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Tytuł :
Cudraxanthone D Ameliorates Psoriasis-like Skin Inflammation in an Imiquimod-Induced Mouse Model via Inhibiting the Inflammatory Signaling Pathways.
Autorzy :
Kim N; Department of Pharmacology, Cell & Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Lee S; Immunoregulatory Materials Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 28116, Korea.
Kang J; Department of Pharmacology, Cell & Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Choi YA; Department of Pharmacology, Cell & Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Jang YH; Departments of Dermatology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Jeong GS; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
Kim SH; Department of Pharmacology, Cell & Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 08; Vol. 26 (19). Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*administration & dosage
Imiquimod/*adverse effects
Keratinocytes/*cytology
Moraceae/*chemistry
Psoriasis/*drug therapy
Xanthones/*administration & dosage
Administration, Oral ; Animals ; Anti-Inflammatory Agents/pharmacology ; Cell Line ; Disease Models, Animal ; Female ; Humans ; Interferon-gamma/adverse effects ; Keratinocytes/drug effects ; Keratinocytes/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; NF-kappa B/pharmacology ; Plant Extracts/chemistry ; Plant Roots/chemistry ; Psoriasis/chemically induced ; Psoriasis/immunology ; Treatment Outcome ; Tumor Necrosis Factor-alpha/pharmacology ; Xanthones/pharmacology
Czasopismo naukowe
Tytuł :
Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties.
Autorzy :
Kukula-Koch W; Department of Pharmacognosy with Garden of Medicinal Plants, Medicinal University in Lublin, 1 Chodźki Str., 20-093 Lublin, Poland.
Szwajgier D; Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences, 8 Skromna Str., 20-704 Lublin, Poland.
Gaweł-Bęben K; Department of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego Str., 35-225 Rzeszów, Poland.
Strzępek-Gomółka M; Department of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego Str., 35-225 Rzeszów, Poland.
Głowniak K; Department of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego Str., 35-225 Rzeszów, Poland.
Meissner HO; Therapeutic Research, TTD International Pty Ltd., 39 Leopard Ave., Gold Coast 4221, Australia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 08; Vol. 26 (19). Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Cyclooxygenase 2/*metabolism
Keratinocytes/*cytology
Melatonin/*pharmacology
Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Ascorbic Acid/pharmacology ; Cell Line ; Down-Regulation ; Drug Synergism ; Free Radicals/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Hydrogen Peroxide/adverse effects ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Melatonin/chemical synthesis ; Melatonin/chemistry ; Phytochemicals/chemistry ; Phytochemicals/pharmacology
Czasopismo naukowe
Tytuł :
Aspergillus oryzae -Fermented Wheat Peptone Enhances the Potential of Proliferation and Hydration of Human Keratinocytes through Activation of p44/42 MAPK.
Autorzy :
Hahm KM; Molecular Dermatology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City 16419, Gyunggi Do, Korea.; Natural Products Laboratory, Daebong LS Co., Ltd., Incheon 21697, Korea.
Park SH; Department of Bio and Chemical Engineering, Hongik University, Sejong City 30016, Korea.
Oh SW; Molecular Dermatology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City 16419, Gyunggi Do, Korea.
Kim JH; Natural Products Laboratory, Daebong LS Co., Ltd., Incheon 21697, Korea.
Yeom HS; Natural Products Laboratory, Daebong LS Co., Ltd., Incheon 21697, Korea.
Lee HJ; Natural Products Laboratory, Daebong LS Co., Ltd., Incheon 21697, Korea.
Yang S; Molecular Dermatology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City 16419, Gyunggi Do, Korea.
Cho JY; Molecular Immunology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City 16419, Gyunggi Do, Korea.
Park JO; Natural Products Laboratory, Daebong LS Co., Ltd., Incheon 21697, Korea.
Lee J; Molecular Dermatology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City 16419, Gyunggi Do, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 08; Vol. 26 (19). Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*administration & dosage
Aspergillus oryzae/*physiology
Keratinocytes/*cytology
Peptones/*administration & dosage
Skin Cream/*administration & dosage
Triticum/*microbiology
Adult ; Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Cell Proliferation/drug effects ; Female ; Gene Expression Regulation/drug effects ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Lipopolysaccharides/adverse effects ; Mice ; Nitric Oxide/metabolism ; Peptones/chemistry ; Peptones/pharmacology ; RAW 264.7 Cells ; Skin Cream/chemistry ; Skin Cream/pharmacology ; Triticum/chemistry ; Young Adult
Czasopismo naukowe
Tytuł :
GPNMB Extracellular Fragment Protects Melanocytes from Oxidative Stress by Inhibiting AKT Phosphorylation Independent of CD44.
Autorzy :
Wang Q; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Kuroda Y; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.; Biological Science Research Laboratories, Kao Corporation, Kanagawa 2500002, Japan.
Yang L; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.
Lai S; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.
Mizutani Y; Department of Cosmetic Health Science, Gifu Pharmaceutical University, Gifu 5011196, Japan.
Iddamalgoda A; Department of Cosmetic Health Science, Gifu Pharmaceutical University, Gifu 5011196, Japan.; Department of Research and Development, Ichimaru Pharcos Co. Ltd., Motosu, Gifu 5010475, Japan.
Guo J; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.
Yamamoto A; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.; Department of Dermatology, Graduate School of Medicine, Osaka City University, Osaka 5458585, Japan.
Murase D; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.; Biological Science Research Laboratories, Kao Corporation, Kanagawa 2500002, Japan.
Takahashi Y; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.; Biological Science Research Laboratories, Kao Corporation, Kanagawa 2500002, Japan.
Xiang L; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Inoue S; Department of Cosmetic Health Science, Gifu Pharmaceutical University, Gifu 5011196, Japan.
Tsuruta D; Department of Dermatology, Graduate School of Medicine, Osaka City University, Osaka 5458585, Japan.
Katayama I; Department of Pigmentation Research and Therapeutics, Graduate School of Medicine, Osaka City University, Osaka 5450051, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 07; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress*
Keratinocytes/*drug effects
Melanins/*metabolism
Melanocytes/*drug effects
Melanoma/*drug therapy
Membrane Glycoproteins/*metabolism
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Humans ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Melanocytes/metabolism ; Melanocytes/pathology ; Melanoma/metabolism ; Melanoma/pathology ; Membrane Glycoproteins/genetics ; Phosphorylation ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Tytuł :
NRF2 deficiency sensitizes human keratinocytes to zinc oxide nanoparticles-induced autophagy and cytotoxicity.
Autorzy :
Yin Y; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China; School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.
Peng H; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China.
Shao J; School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.
Zhang J; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No.23 Back District, Dongcheng Area, Beijing, 100010, China.
Li Y; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China.
Pi J; School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China. Electronic address: .
Guo J; Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China; School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China. Electronic address: .
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Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2021 Oct; Vol. 87, pp. 103721. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Keratinocytes/*drug effects
NF-E2-Related Factor 2/*genetics
Nanoparticles/*toxicity
Zinc Oxide/*toxicity
Autophagy/drug effects ; Cell Line ; Cell Survival/drug effects ; Humans ; Kelch-Like ECH-Associated Protein 1/metabolism ; Keratinocytes/metabolism ; Membrane Potential, Mitochondrial/drug effects ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of desmoglein-1 by aspirin leads to synthetic lethality of keratinocytes in Shuanghuanglian-induced cutaneous eruption response.
Autorzy :
Zhuang P; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Xie L; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Zhang Y; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Yuan Y; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Liu H; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Bi C; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Zhao H; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Li Y; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: .
Zhang Y; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 01; Vol. 349, pp. 145-154. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Aspirin/*toxicity
Desmoglein 1/*antagonists & inhibitors
Drug Eruptions/*etiology
Drugs, Chinese Herbal/*toxicity
Keratinocytes/*drug effects
Animals ; Chlorogenic Acid/analogs & derivatives ; Chlorogenic Acid/toxicity ; Desmoglein 1/metabolism ; Drug Eruptions/metabolism ; Drug Eruptions/pathology ; Female ; HaCaT Cells ; Humans ; Inflammation Mediators/metabolism ; Interleukin-4/metabolism ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Mice, Inbred ICR ; Quinic Acid/analogs & derivatives ; Quinic Acid/toxicity ; Rutin/toxicity ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Keratinocyte membrane-mediated nanodelivery system with dissolving microneedles for targeted therapy of skin diseases.
Autorzy :
Jing Q; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Ruan H; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Li J; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wang Z; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Pei L; Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hu H; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
He Z; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wu T; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Ruan S; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Guo T; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wang Y; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Feng N; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: .
Zhang Y; Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: .
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Źródło :
Biomaterials [Biomaterials] 2021 Nov; Vol. 278, pp. 121142. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Keratinocytes*
Psoriasis*/drug therapy
Administration, Cutaneous ; Drug Carriers/therapeutic use ; Drug Delivery Systems ; Humans ; Imiquimod/therapeutic use ; Needles ; Skin
Czasopismo naukowe
Tytuł :
OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice.
Autorzy :
Schünke H; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Göbel U; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Dikic I; Institute of Biochemistry II, Goethe-Universität Frankfurt am Main, Buchmann Institute for Molecular Life Sciences, Frankfurt, Germany.
Pasparakis M; Institute for Genetics, University of Cologne, Cologne, Germany. .; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. .; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 08; Vol. 12 (1), pp. 5912. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dermatitis/*prevention & control
Endopeptidases/*metabolism
Endopeptidases/*pharmacology
Keratinocytes/*metabolism
Necroptosis/*drug effects
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Animals ; Apoptosis ; Cell Death ; Dermatitis/pathology ; Endopeptidases/genetics ; Epidermis/metabolism ; Female ; Homeostasis ; Inflammation ; Keratinocytes/drug effects ; Male ; Mice ; Mice, Knockout ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptors, Tumor Necrosis Factor, Type I ; Signal Transduction ; Skin/pathology ; Transcriptome
Czasopismo naukowe
Tytuł :
Differential Marker Expression between Keratinocyte Stem Cells and Their Progeny Generated from a Single Colony.
Autorzy :
Ali D; Cell Therapy Center, The University of Jordan, Amman 11942, Jordan.; Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
Alhattab D; Cell Therapy Center, The University of Jordan, Amman 11942, Jordan.; Laboratory for Nanomedicine, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
Jafar H; Cell Therapy Center, The University of Jordan, Amman 11942, Jordan.; Department of Anatomy and Histology, School of Medicine, The University of Jordan, Amman 11942, Jordan.
Alzubide M; Cell Therapy Center, The University of Jordan, Amman 11942, Jordan.
Sharar N; Cell Therapy Center, The University of Jordan, Amman 11942, Jordan.
Bdour S; Department of Clinical Laboratory Sciences, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
Awidi A; Cell Therapy Center, The University of Jordan, Amman 11942, Jordan.; Department of Hematology and Oncology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 06; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Biomarkers/*metabolism
Clone Cells/*metabolism
Epidermal Cells/*metabolism
Keratinocytes/*metabolism
Stem Cells/*metabolism
Cell Differentiation ; Cells, Cultured ; Clone Cells/cytology ; Epidermal Cells/cytology ; Gene Expression Profiling ; Humans ; Keratinocytes/cytology ; Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway.
Autorzy :
Kim D; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.
Kim HJ; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea.
Baek JO; Department of Dermatology, Gachon University College of Medicine, Gil Medical Center, Incheon 21565, Korea.
Roh JY; Department of Dermatology, Gachon University College of Medicine, Gil Medical Center, Incheon 21565, Korea.
Jun HS; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea.; Gachon Medical Research Institute, Gil Hospital, Incheon 21565, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 05; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Gene Expression Regulation/*drug effects
Imiquimod/*toxicity
Keratinocytes/*cytology
Lysophospholipids/*pharmacology
Psoriasis/*drug therapy
Animals ; Apoptosis ; Biomarkers/metabolism ; Cell Cycle ; Cells, Cultured ; Humans ; Interferon Inducers/toxicity ; Keratinocytes/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Psoriasis/chemically induced ; Psoriasis/metabolism ; Psoriasis/pathology ; Receptors, Lysophosphatidic Acid/genetics ; Receptors, Lysophosphatidic Acid/metabolism ; rho-Associated Kinases/genetics ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development.
Autorzy :
Thulabandu V; Dept. of Biology, Case Western Reserve University, Cleveland, OH, USA.
Nehila T; Dept. of Biology, Case Western Reserve University, Cleveland, OH, USA.
Ferguson JW; Dept. of Biology, Case Western Reserve University, Cleveland, OH, USA.
Atit RP; Dept. of Biology, Case Western Reserve University, Cleveland, OH, USA; Dept. of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA; Dept. of Dermatology, Case Western Reserve University, Cleveland, OH, USA. Electronic address: .
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Źródło :
Developmental biology [Dev Biol] 2021 Oct; Vol. 478, pp. 25-40. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dermis/*cytology
Dermis/*embryology
Enhancer of Zeste Homolog 2 Protein/*metabolism
Epidermis/*embryology
Fibroblasts/*cytology
Keratinocytes/*cytology
Polycomb Repressive Complex 2/*metabolism
Animals ; Cell Differentiation ; Cell Proliferation ; Dermis/metabolism ; Enhancer of Zeste Homolog 2 Protein/genetics ; Epidermis/metabolism ; Fibroblasts/metabolism ; Hyperplasia ; Keratinocytes/metabolism ; Mice ; Organogenesis ; Retinoids/pharmacology ; Signal Transduction ; Stem Cells/cytology ; Stem Cells/metabolism ; Tretinoin/metabolism ; Wnt Signaling Pathway ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes.
Autorzy :
Saitoh Y; Laboratory of Bioscience & Biotechnology for Cell Function Control, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka, Shobara, Hiroshima, 727-0023, Japan. .
Yamaguchi Y; Laboratory of Bioscience & Biotechnology for Cell Function Control, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka, Shobara, Hiroshima, 727-0023, Japan.
Okada Y; Laboratory of Bioscience & Biotechnology for Cell Function Control, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka, Shobara, Hiroshima, 727-0023, Japan.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3613-3622. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Dermis/*injuries
Glyoxal/*toxicity
Hydrogen/*pharmacology
Hydrogen Peroxide/*toxicity
Keratinocytes/*metabolism
Cell Line ; Dermis/metabolism ; Dermis/pathology ; Humans ; Keratinocytes/pathology
Czasopismo naukowe
Tytuł :
Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity.
Autorzy :
Rolfes KM; IUF - Leibniz-Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Sondermann NC; IUF - Leibniz-Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Vogeley C; IUF - Leibniz-Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Dairou J; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS, UMR 8601, Université de Paris, F-75006, Paris, France.
Gilardino V; IUF - Leibniz-Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Wirth R; IUF - Leibniz-Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany.
Meller S; Department of Dermatology, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Homey B; Department of Dermatology, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Krutmann J; IUF - Leibniz-Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany; Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Lang D; Bayer AG, Drug Metabolism and Pharmacokinetics, Research Center, 42096, Wuppertal, Germany.
Nakamura M; IUF - Leibniz-Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany; Department of Environmental and Geriatric Dermatology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, 467-8601, Japan.
Haarmann-Stemmann T; IUF - Leibniz-Research Institute for Environmental Medicine, 40225, Düsseldorf, Germany. Electronic address: .
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Źródło :
Redox biology [Redox Biol] 2021 Oct; Vol. 46, pp. 102110. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Keratinocytes*
Receptors, Aryl Hydrocarbon*
Apoptosis ; Carbazoles ; Humans ; Ultraviolet Rays/adverse effects ; Vemurafenib
Czasopismo naukowe
Tytuł :
The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis.
Autorzy :
Gallegos-Alcalá P; Department of Microbiology, Center of Basic Science, Autonomous University of Aguascalientes, Aguascalientes 20100, Mexico.
Jiménez M; Department of Microbiology, Center of Basic Science, Autonomous University of Aguascalientes, Aguascalientes 20100, Mexico.
Cervantes-García D; Department of Microbiology, Center of Basic Science, Autonomous University of Aguascalientes, Aguascalientes 20100, Mexico.; National Council of Science and Technology, Ciudad de México 03940, Mexico.
Salinas E; Department of Microbiology, Center of Basic Science, Autonomous University of Aguascalientes, Aguascalientes 20100, Mexico.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 01; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Dermatitis, Atopic/*etiology
Dermatitis, Atopic/*metabolism
Keratinocytes/*metabolism
Alleles ; Animals ; Biomarkers ; Combined Modality Therapy ; Dermatitis, Atopic/pathology ; Dermatitis, Atopic/therapy ; Disease Management ; Disease Progression ; Disease Susceptibility/immunology ; Genetic Predisposition to Disease ; Host Microbial Interactions ; Humans ; Immunity, Innate ; Keratinocytes/immunology ; Microbiota ; Skin/immunology ; Skin/metabolism ; Skin/pathology ; Skin Physiological Phenomena
Czasopismo naukowe
Tytuł :
Sortilin regulates keratinocyte proliferation and apoptosis through the PI3K-AKT signaling pathway.
Autorzy :
Zhang R; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Wang YH; Department of Cell Biology, School of Biology and Basic Medical, Soochow University, No. 199 Renai Road, Suzhou 215123, China.
Shi X; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Ji J; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Zhan FQ; Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, 215004, China.
Leng H; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119630. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Proliferation*
Adaptor Proteins, Vesicular Transport/*pharmacology
Keratinocytes/*pathology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Psoriasis/*pathology
Adolescent ; Adult ; Aged ; Animals ; Case-Control Studies ; Female ; Gene Expression Regulation ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Psoriasis/drug therapy ; Psoriasis/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Q-switched Nd-YAG laser alone and in combination with innovative hyaluronic acid gels improve keratinocytes wound healing in vitro.
Autorzy :
de Filippis A; Department of Experimental Medicine, Section of Microbiology and Clinical Microbioloy, University of Campania 'Luigi Vanvitelli', Naples, Italy.
D'Agostino A; Department of Mental Health and Physics and Preventive Medicine, Section of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.; Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania Luigi Vanvitelli, via De Crecchio n°7, 80138, Naples, Italy.
Pirozzi AVA; Department of Mental Health and Physics and Preventive Medicine, Section of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.; Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania Luigi Vanvitelli, via De Crecchio n°7, 80138, Naples, Italy.
Tufano MA; Department of Experimental Medicine, Section of Microbiology and Clinical Microbioloy, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Schiraldi C; Department of Mental Health and Physics and Preventive Medicine, Section of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy. .; Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania Luigi Vanvitelli, via De Crecchio n°7, 80138, Naples, Italy. .
Baroni A; Department of Experimental Medicine, Section of Microbiology and Clinical Microbioloy, University of Campania 'Luigi Vanvitelli', Naples, Italy.; Department of Mental Health and Physics and Preventive Medicine, Section of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.
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Źródło :
Lasers in medical science [Lasers Med Sci] 2021 Jul; Vol. 36 (5), pp. 1047-1057. Date of Electronic Publication: 2020 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Hyaluronic Acid/*pharmacology
Keratinocytes/*drug effects
Keratinocytes/*radiation effects
Lasers, Solid-State/*therapeutic use
Wound Healing/*drug effects
Biomarkers/metabolism ; Gels ; Humans ; Keratinocytes/cytology ; Keratinocytes/metabolism
Czasopismo naukowe
Tytuł :
Anti-Psoriatic Effects of Antimony Compounds In Vitro.
Autorzy :
Gendrisch F; Research Center Skinitial, Department of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Haarhaus B; Research Center Skinitial, Department of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Schempp CM; Research Center Skinitial, Department of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Wölfle U; Research Center Skinitial, Department of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 25; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Antimony/*pharmacology
Gene Expression Regulation/*drug effects
Interleukin-23/*metabolism
Keratinocytes/*drug effects
Psoriasis/*drug therapy
Biomarkers ; Cell Differentiation ; Cell Proliferation ; Humans ; In Vitro Techniques ; Keratinocytes/metabolism ; Psoriasis/metabolism ; Psoriasis/pathology
Czasopismo naukowe
Tytuł :
Oat β-glucan ameliorates epidermal barrier disruption by upregulating the expression of CaSR through dectin-1-mediated ERK and p38 signaling pathways.
Autorzy :
Gao S; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Chen Y; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Zhao J; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Jing R; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Guo K; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Wang L; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Li X; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China.
Li C; LB Cosmeceutical Technology Co., Ltd., Shanghai 200233, China.
Hu Z; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China; School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address: .
Xu N; College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 876-889. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article
MeSH Terms :
Avena/*chemistry
Keratinocytes/*cytology
Lectins, C-Type/*metabolism
Receptors, Calcium-Sensing/*metabolism
beta-Glucans/*adverse effects
Animals ; Calcium/metabolism ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Gene Expression Regulation/drug effects ; HaCaT Cells ; Humans ; Hyperplasia ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Lectins, C-Type/genetics ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Receptors, Calcium-Sensing/genetics ; Up-Regulation ; beta-Glucans/pharmacology
Czasopismo naukowe
Tytuł :
The effect of biodegradable silk fibroin-based scaffolds containing glial cell line-derived neurotrophic factor (GDNF) on the corneal regeneration process.
Autorzy :
Gavrilova NA; The A.I. Evdokimov Моscow State University of Medicine and Dentistry of the Ministry of Healthcare the Russian Federation, Moscow, Russian Federation.
Borzenok SA; The A.I. Evdokimov Моscow State University of Medicine and Dentistry of the Ministry of Healthcare the Russian Federation, Moscow, Russian Federation; The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation.
Revishchin AV; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russian Federation.
Tishchenko OE; The A.I. Evdokimov Моscow State University of Medicine and Dentistry of the Ministry of Healthcare the Russian Federation, Moscow, Russian Federation.
Ostrovkiy DS; The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation.
Bobrova MM; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Safonova LA; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Efimov AE; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Agapova OI; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Agammedov MB; The A.I. Evdokimov Моscow State University of Medicine and Dentistry of the Ministry of Healthcare the Russian Federation, Moscow, Russian Federation.
Pavlova GV; Institute of Gene Biology Russian Academy of Sciences, Moscow, Russian Federation.
Agapov II; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 264-276. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Corneal Injuries/*therapy
Fibroins/*chemistry
Glial Cell Line-Derived Neurotrophic Factor/*metabolism
Keratinocytes/*transplantation
Animals ; Biomarkers/metabolism ; Cell Proliferation ; Corneal Injuries/metabolism ; Humans ; Keratinocytes/cytology ; Keratinocytes/metabolism ; Male ; Mice ; Primary Cell Culture ; Tissue Scaffolds
Czasopismo naukowe
Tytuł :
Kahweol Exerts Skin Moisturizing Activities by Upregulating STAT1 Activity.
Autorzy :
Chen H; Department of Integrative Biotechnology, and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea.
Hossain MA; Department of Veterinary Physiology, College of Medicine, Chonbuk National University, Iksan 54596, Korea.
Kim JH; Department of Veterinary Physiology, College of Medicine, Chonbuk National University, Iksan 54596, Korea.
Cho JY; Department of Veterinary Physiology, College of Medicine, Chonbuk National University, Iksan 54596, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Diterpenes/*pharmacology
Gene Expression Regulation/*drug effects
Keratinocytes/*physiology
STAT1 Transcription Factor/*metabolism
Skin/*drug effects
Apoptosis ; Cell Proliferation ; Cells, Cultured ; Humans ; Keratinocytes/cytology ; Keratinocytes/drug effects ; STAT1 Transcription Factor/genetics
Czasopismo naukowe

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