Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2.
Autorzy:
Rodriguez Garcia M; Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA. Schmeckpeper J; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Landim-Vieira M; Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA. Coscarella IL; Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA. Fang X; Department of Cell & Molecular Physiology, Loyola University, Chicago, IL 60660, USA. Ma W; BioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA. Spran PA; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. Yuan S; BioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA. Qi L; BioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA. Kahmini AR; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA. Shoemaker MB; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Atkinson JB; Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Kekenes-Huskey PM; Department of Cell & Molecular Physiology, Loyola University, Chicago, IL 60660, USA. Irving TC; BioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA. Chase PB; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. KnollmannBC; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Pinto JR; Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.
Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease.
Autorzy:
Deb A; Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA. Tow BD; Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA. Qing Y; Beijing Key Laboratory for Agricultural Application and New Technique, College of Plant Science and Technology, Bioinformatics Center, Beijing University of Agriculture, Beijing 102206, China. Walker M; Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA. Hodges ER; School of Pharmacy, Division of BioMolecular Sciences, University of Mississippi, Oxford, MS 38677, USA. Stewart JA Jr; School of Pharmacy, Division of BioMolecular Sciences, University of Mississippi, Oxford, MS 38677, USA. KnollmannBC; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Zheng Y; Beijing Key Laboratory for Agricultural Application and New Technique, College of Plant Science and Technology, Bioinformatics Center, Beijing University of Agriculture, Beijing 102206, China. Wang Y; Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA. Liu B; Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
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Źródło:
Cells [Cells] 2023 Jan 04; Vol. 12 (2). Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathy.
Autorzy:
Radbill AE; Division of Cardiology, Department of Pediatrics, Monroe Carell Jr. Children's Hospital, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America. Lei LY; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada. Paranjape SY; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America. Blackwell DJ; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America. Abraham RL; Division of Cardiovascular Medicine, Arrhythmia Section, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America. Chew DS; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada. Raj SR; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada.; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America. KnollmannBC; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Feb 11; Vol. 16 (2), pp. e0246768. Date of Electronic Publication: 2021 Feb 11 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias.
Autorzy:
Liu B; Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA.; Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA. Lou Q; Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA. Smith H; Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA. Velez-Cortes F; Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA.; Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA. Dillmann WH; Department of Medicine, University of California, San Diego, CA 92093, USA. KnollmannBC; Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Vanderbilt, TN 37232, USA. Armoundas AA; Massachusetts General Hospital, Cardiovascular Research Center, Charlestown, MA 02129, USA. Györke S; Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA.
Chronotropic incompetence as a risk predictor in children and young adults with catecholaminergic polymorphic ventricular tachycardia.
Autorzy:
Franciosi S; Division of Cardiology, Department of Pediatrics, Children's Heart Centre, BC Children's Hospital, University of British Columbia, Vancouver, Canada. Roston TM; Division of Cardiology, Department of Pediatrics, Children's Heart Centre, BC Children's Hospital, University of British Columbia, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada.; Department of Medicine, University of Alberta, Edmonton, Canada. Perry FKG; Division of Cardiology, Department of Pediatrics, Children's Heart Centre, BC Children's Hospital, University of British Columbia, Vancouver, Canada. KnollmannBC; Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee. Kannankeril PJ; Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Pediatrics, Vanderbilt University Medical Center, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee. Sanatani S; Division of Cardiology, Department of Pediatrics, Children's Heart Centre, BC Children's Hospital, University of British Columbia, Vancouver, Canada.
Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes.
Autorzy:
Savio-Galimberti E; Division of Clinical Pharmacology and Oates Institute for Experimental Therapeutics, Department of Medicine, Vanderbilt University School of Medicine, Nashville, United States of America; Division of Cardiovascular Medicine. Department of Medicine, Vanderbilt University School of Medicine, Nashville, United States of America. KnollmannBC; Division of Clinical Pharmacology and Oates Institute for Experimental Therapeutics, Department of Medicine, Vanderbilt University School of Medicine, Nashville, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Jun 29; Vol. 10 (6), pp. e0131179. Date of Electronic Publication: 2015 Jun 29 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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