Autor: "Keller, Denise" - OpacWWW

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Tytuł:: Impact of pretreatment dihydropyrimidine dehydrogenase genotype-guided fluoropyrimidine dosing on chemotherapy associated adverse events.
Autorzy:: Wigle TJ; Department of Physiology and Pharmacology, University of Western Ontario, London, Canada.
Povitz BL; Lawson Health Research Institute, London, Canada.
Medwid S; Department of Physiology and Pharmacology, University of Western Ontario, London, Canada.; Department of Medicine, University of Western Ontario, London, Canada.
Teft WA; Department of Medicine, University of Western Ontario, London, Canada.
Legan RM; Department of Medicine, University of Western Ontario, London, Canada.
Lenehan J; Department of Oncology, University of Western Ontario, London, Canada.
Nevison S; School of Medicine, University of Toronto, Mississauga, Canada.
Panuganty V; Department of Oncology, University of Western Ontario, London, Canada.
Keller D; London Health Sciences Centre, London, Canada.
Mailloux J; Department of Physiology and Pharmacology, University of Western Ontario, London, Canada.; Department of Medicine, University of Western Ontario, London, Canada.
Siebring V; London Health Sciences Centre, London, Canada.
Sarma S; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada.
Choi YH; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada.
Welch S; Department of Oncology, University of Western Ontario, London, Canada.
Winquist E; Department of Oncology, University of Western Ontario, London, Canada.
Schwarz UI; Department of Medicine, University of Western Ontario, London, Canada.
Kim RB; Department of Physiology and Pharmacology, University of Western Ontario, London, Canada.; Department of Medicine, University of Western Ontario, London, Canada.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1338-1348. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antimetabolites, Antineoplastic/*adverse effects
Dihydropyrimidine Dehydrogenase Deficiency/*diagnosis
Dihydrouracil Dehydrogenase (NADP)/*genetics
Neoplasms/*drug therapy
Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/pharmacokinetics ; Canada ; Capecitabine/administration & dosage ; Capecitabine/adverse effects ; Capecitabine/pharmacokinetics ; Dihydropyrimidine Dehydrogenase Deficiency/genetics ; Dihydrouracil Dehydrogenase (NADP)/metabolism ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Fluorouracil/pharmacokinetics ; Heterozygote ; Humans ; Male ; Medical Oncology/standards ; Middle Aged ; Neoplasms/genetics ; Pharmacogenomic Testing/standards ; Pharmacogenomic Variants ; Practice Guidelines as Topic ; Precision Medicine/standards ; Precision Medicine/statistics & numerical data ; Retrospective Studies

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