Autor: "Kerr, D." - OpacWWW

Skocz do pozycji: 1.

Tytuł:: ToxNav germline genetic testing and PROMinet digital mobile application toxicity monitoring: Results of a prospective single-center clinical utility study-PRECISE study.
Autorzy:: Lee LYW; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Starkey T; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Sivakumar S; Department of Oncology, University of Oxford, Oxford, UK.
Fotheringham S; Oxford Cancer Biomarkers, Oxford Science Park, Oxford, UK.
Mozolowski G; Oxford Cancer Biomarkers, Oxford Science Park, Oxford, UK.
Shearwood V; Department of Oncology, University of Oxford, Oxford, UK.
Palles C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Camilleri P; Department of Oncology, University of Oxford, Oxford, UK.
Church D; Department of Oncology, University of Oxford, Oxford, UK.
Kerr R; Department of Oncology, University of Oxford, Oxford, UK.
Kerr D; Oxford Cancer Biomarkers, Oxford Science Park, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2019 Oct; Vol. 8 (14), pp. 6305-6314. Date of Electronic Publication: 2019 Sep 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Biomarkers, Tumor*
Genetic Testing*/methods
Germ-Line Mutation*
Mobile Applications*
Antineoplastic Combined Chemotherapy Protocols/*adverse effects
Colorectal Neoplasms/*diagnosis
Colorectal Neoplasms/*drug therapy
Colorectal Neoplasms/*genetics
Aged ; Alleles ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Colorectal Neoplasms/epidemiology ; Female ; Gene Frequency ; Humans ; Hydro-Lyases/genetics ; Male ; Microsatellite Repeats ; Middle Aged

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Skocz do pozycji: 2.

Tytuł:: Confirmation that somatic mutations of beta-2 microglobulin correlate with a lack of recurrence in a subset of stage II mismatch repair deficient colorectal cancers from the QUASAR trial.
Autorzy:: Barrow P; Department of Surgery, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, UK.
Richman SD; Department of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, St James' University Hospital, Leeds, UK.
Wallace AJ; Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University Hospitals NHS Trust, Manchester, UK.
Handley K; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Hutchins GGA; Department of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, St James' University Hospital, Leeds, UK.
Kerr D; Cancer Medicine, University of Oxford, Oxford, UK.
Magill L; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Evans DG; Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University Hospitals NHS Trust, Manchester, UK.
Gray R; University of Oxford, Oxford, UK.
Quirke P; Department of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, St James' University Hospital, Leeds, UK.
Hill J; Department of Surgery, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, UK.; Pokaż więcej
Źródło:: Histopathology [Histopathology] 2019 Aug; Vol. 75 (2), pp. 236-246. Date of Electronic Publication: 2019 Jul 05.
Typ publikacji:: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms:: Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*pathology
beta 2-Microglobulin/*genetics
Adult ; Aged ; DNA Mismatch Repair/genetics ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local/genetics

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Skocz do pozycji: 3.

Tytuł:: Intratumoral stromal morphometry predicts disease recurrence but not response to 5-fluorouracil-results from the QUASAR trial of colorectal cancer.
Autorzy:: Hutchins GGA; Section of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Treanor D; Section of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Wright A; Section of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Handley K; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Magill L; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Tinkler-Hundal E; Section of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Southward K; Section of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Seymour M; National Cancer Research Network Coordinating Centre, University of Leeds, Leeds, UK.
Kerr D; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Gray R; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Quirke P; Section of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.; Pokaż więcej
Corporate Authors:: QUASAR trial collaborators and the UK National Cancer Research Institute Colorectal Cancer Clinical Studies Group
Źródło:: Histopathology [Histopathology] 2018 Feb; Vol. 72 (3), pp. 391-404. Date of Electronic Publication: 2017 Nov 27.
Typ publikacji:: Journal Article; Randomized Controlled Trial
MeSH Terms:: Tumor Microenvironment*
Colorectal Neoplasms/*drug therapy
Colorectal Neoplasms/*pathology
Image Interpretation, Computer-Assisted/*methods
Neoplasm Recurrence, Local/*pathology
Adult ; Aged ; Antineoplastic Agents/therapeutic use ; Female ; Fluorouracil/therapeutic use ; Humans ; Male ; Middle Aged

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Skocz do pozycji: 4.

Tytuł:: Pharmacoproteomic characterisation of human colon and rectal cancer.
Autorzy:: Frejno M; Department of Oncology, University of Oxford, Oxford, UK.; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Zenezini Chiozzi R; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.; Department of Chemistry, Sapienza - Università di Roma, Rome, Italy.
Wilhelm M; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Koch H; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Zheng R; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Klaeger S; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ruprecht B; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.; Center for Integrated Protein Science (CIPSM), Munich, Germany.
Meng C; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Kramer K; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Jarzab A; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Heinzlmeir S; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Johnstone E; Department of Oncology, University of Oxford, Oxford, UK.
Domingo E; Department of Oncology, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics (WTCHG), University of Oxford, Oxford, UK.
Kerr D; Nuffield Division of Clinical Laboratory Sciences (NDCLS), University of Oxford, Oxford, UK.
Jesinghaus M; Institute of Pathology, Technical University of Munich, Munich, Germany.
Slotta-Huspenina J; Institute of Pathology, Technical University of Munich, Munich, Germany.
Weichert W; Institute of Pathology, Technical University of Munich, Munich, Germany.
Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.
Feller SM; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK .; Institute of Molecular Medicine, Martin-Luther-University, Halle, Germany.
Kuster B; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany .; German Cancer Consortium (DKTK), Munich, Germany.; Center for Integrated Protein Science (CIPSM), Munich, Germany.; Bavarian Biomolecular Mass Spectrometry Center (BayBioMS), Freising, Germany.; Pokaż więcej
Źródło:: Molecular systems biology [Mol Syst Biol] 2017 Nov 03; Vol. 13 (11), pp. 951. Date of Electronic Publication: 2017 Nov 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*therapeutic use
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*genetics
c-Mer Tyrosine Kinase/*genetics
Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/mortality ; Gene Regulatory Networks ; Humans ; Immunohistochemistry ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/genetics ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/antagonists & inhibitors ; MAP Kinase Kinase 2/genetics ; MAP Kinase Kinase 2/metabolism ; Pharmacogenetics/methods ; Prognosis ; Protein Kinase Inhibitors/therapeutic use ; Proteomics/methods ; Signal Transduction ; Survival Analysis ; c-Mer Tyrosine Kinase/antagonists & inhibitors ; c-Mer Tyrosine Kinase/metabolism

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Skocz do pozycji: 5.

Tytuł:: Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1.
Autorzy:: Sveen A; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Johannessen B; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Tengs T; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Danielsen SA; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Eilertsen IA; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Lind GE; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Berg KCG; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Leithe E; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Meza-Zepeda LA; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Genomics Core Facility, Department of Core Facilities, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.
Domingo E; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Myklebost O; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.
Kerr D; Department of Oncology, University of Oxford, Roosevelt Drive, Oxford, OX3 7DQ, UK.
Tomlinson I; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Nesbakken A; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.; Department of Gastrointestinal Surgery, Oslo University Hospital, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Skotheim RI; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway.; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway.
Lothe RA; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway. .; K. G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway. .; Norwegian Cancer Genomics Consortium, Oslo University Hospital, P.O. Box 4953, Nydalen, NO-0424, Oslo, Norway. .; Centre for Cancer Biomedicine, Institute for Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, NO-0424, Oslo, Norway. .; Pokaż więcej
Źródło:: Genome medicine [Genome Med] 2017 May 24; Vol. 9 (1), pp. 46. Date of Electronic Publication: 2017 May 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Microsatellite Instability*
Mutation*
Colorectal Neoplasms/*genetics
Janus Kinase 1/*genetics
Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/metabolism ; DNA Mutational Analysis ; Female ; Gene Expression Profiling ; Genomics ; Humans ; Male ; Middle Aged

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Skocz do pozycji: 6.

Tytuł:: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
Autorzy:: Al-Tassan NA; Department of Genetics, King Faisal Specialist Hospital and Research Center, P.O.Box 3354, Riyadh 11211, Saudi Arabia.
Whiffin N; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Hosking FJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Palles C; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, UK.
Farrington SM; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Dobbins SE; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Harris R; Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
Gorman M; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, UK.
Tenesa A; 1] Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK [2] The Roslin Institute, University of Edinburgh, Easter Bush, Roslin, EH25 9RG, UK.
Meyer BF; Department of Genetics, King Faisal Specialist Hospital and Research Center, P.O.Box 3354, Riyadh 11211, Saudi Arabia.
Wakil SM; Department of Genetics, King Faisal Specialist Hospital and Research Center, P.O.Box 3354, Riyadh 11211, Saudi Arabia.
Kinnersley B; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Campbell H; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Martin L; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, UK.
Smith CG; Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
Idziaszczyk S; Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
Barclay E; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, UK.
Maughan TS; CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Roosevelt Drive, Oxford, OX3 7DQ, UK.
Kaplan R; MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London, WC2B 6NH, UK.
Kerr R; Oxford Cancer Centre, Department of Oncology, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, UK.
Kerr D; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.
Buchanan DD; 1] Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The Univers‡ity of Melbourne, Victoria, Australia [2] Centre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, Australia.
Win AK; Centre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, Australia.
Hopper J; Centre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, Australia.
Jenkins M; Centre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, Australia.
Lindor NM; Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA.
Newcomb PA; Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gallinger S; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Conti D; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Schumacher F; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Casey G; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Dunlop MG; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Tomlinson IP; Wellcome Trust Centre for Human Genetics and NIHR Comprehensive Biomedical Research Centre, Oxford, UK.
Cheadle JP; Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2015 May 20; Vol. 5, pp. 10442. Date of Electronic Publication: 2015 May 20.
Typ publikacji:: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*genetics
Chromosome Mapping ; Female ; Forkhead Transcription Factors/genetics ; Gene Frequency/genetics ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Receptors, Cell Surface/genetics

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Skocz do pozycji: 7.

Tytuł:: Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer.
Autorzy:: Lefevre JH; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.; Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, UK.; Department of Digestive Surgery, Hôpital Saint-Antoine AP-HP, University Paris VI (Pierre and Marie Curie), Paris, France.
Bonilla C; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.; Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, UK.
Colas C; Department of Digestive Surgery, Hôpital Saint-Antoine AP-HP, University Paris VI (Pierre and Marie Curie), Paris, France.; Laboratory of Angiogenetics and Oncogenetics, Hôpital Pitié-Salpétrière AP-HP, University Paris VI (Pierre and Marie Curie), Paris, France.
Winney B; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.
Johnstone E; Department of Clinical Pharmacology, Translational Oncology Group, Oxford, UK.
Tonks S; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.
Day T; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.
Hutnik K; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.
Boumertit A; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.
Soubrier F; Laboratory of Angiogenetics and Oncogenetics, Hôpital Pitié-Salpétrière AP-HP, University Paris VI (Pierre and Marie Curie), Paris, France.
Midgley R; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.
Kerr D; Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Parc Y; Department of Digestive Surgery, Hôpital Saint-Antoine AP-HP, University Paris VI (Pierre and Marie Curie), Paris, France.
Bodmer WF; Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK.; Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, UK.; Pokaż więcej
Źródło:: Journal of human genetics [J Hum Genet] 2012 Nov 26; Vol. 57 (11), pp. 709-716. Date of Electronic Publication: 2012 Aug 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Genetic Variation*
Adenomatous Polyposis Coli/*genetics
Colorectal Neoplasms/*genetics
Adaptor Proteins, Signal Transducing/genetics ; Adenoma/epidemiology ; Adenoma/genetics ; Adult ; Age of Onset ; BRCA2 Protein/genetics ; Case-Control Studies ; Colorectal Neoplasms/epidemiology ; Computer Simulation ; DNA Repair Enzymes/genetics ; Exodeoxyribonucleases/genetics ; France ; Gene Frequency ; Humans ; Middle Aged ; MutL Protein Homolog 1 ; Nuclear Proteins/genetics ; Odds Ratio ; United Kingdom ; beta Catenin/genetics

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Skocz do pozycji: 8.

Tytuł:: The TERT variant rs2736100 is associated with colorectal cancer risk.
Autorzy:: Kinnersley B; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
Migliorini G
Broderick P
Whiffin N
Dobbins SE
Casey G
Hopper J
Sieber O
Lipton L
Kerr DJ
Dunlop MG
Tomlinson IP
Houlston RS; Pokaż więcej
Corporate Authors:: Colon Cancer Family Registry
Źródło:: British journal of cancer [Br J Cancer] 2012 Sep 04; Vol. 107 (6), pp. 1001-8. Date of Electronic Publication: 2012 Aug 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Chromosomes, Human, Pair 5*
Linkage Disequilibrium*
Polymorphism, Single Nucleotide*
Colorectal Neoplasms/*genetics
Membrane Proteins/*genetics
Telomerase/*genetics
Adult ; Aged ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Odds Ratio ; Risk Assessment ; Risk Factors

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Skocz do pozycji: 9.

Tytuł:: A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22.
Autorzy:: Abulí A; Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain.
Fernández-Rozadilla C
Giráldez MD
Muñoz J
Gonzalo V
Bessa X
Bujanda L
Reñé JM
Lanas A
García AM
Saló J
Argüello L
Vilella A
Carreño R
Jover R
Xicola RM
Llor X
Carvajal-Carmona L
Tomlinson IP
Kerr DJ
Houlston RS
Piqué JM
Carracedo A
Castells A
Andreu M
Ruiz-Ponte C
Castellví-Bel S; Pokaż więcej
Corporate Authors:: Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Źródło:: British journal of cancer [Br J Cancer] 2011 Sep 06; Vol. 105 (6), pp. 870-5. Date of Electronic Publication: 2011 Aug 02.
Typ publikacji:: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:: Chromosomes, Human, Pair 3*
Chromosomes, Human, Pair 9*
Genetic Predisposition to Disease*
Colorectal Neoplasms/*genetics
Aged ; Antigens, CD/genetics ; Carrier Proteins/genetics ; Case-Control Studies ; DNA-Binding Proteins/genetics ; GPI-Linked Proteins/genetics ; Genetic Association Studies ; Humans ; Male ; Nuclear Proteins/genetics ; Polymorphism, Single Nucleotide ; Semaphorins/genetics

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Skocz do pozycji: 10.

Tytuł:: Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients.
Autorzy:: Bonilla C; Department of Clinical Pharmacology, University of Oxford, Headington, Oxford, UK.
Lefèvre JH
Winney B
Johnstone E
Tonks S
Colas C
Day T
Hutnik K
Boumertit A
Midgley R
Kerr D
Parc Y
Bodmer WF; Pokaż więcej
Źródło:: Journal of human genetics [J Hum Genet] 2011 Jan; Vol. 56 (1), pp. 58-63. Date of Electronic Publication: 2010 Nov 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Polymorphism, Single Nucleotide*/physiology
Adenoma/*genetics
Colorectal Neoplasms/*genetics
Cyclin D1/*genetics
Neoplasms, Multiple Primary/*genetics
Adenoma/epidemiology ; Adult ; Age of Onset ; Case-Control Studies ; Colorectal Neoplasms/epidemiology ; Female ; France/epidemiology ; Gene Frequency ; Humans ; Male ; Middle Aged ; Neoplasms, Multiple Primary/epidemiology ; United Kingdom/epidemiology

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Skocz do pozycji: 11.

Tytuł:: Genetic prognostic and predictive markers in colorectal cancer.
Autorzy:: Walther A; Department of Medicine, Royal Marsden Hospital, Downs Road, Sutton, SM2 5PT, UK.
Johnstone E
Swanton C
Midgley R
Tomlinson I
Kerr D; Pokaż więcej
Źródło:: Nature reviews. Cancer [Nat Rev Cancer] 2009 Jul; Vol. 9 (7), pp. 489-99. Date of Electronic Publication: 2009 Jun 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*mortality
Biomarkers, Tumor ; Camptothecin/analogs & derivatives ; Camptothecin/therapeutic use ; Capecitabine ; Chromosomes, Human, Pair 18 ; Colorectal Neoplasms/drug therapy ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Fluorouracil/analogs & derivatives ; Fluorouracil/therapeutic use ; Gene Expression Profiling ; Genes, APC ; Genes, p53 ; Genomic Instability ; Humans ; Irinotecan ; Microsatellite Instability ; Mutation ; Organoplatinum Compounds/therapeutic use ; Oxaliplatin ; Pharmacogenetics ; Prognosis ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras) ; beta Catenin/metabolism ; ras Proteins/genetics

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Skocz do pozycji: 12.

Tytuł:: Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
Autorzy:: Houlston RS; Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK. />Webb E
Broderick P
Pittman AM
Di Bernardo MC
Lubbe S
Chandler I
Vijayakrishnan J
Sullivan K
Penegar S
Carvajal-Carmona L
Howarth K
Jaeger E
Spain SL
Walther A
Barclay E
Martin L
Gorman M
Domingo E
Teixeira AS
Kerr D
Cazier JB
Niittymäki I
Tuupanen S
Karhu A
Aaltonen LA
Tomlinson IP
Farrington SM
Tenesa A
Prendergast JG
Barnetson RA
Cetnarskyj R
Porteous ME
Pharoah PD
Koessler T
Hampe J
Buch S
Schafmayer C
Tepel J
Schreiber S
Völzke H
Chang-Claude J
Hoffmeister M
Brenner H
Zanke BW
Montpetit A
Hudson TJ
Gallinger S
Campbell H
Dunlop MG; Pokaż więcej
Corporate Authors:: COGENT Study
Colorectal Cancer Association Study Consortium
CoRGI Consortium
Źródło:: Nature genetics [Nat Genet] 2008 Dec; Vol. 40 (12), pp. 1426-35. Date of Electronic Publication: 2008 Nov 16.
Typ publikacji:: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Colorectal Neoplasms/*genetics
Aged ; Case-Control Studies ; Female ; Genome, Human ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged

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Skocz do pozycji: 13.

Tytuł:: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
Autorzy:: Tomlinson IP; Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK. />Webb E
Carvajal-Carmona L
Broderick P
Howarth K
Pittman AM
Spain S
Lubbe S
Walther A
Sullivan K
Jaeger E
Fielding S
Rowan A
Vijayakrishnan J
Domingo E
Chandler I
Kemp Z
Qureshi M
Farrington SM
Tenesa A
Prendergast JG
Barnetson RA
Penegar S
Barclay E
Wood W
Martin L
Gorman M
Thomas H
Peto J
Bishop DT
Gray R
Maher ER
Lucassen A
Kerr D
Evans DG
Schafmayer C
Buch S
Völzke H
Hampe J
Schreiber S
John U
Koessler T
Pharoah P
van Wezel T
Morreau H
Wijnen JT
Hopper JL
Southey MC
Giles GG
Severi G
Castellví-Bel S
Ruiz-Ponte C
Carracedo A
Castells A
Försti A
Hemminki K
Vodicka P
Naccarati A
Lipton L
Ho JW
Cheng KK
Sham PC
Luk J
Agúndez JA
Ladero JM
de la Hoya M
Caldés T
Niittymäki I
Tuupanen S
Karhu A
Aaltonen L
Cazier JB
Campbell H
Dunlop MG
Houlston RS; Pokaż więcej
Corporate Authors:: CORGI Consortium
EPICOLON Consortium
Źródło:: Nature genetics [Nat Genet] 2008 May; Vol. 40 (5), pp. 623-30. Date of Electronic Publication: 2008 Mar 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Genome, Human*
Polymorphism, Single Nucleotide*
Chromosomes, Human, Pair 10/*genetics
Chromosomes, Human, Pair 8/*genetics
Colorectal Neoplasms/*genetics
Adult ; Aged ; Alleles ; Eukaryotic Initiation Factor-3/genetics ; Female ; Genetic Linkage ; Humans ; Male ; Middle Aged ; Pedigree

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Skocz do pozycji: 14.

Tytuł:: Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Autorzy:: Jaeger E; Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK.
Webb E
Howarth K
Carvajal-Carmona L
Rowan A
Broderick P
Walther A
Spain S
Pittman A
Kemp Z
Sullivan K
Heinimann K
Lubbe S
Domingo E
Barclay E
Martin L
Gorman M
Chandler I
Vijayakrishnan J
Wood W
Papaemmanuil E
Penegar S
Qureshi M
Farrington S
Tenesa A
Cazier JB
Kerr D
Gray R
Peto J
Dunlop M
Campbell H
Thomas H
Houlston R
Tomlinson I; Pokaż więcej
Corporate Authors:: CORGI Consortium
Źródło:: Nature genetics [Nat Genet] 2008 Jan; Vol. 40 (1), pp. 26-8. Date of Electronic Publication: 2007 Dec 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Colorectal Neoplasms/*genetics
Adenoma/genetics ; Cell Line, Tumor ; Cells, Cultured ; Chromosomes, Human, Pair 15 ; Humans ; Jews/genetics ; Polymorphism, Single Nucleotide

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Skocz do pozycji: 15.

Tytuł:: A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
Autorzy:: Broderick P; Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK.
Carvajal-Carmona L
Pittman AM
Webb E
Howarth K
Rowan A
Lubbe S
Spain S
Sullivan K
Fielding S
Jaeger E
Vijayakrishnan J
Kemp Z
Gorman M
Chandler I
Papaemmanuil E
Penegar S
Wood W
Sellick G
Qureshi M
Teixeira A
Domingo E
Barclay E
Martin L
Sieber O
Kerr D
Gray R
Peto J
Cazier JB
Tomlinson I
Houlston RS; Pokaż więcej
Corporate Authors:: CORGI Consortium
Źródło:: Nature genetics [Nat Genet] 2007 Nov; Vol. 39 (11), pp. 1315-7. Date of Electronic Publication: 2007 Oct 14.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Genome, Human*
Colorectal Neoplasms/*genetics
Smad7 Protein/*genetics
Alleles ; Case-Control Studies ; Genetic Linkage ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Risk Factors

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Skocz do pozycji: 16.

Tytuł:: A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
Autorzy:: Tomlinson I; Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK. />Webb E
Carvajal-Carmona L
Broderick P
Kemp Z
Spain S
Penegar S
Chandler I
Gorman M
Wood W
Barclay E
Lubbe S
Martin L
Sellick G
Jaeger E
Hubner R
Wild R
Rowan A
Fielding S
Howarth K
Silver A
Atkin W
Muir K
Logan R
Kerr D
Johnstone E
Sieber O
Gray R
Thomas H
Peto J
Cazier JB
Houlston R; Pokaż więcej
Corporate Authors:: CORGI Consortium
Źródło:: Nature genetics [Nat Genet] 2007 Aug; Vol. 39 (8), pp. 984-8. Date of Electronic Publication: 2007 Jul 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Colorectal Neoplasms/*genetics
Aged ; Chromosomes, Human, Pair 8 ; Female ; Genotype ; Humans ; Male ; Middle Aged

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Skocz do pozycji: 17.

Tytuł:: Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector.
Autorzy:: Chen MJ; Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, UK.
Green NK
Reynolds GM
Flavell JR
Mautner V
Kerr DJ
Young LS
Searle PF; Pokaż więcej
Źródło:: Gene therapy [Gene Ther] 2004 Jul; Vol. 11 (14), pp. 1126-36.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adenoviridae/*genetics
Colorectal Neoplasms/*therapy
Escherichia coli/*enzymology
Genetic Therapy/*methods
Genetic Vectors/*administration & dosage
Nitroreductases/*genetics
Adenovirus E2 Proteins/genetics ; Animals ; Aziridines/metabolism ; Cell Line, Tumor ; Colorectal Neoplasms/metabolism ; Enzyme Activation ; Humans ; Mice ; Mice, Nude ; Prodrugs/metabolism ; Virus Replication

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Skocz do pozycji: 18.

Tytuł:: Clinical development of gene therapy for colorectal cancer.
Autorzy:: Kerr D; National Translational Cancer Research Network, Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK. david.kerr@clinpharm.ox.ac.uk; Pokaż więcej
Źródło:: Nature reviews. Cancer [Nat Rev Cancer] 2003 Aug; Vol. 3 (8), pp. 615-22.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Genetic Therapy*
Colorectal Neoplasms/*therapy
Clinical Trials as Topic ; Colorectal Neoplasms/etiology ; Enzymes/genetics ; Genetic Vectors ; Humans ; Immunotherapy ; Models, Biological ; Prodrugs ; Viruses/genetics