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Tytuł :
[Construction of a striatum-specific Slc20a2 gene knockout mice model by CRISPR/Cas9 AAV system].
Autorzy :
Lin MT; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.; Institute of Neurosciences, Fujian Medical University, Fuzhou 350004, China.
Lai LL; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Zhao M; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Lin BW; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Yao XP; Department of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.; Fujian Key Laboratory of Molecular Neurology, Fuzhou 350005, China.
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Źródło :
Yi chuan = Hereditas [Yi Chuan] 2020 Oct 20; Vol. 42 (10), pp. 1017-1027.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*/genetics
Gene Knockout Techniques*
Models, Animal*
Sodium-Phosphate Cotransporter Proteins, Type III*/genetics
Animals ; Mice ; Mice, Knockout ; RNA, Guide/genetics
Czasopismo naukowe
Tytuł :
[Generation and validation of inducible osteoblast-specific Stat3 knockout mice].
Autorzy :
Gong XY; Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology. Shanghai 200011, China. E-mail:.
Huang XR
Zhou SR
Yang YL
Xu HY
Jin AT
Dai QG
Jiang LY
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Źródło :
Shanghai kou qiang yi xue = Shanghai journal of stomatology [Shanghai Kou Qiang Yi Xue] 2020 Aug; Vol. 29 (4), pp. 337-342.
Typ publikacji :
Journal Article
MeSH Terms :
Mice, Knockout*
Osteoblasts*
STAT3 Transcription Factor*
Tooth Movement Techniques*
Animals ; Gene Knockout Techniques ; Mice ; RNA, Messenger
Czasopismo naukowe
Tytuł :
Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice.
Autorzy :
Ninkina N; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation. Electronic address: .
Tarasova TV; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Chaprov KD; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Roman AY; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Kukharsky MS; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation.
Kolik LG; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation.
Ovchinnikov R; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation.
Ustyugov AA; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Durnev AD; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation.
Buchman VL; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation. Electronic address: .
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Źródło :
Neurobiology of aging [Neurobiol Aging] 2020 Jul; Vol. 91, pp. 76-87. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Aging/*genetics
Aging/*pathology
Corpus Striatum/*metabolism
Corpus Striatum/*pathology
Parkinson Disease/*etiology
Parkinson Disease/*genetics
Substantia Nigra/*metabolism
Substantia Nigra/*pathology
alpha-Synuclein/*genetics
alpha-Synuclein/*metabolism
Aldehyde Dehydrogenase 1 Family/genetics ; Aldehyde Dehydrogenase 1 Family/metabolism ; Animals ; Disease Models, Animal ; Dopamine/metabolism ; Down-Regulation ; Gene Expression/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Targeted Therapy ; Parkinson Disease/therapy ; Retinal Dehydrogenase/genetics ; Retinal Dehydrogenase/metabolism ; Synaptic Transmission/genetics
Czasopismo naukowe
Tytuł :
Sarm1 knockout protects against early but not late axonal degeneration in experimental allergic encephalomyelitis.
Autorzy :
Viar K; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Njoku D; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Secor McVoy J; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Oh U; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jun 25; Vol. 15 (6), pp. e0235110. Date of Electronic Publication: 2020 Jun 25 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Armadillo Domain Proteins*/genetics
Armadillo Domain Proteins*/metabolism
Axons*/metabolism
Axons*/pathology
Cytoskeletal Proteins*/genetics
Cytoskeletal Proteins*/metabolism
Encephalomyelitis, Autoimmune, Experimental*/genetics
Encephalomyelitis, Autoimmune, Experimental*/metabolism
Encephalomyelitis, Autoimmune, Experimental*/pathology
Encephalomyelitis, Autoimmune, Experimental*/prevention & control
Gene Knockout Techniques*
Spinal Cord*/metabolism
Spinal Cord*/pathology
Animals ; Mice ; Mice, Knockout ; Time Factors
Czasopismo naukowe
Tytuł :
Behavioral responses of mGluR3-KO mice to the lipopolysaccharide-induced innate inflammatory reaction.
Autorzy :
Lainiola M; Department of Pharmacology, Faculty of Medicine, University of Helsinki, Finland.
Linden AM; Department of Pharmacology, Faculty of Medicine, University of Helsinki, Finland. Electronic address: .
Aitta-Aho T; Department of Pharmacology, Faculty of Medicine, University of Helsinki, Finland. Electronic address: .
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Źródło :
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Mar; Vol. 190, pp. 172852. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Behavior, Animal/*drug effects
Lipopolysaccharides/*pharmacology
Receptors, Metabotropic Glutamate/*genetics
Animals ; Anxiety/chemically induced ; Body Temperature/drug effects ; Body Weight/drug effects ; Depression/chemically induced ; Drinking/drug effects ; Genotype ; Inflammation/chemically induced ; Locomotion/drug effects ; Locomotion/genetics ; Male ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Loss of voltage-gated proton channel Hv1 leads to diet-induced obesity in mice.
Autorzy :
Pang H; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Li J; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Du H; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Gao Y; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Tianjin Third Central Hospital affiliated to Nankai University, 83 Jintang Road, Hedong District, Tianjin 300170, China.
Lv J; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Liu Y; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.
Li SJ; Department of Biophysics, School of Physics Science,The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, P. R. China .
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Źródło :
BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2020 Feb; Vol. 8 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Diet, High-Fat/*adverse effects
Ion Channels/*genetics
Obesity/*etiology
Obesity/*genetics
Weight Gain/*genetics
Adipocytes/metabolism ; Adipocytes/pathology ; Adipogenesis/genetics ; Adipose Tissue/metabolism ; Adiposity/genetics ; Animals ; Fatty Liver/genetics ; Glucose Intolerance/genetics ; Inflammation/genetics ; Insulin Resistance/genetics ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NADPH Oxidase 2/metabolism ; NADPH Oxidase 4/metabolism
Czasopismo naukowe
Tytuł :
Gene knockout animal models of depression, anxiety and obsessive compulsive disorders.
Autorzy :
Scherma M; Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato.
Giunti E; Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato.
Fratta W; Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato.
Fadda P; Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato.; Centre of Excellence 'Neurobiology of Addiction', University of Cagliari.; Institute of Neuroscience - Cagliari, National Research Council, Cagliari.; National Neuroscience Institute, Torino, Italy.
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Źródło :
Psychiatric genetics [Psychiatr Genet] 2019 Oct; Vol. 29 (5), pp. 191-199.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mice, Knockout*
Anxiety Disorders/*genetics
Depressive Disorder/*genetics
Obsessive-Compulsive Disorder/*genetics
Animals ; Disease Models, Animal ; Gene Knockout Techniques ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns.
Autorzy :
Brommage R; Department of Metabolism Research, Lexicon Pharmaceuticals, 8800 Technology Forest Place, The Woodlands, TX 77381, USA .
Powell DR; Department of Metabolism Research, Lexicon Pharmaceuticals, 8800 Technology Forest Place, The Woodlands, TX 77381, USA.
Vogel P; St. Jude Children's Research Hospital, Pathology, MS 250, Room C5036A, 262 Danny Thomas Place, Memphis, TN 38105, USA.
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Źródło :
Disease models & mechanisms [Dis Model Mech] 2019 May 07; Vol. 12 (5). Date of Electronic Publication: 2019 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Delivery Systems*
Gene Knockout Techniques*
Disease/*genetics
Mutation/*genetics
Animals ; Mice, Knockout ; Phenotype
Czasopismo naukowe
Tytuł :
Roles of T Follicular Helper Cells and T Follicular Regulatory Cells in Autoantibody Production in IL-2-Deficient Mice.
Autorzy :
Xie MM; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.
Liu H; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.
Corn C; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.
Koh BH; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; and.
Kaplan MH; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; and.
Turner MJ; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202.
Dent AL; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; .
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Źródło :
ImmunoHorizons [Immunohorizons] 2019 Jul 12; Vol. 3 (7), pp. 306-316. Date of Electronic Publication: 2019 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Autoantibodies/*biosynthesis
Autoimmunity/*immunology
Interleukin-2/*genetics
T-Lymphocytes, Helper-Inducer/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; Cell Differentiation ; Interleukin-2/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Animal ; Myeloid Differentiation Factor 88/genetics ; Proto-Oncogene Proteins c-bcl-6/genetics ; T-Lymphocytes, Helper-Inducer/metabolism ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Selective Cre-mediated gene deletion identifies connexin 43 as the main connexin channel supporting olfactory ensheathing cell networks.
Autorzy :
Piantanida AP; CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.; Universidad de Buenos Aires, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.
Acosta LE; CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.; Universidad de Buenos Aires, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.
Brocardo L; CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.; Universidad de Buenos Aires, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.
Capurro C; CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.; Universidad de Buenos Aires, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.
Greer CA; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut.; Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut.
Rela L; CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.; Universidad de Buenos Aires, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.
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Źródło :
The Journal of comparative neurology [J Comp Neurol] 2019 May 01; Vol. 527 (7), pp. 1278-1289. Date of Electronic Publication: 2019 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Connexin 43/*physiology
Gap Junctions/*physiology
Neuroglia/*physiology
Olfactory Bulb/*cytology
Aging/metabolism ; Animals ; Connexin 43/deficiency ; Connexin 43/genetics ; Crosses, Genetic ; Female ; Gap Junctions/drug effects ; Genes, Reporter ; Genes, Synthetic ; Integrases/genetics ; Male ; Meclofenamic Acid/pharmacology ; Mice ; Mice, Knockout ; Myelin Proteolipid Protein/genetics ; Olfactory Bulb/metabolism ; Patch-Clamp Techniques ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł :
Know Your Model: A knockout does not always make a null.
Autorzy :
Bello SM; Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME, USA. .
Perry MN; Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME, USA.
Smith CL; Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME, USA.
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Źródło :
Lab animal [Lab Anim (NY)] 2020 Mar; Vol. 49 (3), pp. 59-60.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Gene Knockout Techniques/*methods
Animals ; Mice ; Mice, Knockout ; Mutation/genetics
Czasopismo naukowe
Tytuł :
Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice.
Autorzy :
Ekholm-Reed S; Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA.
Baker R; Department of Neuroscience, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA.
Campos AR; 3Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 02037 USA.
Stouffer D; Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA.
Henze M; Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA.
Wolf DA; 3Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 02037 USA.
Loring JF; Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA.
Thomas EA; Department of Neuroscience, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA.
Reed SI; Department of Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA.
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Źródło :
Communications biology [Commun Biol] 2019 Apr 04; Vol. 2, pp. 125. Date of Electronic Publication: 2019 Apr 04 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Knockout Techniques*
Dopaminergic Neurons/*pathology
Gene Dosage/*genetics
Motor Activity/*genetics
Myeloid Cell Leukemia Sequence 1 Protein/*genetics
Ubiquitin-Protein Ligases/*genetics
Animals ; Behavior, Animal ; Cell Count ; Disease Models, Animal ; Mice ; Mice, Knockout ; Parkinson Disease/genetics ; Phenotype
Czasopismo naukowe
Tytuł :
Kaiso Gene Knockout Promotes Somatic Cell Reprogramming.
Autorzy :
Kaplun DS; Fundamentals of Biotechnology Federal Research Centre, Russian Academy of Sciences, Moscow, 119071, Russia.
Fok RE; Israel-Canada Institute for Medical Research, Hebrew University Medical School, 91120 Jerusalem, Israel.
Korostina VS; Abbott Laboratories LLC, Medical Department, Moscow, 125171, Russia.
Prokhortchouk EB; Fundamentals of Biotechnology Federal Research Centre, Russian Academy of Sciences, Moscow, 119071, Russia.
Zhenilo SV; Fundamentals of Biotechnology Federal Research Centre, Russian Academy of Sciences, Moscow, 119071, Russia. .
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Źródło :
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2019 Mar; Vol. 84 (3), pp. 283-290.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Reprogramming*
Gene Knockout Techniques*
Induced Pluripotent Stem Cells/*cytology
Induced Pluripotent Stem Cells/*metabolism
Transcription Factors/*deficiency
Transcription Factors/*genetics
Animals ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation.
Autorzy :
Shu T; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; University of Chinese Academy of Sciences, Beijing 101408, China.
Zhai G; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Pradhan A; The Life Science Center, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden. Electronic address: .
Olsson PE; The Life Science Center, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden.
Yin Z; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. Electronic address: .
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Źródło :
General and comparative endocrinology [Gen Comp Endocrinol] 2020 Sep 01; Vol. 295, pp. 113490. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Sex Differentiation*/genetics
Signal Transduction*
Androgens/*metabolism
Brain/*physiology
Zebrafish/*physiology
Zebrafish Proteins/*deficiency
Animals ; Behavior, Animal ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Ontology ; Male ; Steroid 17-alpha-Hydroxylase ; Testosterone/analogs & derivatives ; Testosterone/metabolism
Czasopismo naukowe
Tytuł :
Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C 2 C 12 myotubes.
Autorzy :
Blackburn ML; Arkansas Children's Nutrition Center, Little Rock, Arkansas.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Ono-Moore KD; Arkansas Children's Nutrition Center, Little Rock, Arkansas.
Sobhi HF; Center for Organic Synthesis, Department of Natural Sciences, Coppin State University, Baltimore, Maryland.
Adams SH; Arkansas Children's Nutrition Center, Little Rock, Arkansas.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Aug 01; Vol. 319 (2), pp. E265-E275. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Knockout Techniques*
Carnitine O-Palmitoyltransferase/*genetics
Carnitine O-Palmitoyltransferase/*physiology
Insulin Resistance/*physiology
Muscle Fibers, Skeletal/*physiology
Palmitic Acid/*pharmacology
Animals ; Cell Line ; Mice ; Muscle Fibers, Skeletal/cytology ; Muscle Fibers, Skeletal/drug effects ; Palmitoylcarnitine/metabolism ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption.
Autorzy :
Jia K; Beijing Key Laboratory of Animal Genetic Improvement, China Agricultural University, Beijing, 100094, China.
Lu Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhou F; Cambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow University, Suzhou, 215123, China.
Xiong Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhang R; Beijing Key Laboratory of Animal Genetic Improvement, China Agricultural University, Beijing, 100094, China.
Liu Z; Cambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow University, Suzhou, 215123, China.
Ma Y; Cambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow University, Suzhou, 215123, China.
He L; Cambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow University, Suzhou, 215123, China.
Li C; Cambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow University, Suzhou, 215123, China.
Zhu Z; Key Laboratory of MEMS of Ministry of Education, Southeast University, Nanjing, 210096, China.
Pan D; Cambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow University, Suzhou, 215123, China. .
Lian Z; Beijing Key Laboratory of Animal Genetic Improvement, China Agricultural University, Beijing, 100094, China. .
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Źródło :
Protein & cell [Protein Cell] 2019 Nov; Vol. 10 (11), pp. 832-839.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems/*genetics
Gene Editing/*methods
Gene Knockout Techniques/*methods
RNA, Guide/*genetics
Animals ; Mice ; Mice, Knockout
Raport
Tytuł :
[Research progress on composite animal models of inflammatory bowel disease based on gene knockout].
Autorzy :
Zhao H; Zhejiang University School of Medicine, Hangzhou 310058, China.
Tang H; Zhejiang University School of Medicine, Hangzhou 310058, China.
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Źródło :
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2018 Dec 25; Vol. 47 (6), pp. 665-670.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Knockout Techniques*
Inflammatory Bowel Diseases*/genetics
Inflammatory Bowel Diseases*/immunology
Research*
Animals ; Disease Models, Animal ; Humans ; Mice, Knockout
Czasopismo naukowe
Tytuł :
AQP4‑knockout alleviates the lipopolysaccharide‑induced inflammatory response in astrocytes via SPHK1/MAPK/AKT signaling.
Autorzy :
Dai W; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R.China.
Yan J; Department of Gastroenterology, The First People's Hospital of Jiujiang, Jiujiang, Jiangxi 332000, P.R.China.
Chen G; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R.China.
Hu G; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zhou X; Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zeng X; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R.China.
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Źródło :
International journal of molecular medicine [Int J Mol Med] 2018 Sep; Vol. 42 (3), pp. 1716-1722. Date of Electronic Publication: 2018 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockout Techniques*
Aquaporin 4/*genetics
Astrocytes/*enzymology
Astrocytes/*pathology
Inflammation/*pathology
Mitogen-Activated Protein Kinases/*metabolism
Phosphotransferases (Alcohol Group Acceptor)/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Animals ; Aquaporin 4/metabolism ; Astrocytes/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; Cytokines/metabolism ; Lipopolysaccharides ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Generation and Validation of Tissue-Specific Knockout Strains for Toxicology Research.
Autorzy :
Taylor CA; Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas.
Shawlot W; Mouse Genetic Engineering Facility, University of Texas at Austin, Austin, Texas.
Ren JX; Mouse Genetic Engineering Facility, University of Texas at Austin, Austin, Texas.
Mukhopadhyay S; Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas.
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Źródło :
Current protocols in toxicology [Curr Protoc Toxicol] 2019 Sep; Vol. 81 (1), pp. e86.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Knockout Techniques/*methods
Toxicology/*methods
Animals ; Gene Expression Regulation ; Genotype ; Mice ; Mice, Knockout ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Knockout of pde gene in Arthrobacter sp. CGMCC 3584 and transcriptomic analysis of its effects on cAMP production.
Autorzy :
Niu H; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, Nanjing, 210009, People's Republic of China.; National Engineering Technique Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, People's Republic of China.
Sun X; National Engineering Technique Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, People's Republic of China.
Song J; National Engineering Technique Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, People's Republic of China.
Zhu C; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, Nanjing, 210009, People's Republic of China.; National Engineering Technique Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, People's Republic of China.
Chen Y; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, Nanjing, 210009, People's Republic of China.; National Engineering Technique Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, People's Republic of China.
Gao N; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, Nanjing, 210009, People's Republic of China.; National Engineering Technique Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, People's Republic of China.
Qu X; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, People's Republic of China.
Ying H; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, Nanjing, 210009, People's Republic of China.; National Engineering Technique Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, People's Republic of China.
Liu D; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5, Xinmofan Road, Nanjing, 210009, People's Republic of China. .; National Engineering Technique Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, People's Republic of China. .
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Źródło :
Bioprocess and biosystems engineering [Bioprocess Biosyst Eng] 2020 May; Vol. 43 (5), pp. 839-850. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article
MeSH Terms :
Arthrobacter*/genetics
Arthrobacter*/metabolism
Gene Expression Profiling*
Gene Knockout Techniques*
Genes, Bacterial*
Cyclic AMP/*biosynthesis
Cyclic AMP/genetics
Czasopismo naukowe

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