A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
Autorzy :
Routhu NK; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Cheedarla N; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Gangadhara S; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Bollimpelli VS; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Boddapati AK; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Shiferaw A; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Rahman SA; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Sahoo A; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Edara VV; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA. Lai L; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA. Floyd K; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA. Wang S; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Fischinger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Atyeo C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Shin SA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Gumber S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. KirejczykS; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. Upadhyay AA; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Pellegrini K; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Montefiori D; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA. Shi PY; Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA. Menachery VD; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, USA. Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Vanderford TH; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Bosinger SE; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Suthar MS; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA. Amara RR; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 Feb 04. Date of Electronic Publication: 2021 Feb 04.
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Autorzy :
Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Boddapati AK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Viox EG; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Starke CE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA. Upadhyay AA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Nekorchuk M; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA. Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA. Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Tharp GK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Pellegrini KL; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. KirejczykS; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Zandi K; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA. Tao S; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA. Horton TR; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Beagle EN; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Mahar EA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Lee MYH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Delmas OM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Cooney KA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Sayegh MN; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Wang L; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Filev PD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA 30322, USA. Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA. Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Waggoner J; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Piantadosi A; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Al-Shakhshir H; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Schinazi RF; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: . Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: . Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Jan 21; Vol. 184 (2), pp. 460-475.e21. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Urogenital Lesions in Nonhuman Primates at 2 National Primate Research Centers.
Autorzy :
KirejczykS; 1371Emory University, Atlanta, GA, USA. Pinelli C; 1371Emory University, Atlanta, GA, USA.; Current address: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Ave South MCN AA-6206, Nashville, TN 37232, USA. Gonzalez O; 7075Texas Biomedical Research Institute, San Antonio, TX, USA. Kumar S; 7075Texas Biomedical Research Institute, San Antonio, TX, USA. Dick E Jr; 7075Texas Biomedical Research Institute, San Antonio, TX, USA. Gumber S; 1371Emory University, Atlanta, GA, USA.
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Źródło :
Veterinary pathology [Vet Pathol] 2021 Jan; Vol. 58 (1), pp. 147-160. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Autorzy :
Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Boddapati AK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Viox EG; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Starke CE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA. Upadhyay AA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA. Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Tharp GK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Pellegrini KL; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. KirejczykS; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Zandi K; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Tao S; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Horton TR; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Beagle EN; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Mahar EA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Lee MY; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Delmas OM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Cooney KA; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Sayegh MN; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Wang L; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA. Filev PD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, Georgia, USA. Waggoner J; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Piantadosi A; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Al-Shakhshir H; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA. Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Schinazi RF; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA. Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA. Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.
Surgical resection of a left auricular aneurysm in a dog.
Autorzy :
Rosselli D; Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, GA 30602, United States. Electronic address: . Schmiedt C; Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, GA 30602, United States. KirejczykS; Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, GA 30602, United States. Sakamoto K; Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, GA 30602, United States. Sinkin A; Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, GA 30602, United States. Rapoport G; Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, GA 30602, United States.
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