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Tytuł :
A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities.
Autorzy :
Wang J; School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Liang B; Nobel Institute of Biomedicine, Zhuhai, 519000, China.
Chen Y; Nobel Institute of Biomedicine, Zhuhai, 519000, China.
Fuk-Woo Chan J; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Yuan S; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Ye H; Nobel Institute of Biomedicine, Zhuhai, 519000, China.
Nie L; Nobel Institute of Biomedicine, Zhuhai, 519000, China.
Zhou J; Nobel Institute of Biomedicine, Zhuhai, 519000, China; Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, 518172, China.
Wu Y; Nobel Institute of Biomedicine, Zhuhai, 519000, China.
Wu M; Department of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Huang LS; Department of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
An J; Department of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego, La Jolla, CA, 92037, USA.
Warshel A; Department of Chemistry, University of Southern California, Los Angeles, CA, 90089, USA.
Yuen KY; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Ciechanover A; Nobel Institute of Biomedicine, Zhuhai, 519000, China; Technion-Israel Institute of Technology, Haifa, 3109601, Israel.
Huang Z; School of Life Sciences, Tsinghua University, Beijing, 100084, China; Department of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego, La Jolla, CA, 92037, USA; Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, 518172, China. Electronic address: .
Xu Y; Nobel Institute of Biomedicine, Zhuhai, 519000, China; Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, 518172, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 05; Vol. 215, pp. 113267. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*pharmacology
Antineoplastic Agents/*pharmacology
Antiviral Agents/*pharmacology
Ketones/*pharmacology
Proteasome Inhibitors/*pharmacology
SARS-CoV-2/*drug effects
Amides/chemical synthesis ; Amides/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; Binding Sites ; Calpain/chemistry ; Calpain/metabolism ; Cell Line, Tumor ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Drug Screening Assays, Antitumor ; Humans ; Ketones/chemical synthesis ; Ketones/metabolism ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Proteasome Endopeptidase Complex/chemistry ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors/chemical synthesis ; Proteasome Inhibitors/metabolism ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Eribulin Mesylate for the Treatment of Metastatic Hormone-refractory and Triple-negative Breast Cancer: A Multi-institutional Real-world Report on Efficacy and Safety.
Autorzy :
Valerio MR; Medical Oncology Unit.
Arrivas Bajardi E; Medical Oncology Unit, La Maddalena Clinic for Cancer.
Arcara CC; Medical Oncology Unit, La Maddalena Clinic for Cancer.
Borsellino N; Medical Oncology Unit, Ospedale 'Buccheri La Ferla'.
Lo Mauro M; Medical Oncology Unit, Ospedale 'Buccheri La Ferla'.
Cipolla C; Breast Unit.
Santarpia M; Medical Oncology Unit, Department of Human Pathology 'G. Barresi,' University of Messina, Messina.
Firenze A; Risk Management Unit, Policlinico 'P. Giaccone'.
Motta G; Medical Oncology Unit, Policlinico, Catania, Italy.
Vigneri P; Medical Oncology Unit, Policlinico, Catania, Italy.
Gebbia V; Oncology Section, Department 'Promise,' University of Palermo.; Medical Oncology Unit, La Maddalena Clinic for Cancer.
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Źródło :
American journal of clinical oncology [Am J Clin Oncol] 2021 Mar 01; Vol. 44 (3), pp. 105-108.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Furans/*therapeutic use
Ketones/*therapeutic use
Triple Negative Breast Neoplasms/*drug therapy
Adult ; Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Furans/administration & dosage ; Furans/adverse effects ; Humans ; Ketones/administration & dosage ; Ketones/adverse effects ; Middle Aged ; Neoplasms, Hormone-Dependent/drug therapy ; Neoplasms, Hormone-Dependent/mortality ; Neoplasms, Hormone-Dependent/pathology ; Retrospective Studies ; Treatment Outcome ; Triple Negative Breast Neoplasms/mortality ; Triple Negative Breast Neoplasms/pathology
Czasopismo naukowe
Tytuł :
1,3-Diketone Calix[4]arene Derivatives-A New Type of Versatile Ligands for Metal Complexes and Nanoparticles.
Autorzy :
Podyachev SN; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., Kazan 420088, Russia.
Zairov RR; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., Kazan 420088, Russia.
Mustafina AR; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., Kazan 420088, Russia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 24; Vol. 26 (5). Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Calixarenes/*chemistry
Coordination Complexes/*chemistry
Ketones/*chemistry
Nanoparticles/*chemistry
Phenols/*chemistry
Calixarenes/chemical synthesis ; Coordination Complexes/chemical synthesis ; Ketones/chemical synthesis ; Ligands ; Molecular Structure ; Particle Size ; Phenols/chemical synthesis ; Surface Properties
Czasopismo naukowe
Tytuł :
Pre-treatment Neutrophil-to-Lymphocyte Ratio Predicts Efficacy of Eribulin for Soft-tissue Sarcoma.
Autorzy :
Sato Y; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Nakano K; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan; .
Fukuda N; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Wang X; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Urasaki T; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Ohmoto A; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Yunokawa M; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Ono M; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Tomomatsu J; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Hayakawa K; Department of Orthopedic Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Funauchi Y; Department of Orthopedic Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Tanizawa T; Department of Orthopedic Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Ae K; Department of Orthopedic Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Matsumoto S; Department of Orthopedic Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Takahashi S; Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Jan; Vol. 41 (1), pp. 527-532.
Typ publikacji :
Journal Article
MeSH Terms :
Leukocyte Count*
Lymphocytes*
Neutrophils*
Antineoplastic Agents/*therapeutic use
Furans/*therapeutic use
Ketones/*therapeutic use
Sarcoma/*blood
Sarcoma/*drug therapy
Aged ; Aged, 80 and over ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Biomarkers ; Female ; Furans/administration & dosage ; Furans/adverse effects ; Humans ; Kaplan-Meier Estimate ; Ketones/administration & dosage ; Ketones/adverse effects ; Male ; Middle Aged ; Prognosis ; Retreatment ; Retrospective Studies ; Sarcoma/diagnosis ; Sarcoma/mortality ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
Autorzy :
Hoffman RL; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Kania RS; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Brothers MA; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Davies JF; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Ferre RA; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Gajiwala KS; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
He M; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Hogan RJ; Southern Research Institute, 2000 9th Avenue South, Birmingham, Alabama 35205 United States.
Kozminski K; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Li LY; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Lockner JW; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Lou J; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Marra MT; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Mitchell LJ Jr; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Murray BW; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Nieman JA; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Noell S; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Planken SP; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Rowe T; Southern Research Institute, 2000 9th Avenue South, Birmingham, Alabama 35205 United States.
Ryan K; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Smith GJ 3rd; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Solowiej JE; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Steppan CM; Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121 United States.
Taggart B; Southern Research Institute, 2000 9th Avenue South, Birmingham, Alabama 35205 United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12725-12747. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents/*pharmacology
Coronavirus 3C Proteases/*antagonists & inhibitors
Ketones/*pharmacology
Protease Inhibitors/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; COVID-19/drug therapy ; Catalytic Domain ; Chlorocebus aethiops ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Crystallography, X-Ray ; Humans ; Ketones/chemical synthesis ; Ketones/metabolism ; Protease Inhibitors/chemical synthesis ; Protease Inhibitors/metabolism ; Protein Binding ; Vero Cells
Czasopismo naukowe
Tytuł :
Comparison of retentive forces between telescopic crowns made of poly(ether ether ketone) and type 4 gold alloy.
Autorzy :
Nakamura M; Department of Removable Partial Prosthodontics, Tokyo Dental College.
Tanaka A; Department of Removable Partial Prosthodontics, Tokyo Dental College.
Tasaka A; Department of Removable Partial Prosthodontics, Tokyo Dental College.
Yoshinari M; Oral Health Science Center, Tokyo Dental College.
Takemoto S; Department of Biomedical Engineering, Iwate Medical University.
Yamashita S; Department of Removable Partial Prosthodontics, Tokyo Dental College.
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Źródło :
Dental materials journal [Dent Mater J] 2021 Jan 31; Vol. 40 (1), pp. 129-135. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gold Alloys*
Ketones*
Crowns ; Dental Stress Analysis ; Ether
Czasopismo naukowe
Tytuł :
Prognostic Nutritional Index Is Superior to Neutrophil-to-lymphocyte Ratio as a Prognostic Marker in Metastatic Breast Cancer Patients Treated With Eribulin.
Autorzy :
Oba T; Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Maeno K; Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan .
Ono M; Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Ito T; Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Kanai T; Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Ito KI; Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Jan; Vol. 41 (1), pp. 445-452.
Typ publikacji :
Journal Article
MeSH Terms :
Leukocyte Count*
Lymphocytes*
Neutrophils*
Nutrition Assessment*
Breast Neoplasms/*blood
Breast Neoplasms/*drug therapy
Furans/*therapeutic use
Ketones/*therapeutic use
Aged ; Biomarkers ; Biomarkers, Tumor ; Breast Neoplasms/diagnosis ; Breast Neoplasms/mortality ; Female ; Furans/administration & dosage ; Humans ; Kaplan-Meier Estimate ; Ketones/administration & dosage ; Lymphocyte Count ; Middle Aged ; Neoplasm Staging ; Nutritional Status ; Prognosis ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Conducting Polyetheretherketone Nanocomposites with an Electrophoretically Deposited Bioactive Coating for Bone Tissue Regeneration and Multimodal Therapeutic Applications.
Autorzy :
He M; Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
Zhu C; Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
Xu H; School of Materials and Physics, China University of Mining and Technology, Daxue Road, No. 1, Xuzhou, Jiangsu, 221116, China.
Sun D; Advanced Composite Research Group (ACRG), School of Mechanical and Aerospace Engineering, Queen's University Belfast, Belfast, BT9 5AH, UK.
Chen C; Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
Feng G; Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
Liu L; Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
Li Y; Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
Zhang L; Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Dec 23; Vol. 12 (51), pp. 56924-56934. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Regeneration/*drug effects
Coated Materials, Biocompatible/*pharmacology
Graphite/*chemistry
Ketones/*chemistry
Nanocomposites/*chemistry
Polyethylene Glycols/*chemistry
Animals ; Anti-Bacterial Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/radiation effects ; Durapatite/pharmacology ; Electric Conductivity ; Escherichia coli/drug effects ; Female ; Graphite/radiation effects ; Humans ; Infrared Rays ; Ketones/radiation effects ; Mesenchymal Stem Cells/drug effects ; Mice, Inbred BALB C ; Nanocomposites/radiation effects ; Neoplasms/drug therapy ; Osseointegration/drug effects ; Photothermal Therapy/methods ; Polyethylene Glycols/radiation effects ; Quaternary Ammonium Compounds/pharmacology ; Staphylococcus aureus/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.
Autorzy :
Corrigan TS; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
Lotti Diaz LM; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
Border SE; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
Ratigan SC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Kasper KQ; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
Sojka D; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
Fajtova P; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Salvesen GS; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
McElroy CA; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Hadad CM; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
Doğan Ekici Ö; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.; Department of Chemistry and Biochemistry, The Ohio State University at Newark, Newark, OH, USA.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1387-1402.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Aldehydes/*pharmacology
Aza Compounds/*pharmacology
Ketones/*pharmacology
Peptides/*pharmacology
Protease Inhibitors/*pharmacology
Aldehydes/chemistry ; Animals ; Aza Compounds/chemistry ; Cattle ; Crystallography, X-Ray ; Cysteine Endopeptidases/metabolism ; Dose-Response Relationship, Drug ; Humans ; Ketones/chemistry ; Models, Molecular ; Molecular Structure ; Peptides/chemistry ; Protease Inhibitors/chemical synthesis ; Protease Inhibitors/chemistry ; Proteasome Endopeptidase Complex/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Peptidyl Acyloxymethyl Ketones as Activity-Based Probes for the Main Protease of SARS-CoV-2*.
Autorzy :
van de Plassche MAT; Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven, Herestraat 49 box 802, 3000, Leuven, Belgium.
Barniol-Xicota M; Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven, Herestraat 49 box 802, 3000, Leuven, Belgium.
Verhelst SHL; Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven, Herestraat 49 box 802, 3000, Leuven, Belgium.; AG Chemical Proteomics, Leibniz Institute for Analytical Sciences ISAS, Otto-Hahn-Str. 6b, 44227, Dortmund, Germany.
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2020 Dec 01; Vol. 21 (23), pp. 3383-3388. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus M Proteins/*chemistry
Ketones/*chemistry
Molecular Probes/*chemistry
SARS-CoV-2/*enzymology
Binding Sites ; COVID-19/diagnosis ; COVID-19/virology ; Catalytic Domain ; Coronavirus M Proteins/metabolism ; Humans ; Ketones/metabolism ; Kinetics ; Molecular Docking Simulation ; Molecular Probes/metabolism ; Peptides/chemistry ; SARS-CoV-2/isolation & purification
Czasopismo naukowe
Tytuł :
Antitumor Activity of Eribulin After Fulvestrant Plus CDK4/6 Inhibitor in Breast Cancer Patient-derived Xenograft Models.
Autorzy :
Niwa Y; Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
Asano M; Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
Nakagawa T; Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
France D; Oncodesign, Dijon, France.
Semba T; Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
Funahashi Y; Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan; .
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Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 6699-6712.
Typ publikacji :
Journal Article
MeSH Terms :
Xenograft Model Antitumor Assays*
Breast Neoplasms/*drug therapy
Cyclin-Dependent Kinase 4/*antagonists & inhibitors
Cyclin-Dependent Kinase 6/*antagonists & inhibitors
Fulvestrant/*therapeutic use
Furans/*therapeutic use
Ketones/*therapeutic use
Protein Kinase Inhibitors/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase 6/metabolism ; Female ; Fulvestrant/pharmacology ; Furans/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Ketones/pharmacology ; Mice, Inbred BALB C ; Mice, Nude ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications.
Autorzy :
Lloyd CM; Department of Chemistry, Faculty of Science, Durham University, Durham DH1 3LE, UK.
Colgin N; Cambridge Research Biochemicals, 17-18 Belasis Court, Belasis Hall Technology Park, Billingham, Cleveland TS23 4AZ, UK.
Cobb SL; Department of Chemistry, Faculty of Science, Durham University, Durham DH1 3LE, UK.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Nov 28; Vol. 25 (23). Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Ketones/*pharmacology
Peptide Fragments/*pharmacology
Protease Inhibitors/*pharmacology
Animals ; Chemistry, Pharmaceutical ; Humans ; Ketones/chemical synthesis ; Peptide Fragments/chemical synthesis ; Protease Inhibitors/chemical synthesis
Czasopismo naukowe
Tytuł :
Diazaboryl-naphthyl-ketone: A New Scaffold with Bright Fluorescence, Aggregation-Induced Emission, and Application in the Quantitation of Trace Boronic Acids in Drug Intermediates.
Autorzy :
Hackney HE; Department of Chemistry, 4-010 CCIS, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
Paladino M; Department of Chemistry, 4-010 CCIS, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
Fu H; Department of Chemistry, 4-010 CCIS, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
Hall DG; Department of Chemistry, 4-010 CCIS, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Nov 11; Vol. 26 (63), pp. 14324-14329. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Boronic Acids*/analysis
Chemistry, Pharmaceutical*/methods
Ketones*/chemistry
Pharmaceutical Preparations*/chemistry
Pharmaceutical Preparations*/standards
Crystallography, X-Ray ; Luminescence
Czasopismo naukowe
Tytuł :
Ketone bodies: beyond their role as a potential energy substrate in exercise.
Autorzy :
Poffé C; Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium.
Hespel P; Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium.; Bakala Academy-Athletic Performance Center, KU Leuven, Leuven, Belgium.
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Źródło :
The Journal of physiology [J Physiol] 2020 Nov; Vol. 598 (21), pp. 4749-4750. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Ketone Bodies*
Ketones*
Exercise ; Muscle, Skeletal ; Respiration
Czasopismo naukowe
Tytuł :
In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle.
Autorzy :
Petrick HL; Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada.
Brunetta HS; Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada.; Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
Pignanelli C; Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada.
Nunes EA; Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
van Loon LJC; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Burr JF; Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada.
Holloway GP; Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada.
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Źródło :
The Journal of physiology [J Physiol] 2020 Nov; Vol. 598 (21), pp. 4869-4885. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ketone Bodies*/metabolism
Ketones*
Animals ; Mitochondria ; Muscle, Skeletal/metabolism ; Rats ; Respiration
Czasopismo naukowe
Tytuł :
Effect of Eribulin With or Without Pembrolizumab on Progression-Free Survival for Patients With Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer: A Randomized Clinical Trial.
Autorzy :
Tolaney SM; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Barroso-Sousa R; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Oncology Center, Hospital Sírio-Libanês, Brasília, Brazil.
Keenan T; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Boston, Massachusetts.
Li T; Division of Biostatistics, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts.
Trippa L; Division of Biostatistics, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts.
Vaz-Luis I; Unit Inserm 981, Gustave Roussy, Villejuif, France.
Wulf G; Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Spring L; Medical Oncology, Massachusetts General Hospital, Boston.
Sinclair NF; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Andrews C; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Pittenger J; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Richardson ET 3rd; Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Dillon D; Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Lin NU; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Overmoyer B; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Partridge AH; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Van Allen E; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Boston, Massachusetts.
Mittendorf EA; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts.
Winer EP; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Krop IE; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Źródło :
JAMA oncology [JAMA Oncol] 2020 Oct 01; Vol. 6 (10), pp. 1598-1605.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms :
Antibodies, Monoclonal, Humanized/*administration & dosage
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Breast Neoplasms/*drug therapy
Furans/*therapeutic use
Ketones/*therapeutic use
Adult ; Aged ; Antibodies, Monoclonal, Humanized/adverse effects ; B7-H1 Antigen/analysis ; Breast Neoplasms/chemistry ; Breast Neoplasms/mortality ; Cross-Over Studies ; Female ; Furans/administration & dosage ; Furans/adverse effects ; Humans ; Ketones/administration & dosage ; Ketones/adverse effects ; Male ; Middle Aged ; Receptor, ErbB-2/analysis ; Receptors, Estrogen/analysis ; Receptors, Progesterone/analysis
Czasopismo naukowe
Tytuł :
Does 'Dry Hit' vaping of vitamin E acetate contribute to EVALI? Simulating toxic ketene formation during e-cigarette use.
Autorzy :
Narimani M; Department of Chemical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.
da Silva G; Department of Chemical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.
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Źródło :
PloS one [PLoS One] 2020 Sep 03; Vol. 15 (9), pp. e0238140. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ethylenes/*metabolism
Ketones/*metabolism
Lung Injury/*pathology
Vaping/*adverse effects
Vitamin E/*metabolism
Ethylenes/chemistry ; Ethylenes/toxicity ; Humans ; Ketones/chemistry ; Ketones/toxicity ; Kinetics ; Lung Injury/chemically induced ; Temperature ; Vitamin E/chemistry
Czasopismo naukowe
Tytuł :
Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry.
Autorzy :
Citarella A; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy.
Micale N; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 03; Vol. 25 (17). Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Amino Acid Chloromethyl Ketones/*chemical synthesis
Phenylalanine/*analogs & derivatives
SARS Virus/*drug effects
Serine Proteinase Inhibitors/*chemical synthesis
Viral Nonstructural Proteins/*antagonists & inhibitors
Amino Acid Chloromethyl Ketones/pharmacology ; Chemistry, Pharmaceutical/methods ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/metabolism ; HIV/drug effects ; HIV/enzymology ; HIV Protease/chemistry ; HIV Protease/metabolism ; Humans ; Kinetics ; Phenylalanine/chemical synthesis ; Phenylalanine/pharmacology ; SARS Virus/enzymology ; Serine Proteinase Inhibitors/pharmacology ; Structure-Activity Relationship ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection.
Autorzy :
Yin J; School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
Han Q; School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
Zhang J; School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
Liu Y; School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
Gan X; State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Xie K; School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
Xie L; State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Deng Y; School of Chemical Engineering, Sichuan University, Chengdu 610065, China.; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.; Department of Mechanical Engineering, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Oct 14; Vol. 12 (41), pp. 45891-45903. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Bone Neoplasms/*drug therapy
Hydrogels/*pharmacology
Ketones/*pharmacology
Osteosarcoma/*drug therapy
Polyethylene Glycols/*pharmacology
3T3 Cells ; Animals ; Anti-Bacterial Agents/chemistry ; Antineoplastic Agents/chemistry ; Bone Neoplasms/pathology ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Drug Screening Assays, Antitumor ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Humans ; Hydrogels/chemistry ; Ketones/chemistry ; Mice ; Mice, Inbred Strains ; Microbial Sensitivity Tests ; Osteogenesis/drug effects ; Osteosarcoma/pathology ; Particle Size ; Photothermal Therapy ; Polyethylene Glycols/chemistry ; Rats ; Rats, Sprague-Dawley ; Surface Properties
Czasopismo naukowe

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