
Pokaż więcej
Źródło:
Cells [Cells] 2020 Jun 05; Vol. 9 (6). Date of Electronic Publication: 2020 Jun 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling*
Models, Biological*
Neural Stem Cells/*metabolism
3T3 Cells ; Animals ; Coculture Techniques ; Epitopes/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Mice ; Neural Stem Cells/cytology ; Neurons/cytology ; Neurons/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Ribosomal Proteins/metabolism ; Species Specificity ; Transcriptome/genetics
Czasopismo naukowe
Tytuł:
Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.
Autorzy:
Bonham LW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Steele NZR; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Karch CM; Department of Psychiatry, Washington University, St. Louis, MO, USA.
Broce I; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Geier EG; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Wen NL; Department of Psychiatry, Washington University, St. Louis, MO, USA.
Momeni P; Texas Tech University Health Science Center, Laboratory of Neurogenetics, Lubbock, TX, USA.
Hardy J; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Miller ZA; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Gorno-Tempini ML; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Hess CP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Lewis P; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.; School of Pharmacy, University of Reading, Whiteknights, Reading, UK.
Miller BL; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Seeley WW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Manzoni C; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.; School of Pharmacy, University of Reading, Whiteknights, Reading, UK.
Desikan RS; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Baranzini SE; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Ferrari R; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Yokoyama JS; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. .
Pokaż więcej
Corporate Authors:
International FTD-Genomics Consortium (IFGC)
Źródło:
Scientific reports [Sci Rep] 2019 Jul 26; Vol. 9 (1), pp. 10854. Date of Electronic Publication: 2019 Jul 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Regulatory Networks*
Polymorphism, Single Nucleotide*
Apoptosis/*genetics
Primary Progressive Nonfluent Aphasia/*genetics
RNA/*metabolism
Cohort Studies ; DNA-Binding Proteins/genetics ; Databases, Genetic ; Gene Expression Regulation ; Genome-Wide Association Study ; Humans ; Protein Interaction Maps/genetics ; Risk Factors ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology.
Autorzy:
Suárez-Calvet M; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. .; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. .; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Catalonia, Spain. .
Morenas-Rodríguez E; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, Institut d'Investigacions Biomèdiques, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
Kleinberger G; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Schlepckow K; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
Araque Caballero MÁ; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.
Franzmeier N; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.
Capell A; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Fellerer K; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Nuscher B; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Eren E; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.; Izmir International Biomedicine and Genome Institute Dokuz Eylul University, Izmir, Turkey.; Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
Levin J; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
Deming Y; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Piccio L; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA.
Karch CM; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA.; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.
Cruchaga C; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA.; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.
Shaw LM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurodegenerative Disease Research, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Trojanowski JQ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neurodegenerative Disease Research, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Weiner M; University of California at San Francisco, San Francisco, CA, USA.
Ewers M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.
Haass C; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. .; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. .; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. .
Pokaż więcej
Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2019 Jan 10; Vol. 14 (1), pp. 1. Date of Electronic Publication: 2019 Jan 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*cerebrospinal fluid
Alzheimer Disease/*pathology
Membrane Glycoproteins/*cerebrospinal fluid
Nerve Degeneration/*pathology
Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Cross-Sectional Studies ; Female ; Humans ; Male ; Membrane Glycoproteins/genetics ; Middle Aged ; Receptors, Immunologic/genetics ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł:
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
Autorzy:
Twohig D; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16B, 106 91, Stockholm, Sweden.
Rodriguez-Vieitez E; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Sando SB; Department of Neurology, University Hospital of Trondheim, Trondheim, Norway.; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Berge G; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Lauridsen C; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Møller I; Department of Neurology, University Hospital of Trondheim, Trondheim, Norway.
Grøntvedt GR; Department of Neurology, University Hospital of Trondheim, Trondheim, Norway.; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Bråthen G; Department of Neurology, University Hospital of Trondheim, Trondheim, Norway.; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Patra K; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16B, 106 91, Stockholm, Sweden.
Bu G; Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
Benzinger TLS; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Karch CM; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Fagan A; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Bateman RJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Nordberg A; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; The Aging Research Center, Karolinska University Hospital, Stockholm, Sweden.
White LR; Department of Neurology, University Hospital of Trondheim, Trondheim, Norway.; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Nielsen HM; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16B, 106 91, Stockholm, Sweden. .
Pokaż więcej
Corporate Authors:
Dominantly Inherited Alzheimer Network (DIAN)
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2018 Nov 26; Vol. 6 (1), pp. 130. Date of Electronic Publication: 2018 Nov 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*cerebrospinal fluid
Cognitive Dysfunction/*cerebrospinal fluid
alpha-Synuclein/*cerebrospinal fluid
Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/cerebrospinal fluid ; Amyloid beta-Protein Precursor/cerebrospinal fluid ; Amyloid beta-Protein Precursor/genetics ; Aniline Compounds/pharmacokinetics ; Apolipoproteins E/genetics ; Brain/diagnostic imaging ; Brain/drug effects ; Brain/metabolism ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/genetics ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mutation/genetics ; Peptide Fragments/cerebrospinal fluid ; Positron-Emission Tomography ; ROC Curve ; Statistics, Nonparametric ; Thiazoles/pharmacokinetics ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł:
Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex.
Autorzy:
Li Y; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA. .
Barkovich MJ; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Karch CM; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
Nillo RM; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Fan CC; Department of Cognitive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.
Broce IJ; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Tan CH; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Cuneo D; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Hess CP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Dillon WP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Glenn OA; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Glastonbury CM; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.
Olney N; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Yokoyama JS; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Bonham LW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Miller B; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Kao A; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Schmansky N; Athinoula A. Martinos Center, Harvard Medical School, Charlestown, MA, 02129, USA.
Fischl B; Athinoula A. Martinos Center, Harvard Medical School, Charlestown, MA, 02129, USA.; Health Science and Technology Program and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Boston, MA, 02139, USA.
Andreassen OA; NORMENT Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Jernigan T; Department of Cognitive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.
Dale A; Department of Cognitive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.; Departments of Radiology and Neurosciences, University of California, San Diego, La Jolla, California, United States of America.
Barkovich AJ; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.; Departments of Neurology and Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA.
Desikan RS; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.; Departments of Neurology and Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA.
Sugrue LP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Sep 06; Vol. 8 (1), pp. 13373. Date of Electronic Publication: 2018 Sep 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Cerebellum/*metabolism
Neurodevelopmental Disorders/*metabolism
Tuberous Sclerosis/*metabolism
Tuberous Sclerosis Complex 1 Protein/*biosynthesis
Tuberous Sclerosis Complex 2 Protein/*biosynthesis
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cerebellum/pathology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Neurodevelopmental Disorders/pathology ; Tuberous Sclerosis/pathology
Czasopismo naukowe
Tytuł:
Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network.
Autorzy:
Karch CM; Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St. Louis, MO, 63110, USA. .
Hernández D; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.
Wang JC; Department of Neuroscience and Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.
Marsh J; Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Hewitt AW; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Hsu S; Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Norton J; Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Levitch D; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Donahue T; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Sigurdson W; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, 635 Barnhill Drive, MS A 142, Indianapolis, IN, 46202, USA.
Farlow M; Department of Neurology, Indiana University, 635 Barnhill Drive, MS A 142, Indianapolis, IN, 46202, USA.
Chhatwal J; Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, 149 13th Street, Charlestown, MA, 02129, USA.
Berman S; Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, 4-West Montefiore University Hospital, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.
Cruchaga C; Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Morris JC; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Bateman RJ; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Pébay A; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.
Goate AM; Department of Neuroscience and Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA. .
Pokaż więcej
Corporate Authors:
Dominantly Inherited Alzheimer Network (DIAN)
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2018 Jul 25; Vol. 10 (1), pp. 69. Date of Electronic Publication: 2018 Jul 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*genetics
Alzheimer Disease/*pathology
Fibroblasts/*pathology
Stem Cells/*pathology
Adult ; Aged ; Amyloid beta-Protein Precursor/genetics ; Databases, Factual/statistics & numerical data ; Female ; Fibroblasts/metabolism ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Information Services ; International Cooperation ; Karyotyping ; Male ; Middle Aged ; Mutation/genetics ; Presenilin-1/genetics ; Presenilin-2/genetics ; Stem Cells/metabolism ; Transduction, Genetic
Czasopismo naukowe
Tytuł:
Discovery and validation of autosomal dominant Alzheimer's disease mutations.
Autorzy:
Hsu S; Department of Psychiatry, Washington University School of Medicine, 425 S. Euclid Ave, Campus Box 8134, St. Louis, MO, 63110, USA.
Gordon BA; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Hornbeck R; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Norton JB; Department of Psychiatry, Washington University School of Medicine, 425 S. Euclid Ave, Campus Box 8134, St. Louis, MO, 63110, USA.
Levitch D; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Louden A; Department of Psychiatry, Washington University School of Medicine, 425 S. Euclid Ave, Campus Box 8134, St. Louis, MO, 63110, USA.
Ziegemeier E; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Laforce R Jr; Clinique Interdisciplinaire de Mémoire du CHU de Québec, Département des Sciences Neurologiques, Faculté de Médecine, Université Laval, Québec City, Québec, Canada.
Chhatwal J; Massachusetts General Hospital/Martinos Center for Biomedical Imaging, 149 13th Street, Gerontology Research Room 2669, Charlestown, MA, 02129, USA.
Day GS; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
McDade E; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Fagan AM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Benzinger TLS; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Goate AM; Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.
Cruchaga C; Department of Psychiatry, Washington University School of Medicine, 425 S. Euclid Ave, Campus Box 8134, St. Louis, MO, 63110, USA.
Bateman RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Karch CM; Department of Psychiatry, Washington University School of Medicine, 425 S. Euclid Ave, Campus Box 8134, St. Louis, MO, 63110, USA. .
Pokaż więcej
Corporate Authors:
Dominantly Inherited Alzheimer Network (DIAN)
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2018 Jul 18; Vol. 10 (1), pp. 67. Date of Electronic Publication: 2018 Jul 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*genetics
Amyloid beta-Protein Precursor/*genetics
Mutation/*genetics
Presenilin-1/*genetics
Presenilin-2/*genetics
Algorithms ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/metabolism ; Aniline Compounds/metabolism ; Cell Line, Tumor ; Computational Biology ; DNA Mutational Analysis ; Family Health ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroblastoma/pathology ; Peptide Fragments/metabolism ; Positron-Emission Tomography ; Reproducibility of Results ; Thiazoles/metabolism ; Transfection
Czasopismo naukowe
Tytuł:
Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.
Autorzy:
Li Z; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
Del-Aguila JL; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
Dube U; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.; Medical Scientist Training Program, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Budde J; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
Martinez R; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
Black K; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
Xiao Q; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Cairns NJ; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.; Department of Pathology & Immunology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO, 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Dougherty JD; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.; Department of Genetics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Lee JM; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Morris JC; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA.
Bateman RJ; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA.
Karch CM; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
Cruchaga C; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA. .; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA. .; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA. .
Harari O; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA. .
Pokaż więcej
Corporate Authors:
Dominantly Inherited Alzheimer Network (DIAN)
Źródło:
Genome medicine [Genome Med] 2018 Jun 08; Vol. 10 (1), pp. 43. Date of Electronic Publication: 2018 Jun 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Variation*
Alzheimer Disease/*genetics
Alzheimer Disease/*pathology
Cerebral Cortex/*pathology
Adult ; Age of Onset ; Aged, 80 and over ; Alleles ; Apolipoprotein E4/genetics ; Astrocytes/metabolism ; Astrocytes/pathology ; Demography ; Female ; Humans ; Male ; Membrane Glycoproteins/genetics ; Middle Aged ; Nerve Degeneration/genetics ; Nerve Degeneration/pathology ; Neurons/metabolism ; Neurons/pathology ; Receptors, Immunologic/genetics ; Reproducibility of Results ; Sequence Analysis, RNA ; Transcriptome/genetics
Czasopismo naukowe
Tytuł:
Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
Autorzy:
Broce I
Karch CM
Wen N
Fan CC
Wang Y
Tan CH
Kouri N
Ross OA
Höglinger GU
Muller U
Hardy J
Momeni P
Hess CP
Dillon WP
Miller ZA
Bonham LW
Rabinovici GD
Rosen HJ
Schellenberg GD
Franke A
Karlsen TH
Veldink JH
Ferrari R
Yokoyama JS
Miller BL
Andreassen OA
Dale AM
Desikan RS
Sugrue LP
Pokaż więcej
Corporate Authors:
International FTD-Genomics Consortium
Źródło:
PLoS medicine [PLoS Med] 2018 Jan 29; Vol. 15 (1), pp. e1002504. Date of Electronic Publication: 2018 Jan 29 (Print Publication: 2018).
Typ publikacji:
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł:
Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.
Autorzy:
Ridge PG; Department of Biology, Brigham Young University, Provo, UT, 84602, USA.
Karch CM; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Hsu S; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Arano I; Department of Biology, Brigham Young University, Provo, UT, 84602, USA.
Teerlink CC; Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA.
Ebbert MTW; Department of Biology, Brigham Young University, Provo, UT, 84602, USA.; Present address: Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Murcia JDG; Department of Biology, Brigham Young University, Provo, UT, 84602, USA.
Farnham JM; Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA.
Damato AR; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Wang X; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, 32224, USA.
Harari O; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Fernandez VM; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Guerreiro R; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Bras J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Hardy J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Munger R; Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, UT, 84322, USA.
Norton M; Department of Family Consumer & Human Development, Utah State University, Logan, UT, 84322, USA.
Sassi C; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.; National Institute on Aging, Bethesda, MD, 21224, USA.
Singleton A; National Institute on Aging, Bethesda, MD, 21224, USA.
Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Golde TE; Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Department of Neuroscience, Gainesville, FL, 32610, USA.
Price ND; Institute for Systems Biology, 401 Terry Avenue N, Seattle, WA, 98109, USA.
Ertekin-Taner N; Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Cruchaga C; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Goate AM; Departments of Neuroscience, Genetics and Genomic Sciences, and Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Corcoran C; Department of Mathematics and Statistics, Utah State University, Logan, UT, 84322, USA.
Tschanz J; Department of Psychology, Utah State University, Logan, UT, 84322, USA.
Cannon-Albright LA; Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, 84148, USA.
Kauwe JSK; Departments of Biology and Neuroscience, Brigham Young University, Provo, UT, 84602, USA. .
Pokaż więcej
Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Genome medicine [Genome Med] 2018 Jan 12; Vol. 10 (1), pp. 4. Date of Electronic Publication: 2018 Jan 12.
Typ publikacji:
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł:
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
Autorzy:
Broce I; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States of America.
Karch CM; Department of Psychiatry, Washington University, St. Louis, Missouri, United States of America.
Wen N; Department of Psychiatry, Washington University, St. Louis, Missouri, United States of America.
Fan CC; Department of Cognitive Sciences, University of California, San Diego, La Jolla, California, United States of America.
Wang Y; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Tan CH; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States of America.
Kouri N; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Höglinger GU; Department of Neurology, Technical University of Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Muller U; Institut for Humangenetik, Justus-Liebig-Universität, Giessen, Germany.
Hardy J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom.
Momeni P; Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America.
Hess CP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States of America.
Dillon WP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States of America.
Miller ZA; Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America.
Bonham LW; Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America.
Rabinovici GD; Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America.
Rosen HJ; Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America.
Schellenberg GD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Karlsen TH; Norwegian PSC Research Center, Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Division of Gastroenterology, Institute of Medicine, University of Bergen, Bergen, Norway.; K.G. Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Veldink JH; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Ferrari R; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom.
Yokoyama JS; Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America.
Miller BL; Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America.
Andreassen OA; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Dale AM; Department of Cognitive Sciences, University of California, San Diego, La Jolla, California, United States of America.; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.
Desikan RS; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States of America.; Department of Neurology, University of California, San Francisco, San Francisco, California, United States of America.
Sugrue LP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States of America.
Pokaż więcej
Corporate Authors:
International FTD-Genomics Consortium
Źródło:
PLoS medicine [PLoS Med] 2018 Jan 09; Vol. 15 (1), pp. e1002487. Date of Electronic Publication: 2018 Jan 09 (Print Publication: 2018).
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome-Wide Association Study*
Polymorphism, Single Nucleotide*
Frontotemporal Dementia/*genetics
Genetic Predisposition to Disease/*genetics
Aged ; Humans ; Middle Aged
Czasopismo naukowe
Tytuł:
Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.
Autorzy:
Ridge PG; Department of Biology, Brigham Young University, Provo, UT, 84602, USA.
Karch CM; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Hsu S; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Arano I; Department of Biology, Brigham Young University, Provo, UT, 84602, USA.
Teerlink CC; Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA.
Ebbert MTW; Department of Biology, Brigham Young University, Provo, UT, 84602, USA.; Present address: Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Gonzalez Murcia JD; Department of Biology, Brigham Young University, Provo, UT, 84602, USA.
Farnham JM; Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA.
Damato AR; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Wang X; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, 32224, USA.
Harari O; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Fernandez VM; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Guerreiro R; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Bras J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Hardy J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Munger R; Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, UT, 84322, USA.
Norton M; Department of Family Consumer & Human Development, Utah State University, Logan, UT, 84322, USA.
Sassi C; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.; National Institute on Aging, Bethesda, MD, 21224, USA.
Singleton A; National Institute on Aging, Bethesda, MD, 21224, USA.
Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Golde TE; Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Department of Neuroscience, Gainesville, FL, 32610, USA.
Price ND; Institute for Systems Biology, 401 Terry Avenue N, Seattle, WA, 98109, USA.
Ertekin-Taner N; Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Cruchaga C; Washington University School of Medicine, St. Louis, MO, 63110, USA.
Goate AM; Departments of Neuroscience, Genetics and Genomic Sciences, and Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Corcoran C; Department of Mathematics and Statistics, Utah State University, Logan, UT, 84322, USA.
Tschanz J; Department of Psychology, Utah State University, Logan, UT, 84322, USA.
Cannon-Albright LA; Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, 84148, USA.
Kauwe JSK; Departments of Biology and Neuroscience, Brigham Young University, Provo, UT, 84602, USA. .
Pokaż więcej
Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Genome medicine [Genome Med] 2017 Nov 29; Vol. 9 (1), pp. 100. Date of Electronic Publication: 2017 Nov 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Alzheimer Disease/*genetics
rab GTP-Binding Proteins/*genetics
Aged, 80 and over ; Animals ; Brain/metabolism ; Cell Line, Tumor ; Female ; Gene Expression ; Genetic Predisposition to Disease ; Humans ; Male ; Mice ; Monomeric GTP-Binding Proteins/genetics ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł:
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
Autorzy:
Desikan RS; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America.
Fan CC; Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America.
Wang Y; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Schork AJ; Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America.
Cabral HJ; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Thompson WK; Institute for Biological Psychiatry, Sankt Hans Psychiatric Hospital, Roskilde, Denmark.
Besser L; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.
Kukull WA; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.
Holland D; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.
Chen CH; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.
Brewer JB; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.; Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, California, United States of America.
Karow DS; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.
Kauppi K; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.
Witoelar A; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Karch CM; Department of Psychiatry, Washington University, St. Louis, Missouri, United States of America.
Bonham LW; Department of Neurology, University of California, San Francisco, California, United States of America.
Yokoyama JS; Department of Neurology, University of California, San Francisco, California, United States of America.
Rosen HJ; Department of Neurology, University of California, San Francisco, California, United States of America.
Miller BL; Department of Neurology, University of California, San Francisco, California, United States of America.
Dillon WP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America.
Wilson DM; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America.
Hess CP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America.
Pericak-Vance M; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
Haines JL; Department of Epidemiology and Biostatistics, Case Western University, Cleveland, Ohio, United States of America.; Institute for Computational Biology, Case Western University, Cleveland, Ohio, United States of America.
Farrer LA; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Mayeux R; Department of Neurology, Columbia University, New York, New York, United States of America.; Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America.
Hardy J; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom.
Goate AM; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Hyman BT; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
McEvoy LK; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.
Andreassen OA; Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Dale AM; Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America.; Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America.; Department of Radiology, University of California, San Diego, La Jolla, California, United States of America.
Pokaż więcej
Źródło:
PLoS medicine [PLoS Med] 2017 Mar 21; Vol. 14 (3), pp. e1002258. Date of Electronic Publication: 2017 Mar 21 (Print Publication: 2017).
Typ publikacji:
Journal Article; Validation Study
MeSH Terms:
Multifactorial Inheritance*
Polymorphism, Single Nucleotide*
Alzheimer Disease/*epidemiology
Apolipoproteins E/*genetics
Geriatric Assessment/*methods
Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Apolipoproteins E/metabolism ; Female ; Genotype ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; United States/epidemiology
Czasopismo naukowe
Tytuł:
Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.
Autorzy:
Karch CM; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Ezerskiy LA; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Bertelsen S; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, United States of America.
Goate AM; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, United States of America.
Pokaż więcej
Corporate Authors:
Alzheimer’s Disease Genetics Consortium (ADGC)
Źródło:
PloS one [PLoS One] 2016 Feb 26; Vol. 11 (2), pp. e0148717. Date of Electronic Publication: 2016 Feb 26 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Polymorphism, Single Nucleotide*
Alzheimer Disease/*genetics
CELF1 Protein/*genetics
Membrane Glycoproteins/*genetics
Receptors, Immunologic/*genetics
Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Brain/metabolism ; Case-Control Studies ; Databases, Genetic ; Female ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Linkage Disequilibrium ; Male ; Middle Aged ; Mitochondrial Membrane Transport Proteins/genetics ; Quantitative Trait Loci ; Risk Factors ; Zinc Fingers/genetics
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies