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    Wyświetlanie 1-20 z 20
    Tytuł:
    Saffron Pre-Treatment Promotes Reduction in Tissue Inflammatory Profiles and Alters Microbiome Composition in Experimental Colitis Mice.
    Autorzy:
    Banskota S; Farncombe Family Digestive Health Research Institute, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4K1, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.
    Brim H; Department of Pathology, Cancer Center, Howard University College of Medicine, Washington, DC 20059, USA.
    Kwon YH; Farncombe Family Digestive Health Research Institute, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4K1, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.
    Singh G; Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA 94305, USA.
    Sinha SR; Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA 94305, USA.
    Wang H; Farncombe Family Digestive Health Research Institute, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4K1, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.
    Khan WI; Farncombe Family Digestive Health Research Institute, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4K1, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.
    Ashktorab H; Department of Medicine, Gastroenterology Division, Cancer Center, Howard University College of Medicine, Washington, DC 20059, USA.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2021 Jun 02; Vol. 26 (11). Date of Electronic Publication: 2021 Jun 02.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Bacteria/*classification
    Biological Products/*administration & dosage
    Colitis/*drug therapy
    Crocus/*chemistry
    Dextran Sulfate/*adverse effects
    Microbiota/*drug effects
    Administration, Oral ; Animals ; Bacteria/drug effects ; Bacteria/genetics ; Bacteria/isolation & purification ; Biological Products/pharmacology ; Colitis/chemically induced ; Colitis/immunology ; Colitis/pathology ; Cytokines/metabolism ; Disease Models, Animal ; Down-Regulation ; Male ; Mice ; Mice, Inbred C57BL ; Phylogeny ; Pre-Exposure Prophylaxis ; Serotonin/metabolism ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Autophagy: roles in intestinal mucosal homeostasis and inflammation.
    Autorzy:
    Haq S; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, L8N 3Z5, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Room 3N7, Hamilton, ON, L8N 3Z5, Canada.
    Grondin J; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, L8N 3Z5, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Room 3N7, Hamilton, ON, L8N 3Z5, Canada.
    Banskota S; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, L8N 3Z5, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Room 3N7, Hamilton, ON, L8N 3Z5, Canada.
    Khan WI; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, L8N 3Z5, Canada. .; Department of Pathology and Molecular Medicine, McMaster University, Room 3N7, Hamilton, ON, L8N 3Z5, Canada. .
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    Źródło:
    Journal of biomedical science [J Biomed Sci] 2019 Feb 14; Vol. 26 (1), pp. 19. Date of Electronic Publication: 2019 Feb 14.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Autophagy/*physiology
    Homeostasis/*immunology
    Inflammation/*physiopathology
    Intestinal Mucosa/*physiology
    Animals ; Humans ; Intestinal Mucosa/immunology ; Mice ; Rats
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Overlap Chronic Placental Inflammation Is Associated with a Unique Gene Expression Pattern.
    Autorzy:
    Raman K; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
    Wang H; Farncombe Family Digestive Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
    Troncone MJ; Department of Pathology and Molecular Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
    Khan WI; Farncombe Family Digestive Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
    Pare G; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Farncombe Family Digestive Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
    Terry J; Department of Pathology and Molecular Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
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    Źródło:
    PloS one [PLoS One] 2015 Jul 24; Vol. 10 (7), pp. e0133738. Date of Electronic Publication: 2015 Jul 24 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Chorioamnionitis/*genetics
    Chorionic Villi/*pathology
    Inflammation/*genetics
    Placenta Diseases/*genetics
    Chorioamnionitis/pathology ; Chorionic Villi/metabolism ; Chronic Disease ; Female ; Gene Expression Profiling ; Humans ; Immunoglobulins/metabolism ; Inflammation/pathology ; Lymphocytes/metabolism ; Microarray Analysis ; Placenta/metabolism ; Placenta/pathology ; Placenta Diseases/pathology ; Pregnancy ; Pregnancy Complications/genetics ; Pregnancy Complications/metabolism ; Pregnancy Complications/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The role of serotonin and its receptors in activation of immune responses and inflammation.
    Autorzy:
    Shajib MS; Farncombe Family Digestive Health Research Institute, Hamilton, ON, Canada; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada.
    Khan WI
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    Źródło:
    Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2015 Mar; Vol. 213 (3), pp. 561-74. Date of Electronic Publication: 2014 Dec 11.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Signal Transduction*/drug effects
    Inflammation/*metabolism
    Inflammation Mediators/*metabolism
    Receptors, Serotonin/*metabolism
    Serotonin/*metabolism
    Animals ; Anti-Inflammatory Agents/therapeutic use ; Enterochromaffin Cells/immunology ; Enterochromaffin Cells/metabolism ; Humans ; Inflammation/immunology ; Inflammation/prevention & control ; Inflammation Mediators/immunology ; Neurons/immunology ; Neurons/metabolism ; Receptors, Serotonin/drug effects ; Receptors, Serotonin/immunology ; Serotonin/immunology ; Serotonin Antagonists/therapeutic use
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.
    Autorzy:
    Crane JD; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
    Palanivel R; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [3] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
    Mottillo EP; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
    Bujak AL; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
    Wang H; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
    Ford RJ; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
    Collins A; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
    Blümer RM; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
    Fullerton MD; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
    Yabut JM; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
    Kim JJ; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
    Ghia JE; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
    Hamza SM; Cardiovascular Research Centre, Alberta Diabetes Institute, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
    Morrison KM; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
    Schertzer JD; 1] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. [2] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
    Dyck JR; Cardiovascular Research Centre, Alberta Diabetes Institute, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
    Khan WI; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
    Steinberg GR; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
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    Źródło:
    Nature medicine [Nat Med] 2015 Feb; Vol. 21 (2), pp. 166-72. Date of Electronic Publication: 2014 Dec 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Adipose Tissue, Brown/*metabolism
    Insulin Resistance/*genetics
    Ion Channels/*metabolism
    Mitochondrial Proteins/*metabolism
    Non-alcoholic Fatty Liver Disease/*genetics
    Obesity/*genetics
    Serotonin/*biosynthesis
    Thermogenesis/*genetics
    Tryptophan Hydroxylase/*genetics
    Animals ; Diet, High-Fat ; Energy Metabolism/drug effects ; Energy Metabolism/genetics ; Mice ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/metabolism ; Obesity/metabolism ; Thermogenesis/drug effects ; Tryptophan Hydroxylase/antagonists & inhibitors ; Uncoupling Protein 1
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation.
    Autorzy:
    Shajib MS; Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada ; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
    Wang H
    Kim JJ
    Sunjic I
    Ghia JE
    Denou E
    Collins M
    Denburg JA
    Khan WI
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    Źródło:
    PloS one [PLoS One] 2013 Aug 28; Vol. 8 (8), pp. e72774. Date of Electronic Publication: 2013 Aug 28 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Colitis/*metabolism
    Endocrine System/*metabolism
    Interleukin-13/*metabolism
    Macrophages, Peritoneal/*metabolism
    Animals ; Benzenesulfonates/toxicity ; Colitis/chemically induced ; Colitis/genetics ; Colitis/immunology ; Colitis/pathology ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Endocrine System/immunology ; Endocrine System/pathology ; Interleukin-13/genetics ; Interleukin-13/immunology ; Interleukin-13/pharmacology ; Macrophages, Peritoneal/immunology ; Macrophages, Peritoneal/pathology ; Mice ; Mice, Knockout ; Serotonin/genetics ; Serotonin/immunology ; Serotonin/metabolism ; Serotonin/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Gut hormones: emerging role in immune activation and inflammation.
    Autorzy:
    Khan WI; Farncombe Family Digestive Health Research Institute, Department of Pathology and Molecular Medicine, McMaster University, ON, Canada. />Ghia JE
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    Źródło:
    Clinical and experimental immunology [Clin Exp Immunol] 2010 Jul 01; Vol. 161 (1), pp. 19-27. Date of Electronic Publication: 2010 Apr 09.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Chromogranins/*physiology
    Colitis/*physiopathology
    Immunity, Mucosal/*physiology
    Neuroimmunomodulation/*physiology
    Serotonin/*physiology
    Animals ; Celiac Disease/physiopathology ; Colitis/immunology ; Enterochromaffin Cells/metabolism ; Enteroendocrine Cells/metabolism ; Gastrointestinal Motility/physiology ; Humans ; Immunity, Mucosal/drug effects ; Irritable Bowel Syndrome/physiopathology ; Mice ; Mice, Knockout ; Rats ; Receptors, Serotonin/drug effects ; Receptors, Serotonin/physiology ; Serotonin Antagonists/pharmacology ; Serotonin Receptor Agonists/pharmacology ; Tryptophan Hydroxylase/deficiency ; Tryptophan Hydroxylase/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Persistent gut motor dysfunction in a murine model of T-cell-induced enteropathy.
    Autorzy:
    Mizutani T; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Akiho H
    Khan WI
    Murao H
    Ogino H
    Kanayama K
    Nakamura K
    Takayanagi R
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    Źródło:
    Neurogastroenterology and motility [Neurogastroenterol Motil] 2010 Feb; Vol. 22 (2), pp. 196-203, e65. Date of Electronic Publication: 2009 Sep 07.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    CD3 Complex/*immunology
    Enteritis/*physiopathology
    Gastrointestinal Motility/*immunology
    Intestines/*physiopathology
    Muscle Contraction/*immunology
    T-Lymphocytes/*immunology
    Analysis of Variance ; Animals ; Cell Count ; Cytokines/immunology ; Disease Models, Animal ; Enteritis/immunology ; Enteritis/pathology ; Enzyme-Linked Immunosorbent Assay ; Immunohistochemistry ; Intestines/immunology ; Intestines/pathology ; Male ; Mice ; Serotonin/immunology ; Time Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis.
    Autorzy:
    Motomura Y; Intestinal Diseases Research Program, Department of Pathology, McMaster University, Ontario, Canada.
    Wang H
    Deng Y
    El-Sharkawy RT
    Verdu EF
    Khan WI
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    Źródło:
    Clinical and experimental immunology [Clin Exp Immunol] 2009 Jan; Vol. 155 (1), pp. 88-95. Date of Electronic Publication: 2008 Nov 06.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antigens, Helminth/*administration & dosage
    Colitis/*therapy
    Trichinella spiralis/*immunology
    Trichinellosis/*immunology
    Vaccination/*methods
    Animals ; Colitis/immunology ; Colitis/pathology ; Colon/enzymology ; Colon/immunology ; Colon/pathology ; Dinitrofluorobenzene/analogs & derivatives ; Injections ; Interleukin-13/analysis ; Interleukin-1beta/analysis ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Nitric Oxide Synthase Type II/analysis ; Peroxidase/analysis ; Rectum ; Transforming Growth Factor beta/analysis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-20 z 20

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