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Tytuł:
Statistical simulations show that scientists need not increase overall sample size by default when including both sexes in in vivo studies.
Autorzy:
Phillips B; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
Haschler TN; Bioscience Renal, Research and Early Development Cardiovascular, Renal and Metabolism, Biopharmaceutical R&D, AstraZeneca, Cambridge, United Kingdom.
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
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Źródło:
PLoS biology [PLoS Biol] 2023 Jun 08; Vol. 21 (6), pp. e3002129. Date of Electronic Publication: 2023 Jun 08 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Research Design*
Sex Characteristics*
Male ; Female ; Mice ; Animals ; Sample Size ; Analysis of Variance
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correction: Do multiple experimenters improve the reproducibility of animal studies?
Autorzy:
von Kortzfleisch VT
Ambrée O
Karp NA
Meyer N
Novak J
Palme R
Rosso M
Touma C
Würbel H
Kaiser S
Sachser N
Richter SH
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Źródło:
PLoS biology [PLoS Biol] 2022 Dec 20; Vol. 20 (12), pp. e3001948. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2022).
Typ publikacji:
Published Erratum
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A qualitative study of the barriers to using blinding in in vivo experiments and suggestions for improvement.
Autorzy:
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
Pearl EJ; NC3Rs, London, United Kingdom.
Stringer EJ; Biomedical Services Unit, University of Birmingham, Birmingham, United Kingdom.
Barkus C; NC3Rs, London, United Kingdom.
Ulrichsen JC; Early Oncology, AstraZeneca, Cambridge, United Kingdom.
Percie du Sert N; NC3Rs, London, United Kingdom.
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Źródło:
PLoS biology [PLoS Biol] 2022 Nov 17; Vol. 20 (11), pp. e3001873. Date of Electronic Publication: 2022 Nov 17 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Research Personnel*
Animal Experimentation*
Animals ; Humans ; Qualitative Research ; Data Analysis ; Academies and Institutes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Do multiple experimenters improve the reproducibility of animal studies?
Autorzy:
von Kortzfleisch VT; Department of Behavioural Biology, University of Münster, Münster, Germany.; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany.
Ambrée O; Department of Behavioural Biology, University of Osnabrück, Osnabrück, Germany.
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
Meyer N; Department of Behavioural Biology, University of Osnabrück, Osnabrück, Germany.
Novak J; Division of Animal Welfare, University of Bern, Bern, Switzerland.
Palme R; Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria.
Rosso M; Division of Animal Welfare, University of Bern, Bern, Switzerland.
Touma C; Department of Behavioural Biology, University of Osnabrück, Osnabrück, Germany.
Würbel H; Division of Animal Welfare, University of Bern, Bern, Switzerland.
Kaiser S; Department of Behavioural Biology, University of Münster, Münster, Germany.; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany.
Sachser N; Department of Behavioural Biology, University of Münster, Münster, Germany.; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany.
Richter SH; Department of Behavioural Biology, University of Münster, Münster, Germany.; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany.
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Źródło:
PLoS biology [PLoS Biol] 2022 May 05; Vol. 20 (5), pp. e3001564. Date of Electronic Publication: 2022 May 05 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Animal Experimentation*
Animals, Laboratory*
Animals ; Laboratories ; Reference Standards ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Improving reproducibility in animal research by splitting the study population into several 'mini-experiments'.
Autorzy:
von Kortzfleisch VT; Department of Behavioural Biology, University of Münster, Badestraße 13, Münster, Germany. v_.; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany. v_.
Karp NA; Data Sciences and Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Palme R; Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria.
Kaiser S; Department of Behavioural Biology, University of Münster, Badestraße 13, Münster, Germany.; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany.
Sachser N; Department of Behavioural Biology, University of Münster, Badestraße 13, Münster, Germany.; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany.
Richter SH; Department of Behavioural Biology, University of Münster, Badestraße 13, Münster, Germany. .; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2020 Oct 06; Vol. 10 (1), pp. 16579. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Animal Experimentation*
Animals, Laboratory*
Reproducibility of Results*
Research Design*
Animals ; Mice, Inbred Strains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.
Autorzy:
Percie du Sert N; NC3Rs, London, UK.
Hurst V; NC3Rs, London, UK.
Ahluwalia A; The William Harvey Research Institute, London, UK.; Barts Cardiovascular CTU, Queen Mary University of London, London, UK.
Alam S; Taylor & Francis Group, London, UK.
Avey MT; Health Science Practice, ICF, Durham, North Carolina, USA.
Baker M; Nature, San Francisco, California, USA.
Browne WJ; School of Education, University of Bristol, Bristol, UK.
Clark A; PLOS ONE, Cambridge, UK.
Cuthill IC; School of Biological Sciences, University of Bristol, Bristol, UK.
Dirnagl U; QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.
Emerson M; National Heart and Lung Institute, Imperial College London, London, UK.
Garner P; Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, UK.
Holgate ST; Clinical and Experimental Sciences, University of Southampton, Southampton, UK.
Howells DW; Tasmanian School of Medicine, University of Tasmania, Hobart, Australia.
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Lazic SE; Prioris.ai Inc, Ottawa, Canada.
Lidster K; NC3Rs, London, UK.
MacCallum CJ; Hindawi Ltd, London, UK.
Macleod M; University of Edinburgh, Edinburgh, UK.
Pearl EJ; NC3Rs, London, UK.
Petersen OH; Academia Europaea Knowledge Hub, Cardiff University, Cardiff, UK.
Rawle F; Medical Research Council, London, UK.
Reynolds P; Statistics in Anesthesiology Research (STAR) Core & Research Assistant Professor, Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Rooney K; Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Sena ES; University of Edinburgh, Edinburgh, UK.
Silberberg SD; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Steckler T; Janssen Pharmaceutica NV, Beerse, Belgium.
Würbel H; Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2020 Aug; Vol. 177 (16), pp. 3617-3624. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Animal Experimentation*
Animals ; Checklist ; Reproducibility of Results ; Research Design ; Research Report
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.
Autorzy:
Percie du Sert N; Experimental Design and Reporting, NC3Rs, London, UK. .
Hurst V; Experimental Design and Reporting, NC3Rs, London, UK.
Ahluwalia A; The William Harvey Research Institute, London, UK.; Barts Cardiovascular CTU, Queen Mary University of London, London, UK.
Alam S; Publishing Ethics and Integrity, Taylor & Francis Group, London, UK.
Avey MT; Health Science Practice, ICF, Durham, North Carolina, USA.
Baker M; Opinion, Nature, San Francisco, California, USA.
Browne WJ; School of Education, University of Bristol, Bristol, UK.
Clark A; Life Sciences, PLOS ONE, Cambridge, UK.
Cuthill IC; School of Biological Sciences, University of Bristol, Bristol, UK.
Dirnagl U; QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.
Emerson M; National Heart and Lung Institute, Imperial College London, London, UK.
Garner P; Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, UK.
Holgate ST; Clinical and Experimental Sciences, University of Southampton, Southampton, UK.
Howells DW; Tasmanian School of Medicine, University of Tasmania, Hobart, Australia.
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Lazic SE; Prioris.ai Inc, Ottawa, Canada.
Lidster K; Animal Welfare, NC3Rs, London, UK.
MacCallum CJ; Open Science, Hindawi Ltd, London, UK.
Macleod M; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Pearl EJ; Experimental Design and Reporting, NC3Rs, London, UK.
Petersen OH; Academia Europaea Knowledge Hub, Cardiff University, Cardiff, UK.
Rawle F; Policy, Ethics and Governance, Medical Research Council, London, UK.
Reynolds P; Statistics in Anesthesiology Research (STAR), Department of Anesthesiology College of Medicine, University of Florida, Gainesville, Florida, USA.
Rooney K; Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Sena ES; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Silberberg SD; Research Quality, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Steckler T; Janssen Pharmaceutica NV, Beerse, Belgium.
Würbel H; Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
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Źródło:
BMC veterinary research [BMC Vet Res] 2020 Jul 14; Vol. 16 (1), pp. 242. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji:
Duplicate Publication; Journal Article
MeSH Terms:
Animal Experimentation*
Guidelines as Topic*
Research Report*
Animals ; Checklist
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.
Autorzy:
Percie du Sert N; NC3Rs, London, United Kingdom.
Hurst V; NC3Rs, London, United Kingdom.
Ahluwalia A; The William Harvey Research Institute, London, United Kingdom.; Barts Cardiovascular CTU, Queen Mary University of London, London, United Kingdom.
Alam S; Taylor & Francis Group, London, United Kingdom.
Avey MT; Health Science Practice, ICF, Durham, North Carolina, United States of America.
Baker M; Nature, San Francisco, California, United States of America.
Browne WJ; School of Education, University of Bristol, Bristol, United Kingdom.
Clark A; PLOS ONE, Cambridge, United Kingdom.
Cuthill IC; School of Biological Sciences, University of Bristol, Bristol, United Kingdom.
Dirnagl U; QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.
Emerson M; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Garner P; Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Holgate ST; Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.
Howells DW; Tasmanian School of Medicine, University of Tasmania, Hobart, Australia.
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
Lazic SE; Prioris.ai Inc, Ottawa, Canada.
Lidster K; NC3Rs, London, United Kingdom.
MacCallum CJ; Hindawi Ltd, London, United Kingdom.
Macleod M; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Pearl EJ; NC3Rs, London, United Kingdom.
Petersen OH; Academia Europaea Knowledge Hub, Cardiff University, Cardiff, United Kingdom.
Rawle F; Medical Research Council, London, United Kingdom.
Reynolds P; Statistics in Anesthesiology Research (STAR) Core, Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
Rooney K; Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Sena ES; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Silberberg SD; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.
Steckler T; Janssen Pharmaceutica NV, Beerse, Belgium.
Würbel H; Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
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Źródło:
PLoS biology [PLoS Biol] 2020 Jul 14; Vol. 18 (7), pp. e3000410. Date of Electronic Publication: 2020 Jul 14 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Animal Experimentation*
Guidelines as Topic*
Research Report*
Animals ; Checklist
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.
Autorzy:
Percie du Sert N; NC3Rs, London, United Kingdom.
Ahluwalia A; The William Harvey Research Institute, London, United Kingdom.; Barts Cardiovascular CTU, Queen Mary University of London, London, United Kingdom.
Alam S; Taylor & Francis Group, London, United Kingdom.
Avey MT; Health Science Practice, ICF, Durham, North Carolina, United States of America.
Baker M; Nature, San Francisco, California, United States of America.
Browne WJ; School of Education, University of Bristol, Bristol, United Kingdom.
Clark A; PLOS ONE, Cambridge, United Kingdom.
Cuthill IC; School of Biological Sciences, University of Bristol, Bristol, United Kingdom.
Dirnagl U; QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.
Emerson M; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Garner P; Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Holgate ST; Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.
Howells DW; Tasmanian School of Medicine, University of Tasmania, Hobart, Australia.
Hurst V; NC3Rs, London, United Kingdom.
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
Lazic SE; Prioris.ai Inc, Ottawa, Canada.
Lidster K; NC3Rs, London, United Kingdom.
MacCallum CJ; Hindawi Ltd, London, United Kingdom.
Macleod M; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Pearl EJ; NC3Rs, London, United Kingdom.
Petersen OH; Academia Europaea Knowledge Hub, Cardiff University, Cardiff, United Kingdom.
Rawle F; Medical Research Council, London, United Kingdom.
Reynolds P; Statistics in Anesthesiology Research (STAR) Core, Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
Rooney K; Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Sena ES; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Silberberg SD; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.
Steckler T; Janssen Pharmaceutica NV, Beerse, Belgium.
Würbel H; Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Pokaż więcej
Źródło:
PLoS biology [PLoS Biol] 2020 Jul 14; Vol. 18 (7), pp. e3000411. Date of Electronic Publication: 2020 Jul 14 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Animal Experimentation*/ethics
Guidelines as Topic*
Research Report*
Animal Husbandry ; Animals ; Confidence Intervals ; Housing, Animal ; Outcome Assessment, Health Care ; Publications ; Random Allocation ; Reproducibility of Results ; Sample Size
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A multi-batch design to deliver robust estimates of efficacy and reduce animal use - a syngeneic tumour case study.
Autorzy:
Karp NA; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK. Natasha.Karp@astrazeneca.com.
Wilson Z; Early Oncology TDE, R&D Oncology, AstraZeneca, Alderley Park, UK.
Stalker E; Early Oncology TDE, R&D Oncology, AstraZeneca, Alderley Park, UK.; Precision Medicine, R&D Oncology, AstraZeneca, Cambridge, UK.
Mooney L; Early Oncology TDE, R&D Oncology, AstraZeneca, Alderley Park, UK.; Preclinical Science Services, Alderley park Limited, Macclesfield, UK.
Lazic SE; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.; Prioris.ai Inc., Ottawa, ON, Canada.
Zhang B; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Hardaker E; Early TDE Discovery, R&D Oncology, AstraZeneca, Cambridge, UK.
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Źródło:
Scientific reports [Sci Rep] 2020 Apr 10; Vol. 10 (1), pp. 6178. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji:
Journal Article
MeSH Terms:
Data Analysis*
Disease Models, Animal*
Neoplasms/*pathology
Animals ; Cell Line, Tumor/transplantation ; Female ; Mice ; Pilot Projects ; Reproducibility of Results ; Sample Size
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sex bias in preclinical research and an exploration of how to change the status quo.
Autorzy:
Karp NA; Quantitative Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Reavey N; Council for Science and Animal Welfare, AstraZeneca, Cambridge, UK.; Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2019 Nov; Vol. 176 (21), pp. 4107-4118. Date of Electronic Publication: 2018 Dec 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Evaluation, Preclinical*
Sex Characteristics*
Animals ; Biomedical Research ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.
Autorzy:
Moore BA; William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, 95616, CA, USA.
Leonard BC; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Sebbag L; William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, 95616, CA, USA.
Edwards SG; William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, 95616, CA, USA.
Cooper A; William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, 95616, CA, USA.
Imai DM; Comparative Pathology Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Straiton E; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Santos L; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Reilly C; Comparative Pathology Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Griffey SM; Comparative Pathology Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Bower L; Mouse Biology Program, and Department of Surgery, School of Medicine, University of California-Davis, Davis, CA, 95618, USA.
Clary D; Mouse Biology Program, and Department of Surgery, School of Medicine, University of California-Davis, Davis, CA, 95618, USA.
Mason J; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
Roux MJ; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.; Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch-Graffenstaden, France.
Meziane H; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.; Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch-Graffenstaden, France.
Herault Y; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.; Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch-Graffenstaden, France.
McKerlie C; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Flenniken AM; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Nutter LMJ; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Berberovic Z; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Owen C; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Newbigging S; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Adissu H; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Eskandarian M; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Hsu CW; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
Kalaga S; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
Udensi U; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
Asomugha C; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
Bohat R; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Gallegos JJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Seavitt JR; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Heaney JD; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Beaudet AL; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Dickinson ME; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Justice MJ; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Philip V; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Kumar V; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Svenson KL; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Braun RE; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Wells S; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Cater H; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Stewart M; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Clementson-Mobbs S; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Joynson R; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Gao X; SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, 210061, China.
Suzuki T; RIKEN BioResource Center, Tsukuba, Ibaraki, 305-0074, Japan.
Wakana S; RIKEN BioResource Center, Tsukuba, Ibaraki, 305-0074, Japan.
Smedley D; Clinical Pharmacology, Charterhouse Square, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Seong JK; Korea Mouse Phenotyping Consortium (KMPC) and BK21 Program for Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea.
Tocchini-Valentini G; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Adriano Buzzati-Traverso Campus, Via Ramarini, I-00015, Monterotondo Scalo, Italy.
Moore M; International Mouse Phenotyping Consortium, San Anselmo, CA, 94960, USA.
Fletcher C; National Institutes of Health, Bethesda, MD, 20205, USA.
Karp N; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Ramirez-Solis R; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
White JK; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
de Angelis MH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Wurst W; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Thomasy SM; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.; Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.
Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
Parkinson H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
Brown SDM; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Meehan TF; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
Nishina PM; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Murray SA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Krebs MP; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Mallon AM; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center), Harwell, Oxfordshire, OX11 0RD, UK.
Kent Lloyd KC; Mouse Biology Program, and Department of Surgery, School of Medicine, University of California-Davis, Davis, CA, 95618, USA.
Murphy CJ; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA. .; Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA. .
Moshiri A; Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA. .
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Corporate Authors:
International Mouse Phenotyping Consortium
Źródło:
Communications biology [Commun Biol] 2019 Mar 07; Vol. 2, pp. 97. Date of Electronic Publication: 2019 Mar 07 (Print Publication: 2019).
Typ publikacji:
Journal Article; Published Erratum
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.
Autorzy:
Duque-Correa MA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Karp NA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
McCarthy C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Forman S; Lydia Becker Institute of Immunology and Inflammation, Wellcome Trust Centre for Cell Matrix Research and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Goulding D; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Sankaranarayanan G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Jenkins TP; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Reid AJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Cambridge EL; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Ballesteros Reviriego C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Müller W; Lydia Becker Institute of Immunology and Inflammation and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Cantacessi C; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Dougan G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Grencis RK; Lydia Becker Institute of Immunology and Inflammation, Wellcome Trust Centre for Cell Matrix Research and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Berriman M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
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Corporate Authors:
Sanger Mouse Genetics Project
3i consortium
Źródło:
PLoS pathogens [PLoS Pathog] 2019 Jan 14; Vol. 15 (1), pp. e1007265. Date of Electronic Publication: 2019 Jan 14 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Interleukin-10/*metabolism
Receptors, Interleukin-10/*metabolism
Trichuris/*immunology
Animals ; Cytokines/metabolism ; Disease Models, Animal ; Gastrointestinal Microbiome/immunology ; Homeostasis ; Interleukins/metabolism ; Intestines/microbiology ; Intestines/pathology ; Mice ; Mice, Inbred C57BL ; Signal Transduction ; Trichuriasis/immunology ; Trichuris/parasitology ; Interleukin-22
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of genes required for eye development by high-throughput screening of mouse knockouts.
Autorzy:
Moore BA; William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, 95616, CA, USA.
Leonard BC; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Sebbag L; William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, 95616, CA, USA.
Edwards SG; William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, 95616, CA, USA.
Cooper A; William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, 95616, CA, USA.
Imai DM; Comparative Pathology Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Straiton E; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Santos L; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Reilly C; Comparative Pathology Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Griffey SM; Comparative Pathology Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Bower L; Mouse Biology Program, and Department of Surgery, School of Medicine, University of California-Davis, Davis, CA, 95618, USA.
Clary D; Mouse Biology Program, and Department of Surgery, School of Medicine, University of California-Davis, Davis, CA, 95618, USA.
Mason J; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
Roux MJ; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.; Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch-Graffenstaden, France.
Meziane H; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.; Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch-Graffenstaden, France.
Herault Y; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, U1258, Illkirch, France.; Université de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch, France.; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, 67404, Illkirch-Graffenstaden, France.
McKerlie C; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Flenniken AM; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Nutter LMJ; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Berberovic Z; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Owen C; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Newbigging S; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Adissu H; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Eskandarian M; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Hsu CW; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
Kalaga S; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
Udensi U; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
Asomugha C; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.
Bohat R; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Gallegos JJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Seavitt JR; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Heaney JD; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Beaudet AL; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Dickinson ME; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Justice MJ; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Philip V; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Kumar V; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Svenson KL; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Braun RE; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Wells S; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Cater H; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Stewart M; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Clementson-Mobbs S; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Joynson R; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Gao X; SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, 210061, China.
Suzuki T; RIKEN BioResource Center, Tsukuba, Ibaraki, 305-0074, Japan.
Wakana S; RIKEN BioResource Center, Tsukuba, Ibaraki, 305-0074, Japan.
Smedley D; Clinical Pharmacology, Charterhouse Square, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Seong JK; Korea Mouse Phenotyping Consortium (KMPC) and BK21 Program for Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul, 08826, South Korea.
Tocchini-Valentini G; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Adriano Buzzati-Traverso Campus, Via Ramarini, I-00015, Monterotondo Scalo, Italy.
Moore M; International Mouse Phenotyping Consortium, San Anselmo, CA, 94960, USA.
Fletcher C; National Institutes of Health, Bethesda, MD, 20205, USA.
Karp N; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Ramirez-Solis R; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
White JK; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
de Angelis MH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Wurst W; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Thomasy SM; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.; Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.
Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
Parkinson H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
Brown SDM; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Meehan TF; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
Nishina PM; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Murray SA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Krebs MP; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Mallon AM; Medical Research Council Harwell Institute (Mammalian Genetis Unit and Mary Lyon Center, Harwell, Oxfordshire, OX11 0RD, UK.
Lloyd KCK; Mouse Biology Program, and Department of Surgery, School of Medicine, University of California-Davis, Davis, CA, 95618, USA.
Murphy CJ; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA. .; Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA. .
Moshiri A; Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA. .
Pokaż więcej
Corporate Authors:
International Mouse Phenotyping Consortium
Źródło:
Communications biology [Commun Biol] 2018 Dec 21; Vol. 1, pp. 236. Date of Electronic Publication: 2018 Dec 21 (Print Publication: 2018).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reproducible preclinical research-Is embracing variability the answer?
Autorzy:
Karp NA; Quantitative Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
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Źródło:
PLoS biology [PLoS Biol] 2018 Mar 05; Vol. 16 (3), pp. e2005413. Date of Electronic Publication: 2018 Mar 05 (Print Publication: 2018).
Typ publikacji:
Journal Article
MeSH Terms:
Reproducibility of Results*
Research Design/*standards
Animals ; Reference Standards ; Research Design/trends
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Experimental Design Assistant.
Autorzy:
Percie du Sert N; National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), London, United Kingdom.
Bamsey I; Certus Technology Associates Ltd, Exeter, United Kingdom.
Bate ST; GlaxoSmithKline, Stevenage, United Kingdom.
Berdoy M; University of Oxford, Oxford, United Kingdom.
Clark RA; Envigo, Alconbury, United Kingdom.
Cuthill I; University of Bristol, Bristol, United Kingdom.
Fry D; University of Manchester, Manchester, United Kingdom.
Karp NA; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.; Quantitative Biology IMED, AstraZeneca R&D, Cambridge, United Kingdom.
Macleod M; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Moon L; King's College London, London, United Kingdom.
Stanford SC; University College London, London, United Kingdom.
Lings B; Certus Technology Associates Ltd, Exeter, United Kingdom.
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Źródło:
PLoS biology [PLoS Biol] 2017 Sep 28; Vol. 15 (9), pp. e2003779. Date of Electronic Publication: 2017 Sep 28 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Internet*
Research Design*
Software*
Feedback
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project.
Autorzy:
Redfern WS; Drug Safety and Metabolism, AstraZeneca R&D, Babraham Research Campus, Cambridge, United Kingdom.
Tse K; Drug Safety and Metabolism, AstraZeneca R&D, Babraham Research Campus, Cambridge, United Kingdom.
Grant C; Drug Safety and Metabolism, AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom.
Keerie A; Drug Safety and Metabolism, AstraZeneca R&D, Babraham Research Campus, Cambridge, United Kingdom.
Simpson DJ; Drug Safety and Metabolism, AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom.
Pedersen JC; Drug Safety and Metabolism, AstraZeneca R&D, Babraham Research Campus, Cambridge, United Kingdom.
Rimmer V; Drug Safety and Metabolism, AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom.
Leslie L; Drug Safety and Metabolism, AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom.
Klein SK; Drug Safety and Metabolism, AstraZeneca R&D, Babraham Research Campus, Cambridge, United Kingdom.
Karp NA; Quantitative Biology, IMED, AstraZeneca, Darwin Building (Unit 310), Cambridge Science Park, Cambridge, United Kingdom.
Sillito R; Actual Analytics Ltd, Edinburgh, United Kingdom.
Chartsias A; Actual Analytics Ltd, Edinburgh, United Kingdom.
Lukins T; Actual Analytics Ltd, Edinburgh, United Kingdom.
Heward J; Actual Analytics Ltd, Edinburgh, United Kingdom.
Vickers C; NC3Rs, London, United Kingdom.
Chapman K; NC3Rs, London, United Kingdom.
Armstrong JD; Actual Analytics Ltd, Edinburgh, United Kingdom.; School of Informatics, University of Edinburgh, Appleton Tower, Edinburgh, United Kingdom.
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Źródło:
PloS one [PLoS One] 2017 Sep 06; Vol. 12 (9), pp. e0181068. Date of Electronic Publication: 2017 Sep 06 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Behavior, Animal*
Housing, Animal*
Social Behavior*
Temperature*
Video Recording/*methods
Animals ; Automation ; Implants, Experimental ; Male ; Movement ; Radio Frequency Identification Device ; Rats, Wistar ; Reproducibility of Results ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.
Autorzy:
Briend E; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.; Present address: Agenus Ltd, Cambridge, UK.
Ferguson GJ; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.
Mori M; Department of Experimental Medical Science, BMC D12, Lund University, SE-221 84, Lund, Sweden.
Damera G; MedImmune LLC, 1 MedImmune Way, Gaithersburg, MD, USA.
Stephenson K; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.; Present address: University of Nottingham, Nottingham, UK.
Karp NA; Quantitative Biology IMED, AstraZeneca R&D, Cambridge, UK.
Sethi S; Department of Medicine, University at Buffalo, 3495 Bailey Avenue, Buffalo, NY, 14215, USA.
Ward CK; MedImmune LLC, 1 MedImmune Way, Gaithersburg, MD, USA.; Present address: Bristol-Myers Squibb, Princeton, NJ, USA.
Sleeman MA; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.; Present address: Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Erjefält JS; Department of Experimental Medical Science, BMC D12, Lund University, SE-221 84, Lund, Sweden.; Department of Respiratory Medicine and Allergology, Lund University Hospital, Lund, Sweden.
Finch DK; MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, UK. .
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Źródło:
Respiratory research [Respir Res] 2017 Aug 22; Vol. 18 (1), pp. 159. Date of Electronic Publication: 2017 Aug 22.
Typ publikacji:
Journal Article
MeSH Terms:
Severity of Illness Index*
Interferon-gamma/*biosynthesis
Interleukin-18/*biosynthesis
Lung/*metabolism
Lymphocytes/*metabolism
Pulmonary Disease, Chronic Obstructive/*metabolism
Humans ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Longitudinal Studies ; Lung/pathology ; Lymphocytes/pathology ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/pathology ; Sputum/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reporting phenotypes in mouse models when considering body size as a potential confounder.
Autorzy:
Oellrich A; Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire UK ; Social Genetic & Developmental Psychiatry, King's College London, London, UK.
Meehan TF; Samples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, Cambridge UK.
Parkinson H; Samples, Phenotypes and Ontologies, European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD UK.
Sarntivijai S; Samples, Phenotypes and Ontologies, European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD UK ; The Centre for Therapeutic Target Validation, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD UK.
White JK; Mouse Genetics Project, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire UK.
Karp NA; Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire UK.
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Źródło:
Journal of biomedical semantics [J Biomed Semantics] 2016 Feb 09; Vol. 7, pp. 2. Date of Electronic Publication: 2016 Feb 09 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Body Size*
Gene Ontology*
Phenotype*
Animals ; Female ; Genotype ; Male ; Mice ; Models, Animal ; Reference Standards
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A mouse informatics platform for phenotypic and translational discovery.
Autorzy:
Ring N; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Meehan TF; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. .
Blake A; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Brown J; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Chen CK; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Conte N; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Di Fenza A; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Fiegel T; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Horner N; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Jacobsen JO; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Karp N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Lawson T; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Mason JC; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Matthews P; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Morgan H; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Relac M; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Santos L; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Smedley D; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Sneddon D; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Pengelly A; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Tudose I; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Warren JW; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Westerberg H; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Yaikhom G; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
Parkinson H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Mallon AM; MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
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Źródło:
Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2015 Oct; Vol. 26 (9-10), pp. 413-21. Date of Electronic Publication: 2015 Aug 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Computational Biology*
Genome*
Mice, Inbred Strains/*genetics
Mice, Knockout/*genetics
Animals ; Humans ; Mice ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 30

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