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Tytuł:
AI-assisted quantification of hypothalamic atrophy in amyotrophic lateral sclerosis by convolutional neural network-based automatic segmentation.
Autorzy:
Vernikouskaya I; Department of Internal Medicine II, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany. .
Müller HP; Department of Neurology, University of Ulm, Ulm, Germany.
Roselli F; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.
Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.
Rasche V; Department of Internal Medicine II, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany.; Core Facility Small Animal MRI, University of Ulm, Ulm, Germany.
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Źródło:
Scientific reports [Sci Rep] 2023 Dec 06; Vol. 13 (1), pp. 21505. Date of Electronic Publication: 2023 Dec 06.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis*/diagnostic imaging
Humans ; Neural Networks, Computer ; Magnetic Resonance Imaging/methods ; Neuroimaging/methods ; Atrophy ; Image Processing, Computer-Assisted/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis: Machine Learning for Biomarker Development.
Autorzy:
Behler A; Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.
Müller HP; Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.
Ludolph AC; Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 18; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Amyotrophic Lateral Sclerosis*/pathology
Humans ; Diffusion Tensor Imaging/methods ; Magnetic Resonance Imaging ; Biomarkers ; Machine Learning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Multimodal in vivo staging in amyotrophic lateral sclerosis using artificial intelligence.
Autorzy:
Behler A; Department of Neurology, University of Ulm, Germany.
Müller HP; Department of Neurology, University of Ulm, Germany.
Del Tredici K; Department of Neurology, University of Ulm, Germany.
Braak H; Department of Neurology, University of Ulm, Germany.
Ludolph AC; Department of Neurology, University of Ulm, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ulm, Germany.
Lulé D; Department of Neurology, University of Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ulm, Germany.
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Źródło:
Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2022 Jul; Vol. 9 (7), pp. 1069-1079. Date of Electronic Publication: 2022 Jun 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis*
Anisotropy ; Artificial Intelligence ; Brain/pathology ; Diffusion Tensor Imaging/methods ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Body fat compartment determination by encoder-decoder convolutional neural network: application to amyotrophic lateral sclerosis.
Autorzy:
Vernikouskaya I; Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany.
Müller HP; Department of Neurology, University of Ulm, Ulm, Germany.
Felbel D; Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany.
Roselli F; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.
Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.
Rasche V; Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany. .; Core Facility Small Animal MRI, University of Ulm, Ulm, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2022 Apr 01; Vol. 12 (1), pp. 5513. Date of Electronic Publication: 2022 Apr 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis*/diagnostic imaging
Adipose Tissue/diagnostic imaging ; Humans ; Intra-Abdominal Fat ; Magnetic Resonance Imaging/methods ; Neural Networks, Computer
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Challenges and opportunities for Multi-National Investigator-Initiated clinical trials for ALS: European and United States collaborations.
Autorzy:
Lingor P; Department of Neurology, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, München, Germany.
Koch JC; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Statland JM; Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Hussain S; Department of Neurology, University of Miami, Miami, Florida, USA.
Hennecke C; Department for International Cooperations, University Medical Center Göttingen, Göttingen, Germany.
Wuu J; Department of Neurology, University of Miami, Miami, Florida, USA.
Langbein T; Clinical Trials Unit, University Medical Center Göttingen, Göttingen, Germany.
Ahmed R; Department for International Cooperations, University Medical Center Göttingen, Göttingen, Germany.
Günther R; Department of Neurology, Technische Universität Dresden and German Center for Neurodegenerative Diseases, Dresden, Germany.
Ilse B; Department of Neurology, Jena University Hospital, Jena, Germany.
Kassubek J; Department of Neurology, RKU, University of Ulm, Ulm, Germany.
Kollewe K; Department of Neurology, Hannover Medical School, Hannover, Germany.
Kuttler J; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Leha A; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.
Lengenfeld T; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Meyer T; Center for ALS and other Motor Neuron Disorders, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Neuwirth C; Neuromuscular Disease Unit/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Tostmann R; Department for International Cooperations, University Medical Center Göttingen, Göttingen, Germany.
Benatar M; Department of Neurology, University of Miami, Miami, Florida, USA.
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Źródło:
Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2021 Aug; Vol. 22 (5-6), pp. 419-425. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis*/drug therapy
Clinical Trials as Topic ; Europe ; Humans ; United States
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients.
Autorzy:
Bayer D; Department of Neurology, Ulm University, Ulm, Germany.; CEMMA (Cellular and Molecular Mechanisms in Aging) Research Training Group, Ulm, Germany.
Antonucci S; Department of Neurology, Ulm University, Ulm, Germany.
Müller HP; Department of Neurology, Ulm University, Ulm, Germany.
Saad R; Department of Neurology, Ulm University, Ulm, Germany.
Dupuis L; University of Strasbourg, Strasbourg, France.
Rasche V; Department of Internal Medicine II, Ulm University Medical Centre, Ulm, Germany.
Böckers TM; Institute of Anatomy and Cell Biology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases-DZNE, Ulm, Germany.
Ludolph AC; Department of Neurology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases-DZNE, Ulm, Germany.
Kassubek J; Department of Neurology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases-DZNE, Ulm, Germany.
Roselli F; Department of Neurology, Ulm University, Ulm, Germany. .; German Center for Neurodegenerative Diseases-DZNE, Ulm, Germany. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2021 May 31; Vol. 10 (1), pp. 17. Date of Electronic Publication: 2021 May 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*pathology
Hypothalamus/*pathology
Neural Pathways/*pathology
Prefrontal Cortex/*pathology
Amyotrophic Lateral Sclerosis/diagnostic imaging ; Animals ; Brain Mapping ; Case-Control Studies ; Cohort Studies ; Diffusion Tensor Imaging ; Energy Metabolism ; Humans ; Hypothalamus/diagnostic imaging ; Immunohistochemistry ; Mice ; Motor Cortex/growth & development ; Motor Cortex/pathology ; Neural Pathways/diagnostic imaging ; Prefrontal Cortex/diagnostic imaging ; RNA-Binding Protein FUS/genetics ; Superoxide Dismutase-1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Corticoefferent pathology distribution in amyotrophic lateral sclerosis: in vivo evidence from a meta-analysis of diffusion tensor imaging data.
Autorzy:
Gorges M; Department of Neurology, University of Ulm, Ulm, Germany.
Del Tredici K; Department of Neurology, University of Ulm, Ulm, Germany.; Clinical Neuroanatomy, Department of Neurology, University of Ulm, Ulm, Germany.
Dreyhaupt J; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
Braak H; Department of Neurology, University of Ulm, Ulm, Germany.; Clinical Neuroanatomy, Department of Neurology, University of Ulm, Ulm, Germany.
Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany.
Müller HP; Department of Neurology, University of Ulm, Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Ulm, Germany. jan.kassubek@uni-ulm.de.
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Źródło:
Scientific reports [Sci Rep] 2018 Oct 18; Vol. 8 (1), pp. 15389. Date of Electronic Publication: 2018 Oct 18.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*pathology
Brain Mapping/*methods
Diffusion Tensor Imaging/*methods
Image Processing, Computer-Assisted/*methods
Pyramidal Tracts/*pathology
Case-Control Studies ; Cross-Sectional Studies ; Disease Progression ; Humans ; Longitudinal Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The concept and diagnostic criteria of primary lateral sclerosis.
Autorzy:
Wais V; Department of Neurology, University of Ulm, Ulm, Germany.
Rosenbohm A; Department of Neurology, University of Ulm, Ulm, Germany.
Petri S; Department of Neurology, University of Hannover, Hannover, Germany.
Kollewe K; Department of Neurology, University of Hannover, Hannover, Germany.
Hermann A; Department of Neurology, Division for Neurodegenerative Diseases, Dresden University of Technology, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Storch A; Department of Neurology, Division for Neurodegenerative Diseases, Dresden University of Technology, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Medical Center Rostock, Rostock, Germany.
Hanisch F; Department of Neurology, Evangelisches Krankenhaus Königin Elisabeth Herzberge, Berlin, Germany.
Zierz S; Department of Neurology, University of Halle, Halle, Germany.
Nagel G; Institute for Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Ulm, Germany.
Weydt P; Department of Neurology, University of Ulm, Ulm, Germany.
Brettschneider J; CaritasKlinikum, Saarbrücken, Germany.
Weishaupt JH; Department of Neurology, University of Ulm, Ulm, Germany.
Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany.
Dorst J; Department of Neurology, University of Ulm, Ulm, Germany.
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Źródło:
Acta neurologica Scandinavica [Acta Neurol Scand] 2017 Sep; Vol. 136 (3), pp. 204-211. Date of Electronic Publication: 2016 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis/*diagnosis
Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Motor Neurons/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A first approach to a neuropsychological screening tool using eye-tracking for bedside cognitive testing based on the Edinburgh Cognitive and Behavioural ALS Screen.
Autorzy:
Keller J; a Department of Neurology , University of Ulm , Ulm , Germany and.
Krimly A; a Department of Neurology , University of Ulm , Ulm , Germany and.
Bauer L; a Department of Neurology , University of Ulm , Ulm , Germany and.
Schulenburg S; a Department of Neurology , University of Ulm , Ulm , Germany and.
Böhm S; a Department of Neurology , University of Ulm , Ulm , Germany and.
Aho-Özhan HEA; a Department of Neurology , University of Ulm , Ulm , Germany and.
Uttner I; a Department of Neurology , University of Ulm , Ulm , Germany and.
Gorges M; a Department of Neurology , University of Ulm , Ulm , Germany and.
Kassubek J; a Department of Neurology , University of Ulm , Ulm , Germany and.
Pinkhardt EH; a Department of Neurology , University of Ulm , Ulm , Germany and.
Abrahams S; b Human Cognitive Neuroscience-PPLS , Centre for Cognitive Ageing and Cognitive Epidemiology, Euan MacDonald Centre for Motor Neuron Disease Research, and Anne Rowling Regenerative Neurology Clinic, The University of Edinburgh , Edinburgh , UK.
Ludolph AC; a Department of Neurology , University of Ulm , Ulm , Germany and.
Lulé D; a Department of Neurology , University of Ulm , Ulm , Germany and.
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Źródło:
Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2017 Aug; Vol. 18 (5-6), pp. 443-450. Date of Electronic Publication: 2017 Apr 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Eye Movements*/physiology
Neuropsychological Tests*
Point-of-Care Testing*
Amyotrophic Lateral Sclerosis/*psychology
Cognition Disorders/*psychology
Mental Disorders/*psychology
Adult ; Aged ; Amyotrophic Lateral Sclerosis/diagnosis ; Cognition/physiology ; Cognition Disorders/diagnosis ; Female ; Humans ; Male ; Mental Disorders/diagnosis ; Middle Aged ; Photic Stimulation/methods ; Random Allocation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional connectivity changes resemble patterns of pTDP-43 pathology in amyotrophic lateral sclerosis.
Autorzy:
Schulthess I; Department of Neurology, University of Ulm, Ulm, Germany.
Gorges M; Department of Neurology, University of Ulm, Ulm, Germany.
Müller HP; Department of Neurology, University of Ulm, Ulm, Germany.
Lulé D; Department of Neurology, University of Ulm, Ulm, Germany.
Del Tredici K; Clinical Neuroanatomy, Department of Neurology, University of Ulm, Germany.
Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Ulm, Germany.
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Źródło:
Scientific reports [Sci Rep] 2016 Dec 08; Vol. 6, pp. 38391. Date of Electronic Publication: 2016 Dec 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*physiopathology
Brain/*physiopathology
Brain Stem/*physiopathology
Motor Neurons/*pathology
Adult ; Aged ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/metabolism ; Attention/physiology ; Brain Stem/diagnostic imaging ; Connectome ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Neurons/metabolism ; Neural Pathways/pathology ; Neural Pathways/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Perception of Emotional Facial Expressions in Amyotrophic Lateral Sclerosis (ALS) at Behavioural and Brain Metabolic Level.
Autorzy:
Aho-Özhan HE; Department of Neurology, University of Ulm, Ulm, Germany.
Keller J; Department of Neurology, University of Ulm, Ulm, Germany.
Heimrath J; Department of Neurology, University of Ulm, Ulm, Germany.
Uttner I; Department of Neurology, University of Ulm, Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Ulm, Germany.
Birbaumer N; Institute of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls-University of Tübingen, Tübingen, Germany.; The Wyss Center for Bio and Neuroengineering, Geneva, Switzerland.
Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany.
Lulé D; Department of Neurology, University of Ulm, Ulm, Germany.; Institute of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls-University of Tübingen, Tübingen, Germany.
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Źródło:
PloS one [PLoS One] 2016 Oct 14; Vol. 11 (10), pp. e0164655. Date of Electronic Publication: 2016 Oct 14 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Facial Expression*
Amyotrophic Lateral Sclerosis/*physiopathology
Behavior/*physiology
Brain/*metabolism
Emotions/*physiology
Adult ; Aged ; Brain/diagnostic imaging ; Case-Control Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Photic Stimulation ; Regression Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Eye Movement Deficits Are Consistent with a Staging Model of pTDP-43 Pathology in Amyotrophic Lateral Sclerosis.
Autorzy:
Gorges M; Department of Neurology, University of Ulm, Ulm, Germany.
Müller HP; Department of Neurology, University of Ulm, Ulm, Germany.
Lulé D; Department of Neurology, University of Ulm, Ulm, Germany.
Del Tredici K; Section Clinical Neuroanatomy, Department of Neurology, University of Ulm, Ulm, Germany.
Brettschneider J; Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, PA, United States of America.
Keller J; Department of Neurology, University of Ulm, Ulm, Germany.
Pfandl K; Department of Neurology, University of Ulm, Ulm, Germany.
Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany.
Kassubek J; Department of Neurology, University of Ulm, Ulm, Germany.
Pinkhardt EH; Department of Neurology, University of Ulm, Ulm, Germany.
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Źródło:
PloS one [PLoS One] 2015 Nov 11; Vol. 10 (11), pp. e0142546. Date of Electronic Publication: 2015 Nov 11 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*physiopathology
Brain/*pathology
DNA-Binding Proteins/*metabolism
Eye Movements/*physiology
Adult ; Aged ; Aged, 80 and over ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Brain/metabolism ; Brain/physiopathology ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?
Autorzy:
Abdelhak A; Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany. .
Junker A; Institute of Neuropathology, University Hospital Göttingen, Robert-Koch-Str 40, 37075 Göttingen, Germany. .
Brettschneider J; Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany. .
Kassubek J; Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany. jan.kassubek@uni-ulm.de.
Ludolph AC; Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany. .
Otto M; Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany. .
Tumani H; Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2015 Jul 31; Vol. 16 (8), pp. 17565-88. Date of Electronic Publication: 2015 Jul 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Amyotrophic Lateral Sclerosis/*cerebrospinal fluid
Biomarkers/*cerebrospinal fluid
Brain Injuries/*genetics
Multiple Sclerosis, Chronic Progressive/*cerebrospinal fluid
Amyotrophic Lateral Sclerosis/physiopathology ; Brain/pathology ; Brain Injuries/pathology ; Cytoskeleton/pathology ; Humans ; Motor Neurons/metabolism ; Motor Neurons/pathology ; Multiple Sclerosis, Chronic Progressive/physiopathology ; Tubulin/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The diagnostic value of midbrain hyperechogenicity in ALS is limited for discriminating key ALS differential diagnoses.
Autorzy:
Hermann A; Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden and German Center for NeurodegenerativeDiseases (DZNE), Research site Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. .
Reuner U; Department of Neurology, Technische Universität Dresden, Dresden, Germany. .
Schaefer J; Department of Neurology, Technische Universität Dresden, Dresden, Germany. .
Fathinia P; Department of Neurology, University Ulm, Ulm, Germany. .
Leimert T; Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden and German Center for NeurodegenerativeDiseases (DZNE), Research site Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. .
Kassubek J; Department of Neurology, University Ulm, Ulm, Germany. jan.kassubek@uni-ulm.de.
Leimert M; Department of Neurosurgery, Technische Universität Dresden, Dresden, Germany. .
Ludolph AC; Department of Neurology, University Ulm, Ulm, Germany. .
Storch A; Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden and German Center for NeurodegenerativeDiseases (DZNE), Research site Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. .
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Źródło:
BMC neurology [BMC Neurol] 2015 Mar 14; Vol. 15, pp. 33. Date of Electronic Publication: 2015 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis/*diagnostic imaging
Myasthenia Gravis/*diagnostic imaging
Polyradiculoneuropathy/*diagnostic imaging
Spinal Stenosis/*diagnostic imaging
Substantia Nigra/*diagnostic imaging
Adult ; Aged ; Aged, 80 and over ; Amyotrophic Lateral Sclerosis/diagnosis ; Cervical Vertebrae ; Diagnosis, Differential ; Echoencephalography ; Female ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/diagnostic imaging ; Humans ; Male ; Mesencephalon/diagnostic imaging ; Middle Aged ; Myasthenia Gravis/diagnosis ; Polyradiculoneuropathy/diagnosis ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnostic imaging ; Prospective Studies ; ROC Curve ; Sensitivity and Specificity ; Spinal Stenosis/diagnosis ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ex post facto assessment of diffusion tensor imaging metrics from different MRI protocols: preparing for multicentre studies in ALS.
Autorzy:
Rosskopf J; Department of Neurology, University of Ulm , Germany.
Müller HP
Dreyhaupt J
Gorges M
Ludolph AC
Kassubek J
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Źródło:
Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2015 Mar; Vol. 16 (1-2), pp. 92-101. Date of Electronic Publication: 2015 Jan 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diffusion Tensor Imaging*
Magnetic Resonance Imaging*
Amyotrophic Lateral Sclerosis/*diagnosis
Adult ; Aged ; Brain Mapping ; Female ; Humans ; Imaging, Three-Dimensional ; Male ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Additional resources and the default mode network: Evidence of increased connectivity and decreased white matter integrity in amyotrophic lateral sclerosis.
Autorzy:
Heimrath J; Department of Neurology, University of Ulm , Ulm , Germany.
Gorges M
Kassubek J
Müller HP
Birbaumer N
Ludolph AC
Lulé D
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Źródło:
Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2014 Dec; Vol. 15 (7-8), pp. 537-45. Date of Electronic Publication: 2014 May 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*complications
Leukoencephalopathies/*etiology
Leukoencephalopathies/*pathology
Neural Pathways/*pathology
White Matter/*pathology
Adult ; Aged ; Atrophy ; Brain Mapping ; Case-Control Studies ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Diffusion Magnetic Resonance Imaging ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/blood supply ; Neuropsychological Tests ; Oxygen/blood ; Rest ; Statistics, Nonparametric ; White Matter/blood supply
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Adipose Tissue Distribution Predicts Survival in Amyotrophic Lateral Sclerosis.
Autorzy:
Lindauer E; Department of Neurology, University of Ulm, Ulm, Germany.
Dupuis L
Müller HP
Neumann H
Ludolph AC
Kassubek J
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Źródło:
PloS one [PLoS One] 2013 Jun 27; Vol. 8 (6), pp. e67783. Date of Electronic Publication: 2013 Jun 27 (Print Publication: 2013).
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis/*mortality
Body Fat Distribution/*mortality
Intra-Abdominal Fat/*physiopathology
Subcutaneous Fat/*physiopathology
Amyotrophic Lateral Sclerosis/physiopathology ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis.
Autorzy:
Dupuis L; Department of Neurology, University of Ulm, Ulm, Germany.
Dengler R
Heneka MT
Meyer T
Zierz S
Kassubek J
Fischer W
Steiner F
Lindauer E
Otto M
Dreyhaupt J
Grehl T
Hermann A
Winkler AS
Bogdahn U
Benecke R
Schrank B
Wessig C
Grosskreutz J
Ludolph AC
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Corporate Authors:
GERP ALS Study Group
Źródło:
PloS one [PLoS One] 2012; Vol. 7 (6), pp. e37885. Date of Electronic Publication: 2012 Jun 08.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*drug therapy
Anticonvulsants/*administration & dosage
Hypoglycemic Agents/*administration & dosage
Riluzole/*administration & dosage
Thiazolidinediones/*administration & dosage
Aged ; Amyotrophic Lateral Sclerosis/mortality ; Animals ; Disease-Free Survival ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Male ; Mice ; Middle Aged ; Pioglitazone ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
MRI-based functional neuroimaging in ALS: an update.
Autorzy:
Lulé D; Section of Neurophysiology, Department of Neurology, University of Ulm, Albert-Einstein-Allee 47, Ulm, Germany. />Ludolph AC
Kassubek J
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Źródło:
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases [Amyotroph Lateral Scler] 2009 Oct-Dec; Vol. 10 (5-6), pp. 258-68.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Amyotrophic Lateral Sclerosis*/pathology
Amyotrophic Lateral Sclerosis*/physiopathology
Brain/*pathology
Brain/*physiopathology
Image Processing, Computer-Assisted/*methods
Magnetic Resonance Imaging/*methods
Animals ; Brain/anatomy & histology ; Brain/physiology ; Diagnostic Imaging ; Humans ; Neurons/metabolism ; Neurosciences ; Oxygen/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Whole brain-based computerized neuroimaging in ALS and other motor neuron disorders.
Autorzy:
Grosskreutz J; Department of Neurology, Friedrich-Schiller-University Jena, Jena, Germany.
Peschel T
Unrath A
Dengler R
Ludolph AC
Kassubek J
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Źródło:
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases [Amyotroph Lateral Scler] 2008 Aug; Vol. 9 (4), pp. 238-48.
Typ publikacji:
Journal Article
MeSH Terms:
Amyotrophic Lateral Sclerosis/*pathology
Brain/*pathology
Diffusion Magnetic Resonance Imaging/*methods
Imaging, Three-Dimensional/*methods
Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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