Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design.
Autorzy:
Amcheslavsky A; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Wallace AL; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Ejemel M; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Li Q; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. McMahon CT; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Stoppato M; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Giuntini S; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Schiller ZA; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Pondish JR; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Toomey JR; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Schneider RM; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Meisinger J; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Heukers R; QVQ Holdings BV, Utrecht, The Netherlands. Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Barry EM; Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA. Pierce BG; University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. KlempnerMS; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Cavacini LA; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. Wang Y; MassBiologics, University of Massachusetts Medical School, 460 Walk Hill Road, Boston, MA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Feb 02; Vol. 11 (1), pp. 2751. Date of Electronic Publication: 2021 Feb 02.
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