Temat: "Kidney Tubules, Proximal" - OpacWWW

Skocz do pozycji: 61.

Tytuł:: Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis.
Autorzy:: Baraghithy S; Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Soae Y; Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Assaf D; Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Hinden L; Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Udi S; Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Drori A; Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Gabet Y; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
Tam J; Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Feb 17; Vol. 10 (2). Date of Electronic Publication: 2021 Feb 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Blood Glucose/*metabolism
Bone Remodeling/*physiology
Kidney Tubules, Proximal/*drug effects
Osteoporosis/*metabolism
Animals ; Cannabinoids/pharmacology ; Diabetic Nephropathies ; Glucose/pharmacology ; Homeostasis/drug effects ; Homeostasis/physiology ; Humans ; Kidney/drug effects ; Kidney/metabolism ; Kidney Tubules, Proximal/metabolism ; Male ; Mice, Inbred C57BL ; Mice

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Skocz do pozycji: 62.

Tytuł:: Potential Protection Effect of ER Homeostasis of N -(2-Hydroxyethyl)adenosine Isolated from Cordyceps cicadae in Nonsteroidal Anti-Inflammatory Drug-Stimulated Human Proximal Tubular Cells.
Autorzy:: Chyau CC; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Wu HL; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Peng CC; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Huang SH; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Chen CC; Grape King Biotechnology Center, Chung-Li City 320054, Taiwan.
Chen CH; Department of Nephrology, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Peng RY; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 04; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 04.
Typ publikacji:: Journal Article
MeSH Terms:: Homeostasis*
Adenosine/*analogs & derivatives
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cordyceps/*chemistry
Endoplasmic Reticulum Stress/*drug effects
Kidney Tubules, Proximal/*drug effects
Protective Agents/*pharmacology
Adenosine/pharmacology ; Endoplasmic Reticulum Chaperone BiP ; Gene Expression Regulation ; Humans ; Kidney Tubules, Proximal/metabolism ; Oxidative Stress
SCR Organism:: Cordyceps cicadae

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Skocz do pozycji: 63.

Tytuł:: Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage.
Autorzy:: Manabe E; Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. .
Ito S; Division of Pharmaceutical Therapeutics, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan.
Ohno Y; Division of Immunobiology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan.
Tanaka T; Division of Immunobiology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan.
Naito Y; Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Sasaki N; Division of Pharmaceutical Therapeutics, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan.
Asakura M; Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Masuyama T; Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.; Hoshigaoka Medical Center, Japan Community Health Care Organization, Hirakata, Osaka, Japan.
Ishihara M; Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Tsujino T; Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.; Division of Pharmaceutical Therapeutics, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Dec 16; Vol. 10 (1), pp. 22023. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cellular Senescence*
Erythrocytes/*pathology
Kidney Tubules, Proximal/*pathology
Animals ; Bone Marrow Cells/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/ultrastructure ; Erythroid Cells/metabolism ; Erythropoietin/blood ; Half-Life ; Hematopoiesis ; Hemolysis ; Iron Chelating Agents/pharmacology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/physiopathology ; Kidney Tubules, Proximal/ultrastructure ; Male ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Rats, Inbred Dahl ; Sodium Chloride, Dietary ; Spleen/metabolism

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Skocz do pozycji: 64.

Tytuł:: Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells.
Autorzy:: Pirklbauer M; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Bernd M; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Fuchs L; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Staudinger P; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Corazza U; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Leierer J; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Mayer G; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Schramek H; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Nov 01; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 01.
Typ publikacji:: Journal Article
MeSH Terms:: Benzhydryl Compounds/*pharmacology
Chemokine CCL2/*genetics
Endothelin-1/*genetics
Gene Expression/*drug effects
Glucosides/*pharmacology
Interleukin-1beta/*pharmacology
Kidney Tubules, Proximal/*drug effects
Cell Line ; Chemokine CCL2/metabolism ; Endothelin-1/metabolism ; Gene Expression Profiling/methods ; Humans ; Kidney Tubules, Proximal/cytology ; Kidney Tubules, Proximal/metabolism ; Oligonucleotide Array Sequence Analysis/methods

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Skocz do pozycji: 65.

Tytuł:: Phosphatidylinositol metabolism of the renal proximal tubule S3 segment is disturbed in response to diabetes.
Autorzy:: Rietjens RGJ; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands.
Wang G; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands.
van der Velden AIM; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Koudijs A; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Avramut MC; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cell and Chemical Biology (Electron Microscopy), Leiden University Medical Center, Leiden, The Netherlands.
Kooijman S; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine (Endocrinology), Leiden University Medical Center, Leiden, The Netherlands.
Rensen PCN; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine (Endocrinology), Leiden University Medical Center, Leiden, The Netherlands.
van der Vlag J; Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.
Rabelink TJ; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands.
Heijs B; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands.; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
van den Berg BM; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands. b.m.van_den_.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands. b.m.van_den_.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands. b.m.van_den_.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Apr 17; Vol. 13 (1), pp. 6261. Date of Electronic Publication: 2023 Apr 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Diabetic Nephropathies*/metabolism
Diabetes Mellitus*/metabolism
Mice ; Animals ; Kidney/metabolism ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules/metabolism ; Lipid Metabolism

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Skocz do pozycji: 66.

Tytuł:: Transcriptional regulation of proximal tubular metabolism in acute kidney injury.
Autorzy:: Piret SE; Division of Nephrology and Hypertension, Department of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY, 11794, USA. .
Mallipattu SK; Division of Nephrology and Hypertension, Department of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY, 11794, USA.; Renal Division, Northport VA Medical Center, Northport, NY, USA.; Pokaż więcej
Źródło:: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2023 Apr; Vol. 38 (4), pp. 975-986. Date of Electronic Publication: 2022 Oct 01.
Typ publikacji:: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Acute Kidney Injury*/genetics
Acute Kidney Injury*/metabolism
Reperfusion Injury*/metabolism
Humans ; Kidney/metabolism ; Kidney Tubules, Proximal/metabolism ; Amino Acids/metabolism ; Adenosine Triphosphate/metabolism

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Skocz do pozycji: 67.

Tytuł:: The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells.
Autorzy:: Yang Y; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.
Mihajlovic M; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.
Janssen MJ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.
Masereeuw R; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.; Pokaż więcej
Źródło:: Toxins [Toxins (Basel)] 2023 Mar 25; Vol. 15 (4). Date of Electronic Publication: 2023 Mar 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Indican*/toxicity
Indican*/metabolism
Uremic Toxins*
Humans ; Epithelial Cells/metabolism ; Kidney Tubules, Proximal/metabolism ; Fibrosis

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Skocz do pozycji: 68.

Tytuł:: Discrete localization of phospholipase Cβ3 and diacylglycerol kinase ι along the renal proximal tubules of normal rat kidney and gentamicin-induced changes in their expression.
Autorzy:: Hemha P; Electron Microscopy Laboratory, Division of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Chomphoo S; Electron Microscopy Laboratory, Division of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Polsan Y; Electron Microscopy Laboratory, Division of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Goto K; Department of Anatomy, School of Medicine, Yamagata University, Yamagata, Japan.
Watanabe M; Department of Anatomy, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kondo H; Electron Microscopy Laboratory, Division of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Hipkaeo W; Electron Microscopy Laboratory, Division of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. .; Pokaż więcej
Źródło:: Histochemistry and cell biology [Histochem Cell Biol] 2023 Mar; Vol. 159 (3), pp. 293-307. Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:: Journal Article
MeSH Terms:: Diacylglycerol Kinase*/metabolism
Phospholipases*/metabolism
Rats ; Animals ; Gentamicins/metabolism ; Isoenzymes/metabolism ; Kidney/metabolism ; Kidney Tubules, Proximal

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Skocz do pozycji: 69.

Tytuł:: Immunohistochemical Panels to Evaluate Important Immunophenotypes of Human Mesonephros.
Autorzy:: Zhang PL; Division of Anatomic Pathology, Beaumont Labs, Beaumont Health, Royal Oak, MI, USA.
Macknis JK; Division of Anatomic Pathology, Beaumont Labs, Beaumont Health, Royal Oak, MI, USA.; Pokaż więcej
Źródło:: Fetal and pediatric pathology [Fetal Pediatr Pathol] 2023 Feb; Vol. 42 (1), pp. 1-17. Date of Electronic Publication: 2022 Mar 15.
Typ publikacji:: Journal Article
MeSH Terms:: Mesonephros*/blood supply
Mesonephros*/chemistry
Kidney Glomerulus*
Humans ; Kidney Tubules, Proximal ; Kidney

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Skocz do pozycji: 70.

Tytuł:: Estrogen and estrogen receptors in kidney diseases.
Autorzy:: Ma HY; Department of Geriatrics, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Chen S; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Du Y; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.; Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.; Pokaż więcej
Źródło:: Renal failure [Ren Fail] 2021 Jan 01; Vol. 43 (1), pp. 619-642.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Acute Kidney Injury/*metabolism
Estrogens/*metabolism
Kidney Tubules, Proximal/*metabolism
Receptors, Estrogen/*metabolism
Renal Insufficiency, Chronic/*metabolism
Acute Kidney Injury/pathology ; Animals ; Disease Progression ; Humans ; Kidney Tubules, Proximal/pathology ; Mitochondria/metabolism ; Renal Insufficiency, Chronic/pathology ; Signal Transduction

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Skocz do pozycji: 71.

Tytuł:: Sodium-Glucose Co-Transporter 2 Inhibitors Correct Metabolic Maladaptation of Proximal Tubular Epithelial Cells in High-Glucose Conditions.
Autorzy:: Shirakawa K; Department of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
Sano M; Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Oct 16; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 16.
Typ publikacji:: Journal Article
MeSH Terms:: Glucose/*metabolism
Kidney Tubules, Proximal/*metabolism
Sodium-Glucose Transporter 2/*metabolism
Adaptation, Physiological ; Animals ; Cells, Cultured ; Glucose Transporter Type 2/metabolism ; Kidney Tubules, Proximal/cytology ; Kidney Tubules, Proximal/drug effects ; Mice ; Mice, Inbred C57BL ; Osteopontin/genetics ; Osteopontin/metabolism ; Reactive Oxygen Species/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology

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Skocz do pozycji: 72.

Tytuł:: Single-cell RNA sequencing analysis of human kidney reveals the presence of ACE2 receptor: A potential pathway of COVID-19 infection.
Autorzy:: He Q; First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.; Pediatric Cardiac Surgery Center, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Mok TN; First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Yun L; First Medical College of Southern Medical University, Guangzhou, Guangdong, China.
He C; Heyu Health Technology Co, Ltd. Guangzhou, Guangdong, China.
Li J; First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Pan J; First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.; Pokaż więcej
Źródło:: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Oct; Vol. 8 (10), pp. e1442. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Acute Kidney Injury/*virology
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*pathology
Kidney Glomerulus/*metabolism
Kidney Tubules, Proximal/*metabolism
Receptors, Virus/*genetics
Acute Kidney Injury/pathology ; Angiotensin-Converting Enzyme 2/genetics ; Base Sequence ; Humans ; Kidney Glomerulus/pathology ; Kidney Glomerulus/virology ; Kidney Tubules, Proximal/pathology ; Kidney Tubules, Proximal/virology ; Principal Component Analysis ; SARS-CoV-2/metabolism ; Sequence Analysis, RNA ; Serine Endopeptidases/metabolism ; Single-Cell Analysis

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Skocz do pozycji: 73.

Tytuł:: Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells.
Autorzy:: Liu G; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
Zhang K; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
Dong W; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
Tan Y; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
Long M; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
Zou H; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
Liu Z; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2020 Sep; Vol. 22 (3), pp. 2551-2563. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji:: Journal Article
MeSH Terms:: Cadmium/*adverse effects
Endoplasmic Reticulum Stress/*drug effects
Isoflavones/*pharmacology
Kidney Tubules, Proximal/*cytology
NF-E2-Related Factor 2/*metabolism
Animals ; Autophagy/drug effects ; Cell Count ; Cell Line ; Cell Survival ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Malondialdehyde/metabolism ; Rats ; Reactive Oxygen Species/metabolism

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Skocz do pozycji: 74.

Tytuł:: Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity.
Autorzy:: Ji HJ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Xianlin Road #138, Nanjing 210023, China.; Shanghai Institue of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; Department of Pharmacy, Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng 224001, China.
Li JY; Shanghai Institue of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Wu SF; Shanghai Institue of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Wu WY; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Xianlin Road #138, Nanjing 210023, China.
Yao CL; Shanghai Institue of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yao S; Shanghai Institue of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhang JQ; Shanghai Institue of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Guo DA; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Xianlin Road #138, Nanjing 210023, China.; Shanghai Institue of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2020 Dec 23; Vol. 26 (1). Date of Electronic Publication: 2020 Dec 23.
Typ publikacji:: Journal Article
MeSH Terms:: Aristolochia/*chemistry
Aristolochic Acids/*pharmacology
Carcinogens/*pharmacology
Cytotoxins/*pharmacology
Kidney Tubules, Proximal/*pathology
Plant Roots/*chemistry
Cell Proliferation ; Cells, Cultured ; Humans ; Kidney Tubules, Proximal/drug effects

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Skocz do pozycji: 75.

Tytuł:: Single-cell RNA sequencing confirms IgG transcription and limited diversity of V H DJ H rearrangements in proximal tubular epithelial cells.
Autorzy:: Deng Z; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Wang X; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Liu Y; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Tian X; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Deng S; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Sun Y; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Wang S; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Zheng D; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Cui Z; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Pan Y; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
A L; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China.
Yan H; Department of Immunology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, People's Republic of China.
Qiu X; Department of Immunology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, People's Republic of China. .
Wang Y; Department of Nephrology, Peking University Third Hospital, 49 Huayuanbei Road, Beijing, 100191, People's Republic of China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Nov 12; Vol. 10 (1), pp. 19657. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Rearrangement*
Epithelial Cells/*metabolism
Immunoglobulin G/*genetics
Immunoglobulin Heavy Chains/*genetics
Immunoglobulin Variable Region/*genetics
Kidney Tubules, Proximal/*metabolism
Sequence Analysis, RNA/*methods
Single-Cell Analysis/*methods
Humans ; Immunoglobulin G/metabolism ; Kidney Tubules, Proximal/immunology ; Transcriptome

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Skocz do pozycji: 76.

Tytuł:: HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Autorzy:: Jiang N; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Zhao H; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Han Y; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Li L; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Xiong S; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Zeng L; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Xiao Y; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Wei L; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Xiong X; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Gao P; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Yang M; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Liu Y; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Sun L; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2020 Nov; Vol. 53 (11), pp. e12909. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji:: Journal Article
MeSH Terms:: Mitochondrial Dynamics*
Diabetic Nephropathies/*pathology
Heme Oxygenase-1/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Kidney Tubules, Proximal/*pathology
Animals ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/metabolism ; Gene Deletion ; Gene Knockout Techniques ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Kidney Tubules, Proximal/metabolism ; Male ; Mice ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/pathology

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Skocz do pozycji: 77.

Tytuł:: RNA-seq reveals altered gene expression levels in proximal tubular cell cultures compared to renal cortex but not during early glucotoxicity.
Autorzy:: Nilsson LM; Science for Life Laboratory, Department of Applied Physics, Royal Institute of Technology, Box 1031, 171 21, Solna, Sweden.
Castresana-Aguirre M; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden.
Scott L; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Brismar H; Science for Life Laboratory, Department of Applied Physics, Royal Institute of Technology, Box 1031, 171 21, Solna, Sweden. .; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jun 25; Vol. 10 (1), pp. 10390. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*
Gene Expression Regulation/*drug effects
Glucose/*pharmacology
Kidney Cortex/*metabolism
Kidney Tubules, Proximal/*metabolism
RNA-Seq/*methods
Animals ; Cells, Cultured ; Kidney Cortex/drug effects ; Kidney Cortex/pathology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/pathology ; Male ; Rats ; Rats, Sprague-Dawley ; Sweetening Agents/pharmacology

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Skocz do pozycji: 78.

Tytuł:: Time-series proteomic study of the response of HK-2 cells to hyperglycemic, hypoxic diabetic-like milieu.
Autorzy:: Valdés A; Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
Castro-Puyana M; Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, España.; Instituto de Investigación Química Andrés M del Rio, IQAR, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
García-Pastor C; Departamento de Biología de Sistemas, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
Lucio-Cazaña FJ; Departamento de Biología de Sistemas, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
Marina ML; Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, España.; Instituto de Investigación Química Andrés M del Rio, IQAR, Universidad de Alcalá, Alcalá de Henares, Madrid, España.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jun 24; Vol. 15 (6), pp. e0235118. Date of Electronic Publication: 2020 Jun 24 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Epithelial Cells/*metabolism
Glucose/*metabolism
Kidney Tubules, Proximal/*metabolism
Proteome/*metabolism
Proteomics/*methods
Cell Hypoxia ; Cell Line ; Chromatography, High Pressure Liquid/methods ; Diabetic Nephropathies/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Glucose/pharmacology ; Humans ; Kidney Tubules, Proximal/cytology ; Kidney Tubules, Proximal/drug effects ; Protein Interaction Maps/drug effects ; Tandem Mass Spectrometry/methods ; Time Factors

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Skocz do pozycji: 79.

Tytuł:: Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents.
Autorzy:: Lin N; Key Laboratory of Beijing for Safety Evaluation of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Street, Beijing Economic-Technological Development Area, Beijing, 100176, P. R. China.; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.; Beijing Institute for Drug Control, 25 Science Park Road, Changping District, Beijing, 102206, China.
Zhou X; Key Laboratory of Beijing for Safety Evaluation of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Street, Beijing Economic-Technological Development Area, Beijing, 100176, P. R. China.
Geng X; Key Laboratory of Beijing for Safety Evaluation of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Street, Beijing Economic-Technological Development Area, Beijing, 100176, P. R. China.
Drewell C; Technische Universitaet Berlin, Institute of Biotechnology, Department Medical Biotechnology, Gustav-Meyer-Allee 25, 13355, Berlin, Germany.
Hübner J; Technische Universitaet Berlin, Institute of Biotechnology, Department Medical Biotechnology, Gustav-Meyer-Allee 25, 13355, Berlin, Germany.
Li Z; Key Laboratory of Beijing for Safety Evaluation of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Street, Beijing Economic-Technological Development Area, Beijing, 100176, P. R. China.
Zhang Y; Key Laboratory of Beijing for Safety Evaluation of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Street, Beijing Economic-Technological Development Area, Beijing, 100176, P. R. China.
Xue M; Department of Pharmacology, Beijing Laboratory for Biomedical Detection Technology and Instrument, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. .
Marx U; TissUse GmbH, Oudenarder Strasse 16, 13347, Berlin, Germany. .
Li B; National Institutes for Food and Drug Control, 31 Hua Tuo road, Daxing district, Beijing, 102629, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jun 01; Vol. 10 (1), pp. 8879. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Coculture Techniques/*instrumentation
Cyclosporine/*pharmacology
Kidney Tubules, Proximal/*cytology
Liver/*cytology
Microfluidic Analytical Techniques/*instrumentation
Rifampin/*pharmacology
Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Drug Evaluation, Preclinical ; Drug Therapy, Combination ; Equipment Design ; Gene Regulatory Networks/drug effects ; Humans ; Kidney Tubules, Proximal/chemistry ; Kidney Tubules, Proximal/drug effects ; Lab-On-A-Chip Devices ; Liver/chemistry ; Liver/drug effects ; Spheroids, Cellular/cytology

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Skocz do pozycji: 80.

Tytuł:: Acute Kidney Injury in SARS-CoV-2 Infection: Direct Effect of Virus on Kidney Proximal Tubule Cells.
Autorzy:: Soleimani M; Medicine and Research Services, VA Medical Center, Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 May 05; Vol. 21 (9). Date of Electronic Publication: 2020 May 05.
Typ publikacji:: Journal Article
MeSH Terms:: Acute Kidney Injury/*mortality
Acute Kidney Injury/*virology
Betacoronavirus/*pathogenicity
Coronavirus Infections/*virology
Kidney Tubules, Proximal/*metabolism
Kidney Tubules, Proximal/*virology
Pneumonia, Viral/*virology
Acute Kidney Injury/physiopathology ; Acute Kidney Injury/prevention & control ; Angiotensin II/pharmacology ; Angiotensin-Converting Enzyme 2 ; COVID-19 ; Cathepsins/metabolism ; Cell Death/drug effects ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Coronavirus Infections/physiopathology ; Creatinine/blood ; Critical Illness/mortality ; Endosomes/drug effects ; Endosomes/enzymology ; Endosomes/metabolism ; Humans ; Hydrogen-Ion Concentration ; Incidence ; Kidney Tubules, Proximal/physiopathology ; Lysosomes/drug effects ; Lysosomes/enzymology ; Lysosomes/metabolism ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/mortality ; Pneumonia, Viral/pathology ; Pneumonia, Viral/physiopathology ; Receptors, Virus/metabolism ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/blood ; Severe Acute Respiratory Syndrome/mortality ; Severe Acute Respiratory Syndrome/physiopathology ; Virus Internalization ; Virus Replication

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