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Tytuł :
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma.
Autorzy :
Sahin U; BioNTech, Mainz, Germany. .; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany. .; Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University Mainz, Mainz, Germany. .; HI-TRON, Helmholtz Institute for Translational Oncology Mainz - A Helmholtz Institute of the DKFZ, Mainz, Germany. .
Oehm P; BioNTech, Mainz, Germany.
Derhovanessian E; BioNTech, Mainz, Germany.
Jabulowsky RA; BioNTech, Mainz, Germany.
Vormehr M; BioNTech, Mainz, Germany.
Gold M; BioNTech, Mainz, Germany.
Maurus D; BioNTech, Mainz, Germany.
Schwarck-Kokarakis D; BioNTech, Mainz, Germany.
Kuhn AN; BioNTech, Mainz, Germany.
Omokoko T; BioNTech, Mainz, Germany.
Kranz LM; BioNTech, Mainz, Germany.
Diken M; BioNTech, Mainz, Germany.; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany.
Kreiter S; BioNTech, Mainz, Germany.; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany.
Haas H; BioNTech, Mainz, Germany.
Attig S; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University Mainz, Mainz, Germany.
Rae R; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany.
Cuk K; BioNTech, Mainz, Germany.
Kemmer-Brück A; BioNTech, Mainz, Germany.
Breitkreuz A; BioNTech, Mainz, Germany.
Tolliver C; BioNTech, Mainz, Germany.
Caspar J; BioNTech, Mainz, Germany.
Quinkhardt J; BioNTech, Mainz, Germany.
Hebich L; BioNTech, Mainz, Germany.
Stein M; BioNTech, Mainz, Germany.
Hohberger A; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany.
Vogler I; BioNTech, Mainz, Germany.
Liebig I; BioNTech, Mainz, Germany.
Renken S; BioNTech, Mainz, Germany.
Sikorski J; BioNTech, Mainz, Germany.
Leierer M; Department of Dermatology and National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany.
Müller V; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Mannheim, Germany.
Mitzel-Rink H; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Miederer M; Department of Nuclear Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Huber C; BioNTech, Mainz, Germany.; TRON, Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz gGmbH, Mainz, Germany.
Grabbe S; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Utikal J; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Mannheim, Germany.
Pinter A; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.
Kaufmann R; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.
Hassel JC; Department of Dermatology and National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany.
Loquai C; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Türeci Ö; BioNTech, Mainz, Germany.; HI-TRON, Helmholtz Institute for Translational Oncology Mainz - A Helmholtz Institute of the DKFZ, Mainz, Germany.
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7823), pp. 107-112. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Cancer Vaccines/*genetics
Cancer Vaccines/*immunology
Melanoma/*immunology
Melanoma/*therapy
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
RNA, Neoplasm/*genetics
T-Lymphocytes/*immunology
Antigens, Neoplasm/immunology ; Antineoplastic Agents/pharmacology ; Cancer Vaccines/administration & dosage ; Cancer Vaccines/adverse effects ; Combined Modality Therapy ; Humans ; Melanoma/drug therapy ; Melanoma/pathology ; Neoplasm Staging ; T-Lymphocytes/cytology ; T-Lymphocytes, Cytotoxic/cytology ; T-Lymphocytes, Cytotoxic/immunology ; Vaccination
Czasopismo naukowe
Tytuł :
Surgical approach to patients with low-burden stage III melanoma: Is it time to consider conservative surgery?
Autorzy :
Moreno-Ramírez D; Chair of the Department of Medical-&-Surgical Dermatology. Professor of Dermatology, Hospital Universitario Virgen Macarena, University of Seville, Spain. Electronic address: .
Vieira R; Dermatology Department, University of Coimbra, Portugal. Electronic address: .
Kaufmann R; Professor of Dermatology. Direktor der Klinik für Dermatologie, Venerologie und Allergologie. Universitätsklinik Frankfurt, Germany. Electronic address: kaufmann@em.uni-frankfurt.de.
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Źródło :
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2020 Apr; Vol. 46 (4 Pt A), pp. 498-500. Date of Electronic Publication: 2019 Nov 16.
Typ publikacji :
Editorial
MeSH Terms :
Lymph Node Excision/*methods
Melanoma/*surgery
Sentinel Lymph Node/*pathology
Skin Neoplasms/*surgery
Chemotherapy, Adjuvant ; Disease-Free Survival ; Humans ; Imidazoles/therapeutic use ; Melanoma/drug therapy ; Melanoma/pathology ; Molecular Targeted Therapy ; Neoadjuvant Therapy ; Neoplasm Staging ; Oximes/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Pyridones/therapeutic use ; Pyrimidinones/therapeutic use ; Sentinel Lymph Node Biopsy/methods ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Survival Rate ; Tumor Burden
Opinia redakcyjna
Tytuł :
G protein-coupled receptor 40 expression in human melanoma - correlation with tumour thickness, AJCC stage and survival.
Autorzy :
Kleemann J; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Hrgovic I; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Kleimann P; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Ter-Nedden J; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Glaser M; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Steinhorst K; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Härle K; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Müller J; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Kaufmann R; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Kippenberger S; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
Meissner M; Department of Dermatology, Venereology and Allergy, Goethe University Hospital, Frankfurt/Main, Germany.
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Źródło :
Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2020 Feb; Vol. 34 (2), pp. 285-292. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Melanoma/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Skin Neoplasms/*metabolism
Biomarkers, Tumor/metabolism ; Female ; Humans ; Male ; Melanoma/pathology ; Middle Aged ; Neoplasm Staging ; Skin Neoplasms/pathology ; Survival Analysis
Czasopismo naukowe
Tytuł :
Neoadjuvant therapy with vemurafenib in Horner's syndrome as a very rare first diagnosis of a malignant melanoma of unknown primary.
Autorzy :
Gebauer K; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Schirren J; Department of Thoracic Surgery, Agaplesion Markus Hospital Frankfurt, Frankfurt am Main, Germany.
Jaeschke B; Department of Haematology, Medical Oncology and Palliative Care, Helios Dr. Horst Schmidt Hospital Wiesbaden, Wiesbaden, Germany.
Kaufmann R; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Meissner M; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
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Źródło :
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2020 Jan; Vol. 18 (1), pp. 47-49. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Neoadjuvant Therapy*
Horner Syndrome/*drug therapy
Melanoma/*secondary
Neoplasms, Unknown Primary/*diagnostic imaging
Pancoast Syndrome/*secondary
Protein Kinase Inhibitors/*therapeutic use
Proto-Oncogene Proteins B-raf/*antagonists & inhibitors
Vemurafenib/*therapeutic use
Female ; Horner Syndrome/etiology ; Humans ; Magnetic Resonance Imaging ; Melanoma/complications ; Middle Aged ; Pancoast Syndrome/diagnostic imaging ; Pancoast Syndrome/drug therapy ; Tomography, X-Ray Computed
Raport
Tytuł :
Fatty acid receptor GPR120: a novel marker for human melanoma.
Autorzy :
Kleemann J; Department of Dermatology, Venereology and Allergy, University Hospital Frankfurt, Frankfurt/Main, Germany.
Hrgovic I
Ter-Nedden J
Kleimann P
Steinhorst K
Härle K
Müller J
Kaufmann R
Meissner M
Kippenberger S
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Źródło :
Melanoma research [Melanoma Res] 2018 Aug; Vol. 28 (4), pp. 271-276.
Typ publikacji :
Journal Article
MeSH Terms :
Melanoma/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Skin Neoplasms/*metabolism
Female ; Humans ; Immunohistochemistry ; Male ; Melanoma/genetics ; Melanoma/pathology ; Middle Aged ; Receptors, G-Protein-Coupled/genetics ; Retrospective Studies ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Vacuum sealing with a 'flipper' for the treatment of plantar excision defects.
Autorzy :
Bechstein S; Department of Dermatology, Venereology and Allergology, Frankfurt University Hospital, Frankfurt a. M., Germany.
Meissner M; Department of Dermatology, Venereology and Allergology, Frankfurt University Hospital, Frankfurt a. M., Germany.
Kaufmann R; Department of Dermatology, Venereology and Allergology, Frankfurt University Hospital, Frankfurt a. M., Germany.
Valesky EM; Department of Dermatology, Venereology and Allergology, Frankfurt University Hospital, Frankfurt a. M., Germany.
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Źródło :
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2017 Nov; Vol. 15 (11), pp. 1170-1172. Date of Electronic Publication: 2017 Oct 25.
Typ publikacji :
Journal Article
MeSH Terms :
Foot Diseases/*surgery
Forefoot, Human/*surgery
Hutchinson's Melanotic Freckle/*surgery
Melanoma/*surgery
Negative-Pressure Wound Therapy/*methods
Skin Neoplasms/*surgery
Toes/*surgery
Bandages ; Humans ; Margins of Excision ; Suture Techniques ; Wound Healing
Czasopismo naukowe
Tytuł :
Dimethylfumarate inhibits melanoma cell proliferation via p21 and p53 induction and bcl-2 and cyclin B1 downregulation.
Autorzy :
Kaluzki I; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Hrgovic I; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Hailemariam-Jahn T; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Doll M; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Kleemann J; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Valesky EM; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Kippenberger S; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Kaufmann R; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Zoeller N; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Meissner M; Department of Dermatology, Venereology and Allergology, Goethe-University, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany. .
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Źródło :
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2016 Oct; Vol. 37 (10), pp. 13627-13635. Date of Electronic Publication: 2016 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Cell Proliferation/*drug effects
Cyclin B2/*metabolism
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Dimethyl Fumarate/*pharmacology
Melanoma/*pathology
Proto-Oncogene Proteins c-bcl-2/*metabolism
Tumor Suppressor Protein p53/*metabolism
Apoptosis/drug effects ; Blotting, Western ; Cell Adhesion/drug effects ; Cell Cycle/drug effects ; Dermatologic Agents/pharmacology ; Flow Cytometry ; Humans ; Immunoenzyme Techniques ; Melanoma/drug therapy ; Melanoma/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Adjuvant treatment with pegylated interferon α-2a versus low-dose interferon α-2a in patients with high-risk melanoma: a randomized phase III DeCOG trial.
Autorzy :
Eigentler TK; Department of Dermatology, Center for Dermatooncology, University Medical Center Tübingen, Tübingen .
Gutzmer R; Department of Dermatology and Allergy, Hannover Medical School, Hannover.
Hauschild A; Department of Dermatology, University Hospital Kiel, Kiel.
Heinzerling L; Department of Dermatology, University Hospital Erlangen, Erlangen.
Schadendorf D; Department of Dermatology, University Essen-Duisburg, Essen.
Nashan D; Department of Dermatology, Hospital Dortmund, Dortmund.
Hölzle E; Department of Dermatology, Hospital Oldenburg, Oldenburg.
Kiecker F; Department of Dermatology, Charité Berlin, Berlin.
Becker J; Department of Dermatology, University Essen-Duisburg, Essen.
Sunderkötter C; Department of Dermatology, University Hospital Münster, Münster.
Moll I; Department of Dermatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Richtig E; Department of Dermatology, University Hospital Graz, Graz, Austria.
Pönitzsch I; Department of Dermatology, University Hospital Leipzig, Leipzig, Germany.
Pehamberger H; Department of Dermatology, AKH Wien, University Hospital Vienna, Vienna, Austria.
Kaufmann R; Department of Dermatology, University Hospital Frankfurt am Main, Frankfurt/Main.
Pföhler C; Department of Dermatology, Saarland University Medical School, Homburg/Saar.
Vogt T; Department of Dermatology, Saarland University Medical School, Homburg/Saar.
Berking C; Department of Dermatology and Allergy, University Hospital of Munich, Munich, Germany.
Praxmarer M; Assign Group, Innsbruck, Austria.
Garbe C; Department of Dermatology, Center for Dermatooncology, University Medical Center Tübingen, Tübingen.
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Corporate Authors :
Dermatologic Cooperative Oncology Group (DeCOG)
Źródło :
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2016 Aug; Vol. 27 (8), pp. 1625-32. Date of Electronic Publication: 2016 Jun 10.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
MeSH Terms :
Chemotherapy, Adjuvant/*methods
Drug-Related Side Effects and Adverse Reactions/*pathology
Interferon-alpha/*administration & dosage
Melanoma/*drug therapy
Polyethylene Glycols/*administration & dosage
Adolescent ; Adult ; Aged ; Chemotherapy, Adjuvant/adverse effects ; Disease-Free Survival ; Dose-Response Relationship, Drug ; Female ; Humans ; Interferon-alpha/adverse effects ; Male ; Melanoma/pathology ; Middle Aged ; Polyethylene Glycols/adverse effects ; Quality of Life ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Melanoma, sentinel node, and full-thickness skin graft: modification of Junod's procedure.
Autorzy :
Valesky EM; Department of Dermatology, Venereology, and Allergology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Kaufmann R; Department of Dermatology, Venereology, and Allergology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Meissner M; Department of Dermatology, Venereology, and Allergology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
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Źródło :
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2015 Jul; Vol. 13 (7), pp. 710-2. Date of Electronic Publication: 2015 Jun 02.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Melanoma/*secondary
Melanoma/*surgery
Sentinel Lymph Node Biopsy/*methods
Skin Neoplasms/*pathology
Skin Neoplasms/*surgery
Skin Transplantation/*methods
Dermatologic Surgical Procedures/methods ; Humans ; Melanoma/pathology
Czasopismo naukowe
Tytuł :
Visible light is a better co-inducer of apoptosis for curcumin-treated human melanoma cells than UVA.
Autorzy :
Buss S; Department of Dermatology, Venereology, and Allergology, University Hospital, J.W. Goethe-University, Frankfurt/Main, Germany.
Dobra J
Goerg K
Hoffmann S
Kippenberger S
Kaufmann R
Hofmann M
Bernd A
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Źródło :
PloS one [PLoS One] 2013 Nov 08; Vol. 8 (11), pp. e79748. Date of Electronic Publication: 2013 Nov 08 (Print Publication: 2013).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Apoptosis/*radiation effects
Curcumin/*pharmacology
Light/*adverse effects
Melanoma/*metabolism
Ultraviolet Rays/*adverse effects
Caspases/metabolism ; Cell Line, Tumor ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cell Survival/drug effects ; Cell Survival/radiation effects ; DNA Fragmentation/drug effects ; DNA Replication/drug effects ; DNA Replication/radiation effects ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Enzyme Activation/radiation effects ; Humans ; L-Lactate Dehydrogenase/metabolism ; Melanins/pharmacology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Prospective randomized multicenter adjuvant dermatologic cooperative oncology group trial of low-dose interferon alfa-2b with or without a modified high-dose interferon alfa-2b induction phase in patients with lymph node-negative melanoma.
Autorzy :
Hauschild A; Department of Dermatology, University Hospital of Schleswig-Holstein, Campus Kiel, Schittenhelmstr 7, D-24105 Kiel, Germany. />Weichenthal M
Rass K
Linse R
Ulrich J
Stadler R
Volkenandt M
Grabbe S
Proske U
Schadendorf D
Brockmeyer N
Vogt T
Rompel R
Kaufmann R
Kaatz M
Näher H
Mohr P
Eigentler T
Livingstone E
Garbe C
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Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2009 Jul 20; Vol. 27 (21), pp. 3496-502. Date of Electronic Publication: 2009 May 11.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Melanoma*/drug therapy
Skin Neoplasms*/drug therapy
Antineoplastic Agents/*administration & dosage
Interferon-alpha/*administration & dosage
Adult ; Aged ; Female ; Humans ; Infusions, Subcutaneous ; Interferon alpha-2 ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Recombinant Proteins ; Young Adult
Czasopismo naukowe
Tytuł :
Short German guidelines: malignant melanoma.
Autorzy :
Garbe C; Sektion Dermatologische Onkologie, Universitäts-Hautklinik, Liebermeister Strasse 25, D-72076 Tübingen, Germany. />Schadendorf D
Stolz W
Volkenandt M
Reinhold U
Kortmann RD
Kettelhack C
Frerich B
Keilholz U
Dummer R
Sebastian G
Tilgen W
Schuler G
Mackensen A
Kaufmann R
Hauschild A
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Źródło :
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2008 May; Vol. 6 Suppl 1, pp. S9-S14.
Typ publikacji :
Journal Article
MeSH Terms :
Practice Guidelines as Topic*
Dermatology/*standards
Medical Oncology/*standards
Melanoma/*diagnosis
Melanoma/*therapy
Skin Neoplasms/*diagnosis
Skin Neoplasms/*therapy
Germany ; Humans
Czasopismo naukowe
Tytuł :
Temozolomide plus pegylated interferon alfa-2b as first-line treatment for stage IV melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group (DeCOG).
Autorzy :
Spieth K; Department of Dermatology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. />Kaufmann R
Dummer R
Garbe C
Becker JC
Hauschild A
Tilgen W
Ugurel S
Beyeler M
Bröcker EB
Kaehler KC
Pföhler C
Gille J
Leiter U
Schadendorf D
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Źródło :
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2008 Apr; Vol. 19 (4), pp. 801-6. Date of Electronic Publication: 2008 Jan 04.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Melanoma/*drug therapy
Melanoma/*secondary
Skin Neoplasms/*drug therapy
Skin Neoplasms/*pathology
Adult ; Aged ; Antineoplastic Agents, Alkylating/administration & dosage ; Antineoplastic Agents, Alkylating/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Dacarbazine/administration & dosage ; Dacarbazine/adverse effects ; Dacarbazine/analogs & derivatives ; Disease-Free Survival ; Drug Administration Schedule ; Female ; Humans ; Interferon alpha-2 ; Interferon-alpha/administration & dosage ; Interferon-alpha/adverse effects ; Male ; Middle Aged ; Neoplasm Staging ; Polyethylene Glycols ; Prospective Studies ; Recombinant Proteins ; Temozolomide ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Evidence-based and interdisciplinary consensus-based German guidelines: systemic medical treatment of melanoma in the adjuvant and palliative setting.
Autorzy :
Garbe C; University Department of Dermatology, Tübingen, Germany. />Hauschild A
Volkenandt M
Schadendorf D
Stolz W
Reinhold U
Kortmann RD
Kettelhack C
Frerich B
Keilholz U
Dummer R
Sebastian G
Tilgen W
Schuler G
Mackensen A
Kaufmann R
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Źródło :
Melanoma research [Melanoma Res] 2008 Apr; Vol. 18 (2), pp. 152-60.
Typ publikacji :
Journal Article; Practice Guideline
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Melanoma/*therapy
Skin Neoplasms/*therapy
Chemotherapy, Adjuvant ; Combined Modality Therapy ; Cytokines/therapeutic use ; Germany ; Humans ; Immunotherapy ; Interferon-alpha/therapeutic use ; Melanoma/drug therapy ; Melanoma/secondary ; Palliative Care ; Quality of Life ; Skin Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma.
Autorzy :
Garbe C; University Department of Dermatology, Tübingen, Germany. />Hauschild A
Volkenandt M
Schadendorf D
Stolz W
Reinhold U
Kortmann RD
Kettelhack C
Frerich B
Keilholz U
Dummer R
Sebastian G
Tilgen W
Schuler G
Mackensen A
Kaufmann R
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Źródło :
Melanoma research [Melanoma Res] 2008 Feb; Vol. 18 (1), pp. 61-7.
Typ publikacji :
Consensus Development Conference; Journal Article; Practice Guideline
MeSH Terms :
Melanoma/*radiotherapy
Melanoma/*surgery
Skin Neoplasms/*radiotherapy
Skin Neoplasms/*surgery
Combined Modality Therapy ; Humans ; Lymph Node Excision
Czasopismo naukowe
Tytuł :
Evidence and interdisciplinary consense-based German guidelines: diagnosis and surveillance of melanoma.
Autorzy :
Garbe C; University Department of Dermatology, Tübingen, Germany. />Hauschild A
Volkenandt M
Schadendorf D
Stolz W
Reinhold U
Kortmann RD
Kettelhack C
Frerich B
Keilholz U
Dummer R
Sebastian G
Tilgen W
Schuler G
Mackensen A
Kaufmann R
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Źródło :
Melanoma research [Melanoma Res] 2007 Dec; Vol. 17 (6), pp. 393-9.
Typ publikacji :
Consensus Development Conference; Journal Article
MeSH Terms :
Lymphatic Metastasis/*diagnosis
Melanoma/*diagnosis
Skin Neoplasms/*diagnosis
Diagnosis, Differential ; Follow-Up Studies ; Germany ; Humans ; Lymph Nodes ; Melanoma/epidemiology ; Melanoma/pathology ; Melanoma/secondary ; Neoplasm Invasiveness ; Neoplasm Staging ; Practice Guidelines as Topic ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology ; Skin Neoplasms/secondary
Czasopismo naukowe
Tytuł :
Topical imiquimod: effectiveness in intraepithelial melanoma of oral mucosa.
Autorzy :
Spieth K; Department of Dermatology, J W Goethe-University, Frankfurt am Main, Germany. />Kovács A
Wolter M
Bug R
Kaufmann R
Gille J
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Źródło :
The Lancet. Oncology [Lancet Oncol] 2006 Dec; Vol. 7 (12), pp. 1036-7.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Aminoquinolines/*therapeutic use
Antineoplastic Agents/*therapeutic use
Carcinoma in Situ/*drug therapy
Melanoma/*drug therapy
Mouth Mucosa/*pathology
Mouth Neoplasms/*drug therapy
Skin Neoplasms/*drug therapy
Administration, Topical ; Aged ; Female ; Humans ; Imiquimod
Czasopismo naukowe
Tytuł :
Restoration of E-cadherin sensitizes human melanoma cells for apoptosis.
Autorzy :
Kippenberger S; Department of Dermatology, Division of Pneumology, University of Frankfurt Medical School, Frankfurt/Main, Germany. />Loitsch S
Thaçi D
Müller J
Guschel M
Kaufmann R
Bernd A
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Źródło :
Melanoma research [Melanoma Res] 2006 Oct; Vol. 16 (5), pp. 393-403.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Cadherins/*biosynthesis
Melanoma/*metabolism
Melanoma/*pathology
Caspase 3/metabolism ; Caspase 8/metabolism ; Catenins/metabolism ; Cell Adhesion ; Cell Line, Tumor ; Cytochromes c/metabolism ; Cytosol/metabolism ; DNA Fragmentation ; Humans ; Neoplasm Metastasis ; Protein Structure, Tertiary ; Staurosporine/pharmacology
Czasopismo naukowe
Tytuł :
[Brief guidelines: malignant melanoma of the skin].
Autorzy :
Garbe C; Universitäts-Hautklinik Tübingen. />Hauschild A
Volkenandt M
Schadendorf D
Stolz W
Kortmann RD
Kettelhack C
Frerich B
Keilholz U
Dummer R
Sebastian G
Tilgen W
Schuler G
Mackensen A
Kaufmann R
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Transliterated Title :
Kurzleitlinie: Malignes Melanom der Haut.
Źródło :
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2006 Apr; Vol. 4 (4), pp. 344-9.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Practice Guidelines as Topic*
Antineoplastic Agents/*therapeutic use
Melanoma/*diagnosis
Melanoma/*therapy
Practice Patterns, Physicians'/*standards
Skin Neoplasms/*diagnosis
Skin Neoplasms/*therapy
Germany ; Humans
Czasopismo naukowe

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