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Tytuł:
PSEN1 His214Asn Mutation in a Korean Patient with Familial EOAD and the Importance of Histidine-Tryptophan Interactions in TM-4 Stability.
Autorzy:
Bagyinszky E; Department of Industrial and Environmental Engineering, Graduate School of Environment, Gachon University, Seongnam 13120, Republic of Korea.
Kim M; Department of Neurology, Seoul National University College of Medicine & Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
Park YH; Department of Neurology, Seoul National University College of Medicine & Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
An SSA; Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam 13120, Republic of Korea.
Kim S; Department of Neurology, Seoul National University College of Medicine & Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 21; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Case Reports
MeSH Terms:
Histidine*/genetics
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Humans ; Male ; Tryptophan ; Presenilin-1/genetics ; Amyloid Precursor Protein Secretases ; Mutation ; Amyloidogenic Proteins ; Cations ; Republic of Korea
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impacts of baseline biomarkers on cognitive trajectories in subjective cognitive decline: the CoSCo prospective cohort study.
Autorzy:
Hong YJ; Department of Neurology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
Ho S; Department of Neurology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
Jeong JH; Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, South Korea.
Park KH; Department of Neurology, Gachon University Gil Hospital, Incheon, South Korea.
Kim S; Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Wang MJ; Department of Neurology, Roa Neurology Clinic, Seongnam, South Korea.
Choi SH; Department of Neurology, Inha University School of Medicine, Incheon, South Korea.
Yang DW; Department of Neurology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea. .
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Corporate Authors:
CoSCo study group
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Aug 07; Vol. 15 (1), pp. 132. Date of Electronic Publication: 2023 Aug 07.
Typ publikacji:
Observational Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/pathology
Cognitive Dysfunction*/diagnostic imaging
Humans ; Middle Aged ; Amyloid beta-Peptides ; Longitudinal Studies ; Prospective Studies ; Positron-Emission Tomography ; Cognition ; Cohort Studies ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer's disease.
Autorzy:
Shim KH; Department of Bionano Technology, Gachon University, Seongnam-Si, Gyeonggi-Do, Republic of Korea.
Kang MJ; Department of Neurology, Veterans Health Service Medical Center, Veterans Medical Research Institute, Seoul, Republic of Korea.
Youn YC; Department of Neurology, Chung-Ang University Hospital, Seoul, Republic of Korea.
An SSA; Department of Bionano Technology, Gachon University, Seongnam-Si, Gyeonggi-Do, Republic of Korea. .
Kim S; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-Si, Gyeonggi-Do, Republic of Korea. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Dec 31; Vol. 14 (1), pp. 201. Date of Electronic Publication: 2022 Dec 31.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/pathology
Humans ; alpha-Synuclein/metabolism ; tau Proteins/metabolism ; Amyloid beta-Peptides ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prediction of amyloid PET positivity via machine learning algorithms trained with EDTA-based blood amyloid-β oligomerization data.
Autorzy:
Youn YC; Department of Neurology, Chung-Ang University College of Medicine, Seoul, 06973, Republic of Korea. .; Department of Medical Informatics, Chung-Ang University College of Medicine, Seoul, 06973, Republic of Korea. .
Kim HR; Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, 06973, Republic of Korea.
Shin HW; Department of Neurology, Chung-Ang University College of Medicine, Seoul, 06973, Republic of Korea.
Jeong HB; Department of Neurology, Chung-Ang University College of Medicine, Seoul, 06973, Republic of Korea.
Han SW; Department of Neurology, Chung-Ang University College of Medicine, Seoul, 06973, Republic of Korea.
Pyun JM; Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, 04401, Republic of Korea.
Ryoo N; Department of Neurology, The Catholic University of Korea Eunpyeong St. Mary's Hospital, Seoul, 03312, Republic of Korea.
Park YH; Department of Neurology, Seoul National University College of Medicine and Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeoggi-do, 13629, Republic of Korea.
Kim S; Department of Neurology, Seoul National University College of Medicine and Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeoggi-do, 13629, Republic of Korea. .
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Źródło:
BMC medical informatics and decision making [BMC Med Inform Decis Mak] 2022 Nov 07; Vol. 22 (1), pp. 286. Date of Electronic Publication: 2022 Nov 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Cognitive Dysfunction*/diagnosis
Humans ; Edetic Acid ; Amyloid beta-Peptides ; Positron-Emission Tomography ; Biomarkers ; Machine Learning ; Algorithms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer's Disease.
Autorzy:
Yang Y; Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan 31151, Korea.
Bagyinszky E; Graduate School of Environment Department of Industrial and Environmental Engineering, Gachon University, Seongnam 13120, Korea.
An SSA; Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam 13120, Korea.
Kim S; Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 01; Vol. 23 (21). Date of Electronic Publication: 2022 Nov 01.
Typ publikacji:
Case Reports
MeSH Terms:
Alzheimer Disease*/genetics
Neurodegenerative Diseases*
Humans ; Presenilin-2/genetics ; Mutation ; Asian People ; Presenilin-1/genetics ; Amyloid beta-Protein Precursor/genetics
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions.
Autorzy:
Kang BW; Pharmacology Team, AriBio Co., Ltd, 56 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea.
Kim F; Pharmacology Team, AriBio Co., Ltd, 56 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea.
Cho JY; Department of Exercise Biochemistry, Korea National Sport University, Seoul, 05541, Republic of Korea.
Kim S; Department of Neurology, Seoul National University College of Medicine & Seoul National University Bundang Hospital, 82 Gumi-ro 173-beongil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.
Rhee J; Pharmacology Team, AriBio Co., Ltd, 56 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea. .
Choung JJ; Pharmacology Team, AriBio Co., Ltd, 56 Dongpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13535, Republic of Korea. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Jul 08; Vol. 14 (1), pp. 92. Date of Electronic Publication: 2022 Jul 08.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Neuroblastoma*
Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/toxicity ; Animals ; Cyclic GMP ; Disease Models, Animal ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Mice ; Phosphodiesterase 5 Inhibitors/pharmacology ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Phosphorylation ; Pyrimidinones ; Sulfonamides ; beta Catenin/metabolism ; beta Catenin/therapeutic use ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease.
Autorzy:
Park YH; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea.
Pyun JM; Department of Neurology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Republic of Korea.
Hodges A; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Jang JW; Department of Neurology, Kangwon National University Hospital, Chuncheon, Republic of Korea.
Bice PJ; Department of Radiology and Imaging Sciences, and the Indiana Alzheimer Disease Center, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
Kim S; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea.
Saykin AJ; Department of Radiology and Imaging Sciences, and the Indiana Alzheimer Disease Center, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Nho K; Department of Radiology and Imaging Sciences, and the Indiana Alzheimer Disease Center, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA. .; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA. .
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Corporate Authors:
AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Nov 03; Vol. 13 (1), pp. 183. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Amyloid beta-Protein Precursor*/metabolism
Endopeptidases*/genetics
Membrane Proteins*/genetics
Atrophy/pathology ; Brain/diagnostic imaging ; Brain/pathology ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment.
Autorzy:
Pyun JM; Department of Neurology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Republic of Korea.
Park YH; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea. .
Lee KJ; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea.
Kim S; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea.
Saykin AJ; Department of Radiology and Imaging Sciences, and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Nho K; Department of Radiology and Imaging Sciences, and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. .; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA. .
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Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Translational neurodegeneration [Transl Neurodegener] 2021 Aug 31; Vol. 10 (1), pp. 32. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Disease Progression*
Alzheimer Disease/*genetics
Apolipoprotein E4/*genetics
Cognitive Dysfunction/*genetics
Multifactorial Inheritance/*genetics
Aged ; Alzheimer Disease/blood ; Alzheimer Disease/diagnostic imaging ; Apolipoprotein E4/blood ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/diagnostic imaging ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging/trends ; Male ; Polymorphism, Single Nucleotide/genetics ; Predictive Value of Tests ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association between statin use and Alzheimer's disease with dose response relationship.
Autorzy:
Jeong SM; Department of Family Medicine, Samsung Medical Center, Supportive Care Center, Samsung Comprehensive Cancer Hospital, 81 Irwon-Ro, Gangnam-gu, Seoul, Republic of Korea.
Shin DW; Department of Family Medicine, Samsung Medical Center, Supportive Care Center, Samsung Comprehensive Cancer Hospital, 81 Irwon-Ro, Gangnam-gu, Seoul, Republic of Korea. .; Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea. .
Yoo TG; Department of Family Medicine, Hongseong Medical Center, Hongseong, Republic of Korea.
Cho MH; Samsung C&T Medical Clinic, Kangbuk Samsung Hospital, Seoul, Republic of Korea.
Jang W; Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea.
Lee J; Department of Economics & Center for Economic & Social Research, Los Angeles, & RANC Corporation, University of Southern California, Santa Monica, CA, USA.
Kim S; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 27; Vol. 11 (1), pp. 15280. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*drug therapy
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
Dose-Response Relationship, Drug ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Proportional Hazards Models ; Republic of Korea ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status.
Autorzy:
Babapour Mofrad R; Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands. .; Alzheimer Center & Department of Neurology Amsterdam, Neuroscience Campus Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. .
Scheltens P; Alzheimer Center & Department of Neurology Amsterdam, Neuroscience Campus Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Kim S; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea.
Kang S; Department of Research and Development, PeopleBio Inc, Seongnam-si, Republic of Korea.
Youn YC; Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
An SSA; Department of Bionanotechnology, Gachon University, Incheon, Republic of Korea.
Tomassen J; Alzheimer Center & Department of Neurology Amsterdam, Neuroscience Campus Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
van Berckel BNM; Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Visser PJ; Alzheimer Center & Department of Neurology Amsterdam, Neuroscience Campus Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
van der Flier WM; Alzheimer Center & Department of Neurology Amsterdam, Neuroscience Campus Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Epidemiology and Biostatistics, Amsterdam UMC, VU University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Teunissen CE; Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Jul 26; Vol. 13 (1), pp. 133. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*
Amyloidosis*
Aged ; Amyloid ; Amyloid beta-Peptides ; Biomarkers ; Female ; Humans ; Male ; Middle Aged ; Peptide Fragments ; Positron-Emission Tomography ; tau Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Change in cognitive function according to cholinesterase inhibitor use and amyloid PET positivity in patients with mild cognitive impairment.
Autorzy:
Pyun JM; Department of Neurology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.
Ryoo N; Department of Neurology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.
Park YH; Department of Neurology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.
Kim S; Department of Neurology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Jan 05; Vol. 13 (1), pp. 10. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji:
Journal Article; Observational Study
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/drug therapy
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/drug therapy
Cholinesterase Inhibitors/therapeutic use ; Cognition ; Disease Progression ; Humans ; Positron-Emission Tomography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer's disease as an indicator of tau phosphorylation.
Autorzy:
Shim KH; Department of Neurology, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Kang MJ; Department of Neurology, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Suh JW; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, Republic of Korea.
Pyun JM; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, Republic of Korea.
Ryoo N; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, Republic of Korea.
Park YH; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, Republic of Korea.
Youn YC; Department of Neurology, Chung-Ang University Hospital, Seoul, Republic of Korea.
Jang JW; Department of Neurology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chouncheon, South Korea.
Jeong JH; Department of Neurology, Ewha Womans University Mokdong HospitalEwha Womans University, Seoul, Republic of Korea.
Park KW; Department of Neurology, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, Republic of Korea.
Choi SH; Department of Neurology, Inha University School of Medicine, Incheon, Republic of Korea.
Suk K; Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
Lee HW; Department of Neurology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
Ko PW; Department of Neurology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
Lee CN; Department of Neurology, Korea University Medicine, Seoul, Republic of Korea.
Lim TS; Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
An SSA; Department of Bionano Technology, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea. .
Kim S; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, Republic of Korea. .
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Corporate Authors:
Alzheimer’s Disease All Markers (ADAM) Research group
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2020 Jul 13; Vol. 12 (1), pp. 83. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/diagnosis
alpha-Synuclein*
Amyloid beta-Peptides ; Biomarkers ; Cross-Sectional Studies ; Humans ; Peptide Fragments ; Phosphorylation ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer's disease.
Autorzy:
Meng X; Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital), Beijing, 100191, China.; National Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, 100191, China.; State Key Laboratory of Membrane Biology, School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
Li T; Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital), Beijing, 100191, China.; National Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, 100191, China.
Wang X; Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital), Beijing, 100191, China.; National Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, 100191, China.
Lv X; Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital), Beijing, 100191, China.; National Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, 100191, China.
Sun Z; Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital), Beijing, 100191, China.
Zhang J; Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital), Beijing, 100191, China.; State Key Laboratory of Membrane Biology, School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
Su F; State Key Laboratory of Membrane Biology, School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
Kang S; Department of Research and Development, PeopleBio, Inc., Seongnam-si, Gyeonggi-do, Republic of Korea.
Kim S; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82, Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.
An SSA; Department of Bionano Technology, Gachon University, Sujeong-gu, Seongnam-si, Gyeonggi-do, 461-701, Republic of Korea.
Yu X; Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital), Beijing, 100191, China. .; National Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, 100191, China. .
Zhang C; State Key Laboratory of Membrane Biology, School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China. .
Wang H; Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital), Beijing, 100191, China. huali_.; National Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, 100191, China. huali_.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2019 Oct 25; Vol. 11 (1), pp. 89. Date of Electronic Publication: 2019 Oct 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Memory, Episodic*
Alzheimer Disease/*blood
Amyloid beta-Peptides/*blood
Memory Disorders/*blood
Aged ; Aged, 80 and over ; Alzheimer Disease/psychology ; Biomarkers/blood ; Cognition/physiology ; Female ; Humans ; Male ; Memory Disorders/psychology ; Middle Aged ; Neuropsychological Tests
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
APP, PSEN1 , and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease.
Autorzy:
Giau VV; Graduate School of Environment Department of Industrial and Environmental Engineering, Gachon University, 1342 Sungnam-daero, Sujung-gu, Seongnam-si, Gyeonggi-do 461-701, Korea. .
Bagyinszky E; Graduate School of Environment Department of Industrial and Environmental Engineering, Gachon University, 1342 Sungnam-daero, Sujung-gu, Seongnam-si, Gyeonggi-do 461-701, Korea. .
Youn YC; Department of Neurology, College of Medicine, Chung-Ang University, Seoul 06973, Korea. .
An SSA; Department of BionanoTechnology, Gachon Medical Research Institute, Gachon University, 1342 Sungnam-daero, Sujung-gu, Seongnam-si, Gyeonggi-do 461-701, Korea. .
Kim S; Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, 300 Gumidong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Sep 25; Vol. 20 (19). Date of Electronic Publication: 2019 Sep 25.
Typ publikacji:
Journal Article
MeSH Terms:
Mutation*
Alzheimer Disease/*epidemiology
Alzheimer Disease/*genetics
Amyloid beta-Protein Precursor/*genetics
Asian People/*genetics
Presenilin-1/*genetics
Presenilin-2/*genetics
Adult ; Age of Onset ; Aged ; Alleles ; Amino Acid Substitution ; Amyloid beta-Protein Precursor/chemistry ; Asia/epidemiology ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Population Surveillance ; Presenilin-1/chemistry ; Presenilin-2/chemistry ; Protein Domains
Czasopismo naukowe
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Tytuł:
Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer's disease.
Autorzy:
Youn YC; Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Kang S; Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea.
Suh J; Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
Park YH; Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
Kang MJ; Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.; Department of Neurology, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Pyun JM; Department of Neurology, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Choi SH; Department of Neurology, Inha University School of Medicine, Incheon, Republic of Korea.
Jeong JH; Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.
Park KW; Department of Neurology, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, Republic of Korea.
Lee HW; Department of Neurology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
An SSA; Department of Bionanotechnology, Gachon University, Incheon, Republic of Korea.
Dominguez JC; Institute for Neurosciences, St. Luke`s Medical Center, Quezon City, Philippines.
Kim S; Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2019 May 10; Vol. 11 (1), pp. 40. Date of Electronic Publication: 2019 May 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*blood
Alzheimer Disease/*pathology
Amyloid beta-Peptides/*blood
Brain/*pathology
Aged ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/pathology ; Female ; Gray Matter/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; White Matter/pathology
Czasopismo naukowe
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Tytuł:
Safety and tolerability of donepezil 23 mg with or without intermediate dose titration in patients with Alzheimer's disease taking donepezil 10 mg: a multicenter, randomized, open-label, parallel-design, three-arm, prospective trial.
Autorzy:
Hong YJ; Neurology, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu, South Korea.; Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Han HJ; Neurology, Dementia and Neurocognitive Center, Hanyang University College of Medicine, Myongji Hospital, Ilsan, South Korea.
Youn YC; Neurology, Chung-Ang University Hospital, Seoul, South Korea.
Park KW; Neurology, Dong-A University College of Medicine, Busan, South Korea.
Yang DW; Neurology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea.
Kim S; Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
Kim HJ; Preventive Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Kim JE; Neurology, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, South Korea.
Lee JH; Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. .
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Corporate Authors:
ODESA study (Optimal Dose Escalation Strategy to Successful Achievement of High Dose Donepezil 23 mg)
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2019 May 01; Vol. 11 (1), pp. 37. Date of Electronic Publication: 2019 May 01.
Typ publikacji:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*adverse effects
Donepezil/*adverse effects
Aged ; Aged, 80 and over ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Prospective Studies ; Treatment Outcome
Czasopismo naukowe
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Tytuł:
Analysis of 50 Neurodegenerative Genes in Clinically Diagnosed Early-Onset Alzheimer's Disease.
Autorzy:
Giau VV; Department of Bionano Technology, Gachon University, Sungnam 13120, Korea. .
Senanarong V; Department of Medicine, Mahidol University, Bangkok 10700, Thailand. .
Bagyinszky E; Department of Bionano Technology, Gachon University, Sungnam 13120, Korea. .
An SSA; Department of Bionano Technology, Gachon University, Sungnam 13120, Korea. .
Kim S; Department of Neurology, Seoul National University College of Medicine and Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Sungnam 13620, Korea. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Mar 26; Vol. 20 (6). Date of Electronic Publication: 2019 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*genetics
Adult ; Age of Onset ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/genetics ; Female ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Male ; Membrane Glycoproteins/genetics ; Middle Aged ; Mutation, Missense ; Presenilin-1/genetics ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Receptors, Immunologic/genetics ; tau Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PSEN1 p.Thr116Ile Variant in Two Korean Families with Young Onset Alzheimer's Disease.
Autorzy:
Bagyinszky E; Department of Bionano Technology, Gachon University, Sungnam 13120, Korea. .
Lee HM; Department of Neurology, Korea University Guro Hosipital, Korea University, Seoul 08308, Korea. .
Van Giau V; Department of Bionano Technology, Gachon University, Sungnam 13120, Korea. .
Koh SB; Department of Neurology, Korea University Guro Hosipital, Korea University, Seoul 08308, Korea. .
Jeong JH; Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University, Seoul 07985, Korea. .
An SSA; Department of Bionano Technology, Gachon University, Sungnam 13120, Korea. .
Kim S; Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Sungnam 13620, Korea. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Sep 02; Vol. 19 (9). Date of Electronic Publication: 2018 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Amino Acid Substitution*
Alzheimer Disease/*genetics
Presenilin-1/*chemistry
Presenilin-1/*genetics
Adult ; Age of Onset ; Female ; Genetic Predisposition to Disease ; Humans ; Hydrogen Bonding ; Isoleucine/genetics ; Male ; Middle Aged ; Models, Molecular ; Pedigree ; Protein Structure, Secondary ; Republic of Korea ; Sequence Analysis, DNA ; Structural Homology, Protein ; Threonine/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A 'Comprehensive Visual Rating Scale' for predicting progression to dementia in patients with mild cognitive impairment.
Autorzy:
Jang JW; Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Republic of Korea.
Park JH; Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Republic of Korea.
Kim S; Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Republic of Korea.
Park YH; Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Pyun JM; Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Lim JS; Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea.
Kim Y; Department of Biomedical Engineering, Seoul National University Hospital, Seoul, Republic of Korea.
Youn YC; Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Kim S; Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.
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Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
PloS one [PLoS One] 2018 Aug 20; Vol. 13 (8), pp. e0201852. Date of Electronic Publication: 2018 Aug 20 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Alzheimer Disease/*diagnostic imaging
Brain/*diagnostic imaging
Cognitive Dysfunction/*diagnostic imaging
Aged ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Apolipoproteins E/genetics ; Atrophy ; Brain/metabolism ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/genetics ; Cerebrovascular Disorders/metabolism ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/metabolism ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Image Processing, Computer-Assisted ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Positron-Emission Tomography ; Prognosis ; Time Factors
Czasopismo naukowe
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Tytuł:
Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer's disease.
Autorzy:
Wang MJ; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82, Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.
Yi S; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82, Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.
Han JY; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82, Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.
Park SY; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82, Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.
Jang JW; Department of Neurology, Kangwon National University Hospital, Chuncheon-si, Republic of Korea.
Chun IK; Department of Nuclear Medicine, Kangwon National University Hospital and School of Medicine, Kangwon National University, Chuncheon-si, Republic of Korea.
Kim SE; Department of Nuclear Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, Republic of Korea.
Lee BS; Department of Research and Development, PeopleBio, Inc, Seongnam-si, Republic of Korea.
Kim GJ; Department of Research and Development, PeopleBio, Inc, Seongnam-si, Republic of Korea.
Yu JS; Department of Research and Development, PeopleBio, Inc, Seongnam-si, Republic of Korea.
Lim K; Department of Research and Development, PeopleBio, Inc, Seongnam-si, Republic of Korea.
Kang SM; Department of Research and Development, PeopleBio, Inc, Seongnam-si, Republic of Korea.
Park YH; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82, Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.
Youn YC; Department of Neurology, Chung-Ang University Hospital, Seoul, Republic of Korea.
An SSA; Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, 1342, Sengnamdaero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 461-701, Republic of Korea. .
Kim S; Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82, Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2017 Dec 15; Vol. 9 (1), pp. 98. Date of Electronic Publication: 2017 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*blood
Amyloid beta-Peptides/*blood
Peptide Fragments/*blood
Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/cerebrospinal fluid ; Aniline Compounds ; Benzothiazoles/pharmacokinetics ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Peptide Fragments/cerebrospinal fluid ; Positron-Emission Tomography ; Psychiatric Status Rating Scales ; Republic of Korea ; Retrospective Studies ; Thiazoles ; tau Proteins/blood ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
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Wyświetlanie 1-20 z 45

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