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Tytuł:
Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation.
Autorzy:
Gounaris E; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Heiferman MJ; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Heiferman JR; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Shrivastav M; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Vitello D; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Blatner NR; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Knab LM; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Phillips JD; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Cheon EC; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Grippo PJ; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Khazaie K; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Munshi HG; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Bentrem DJ; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Mar 06; Vol. 10 (3), pp. e0121402. Date of Electronic Publication: 2015 Mar 06 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Hydroxyurea/*analogs & derivatives
Inflammatory Bowel Diseases/*prevention & control
Intestinal Polyposis/*prevention & control
Lipoxygenase Inhibitors/*pharmacology
Animals ; Colonic Neoplasms/pathology ; Colonic Neoplasms/prevention & control ; Disease Models, Animal ; Female ; Humans ; Hydroxyurea/pharmacology ; Inflammatory Bowel Diseases/pathology ; Intestinal Polyposis/pathology ; Male ; Mice ; Mice, Mutant Strains
Czasopismo naukowe
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