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Tytuł :
Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice.
Autorzy :
Määttä J; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research (J. Määttä, R.S., V.I., J. Myllyharju, E.Y.D., P.K.), University of Oulu, Finland.
Serpi R; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research (J. Määttä, R.S., V.I., J. Myllyharju, E.Y.D., P.K.), University of Oulu, Finland.
Hörkkö S; Institute of Biomedicine (S.H.), University of Oulu, Finland.
Izzi V; Faculty of Medicine (V.I.), University of Oulu, Finland.; Finnish Cancer Institute, Helsinki, Finland (V.I.).
Myllyharju J; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research (J. Määttä, R.S., V.I., J. Myllyharju, E.Y.D., P.K.), University of Oulu, Finland.
Dimova EY; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research (J. Määttä, R.S., V.I., J. Myllyharju, E.Y.D., P.K.), University of Oulu, Finland.
Koivunen P; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research (J. Määttä, R.S., V.I., J. Myllyharju, E.Y.D., P.K.), University of Oulu, Finland.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jul; Vol. 41 (7), pp. 2128-2140. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Plaque, Atherosclerotic*
Aorta/*enzymology
Aortic Diseases/*prevention & control
Atherosclerosis/*prevention & control
Liver/*enzymology
Prolyl Hydroxylases/*deficiency
Animals ; Aorta/pathology ; Aortic Diseases/enzymology ; Aortic Diseases/genetics ; Aortic Diseases/pathology ; Atherosclerosis/enzymology ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Autoantibodies/blood ; Diet, High-Fat ; Disease Models, Animal ; Lipoprotein Lipase/metabolism ; Lipoproteins, LDL/immunology ; Lipoproteins, LDL/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Prolyl Hydroxylases/genetics ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Transcriptome ; Triglycerides/blood
Czasopismo naukowe
Tytuł :
Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.
Autorzy :
Li Y; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.; School of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
Li H; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.; Key Laboratory of Molecular and Cellular Biology of Ministry of Education, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Xing W; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.; School of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
Li J; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Du R; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Cao D; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Wang Y; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.; School of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
Yang X; Institute of Biomechanics and Medical Engineering, Tsinghua University, Beijing, China.
Zhong G; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.; School of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
Zhao Y; Key Laboratory of Molecular and Cellular Biology of Ministry of Education, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Sun W; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Liu C; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Gao X; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Li Y; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.; School of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
Liu Z; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Jin X; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Zhao D; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Tan Y; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Wang Y; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Liu S; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Yuan M; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Song J; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Chang YZ; Key Laboratory of Molecular and Cellular Biology of Ministry of Education, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Gao F; School of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
Ling S; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Li Y; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Nov; Vol. 35 (11), pp. e21947.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin II/*pharmacology
Gene Knockout Techniques/*methods
Hypertension/*chemically induced
Hypertension/*metabolism
MicroRNAs/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Signal Transduction/*genetics
Smad7 Protein/*metabolism
Up-Regulation/*genetics
Animals ; Blood Pressure/drug effects ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cells, Cultured ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; MicroRNAs/genetics ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Signal Transduction/drug effects ; Up-Regulation/drug effects ; Vascular Remodeling/genetics
Czasopismo naukowe
Tytuł :
CTRP4 ablation impairs associative learning and memory.
Autorzy :
Sarver DC; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xu C; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Cheng Y; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Terrillion CE; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wong GW; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Nov; Vol. 35 (11), pp. e21910.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression*
Maze Learning*
Spatial Memory*
Adipokines/*genetics
Gene Knockout Techniques/*methods
Adipokines/metabolism ; Animals ; Anxiety/genetics ; Behavior, Animal ; Cerebellar Cortex/metabolism ; Female ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Rotarod Performance Test
Czasopismo naukowe
Tytuł :
Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.
Autorzy :
Pryce BR; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Labrèche C; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Hamoudi D; Centre de Recherche du Centre Hospitalier Universitaire de Québec-Centre Hospitalier de L'Université Laval, Université Laval, Quebec City, Quebec, Canada.
Abou-Hamad J; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Al-Zahrani KN; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Hodgins JJ; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Boulanger-Piette A; Centre de Recherche du Centre Hospitalier Universitaire de Québec-Centre Hospitalier de L'Université Laval, Université Laval, Quebec City, Quebec, Canada.
Bossé S; Centre de Recherche du Centre Hospitalier Universitaire de Québec-Centre Hospitalier de L'Université Laval, Université Laval, Quebec City, Quebec, Canada.
Balog-Alvarez C; Department of Veterinary Integrative Biosciences, Texas A&M University College of Veterinary Medicine & Biomedical Sciences, College Station, TX, USA.
Frénette J; Centre de Recherche du Centre Hospitalier Universitaire de Québec-Centre Hospitalier de L'Université Laval, Université Laval, Quebec City, Quebec, Canada; Département de Réadaptation, Faculté de Médecine, Université Laval, Quebec City, Quebec, Canada.
Ardolino M; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Kornegay JN; Department of Veterinary Integrative Biosciences, Texas A&M University College of Veterinary Medicine & Biomedical Sciences, College Station, TX, USA.
Sabourin LA; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Feb; Vol. 1868 (2), pp. 118917. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
MAP Kinase Signaling System/*genetics
Muscle Development/*genetics
Muscle, Skeletal/*metabolism
Muscular Dystrophy, Duchenne/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Cells, Cultured ; Disease Models, Animal ; Dogs ; Mice ; Mice, Inbred mdx ; Mice, Knockout ; Muscular Dystrophy, Duchenne/pathology ; Myoblasts/metabolism ; Myogenin/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria.
Autorzy :
Singh K; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.; WuXi AppTec Inc., 8th Floor, 55 Cambridge Parkway, Cambridge, MA, 02142, USA.
Cornell CS; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Jackson R; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Kabiri M; Transgenic Model and Technology, Translational In-Vivo Research Platform, Industrie Park Hoechst, Sanofi, Frankfurt, Germany.
Phipps M; Transgenic Model and Technology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
Desai M; Global Bioimaging, Translational In-Vivo Models Research Platform, Sanofi, Framingham, MA, 01701, USA.
Fogle R; Global Bioimaging, Translational In-Vivo Models Research Platform, Sanofi, Framingham, MA, 01701, USA.
Ying X; Global Bioimaging, Translational In-Vivo Models Research Platform, Sanofi, Framingham, MA, 01701, USA.
Anarat-Cappillino G; Pre-Development Sciences NA, Analytical R&D, Sanofi, Framingham, MA, 01701, USA.
Geller S; Pre-Development Sciences NA, Analytical R&D, Sanofi, Framingham, MA, 01701, USA.
Johnson J; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
Roberts E; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
Malley K; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
Devlin T; Transgenic Model and Technology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
DeRiso M; Transgenic Model and Technology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
Berthelette P; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Zhang YV; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Ryan S; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
Rao S; Translational In-Vivo Models Research Platform, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.
Thurberg BL; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA.
Bangari DS; Global Discovery Pathology, Translational In-Vivo Models Research Platform, Sanofi, 5 The Mountain Road, Framingham, MA, 01701, USA. .
Kyostio-Moore S; Genomic Medicine Unit, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Mar 31; Vol. 11 (1), pp. 7254. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*
Disease Models, Animal*
Gene Knockout Techniques*
Phenylalanine Hydroxylase/*genetics
Phenylketonurias/*genetics
Animals ; Male ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Brain iron deficiency and affected contextual fear memory in mice with conditional Ferroportin1 ablation in the brain.
Autorzy :
Wu Q; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.; College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China.; Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Shijiazhuang, China.
Hao Q; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Li H; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Wang B; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Wang P; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Jin X; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Yu P; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Gao G; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.
Chang YZ; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Feb; Vol. 35 (2), pp. e21174. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fear*
Gene Knockout Techniques*
Memory*
Blood-Brain Barrier/*metabolism
Cation Transport Proteins/*genetics
Hippocampus/*metabolism
Iron/*deficiency
Animals ; Astrocytes/metabolism ; Cation Transport Proteins/metabolism ; Cells, Cultured ; Endothelial Cells/metabolism ; Homeostasis/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/metabolism ; Stress Disorders, Post-Traumatic/metabolism
Czasopismo naukowe
Tytuł :
[Construction of a striatum-specific Slc20a2 gene knockout mice model by CRISPR/Cas9 AAV system].
Autorzy :
Lin MT; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.; Institute of Neurosciences, Fujian Medical University, Fuzhou 350004, China.
Lai LL; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Zhao M; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Lin BW; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Yao XP; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.; Fujian Key Laboratory of Molecular Neurology, Fuzhou 350005, China.
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Źródło :
Yi chuan = Hereditas [Yi Chuan] 2020 Oct 20; Vol. 42 (10), pp. 1017-1027.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*/genetics
Gene Knockout Techniques*
Models, Animal*
Sodium-Phosphate Cotransporter Proteins, Type III*/genetics
Animals ; Mice ; Mice, Knockout ; RNA, Guide/genetics
Czasopismo naukowe
Tytuł :
Dedicated transcriptomics combined with power analysis lead to functional understanding of genes with weak phenotypic changes in knockout lines.
Autorzy :
Xie C; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Bekpen C; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Künzel S; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Keshavarz M; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Krebs-Wheaton R; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Skrabar N; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Ullrich KK; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Zhang W; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Tautz D; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Nov 12; Vol. 16 (11), pp. e1008354. Date of Electronic Publication: 2020 Nov 12 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Gene Knockout Techniques*
Gene Expression Profiling/*methods
Genetic Association Studies/*methods
Animals ; Behavior, Animal ; Computational Biology ; Extremities/anatomy & histology ; Female ; Gene Expression Profiling/statistics & numerical data ; Genetic Association Studies/statistics & numerical data ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Genetic ; Phenotype ; Proof of Concept Study ; RNA-Seq/statistics & numerical data ; Transcriptome
Czasopismo naukowe
Tytuł :
Conditional RAC1 knockout in motor neurons restores H-reflex rate-dependent depression after spinal cord injury.
Autorzy :
Benson CA; Department of Neurology, Yale University School of Medicine, 950 Campbell Avenue, Building 34, New Haven, CT, 06510, USA.; Department of Veterans Affairs, Center for Neuroscience and Regeneration Research (127A), West Haven VA Medical Center, 950 Campbell Avenue, Building 34, West Haven, CT, 06516, USA.
Olson KL; Department of Neurology, Yale University School of Medicine, 950 Campbell Avenue, Building 34, New Haven, CT, 06510, USA.; Department of Veterans Affairs, Center for Neuroscience and Regeneration Research (127A), West Haven VA Medical Center, 950 Campbell Avenue, Building 34, West Haven, CT, 06516, USA.
Patwa S; Department of Neurology, Yale University School of Medicine, 950 Campbell Avenue, Building 34, New Haven, CT, 06510, USA.; Department of Veterans Affairs, Center for Neuroscience and Regeneration Research (127A), West Haven VA Medical Center, 950 Campbell Avenue, Building 34, West Haven, CT, 06516, USA.
Reimer ML; Department of Neurology, Yale University School of Medicine, 950 Campbell Avenue, Building 34, New Haven, CT, 06510, USA.; Department of Veterans Affairs, Center for Neuroscience and Regeneration Research (127A), West Haven VA Medical Center, 950 Campbell Avenue, Building 34, West Haven, CT, 06516, USA.
Bangalore L; Department of Neurology, Yale University School of Medicine, 950 Campbell Avenue, Building 34, New Haven, CT, 06510, USA.; Department of Veterans Affairs, Center for Neuroscience and Regeneration Research (127A), West Haven VA Medical Center, 950 Campbell Avenue, Building 34, West Haven, CT, 06516, USA.
Hill M; Department of Neurology, Yale University School of Medicine, 950 Campbell Avenue, Building 34, New Haven, CT, 06510, USA.; Department of Veterans Affairs, Center for Neuroscience and Regeneration Research (127A), West Haven VA Medical Center, 950 Campbell Avenue, Building 34, West Haven, CT, 06516, USA.
Waxman SG; Department of Neurology, Yale University School of Medicine, 950 Campbell Avenue, Building 34, New Haven, CT, 06510, USA.; Department of Veterans Affairs, Center for Neuroscience and Regeneration Research (127A), West Haven VA Medical Center, 950 Campbell Avenue, Building 34, West Haven, CT, 06516, USA.
Tan AM; Department of Neurology, Yale University School of Medicine, 950 Campbell Avenue, Building 34, New Haven, CT, 06510, USA. .; Department of Veterans Affairs, Center for Neuroscience and Regeneration Research (127A), West Haven VA Medical Center, 950 Campbell Avenue, Building 34, West Haven, CT, 06516, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Apr 09; Vol. 11 (1), pp. 7838. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Anterior Horn Cells/*metabolism
Depression/*metabolism
Gene Knockout Techniques/*methods
H-Reflex/*genetics
Neuropeptides/*metabolism
Spinal Cord Injuries/*metabolism
rac1 GTP-Binding Protein/*metabolism
Animals ; Dendritic Spines/metabolism ; Dependovirus/genetics ; Depression/genetics ; Disease Models, Animal ; Female ; Locomotion/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle Spasticity/metabolism ; Neuronal Plasticity/genetics ; Neuropeptides/genetics ; Spinal Cord Injuries/genetics ; rac1 GTP-Binding Protein/genetics
Czasopismo naukowe
Tytuł :
Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice.
Autorzy :
Ninkina N; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation. Electronic address: .
Tarasova TV; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Chaprov KD; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Roman AY; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Kukharsky MS; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation.
Kolik LG; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation.
Ovchinnikov R; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation.
Ustyugov AA; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Durnev AD; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation.
Buchman VL; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation. Electronic address: .
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Źródło :
Neurobiology of aging [Neurobiol Aging] 2020 Jul; Vol. 91, pp. 76-87. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Aging/*genetics
Aging/*pathology
Corpus Striatum/*metabolism
Corpus Striatum/*pathology
Parkinson Disease/*etiology
Parkinson Disease/*genetics
Substantia Nigra/*metabolism
Substantia Nigra/*pathology
alpha-Synuclein/*genetics
alpha-Synuclein/*metabolism
Aldehyde Dehydrogenase 1 Family/genetics ; Aldehyde Dehydrogenase 1 Family/metabolism ; Animals ; Disease Models, Animal ; Dopamine/metabolism ; Down-Regulation ; Gene Expression/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Targeted Therapy ; Parkinson Disease/therapy ; Retinal Dehydrogenase/genetics ; Retinal Dehydrogenase/metabolism ; Synaptic Transmission/genetics
Czasopismo naukowe
Tytuł :
Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout.
Autorzy :
Jeon SJ; School of Life Sciences and Integrated Institute of Biomedical Research (IIBR), Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.
Ham J; Department of Biomedical Science and Engineering (BMSE), Institute of Integrated Technology (IIT), Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.
Park CS; School of Life Sciences and Integrated Institute of Biomedical Research (IIBR), Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.
Lee B; Department of Biomedical Science and Engineering (BMSE), Institute of Integrated Technology (IIT), Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.
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Źródło :
BMB reports [BMB Rep] 2020 Sep; Vol. 53 (9), pp. 484-489.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockout Techniques*
Adaptor Proteins, Signal Transducing/*metabolism
Seizures/*metabolism
Adaptor Proteins, Signal Transducing/deficiency ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Brain/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Pentylenetetrazole ; Seizures/chemically induced
Czasopismo naukowe
Tytuł :
[Generation and validation of inducible osteoblast-specific Stat3 knockout mice].
Autorzy :
Gong XY; Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology. Shanghai 200011, China. E-mail:.
Huang XR
Zhou SR
Yang YL
Xu HY
Jin AT
Dai QG
Jiang LY
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Źródło :
Shanghai kou qiang yi xue = Shanghai journal of stomatology [Shanghai Kou Qiang Yi Xue] 2020 Aug; Vol. 29 (4), pp. 337-342.
Typ publikacji :
Journal Article
MeSH Terms :
Mice, Knockout*
Osteoblasts*
STAT3 Transcription Factor*
Tooth Movement Techniques*
Animals ; Gene Knockout Techniques ; Mice ; RNA, Messenger
Czasopismo naukowe
Tytuł :
Tamoxifen feeding method is suitable for efficient conditional knockout.
Autorzy :
Yoshinobu K; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Araki M; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Morita A; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Araki M; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Kokuba S; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Nakagata N; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Araki K; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
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Źródło :
Experimental animals [Exp Anim] 2021 Feb 06; Vol. 70 (1), pp. 91-100. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article
MeSH Terms :
Feeding Methods*
Mice, Knockout*
Gene Knockout Techniques/*methods
Tamoxifen/*administration & dosage
Administration, Oral ; Animals ; Injections, Intraperitoneal ; Integrases/genetics ; Powders ; Recombination, Genetic
Czasopismo naukowe
Tytuł :
The relationship between melanin production and lipofuscin formation in Tyrosinase gene knockout melanocytes using CRISPR/Cas9 system.
Autorzy :
Kim JH; Department of Applied Chemistry, Dong-Eui University, Busan 614-714, Republic of Korea.
Kim MM; Department of Applied Chemistry, Dong-Eui University, Busan 614-714, Republic of Korea. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 01; Vol. 284, pp. 119915. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockout Techniques*
CRISPR-Cas Systems/*genetics
Lipofuscin/*metabolism
Melanins/*biosynthesis
Melanocytes/*enzymology
Monophenol Monooxygenase/*genetics
Animals ; Antioxidants/metabolism ; Base Sequence ; Cell Survival/radiation effects ; Gene Expression Regulation, Neoplastic ; Melanoma, Experimental/genetics ; Melanoma, Experimental/pathology ; Mice ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Sarm1 knockout protects against early but not late axonal degeneration in experimental allergic encephalomyelitis.
Autorzy :
Viar K; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Njoku D; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Secor McVoy J; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Oh U; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jun 25; Vol. 15 (6), pp. e0235110. Date of Electronic Publication: 2020 Jun 25 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Armadillo Domain Proteins*/genetics
Armadillo Domain Proteins*/metabolism
Axons*/metabolism
Axons*/pathology
Cytoskeletal Proteins*/genetics
Cytoskeletal Proteins*/metabolism
Encephalomyelitis, Autoimmune, Experimental*/genetics
Encephalomyelitis, Autoimmune, Experimental*/metabolism
Encephalomyelitis, Autoimmune, Experimental*/pathology
Encephalomyelitis, Autoimmune, Experimental*/prevention & control
Gene Knockout Techniques*
Spinal Cord*/metabolism
Spinal Cord*/pathology
Animals ; Mice ; Mice, Knockout ; Time Factors
Czasopismo naukowe
Tytuł :
Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination.
Autorzy :
Navarro-Serna S; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.; IMIB-Arrixaca, Murcia, Spain.
Hachem A; Department of Pharmacology, University of Oxford, Oxford, United Kingdom.; Department of Anatomy, College of Veterinary Medicine, University of Al Qadisiyah, Al Diwaniyah, Iraq.
Canha-Gouveia A; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.; IMIB-Arrixaca, Murcia, Spain.
Hanbashi A; Department of Pharmacology, University of Oxford, Oxford, United Kingdom.; Department of Pharmacology, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Garrappa G; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.
Lopes JS; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.; IMIB-Arrixaca, Murcia, Spain.
París-Oller E; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.; IMIB-Arrixaca, Murcia, Spain.
Sarrías-Gil L; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.
Flores-Flores C; Molecular Biology Section, Scientific and Technical Research Area (ACTI), University of Murcia, Murcia, Spain.
Bassett A; Gene Editing and Cellular Research and Development, Wellcome Sanger Institute, Cambridge, United Kingdom.
Sánchez R; Department of Animal Reproduction, INIA, Madrid, Spain.
Bermejo-Álvarez P; Department of Animal Reproduction, INIA, Madrid, Spain.
Matás C; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.; IMIB-Arrixaca, Murcia, Spain.
Romar R; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.; IMIB-Arrixaca, Murcia, Spain.
Parrington J; Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Gadea J; Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Murcia, Spain.; IMIB-Arrixaca, Murcia, Spain.
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Źródło :
The CRISPR journal [CRISPR J] 2021 Feb; Vol. 4 (1), pp. 132-146.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Insemination*
Oocytes*
Gene Knockout Techniques/*methods
Microinjections/*methods
Swine/*genetics
Animals ; Calcium Channels/genetics ; Embryo Transfer ; Embryo, Mammalian ; Female ; Fertilization ; Fetus ; Germ Cells ; Karyotype ; Male ; Mice ; Mice, Knockout ; Models, Animal ; Mosaicism ; Mutation ; Phenotype ; RNA, Guide ; Zygote
Czasopismo naukowe
Tytuł :
Behavioral responses of mGluR3-KO mice to the lipopolysaccharide-induced innate inflammatory reaction.
Autorzy :
Lainiola M; Department of Pharmacology, Faculty of Medicine, University of Helsinki, Finland.
Linden AM; Department of Pharmacology, Faculty of Medicine, University of Helsinki, Finland. Electronic address: .
Aitta-Aho T; Department of Pharmacology, Faculty of Medicine, University of Helsinki, Finland. Electronic address: .
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Źródło :
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Mar; Vol. 190, pp. 172852. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Behavior, Animal/*drug effects
Lipopolysaccharides/*pharmacology
Receptors, Metabotropic Glutamate/*genetics
Animals ; Anxiety/chemically induced ; Body Temperature/drug effects ; Body Weight/drug effects ; Depression/chemically induced ; Drinking/drug effects ; Genotype ; Inflammation/chemically induced ; Locomotion/drug effects ; Locomotion/genetics ; Male ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Loss of voltage-gated proton channel Hv1 leads to diet-induced obesity in mice.
Autorzy :
Pang H; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Li J; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Du H; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Gao Y; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Tianjin Third Central Hospital affiliated to Nankai University, 83 Jintang Road, Hedong District, Tianjin 300170, China.
Lv J; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Liu Y; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Li SJ; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China .
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Źródło :
BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2020 Feb; Vol. 8 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Diet, High-Fat/*adverse effects
Ion Channels/*genetics
Obesity/*etiology
Obesity/*genetics
Weight Gain/*genetics
Adipocytes/metabolism ; Adipocytes/pathology ; Adipogenesis/genetics ; Adipose Tissue/metabolism ; Adiposity/genetics ; Animals ; Fatty Liver/genetics ; Glucose Intolerance/genetics ; Inflammation/genetics ; Insulin Resistance/genetics ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NADPH Oxidase 2/metabolism ; NADPH Oxidase 4/metabolism
Czasopismo naukowe
Tytuł :
Gene knockout in highly purified mouse hematopoietic stem cells by CRISPR/Cas9 technology.
Autorzy :
Dong Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
Bai H; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
Dong F; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
Zhang XB; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China; Department of Medicine, Loma Linda University, Loma Linda, CA, United States of America.
Ema H; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China. Electronic address: .
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Źródło :
Journal of immunological methods [J Immunol Methods] 2021 Aug; Vol. 495, pp. 113070. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Clustered Regularly Interspaced Short Palindromic Repeats*
Gene Editing*
Gene Knockout Techniques*
CRISPR-Associated Protein 9/*genetics
Hematopoietic Stem Cells/*metabolism
PAX5 Transcription Factor/*genetics
Animals ; CRISPR-Associated Protein 9/metabolism ; Cells, Cultured ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Hematopoietic Stem Cells/immunology ; Mice, Inbred C57BL ; Mice, Transgenic ; PAX5 Transcription Factor/deficiency ; Phenotype ; RNA, Guide/genetics ; RNA, Guide/metabolism ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
STAT-1 Knockout Mice as a Model for Wild-Type Sudan Virus (SUDV).
Autorzy :
Escaffre O; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Juelich TL; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Neef N; XTR Toxicologic Pathology Services LLC, Sterling, VA 20165, USA.
Massey S; Office of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Smith J; Office of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Brasel T; Office of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; The Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Smith JK; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Kalveram B; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Zhang L; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Perez D; Texas A&M University Division of Research, Texas A&M University, College Station, TX 77843, USA.
Ikegami T; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; The Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Freiberg AN; Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; The Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Comer JE; Office of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; The Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.; Institute of Translational Sciences, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
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Źródło :
Viruses [Viruses] 2021 Jul 17; Vol. 13 (7). Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Mice, Knockout*
Ebolavirus/*genetics
STAT1 Transcription Factor/*genetics
Amides/therapeutic use ; Animals ; Antibodies, Viral/blood ; Antiviral Agents/therapeutic use ; Ebolavirus/classification ; Ebolavirus/drug effects ; Ebolavirus/pathogenicity ; Female ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/virology ; Male ; Mice ; Pyrazines/therapeutic use ; Viral Proteins/genetics
Czasopismo naukowe

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