Autor: "Kipp ZA" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease.
Autorzy:: Bates EA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Kipp ZA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Martinez GJ; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Badmus OO; Department of Physiology & Biophysics, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Soundarapandian MM; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Foster D; Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.
Xu M; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Creeden JF; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Greer JR; Department of Physiology & Biophysics, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Morris AJ; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Stec DE; Department of Physiology & Biophysics, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Hinds TD Jr; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.; Barnstable Brown Diabetes Center, University of Kentucky, Lexington, KY 40508, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40508, USA.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2023 Jan 29; Vol. 13 (2). Date of Electronic Publication: 2023 Jan 29.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Non-alcoholic Fatty Liver Disease*/metabolism
Insulin Resistance*/genetics
Mice ; Animals ; Male ; Urobilin/metabolism ; Bilirubin ; Mice, Inbred C57BL ; Liver/metabolism ; Signal Transduction ; Lipids

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Skocz do pozycji: 2.

Tytuł:: Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.
Autorzy:: Hinds TD Jr; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.; Barnstable Brown Diabetes Center, University of Kentucky, Lexington, KY 40508, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40508, USA.
Kipp ZA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Xu M; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.
Yiannikouris FB; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40508, USA.; Barnstable Brown Diabetes Center, University of Kentucky, Lexington, KY 40508, USA.
Morris AJ; Division of Cardiovascular Medicine, College of Medicine, University of Kentucky, Lexington, KY 40508, USA.; Lexington Veterans Affairs Medical Center, Lexington, KY 40508, USA.
Stec DF; Small Molecule NMR Facility Core, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA.
Wahli W; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, Singapore 308232, Singapore.; Toxalim Research Center in Food Toxicology (UMR 1331), INRAE, ENVT, INP-PURPAN, UPS, Université de Toulouse, F-31300 Toulouse, France.; Center for Integrative Genomics, Université de Lausanne, Le Génopode, CH-1015 Lausanne, Switzerland.
Stec DE; Department of Physiology & Biophysics, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Dec 21; Vol. 11 (1). Date of Electronic Publication: 2021 Dec 21.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Cell Polarity*
Lipogenesis*
Adipose Tissue, White/*metabolism
Inflammation/*pathology
Macrophages/*pathology
PPAR alpha/*deficiency
Protein Serine-Threonine Kinases/*metabolism
Sterol Regulatory Element Binding Protein 1/*metabolism
Adipocytes/metabolism ; Adiposity ; Amino Acids/blood ; Animals ; Biomarkers/metabolism ; Body Weight ; Cholesterol/blood ; Diet, High-Fat ; Female ; Inflammation/blood ; Lipidomics ; Macrophages/metabolism ; Male ; Metabolome ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Biological ; Organ Size ; Organ Specificity ; PPAR alpha/metabolism ; Signal Transduction ; Mice

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Skocz do pozycji: 3.

Tytuł:: Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha).
Autorzy:: Gordon DM; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Hong SH; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Kipp ZA; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, 760 Press Avenue, Healthy Kentucky Research Building, Lexington, KY 40508, USA.
Hinds TD Jr; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, 760 Press Avenue, Healthy Kentucky Research Building, Lexington, KY 40508, USA.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 May 17; Vol. 26 (10). Date of Electronic Publication: 2021 May 17.
Typ publikacji:: Journal Article
MeSH Terms:: Bilirubin/*metabolism
PPAR alpha/*metabolism
Bilirubin/physiology ; Binding, Competitive ; HEK293 Cells ; Humans ; Ligands ; PPAR alpha/physiology ; Protein Binding/physiology

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