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    Wyświetlanie 1-20 z 20
    Tytuł:
    Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Autorzy:
    Andrew PV; Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Beech Hill Road, Sheffield, UK. .
    Pinnock A; Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Beech Hill Road, Sheffield, UK.
    Poyner A; Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Beech Hill Road, Sheffield, UK.
    Brown K; Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Beech Hill Road, Sheffield, UK.
    Chittock J; Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Beech Hill Road, Sheffield, UK.
    Kay LJ; Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Beech Hill Road, Sheffield, UK.
    Cork MJ; Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Beech Hill Road, Sheffield, UK.; Sheffield Teaching Hospitals NHS Foundation Trust, The Royal Hallamshire Hospital, Sheffield, UK.; Sheffield Children's NHS Foundation Trust, Sheffield Children's Hospital, Western Bank, Sheffield, UK.
    Danby SG; Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Beech Hill Road, Sheffield, UK.
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    Źródło:
    Dermatology and therapy [Dermatol Ther (Heidelb)] 2024 Feb; Vol. 14 (2), pp. 391-408. Date of Electronic Publication: 2024 Jan 04.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis.
    Autorzy:
    Danby SG; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Andrew PV; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Taylor RN; Statistical Services Unit, University of Sheffield, Sheffield, UK.
    Kay LJ; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Chittock J; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Pinnock A; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Ulhaq I; Sheffield Children's Hospital, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
    Fasth A; Perrigo Nordic, Kista, Stockholm, Sweden.
    Carlander K; Perrigo Nordic, Kista, Stockholm, Sweden.
    Holm T; Perrigo Nordic, Kista, Stockholm, Sweden.
    Cork MJ; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.; Sheffield Children's Hospital, Sheffield Children's NHS Foundation Trust, Sheffield, UK.; Department of Dermatology, The Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
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    Źródło:
    Clinical and experimental dermatology [Clin Exp Dermatol] 2022 Jun; Vol. 47 (6), pp. 1154-1164. Date of Electronic Publication: 2022 Apr 12.
    Typ publikacji:
    Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
    MeSH Terms:
    Dermatitis, Atopic*/drug therapy
    Eczema*/drug therapy
    Adult ; Child ; Emollients/therapeutic use ; Glycerol ; Humans ; Irritants ; Paraffin/pharmacology ; Paraffin/therapeutic use ; Prospective Studies ; Pruritus/drug therapy ; Skin Cream/therapeutic use ; Urea/therapeutic use ; Water Loss, Insensible
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Response to: Letter to the Editor Regarding "An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-Vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1".
    Autorzy:
    Danby SG; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK. .
    Andrew PV; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Brown K; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Chittock J; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Kay LJ; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.
    Cork MJ; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK.; Sheffield Children's NHS Foundation Trust, Sheffield Children's Hospital, Western Bank, Sheffield, UK.; Sheffield Teaching Hospitals NHS Foundation Trust, The Royal Hallamshire Hospital, Sheffield, UK.
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    Źródło:
    Dermatology and therapy [Dermatol Ther (Heidelb)] 2021 Dec; Vol. 11 (6), pp. 2249-2252. Date of Electronic Publication: 2021 Oct 18.
    Typ publikacji:
    Letter
    Opinia redakcyjna
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    National Early Warning Score 2 (NEWS2) to identify inpatient COVID-19 deterioration: a retrospective analysis.
    Autorzy:
    Baker KF; Translational and Clinical Research Institute, Newcastle University, UK and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
    Hanrath AT; Translational and Clinical Research Institute, Newcastle University, UK.
    Schim van der Loeff I; Translational and Clinical Research Institute, Newcastle University, UK.
    Kay LJ; Translational and Clinical Research Institute, Newcastle University, UK, consultant rheumatologist, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK, and deputy medical director, Healthcare Safety Investigation Branch (HSIB), Farnborough, UK.
    Back J; Healthcare Safety Investigation Branch (HSIB), Farnborough, UK.
    Duncan CJ; Translational and Clinical Research Institute, Newcastle University, UK, and honorary consultant in infectious diseases, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK .
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    Źródło:
    Clinical medicine (London, England) [Clin Med (Lond)] 2021 Mar; Vol. 21 (2), pp. 84-89. Date of Electronic Publication: 2021 Feb 05.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    COVID-19*
    Early Warning Score*
    Adult ; Aged ; Cohort Studies ; Disease Progression ; Humans ; Inpatients ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1.
    Autorzy:
    Danby SG; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield Medical School, Sheffield, UK. .
    Andrew PV; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield Medical School, Sheffield, UK.
    Brown K; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield Medical School, Sheffield, UK.
    Chittock J; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield Medical School, Sheffield, UK.
    Kay LJ; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield Medical School, Sheffield, UK.
    Cork MJ; Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield Medical School, Sheffield, UK.; Sheffield Teaching Hospitals NHS Foundation Trust, The Royal Hallamshire Hospital, Sheffield, UK.; Sheffield Children's NHS Foundation Trust, Sheffield Children's Hospital, Western Bank, Sheffield, UK.
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    Źródło:
    Dermatology and therapy [Dermatol Ther (Heidelb)] 2020 Oct; Vol. 10 (5), pp. 1031-1041. Date of Electronic Publication: 2020 Jul 15.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The anti-inflammatory effects of PGE 2 on human lung macrophages are mediated by the EP 4 receptor.
    Autorzy:
    Gill SK; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
    Yao Y; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
    Kay LJ; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
    Bewley MA; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
    Marriott HM; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK.
    Peachell PT; Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, The Medical School (Floor L), University of Sheffield, Sheffield, UK. .
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    Źródło:
    British journal of pharmacology [Br J Pharmacol] 2016 Nov; Vol. 173 (21), pp. 3099-3109. Date of Electronic Publication: 2016 Sep 06.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anti-Bacterial Agents/*pharmacology
    Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
    Dinoprostone/*pharmacology
    Macrophages, Alveolar/*drug effects
    Receptors, Prostaglandin E, EP4 Subtype/*metabolism
    Anti-Bacterial Agents/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Dinoprostone/chemistry ; Humans ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/microbiology ; Microbial Sensitivity Tests ; Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors ; Receptors, Prostaglandin E, EP4 Subtype/genetics ; Streptococcus pneumoniae/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Serotonin 2C receptor antagonists induce fast-onset antidepressant effects.
    Autorzy:
    Opal MD; 1] Committee on Neurobiology, University of Chicago, Chicago, IL, USA [2] Department of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, IL, USA.
    Klenotich SC; 1] Committee on Neurobiology, University of Chicago, Chicago, IL, USA [2] Department of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, IL, USA.
    Morais M; 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal [2] ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
    Bessa J; 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal [2] ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
    Winkle J; Department of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, IL, USA.
    Doukas D; Department of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, IL, USA.
    Kay LJ; 1] Committee on Neurobiology, University of Chicago, Chicago, IL, USA [2] Institute for Mind and Body, University of Chicago, Chicago, IL, USA [3] Department of Psychology, University of Chicago, Chicago, IL, USA.
    Sousa N; 1] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal [2] ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
    Dulawa SM; 1] Committee on Neurobiology, University of Chicago, Chicago, IL, USA [2] Department of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, IL, USA.
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    Źródło:
    Molecular psychiatry [Mol Psychiatry] 2014 Oct; Vol. 19 (10), pp. 1106-14. Date of Electronic Publication: 2013 Oct 29.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antidepressive Agents/*pharmacology
    Serotonin 5-HT2 Receptor Antagonists/*pharmacology
    Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Chronic Disease ; Citalopram/pharmacology ; Cyclic AMP Response Element-Binding Protein/metabolism ; Depressive Disorder/drug therapy ; Depressive Disorder/pathology ; Depressive Disorder/physiopathology ; Disease Models, Animal ; Elongation Factor 2 Kinase/metabolism ; Female ; Mice, Inbred BALB C ; Olfactory Bulb/physiopathology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/pathology ; Prefrontal Cortex/physiopathology ; Pyramidal Cells/drug effects ; Pyramidal Cells/pathology ; Pyramidal Cells/physiopathology ; Receptor, Serotonin, 5-HT2C/metabolism ; Receptors, Dopamine D1/antagonists & inhibitors ; Receptors, Dopamine D1/metabolism ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Stress, Psychological ; TOR Serine-Threonine Kinases/metabolism ; Time Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Characterization of syk expression in human lung mast cells: relationship with function.
    Autorzy:
    Havard S; Academic Unit of Respiratory Medicine, The Medical School (Floor M), University of Sheffield, Sheffield, UK.
    Scola AM
    Kay LJ
    Ishmael SS
    MacGlashan DW Jr
    Peachell PT
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    Źródło:
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2011 Mar; Vol. 41 (3), pp. 378-88. Date of Electronic Publication: 2011 Jan 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Lung/*immunology
    Mast Cells/*metabolism
    Protein-Tyrosine Kinases/*biosynthesis
    Signal Transduction/*immunology
    Cell Degranulation/immunology ; Cell Separation ; Flow Cytometry ; Histamine Release/immunology ; Humans ; Immunoblotting ; Immunoglobulin E/immunology ; Intracellular Signaling Peptides and Proteins ; Lung/cytology ; Mast Cells/immunology ; Syk Kinase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Influence of beta2-adrenoceptor gene polymorphisms on beta2-adrenoceptor-mediated responses in human lung mast cells.
    Autorzy:
    Kay LJ; Academic Unit of Molecular Pharmacology, University of Sheffield, The Royal Hallamshire Hospital (Floor M), Sheffield, S Yorks S10 2JF, UK.
    Rostami-Hodjegan A
    Suvarna SK
    Peachell PT
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    Źródło:
    British journal of pharmacology [Br J Pharmacol] 2007 Oct; Vol. 152 (3), pp. 323-31. Date of Electronic Publication: 2007 Jul 23.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Polymorphism, Genetic*
    Lung/*drug effects
    Mast Cells/*metabolism
    Receptors, Adrenergic, beta-2/*genetics
    Adrenergic beta-Agonists/pharmacology ; Desensitization, Immunologic ; Female ; Genotype ; Haplotypes ; Histamine/metabolism ; Humans ; Immunoglobulin E/drug effects ; Immunoglobulin E/metabolism ; Isoproterenol/pharmacology ; Lung/cytology ; Male ; Mast Cells/drug effects ; Open Reading Frames ; Promoter Regions, Genetic ; Time Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-20 z 20

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