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Wyszukujesz frazę ""Kidney Tubules, Proximal"" wg kryterium: Temat


Tytuł :
Empagliflozin Inhibits IL-1β-Mediated Inflammatory Response in Human Proximal Tubular Cells.
Autorzy :
Pirklbauer M; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Sallaberger S; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Staudinger P; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Corazza U; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Leierer J; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Mayer G; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Schramek H; Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 11; Vol. 22 (10). Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Benzhydryl Compounds/*pharmacology
Gene Expression Regulation/*drug effects
Glucosides/*pharmacology
Inflammation/*immunology
Interleukin-1beta/*pharmacology
Kidney Tubules, Proximal/*immunology
Gene Expression Profiling ; Humans ; Inflammation/chemically induced ; Inflammation/pathology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
NAM protects against cisplatin-induced acute kidney injury by suppressing the PARP1/p53 pathway.
Autorzy :
Wu W; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Fu Y; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Liu Z; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Shu S; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Wang Y; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Tang C; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China.
Cai J; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China. Electronic address: .
Dong Z; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University; Changsha 410011, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA.. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 May 01; Vol. 418, pp. 115492. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cisplatin*
Acute Kidney Injury/*prevention & control
Kidney Tubules, Proximal/*drug effects
Niacinamide/*pharmacology
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Tumor Suppressor Protein p53/*metabolism
Acute Kidney Injury/chemically induced ; Acute Kidney Injury/enzymology ; Acute Kidney Injury/pathology ; Animals ; Apoptosis/drug effects ; Cell Line ; Disease Models, Animal ; Histones/metabolism ; Kidney Tubules, Proximal/enzymology ; Kidney Tubules, Proximal/pathology ; Male ; Mice, Inbred C57BL ; Phosphoproteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
Expression of immunoglobulin G in human proximal tubular epithelial cells.
Autorzy :
Deng Z; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
Jing Z; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
Guo Y; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
Ma J; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, P.R. China.
Yan H; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, P.R. China.
Shi Z; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, P.R. China.
Deng H; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
Liang Y; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
Wang S; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
Cui Z; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
Pan Y; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
Qiu X; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, P.R. China.
Wang Y; Department of Nephrology, Peking University Third Hospital, Beijing 100191, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 May; Vol. 23 (5). Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Fibrosis/*genetics
Immunoglobulin G/*genetics
Kidney Tubules, Proximal/*immunology
Transforming Growth Factor beta1/*genetics
Cell Line ; Epithelial Cells/immunology ; Epithelial Cells/pathology ; Epithelial-Mesenchymal Transition ; Fibrosis/pathology ; Gene Expression Regulation ; Humans ; Immunoglobulin G/immunology ; Kidney Tubules, Proximal/pathology ; Podocytes/immunology ; Podocytes/metabolism ; RNA, Messenger/genetics ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Fucoidan from Laminaria japonica Inhibits Expression of GLUT9 and URAT1 via PI3K/Akt, JNK and NF-κB Pathways in Uric Acid-Exposed HK-2 Cells.
Autorzy :
Zhang Y; College of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.; Guangxi Key Laboratory of Buffalo Genetics, Reproduction and Breeding, Guangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, China.
Tan X; College of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.; Guangxi Key Laboratory of Buffalo Genetics, Reproduction and Breeding, Guangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, China.
Lin Z; College of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.
Li F; College of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.
Yang C; Guangxi Key Laboratory of Buffalo Genetics, Reproduction and Breeding, Guangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, China.
Zheng H; Guangxi Key Laboratory of Buffalo Genetics, Reproduction and Breeding, Guangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, China.
Li L; Guangxi Key Laboratory of Buffalo Genetics, Reproduction and Breeding, Guangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, China.
Liu H; College of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.
Shang J; Guangxi Key Laboratory of Buffalo Genetics, Reproduction and Breeding, Guangxi Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning 530001, China.
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Źródło :
Marine drugs [Mar Drugs] 2021 Apr 23; Vol. 19 (5). Date of Electronic Publication: 2021 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Laminaria*/chemistry
Glucose Transport Proteins, Facilitative/*metabolism
Gout Suppressants/*pharmacology
JNK Mitogen-Activated Protein Kinases/*metabolism
Kidney Tubules, Proximal/*drug effects
NF-kappa B/*metabolism
Organic Anion Transporters/*metabolism
Organic Cation Transport Proteins/*metabolism
Phosphatidylinositol 3-Kinase/*metabolism
Polysaccharides/*pharmacology
Proto-Oncogene Proteins c-akt/*metabolism
Cell Line ; Gout Suppressants/isolation & purification ; Humans ; Kidney Tubules, Proximal/enzymology ; Polysaccharides/isolation & purification ; Signal Transduction ; Uric Acid/toxicity
Czasopismo naukowe
Tytuł :
MicroRNA-363-3p promotes apoptosis in response to cadmium-induced renal injury by down-regulating phosphoinositide 3-kinase expression.
Autorzy :
Chen J; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510310, Guangdong, China.
Lai W; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510310, Guangdong, China; Department of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510310, Guangdong, China.
Deng Y; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Liu M; Dongguan Maternal and Child Healthcare Hospital, Dongguan, 523700, Guangdong, China.
Dong M; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510310, Guangdong, China.
Liu Z; Huizhou Hospital for Occupational Disease Prevention and Treatment, Huizhou, 516008, Guangdong, China.
Wang T; Huizhou Hospital for Occupational Disease Prevention and Treatment, Huizhou, 516008, Guangdong, China.
Li X; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510310, Guangdong, China.
Zhao Z; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510310, Guangdong, China.
Yin X; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510310, Guangdong, China.
Yang J; School of Public Health, Guangzhou Medical University, Guangzhou, 511436, Guangdong, China.
Yu R; Department of Occupational and Environmental Health, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510310, Guangdong, China.
Liu L; Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510310, Guangdong, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jul 01; Vol. 345, pp. 12-23. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cadmium/*adverse effects
Kidney Diseases/*chemically induced
Kidney Tubules, Proximal/*drug effects
MicroRNAs/*metabolism
Occupational Exposure/*adverse effects
Phosphatidylinositol 3-Kinase/*metabolism
Adult ; Animals ; Case-Control Studies ; Cell Line ; Cell Proliferation/drug effects ; Down-Regulation ; Female ; Gene Expression Regulation, Enzymologic ; Humans ; Kidney Diseases/enzymology ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Kidney Tubules, Proximal/enzymology ; Kidney Tubules, Proximal/pathology ; Male ; MicroRNAs/genetics ; Middle Aged ; Occupational Health ; Phosphatidylinositol 3-Kinase/genetics ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
Modulation of Tubular pH by Acetazolamide in a Ca Transport Deficient Mice Facilitates Calcium Nephrolithiasis.
Autorzy :
Awuah Boadi E; Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
Shin S; Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
Yeroushalmi S; Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.; Division of Renal Diseases & Hypertension, Department of Medicine, The George Washington University, Washington, DC 20037, USA.
Choi BE; Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
Li P; Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
Bandyopadhyay BC; Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.; Division of Renal Diseases & Hypertension, Department of Medicine, The George Washington University, Washington, DC 20037, USA.; Department of Biomedical Engineering, The Catholic University of America, 620 Michigan Avenue NE, Washington, DC 20064, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 17; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Acetazolamide/*pharmacology
Calcium/*metabolism
Kidney Tubules, Proximal/*metabolism
Kidney Tubules, Proximal/*pathology
Nephrolithiasis/*metabolism
Nephrolithiasis/*pathology
Animals ; Biological Transport/drug effects ; Calcinosis/complications ; Endoplasmic Reticulum Stress/drug effects ; Fibrosis ; Hydrogen-Ion Concentration ; Inflammation/pathology ; Kidney Tubules, Proximal/drug effects ; Mice ; Nephrolithiasis/urine ; Oxidative Stress/drug effects ; TRPC Cation Channels/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Danegaptide Prevents TGFβ1-Induced Damage in Human Proximal Tubule Epithelial Cells of the Kidney.
Autorzy :
Squires PE; School of Life Sciences, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7DL, UK.
Price GW; School of Life Sciences, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7DL, UK.
Mouritzen U; Ciana Therapeutics, Ved Hegnet 2, 2960 Rungsted Kyst, Copenhagen, Denmark.
Potter JA; School of Life Sciences, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7DL, UK.
Williams BM; School of Life Sciences, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7DL, UK.
Hills CE; School of Life Sciences, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7DL, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 10; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial Cells*/metabolism
Epithelial Cells*/pathology
Kidney Tubules, Proximal*/injuries
Kidney Tubules, Proximal*/metabolism
Kidney Tubules, Proximal*/pathology
Renal Insufficiency, Chronic*/drug therapy
Renal Insufficiency, Chronic*/metabolism
Renal Insufficiency, Chronic*/pathology
Dipeptides/*pharmacology
Transforming Growth Factor beta1/*metabolism
Cell Line ; Humans
Czasopismo naukowe
Tytuł :
Activation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats.
Autorzy :
Gohar EY; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Almutlaq RN; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Daugherty EM; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Butt MK; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Jin C; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Pollock JS; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Pollock DM; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
De Miguel C; Cardio-Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2021 Mar 01; Vol. 320 (3), pp. R297-R306. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Albuminuria/*prevention & control
Cyclopentanes/*pharmacology
Kidney Diseases/*prevention & control
Kidney Glomerulus/*drug effects
Kidney Tubules, Proximal/*drug effects
Quinolines/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Albuminuria/etiology ; Albuminuria/metabolism ; Albuminuria/pathology ; Animals ; Arterial Pressure ; Cell Adhesion Molecules/metabolism ; Disease Models, Animal ; Female ; Hypertension/etiology ; Hypertension/physiopathology ; Kidney Diseases/etiology ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/pathology ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Rats, Inbred Dahl ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Sodium Chloride, Dietary
Czasopismo naukowe
Tytuł :
Circular RNA circ_0068,888 protects against lipopolysaccharide-induced HK-2 cell injury via sponging microRNA-21-5p.
Autorzy :
Wei W; Department of Intensive Care Unit, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China. Electronic address: .
Yao Y; Department of General Internal Medicine, Harbin Red Cross Center Hospital, Harbin, 150080, People's Republic of China.
Bi H; Department of Intensive Care Unit, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Xu W; Department of Intensive Care Unit, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Gao Y; Department of Intensive Care Unit, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Feb 12; Vol. 540, pp. 1-7. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Kidney Tubules, Proximal/*metabolism
Lipopolysaccharides/*immunology
MicroRNAs/*genetics
RNA, Circular/*genetics
Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Base Sequence ; Cell Line ; Cell Survival/genetics ; Humans ; Inflammation/genetics ; Kidney Tubules, Proximal/cytology ; Kidney Tubules, Proximal/immunology ; Kidney Tubules, Proximal/pathology ; NF-kappa B/metabolism ; Oxidative Stress/genetics
Czasopismo naukowe
Tytuł :
Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation.
Autorzy :
Xie YH; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.
Xiao Y; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.
Huang Q; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Hu XF; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Gong ZC; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address: .
Du J; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Feb 05; Vol. 892, pp. 173755. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Adipokines/*metabolism
Collagen/*metabolism
Fatty Acids/*metabolism
Kidney Diseases/*enzymology
Kidney Tubules, Proximal/*enzymology
Acyl-CoA Oxidase/genetics ; Acyl-CoA Oxidase/metabolism ; Adipokines/genetics ; Animals ; Carnitine O-Palmitoyltransferase/genetics ; Carnitine O-Palmitoyltransferase/metabolism ; Cell Line ; Collagen/genetics ; Disease Models, Animal ; Fibrosis ; Humans ; Kidney Diseases/etiology ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/pathology ; Male ; Mice ; Oxidation-Reduction ; Phosphorylation ; Signal Transduction ; Transforming Growth Factor beta1/pharmacology ; Ureteral Obstruction/complications
Czasopismo naukowe
Tytuł :
Predicting changes in renal metabolism after compound exposure with a genome-scale metabolic model.
Autorzy :
Rawls KD; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Dougherty BV; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Vinnakota KC; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD 21702, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD 20817, USA.
Pannala VR; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD 21702, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD 20817, USA.
Wallqvist A; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD 21702, USA.
Kolling GL; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA.
Papin JA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA; Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA; Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Feb 01; Vol. 412, pp. 115390. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Energy Metabolism/*drug effects
Epithelial Cells/*drug effects
Kidney Diseases/*chemically induced
Kidney Tubules, Proximal/*drug effects
Metabolome/*drug effects
Transcriptome/*drug effects
Acetaminophen/toxicity ; Animals ; Cells, Cultured ; Databases, Genetic ; Energy Metabolism/genetics ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Gene Expression Profiling ; Gene Regulatory Networks ; Gentamicins/toxicity ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Metabolome/genetics ; Metabolomics ; Polychlorinated Dibenzodioxins/toxicity ; Rats, Sprague-Dawley ; Trichloroethylene/toxicity
Czasopismo naukowe
Tytuł :
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Autorzy :
Unterschemmann K; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
Ehrmann A; Drug Discovery Sciences, Bayer Pharmaceuticals, Wuppertal, Germany.
Herzig I; Drug Discovery Sciences, Bayer Pharmaceuticals, Wuppertal, Germany.
Andreevski AL; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
Lustig K; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
Schmeck C; Drug Discovery Sciences, Bayer Pharmaceuticals, Wuppertal, Germany.
Eitner F; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
Grundmann M; Research and Early Development, Bayer Pharmaceuticals, Wuppertal, Germany.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Jan 01; Vol. 320 (1), pp. F61-F73. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*prevention & control
Amidohydrolases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Kidney Tubules, Proximal/*drug effects
Nephritis, Hereditary/*prevention & control
Oxidative Stress/*drug effects
Renal Insufficiency, Chronic/*prevention & control
Reperfusion Injury/*prevention & control
Acute Kidney Injury/enzymology ; Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Amidohydrolases/genetics ; Amidohydrolases/metabolism ; Animals ; Apoptosis/drug effects ; Autoantigens/genetics ; Autoantigens/metabolism ; Cell Line ; Collagen Type IV/genetics ; Collagen Type IV/metabolism ; Disease Models, Animal ; Enzyme Inhibitors/pharmacokinetics ; Fibrosis ; GPI-Linked Proteins/antagonists & inhibitors ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Humans ; Kidney Tubules, Proximal/enzymology ; Kidney Tubules, Proximal/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Nephritis, Hereditary/enzymology ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/pathology ; Renal Insufficiency, Chronic/enzymology ; Renal Insufficiency, Chronic/genetics ; Renal Insufficiency, Chronic/pathology ; Reperfusion Injury/enzymology ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology
Czasopismo naukowe
Tytuł :
Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells.
Autorzy :
Lee HY; Department of Anesthesiology and Pain Medicine, South Korea.
Oh SH; School of Medicine, Chosun University, 309 Pilmundaero, Dong-gu, Gwangju, 61452, South Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 01; Vol. 534, pp. 128-133. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Cadmium/*toxicity
Kidney Tubules, Proximal/*cytology
Tumor Suppressor Protein p53/*metabolism
Apoptosis/physiology ; Autophagy/physiology ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Cell Line ; Epithelial Cells ; Humans ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Membrane Proteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; RNA Interference ; Tumor Suppressor Protein p53/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Protective effect of carnosine on hydrogen peroxide-induced oxidative stress in human kidney tubular epithelial cells.
Autorzy :
Cao Y; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China.
Xu J; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China.
Cui D; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China.
Liu L; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China.
Zhang S; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China.
Shen B; School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
Wu Y; Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China. Electronic address: .
Zhang Q; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 01; Vol. 534, pp. 576-582. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carnosine/*pharmacology
Kidney Tubules, Proximal/*drug effects
Kidney Tubules, Proximal/*metabolism
Oxidative Stress/*drug effects
Apoptosis/drug effects ; Cell Line ; Cell Survival/drug effects ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Humans ; Hydrogen Peroxide/toxicity ; Kidney Tubules, Proximal/pathology ; Membrane Potential, Mitochondrial/drug effects ; NADPH Oxidase 4/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor.
Autorzy :
Eleftheriadis T; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Pissas G; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Filippidis G; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Liakopoulos V; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Stefanidis I; Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Kidney Tubules, Proximal/*cytology
Oxygen/*adverse effects
Reactive Oxygen Species/*metabolism
Receptors, Aryl Hydrocarbon/*metabolism
Reperfusion Injury/*metabolism
Animals ; Azo Compounds/pharmacology ; Cell Hypoxia ; Cells, Cultured ; Cytochrome P-450 CYP1A1/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Ferroptosis ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Isoquinolines/pharmacology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Lipid Peroxidation ; Mice ; Models, Biological ; NF-E2-Related Factor 2/metabolism ; Oxygen/pharmacology ; Pyrazoles/pharmacology ; Reperfusion Injury/chemically induced ; alpha-Tocopherol/pharmacology
Czasopismo naukowe
Tytuł :
Putting the pressure on endocytosis in the kidney.
Autorzy :
Van Giel D; Laboratory of Ion Channel Research, TRP Research Platform Leuven, VIB Center for Brain and Disease Research, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium.
Vennekens R; Laboratory of Ion Channel Research, TRP Research Platform Leuven, VIB Center for Brain and Disease Research, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2021 Mar; Vol. 94, pp. 102338. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Kidney Tubules, Proximal*
TRPV Cation Channels*
Albumins ; Endocytosis
Czasopismo naukowe
Tytuł :
Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
Autorzy :
Geng H; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Lan R; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Liu Y; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Chen W; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Wu M; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Saikumar P; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Weinberg JM; Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Venkatachalam MA; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Mar 01; Vol. 320 (3), pp. F359-F374. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acute Kidney Injury/*metabolism
Cytokines/*metabolism
Kidney Tubules, Proximal/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Reperfusion Injury/*metabolism
Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Animals ; Cell Line ; Connective Tissue Growth Factor/metabolism ; Disease Models, Animal ; ErbB Receptors/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fibrosis ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Kidney Tubules, Proximal/pathology ; Lymphokines/metabolism ; Male ; Mice ; Phosphorylation ; Platelet-Derived Growth Factor/metabolism ; Rats, Sprague-Dawley ; Receptors, Lysophosphatidic Acid/genetics ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology ; Signal Transduction ; Transcription Factor AP-1/metabolism ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
Potential Protection Effect of ER Homeostasis of N -(2-Hydroxyethyl)adenosine Isolated from Cordyceps cicadae in Nonsteroidal Anti-Inflammatory Drug-Stimulated Human Proximal Tubular Cells.
Autorzy :
Chyau CC; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Wu HL; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Peng CC; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Huang SH; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
Chen CC; Grape King Biotechnology Center, Chung-Li City 320054, Taiwan.
Chen CH; Department of Nephrology, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Peng RY; Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 04; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Homeostasis*
Adenosine/*analogs & derivatives
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cordyceps/*chemistry
Endoplasmic Reticulum Stress/*drug effects
Kidney Tubules, Proximal/*drug effects
Protective Agents/*pharmacology
Adenosine/pharmacology ; Gene Expression Regulation ; Humans ; Kidney Tubules, Proximal/metabolism ; Oxidative Stress
SCR Organism :
Cordyceps cicadae
Czasopismo naukowe
Tytuł :
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation.
Autorzy :
Lawlor KT; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Vanslambrouck JM; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Higgins JW; Organovo, San Diego, CA, USA.
Chambon A; Organovo, San Diego, CA, USA.
Bishard K; Organovo, San Diego, CA, USA.
Arndt D; Organovo, San Diego, CA, USA.
Er PX; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Wilson SB; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Howden SE; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Tan KS; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Li F; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Hale LJ; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Shepherd B; Organovo, San Diego, CA, USA.
Pentoney S; Organovo, San Diego, CA, USA.
Presnell SC; Organovo, San Diego, CA, USA.
Chen AE; Organovo, San Diego, CA, USA.
Little MH; Murdoch Children's Research Institute, Melbourne, Victoria, Australia. .; Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia. .; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia. .
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Źródło :
Nature materials [Nat Mater] 2021 Feb; Vol. 20 (2), pp. 260-271. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bioprinting*
Kidney Tubules, Proximal/*metabolism
Organoids/*metabolism
Pluripotent Stem Cells/*metabolism
Humans ; Kidney Tubules, Proximal/cytology ; Organoids/cytology ; Pluripotent Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury.
Autorzy :
Hu Y; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Yang C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Department of Clinical Laboratory, the 4th Hospital of Harbin Medical University, Harbin, China.
Amorim T; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Maqbool M; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Lin J; Department of Medicine, University of California San Diego, La Jolla, California.
Li C; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.; College of Food Science and Technology, Agricultural University of Hebei, Baoding, Hebei, China.
Fang C; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.; Department of Clinical Laboratory, the 4th Hospital of Harbin Medical University, Harbin, China.
Xue L; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Department of Clinical Laboratory, the 4th Hospital of Harbin Medical University, Harbin, China.
Kwart A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Division of Hand Surgery, Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, New York.
Fang H; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Yin M; Image Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Janocha AJ; The Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Tsuchimoto D; Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Japan.
Nakabeppu Y; Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Japan.
Jiang X; Department of Clinical Laboratory, the 4th Hospital of Harbin Medical University, Harbin, China.
Mejia-Garcia A; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
Anwer F; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
Khouri J; Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
Qi X; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Zheng QY; Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio.
Yu JS; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
Yan S; Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, North Carolina.
LaFramboise T; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Anderson KC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Herlitz LC; Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
Munshi NC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; VA Boston Healthcare System, Boston, Massachusetts.
Lin J; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio. .
Zhao J; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. .
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Źródło :
Cancer research [Cancer Res] 2021 Feb 01; Vol. 81 (3), pp. 713-723. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Kidney Injury/*chemically induced
Antineoplastic Agents/*adverse effects
Cisplatin/*adverse effects
DNA-(Apurinic or Apyrimidinic Site) Lyase/*metabolism
Endonucleases/*metabolism
Kidney Tubules, Proximal/*drug effects
Multifunctional Enzymes/*metabolism
Myosin Heavy Chains/*metabolism
Acute Kidney Injury/prevention & control ; Animals ; Carboplatin/adverse effects ; DNA Damage ; DNA, Mitochondrial/drug effects ; DNA-(Apurinic or Apyrimidinic Site) Lyase/drug effects ; DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics ; Endonucleases/drug effects ; Endonucleases/genetics ; Hearing Loss, Sensorineural/chemically induced ; Humans ; Kidney Tubules, Proximal/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Diseases/genetics ; Multifunctional Enzymes/drug effects ; Multifunctional Enzymes/genetics ; Mutation ; Myosin Heavy Chains/genetics ; Nephritis/chemically induced ; Oxaliplatin/adverse effects ; Phenotype ; Thrombocytopenia/chemically induced ; Up-Regulation/drug effects
SCR Disease Name :
Macrothrombocytopenia progressive deafness
Czasopismo naukowe

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