Expanding the space of protein geometries by computational design of de novo fold families.
Autorzy:
Pan X; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. .; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco, CA, USA. Thompson MC; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. Zhang Y; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. Liu L; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.; Quantitative Biosciences Institute, University of California, San Francisco, CA, USA. KellyMJS; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. Kortemme T; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. .; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco, CA, USA.; Quantitative Biosciences Institute, University of California, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Computational design of a modular protein sense-response system.
Autorzy:
Glasgow AA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Huang YM; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Mandell DJ; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Bioinformatics Graduate Program, University of California San Francisco, San Francisco, CA, USA. Thompson M; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Ritterson R; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Loshbaugh AL; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Biophysics Graduate Program, University of California San Francisco, San Francisco, CA, USA. Pellegrino J; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Biophysics Graduate Program, University of California San Francisco, San Francisco, CA, USA. Krivacic C; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA. Pache RA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Barlow KA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Bioinformatics Graduate Program, University of California San Francisco, San Francisco, CA, USA. Ollikainen N; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Bioinformatics Graduate Program, University of California San Francisco, San Francisco, CA, USA. Jeon D; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. KellyMJS; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA. Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Biophysics Graduate Program, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA, USA. Kortemme T; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. .; Bioinformatics Graduate Program, University of California San Francisco, San Francisco, CA, USA.; Biophysics Graduate Program, University of California San Francisco, San Francisco, CA, USA.; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.
The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles.
Autorzy:
Citron YR; Department of Biochemistry and Biophysics and the Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America. Fagerstrom CJ; Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America. Keszthelyi B; Department of Biochemistry and Biophysics and the Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America. Huang B; Department of Pharmaceutical Chemistry and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America. Rusan NM; Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America. KellyMJS; Department of Pharmaceutical Chemistry and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America. Agard DA; Department of Biochemistry and Biophysics and the Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America.
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Źródło:
PloS one [PLoS One] 2018 Jan 09; Vol. 13 (1), pp. e0190530. Date of Electronic Publication: 2018 Jan 09 (Print Publication: 2018).
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