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Wyświetlanie 1-18 z 18
Tytuł :
Regional hypometabolism in the 3xTg mouse model of Alzheimer's disease.
Autorzy :
Adlimoghaddam A; St. Boniface Hospital Research, Canada; Dept. of Pharmacology & Therapeutics, University of Manitoba, Canada. Electronic address: .
Snow WM; St. Boniface Hospital Research, Canada.
Stortz G; University of British Columbia, Canada.
Perez C; St. Boniface Hospital Research, Canada; Dept. of Pharmacology & Therapeutics, University of Manitoba, Canada.
Djordjevic J; St. Boniface Hospital Research, Canada; Dept. of Pharmacology & Therapeutics, University of Manitoba, Canada.
Goertzen AL; Dept. of Radiology, University of Manitoba, Canada.
Ko JH; Dept. of Human Anatomy and Cell Science, University of Manitoba, Canada; Health Sciences Centre, Canada.
Albensi BC; St. Boniface Hospital Research, Canada; Dept. of Pharmacology & Therapeutics, University of Manitoba, Canada. Electronic address: .
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2019 Jul; Vol. 127, pp. 264-277. Date of Electronic Publication: 2019 Mar 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*metabolism
Brain/*metabolism
Mitochondria/*metabolism
Neurofibrillary Tangles/*metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Oxidative Phosphorylation ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Network Structure and Function in Parkinson's Disease.
Autorzy :
Ko JH; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
Spetsieris PG; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
Eidelberg D; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.; Department of Neurology, Northwell Health, Manhasset, NY, USA.
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Źródło :
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2018 Dec 01; Vol. 28 (12), pp. 4121-4135.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain/*metabolism
Parkinson Disease/*metabolism
Animals ; Brain Mapping/methods ; Female ; Humans ; Macaca ; Male ; Neural Pathways/metabolism ; Parkinson Disease/diagnostic imaging ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Distinct brain metabolic patterns separately associated with cognition, motor function, and aging in Parkinson's disease dementia.
Autorzy :
Ko JH; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Manitoba, Canada. Electronic address: ji.ko@umanitoba.ca.
Katako A; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Manitoba, Canada.
Aljuaid M; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Manitoba, Canada.
Goertzen AL; Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Borys A; Section of Neurology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Hobson DE; Section of Neurology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Kim SM; Institute of Parkinson's Clinical Research, Ulsan University College of Medicine, Seoul, South Korea.
Lee CS; Institute of Parkinson's Clinical Research, Ulsan University College of Medicine, Seoul, South Korea; Department of Neurology, Asan Medical Center, Seoul, South Korea.
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Corporate Authors :
Alzheimer's Disease Neuroimaging Initiative
Źródło :
Neurobiology of aging [Neurobiol Aging] 2017 Dec; Vol. 60, pp. 81-91. Date of Electronic Publication: 2017 Aug 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Aging/*metabolism
Aging/*psychology
Brain/*metabolism
Cognition/*physiology
Dementia/*metabolism
Dementia/*psychology
Motor Activity/*physiology
Parkinson Disease/*metabolism
Parkinson Disease/*psychology
Brain/diagnostic imaging ; Dementia/etiology ; Dementia/physiopathology ; Humans ; Parkinson Disease/etiology ; Parkinson Disease/physiopathology ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Metabolic network expression in parkinsonism: Clinical and dopaminergic correlations.
Autorzy :
Ko JH; 1 Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
Lee CS; 2 Department of Neurology, Asan Medical Center, Seoul, Republic of Korea.
Eidelberg D; 1 Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2017 Feb; Vol. 37 (2), pp. 683-693. Date of Electronic Publication: 2016 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Networks and Pathways*
Brain/*metabolism
Dopamine/*metabolism
Dopamine Plasma Membrane Transport Proteins/*metabolism
Parkinsonian Disorders/*metabolism
Brain/diagnostic imaging ; Dopamine/analysis ; Dopamine Plasma Membrane Transport Proteins/analysis ; Glucose/analysis ; Glucose/metabolism ; Humans ; Middle Aged ; Parkinsonian Disorders/complications ; Parkinsonian Disorders/diagnostic imaging ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study.
Autorzy :
Parkinson FE; Departments of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.; Neuroscience Research Program, Health Sciences Centre, Winnipeg, MB, Canada.
Paul S; Departments of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.; Neuroscience Research Program, Health Sciences Centre, Winnipeg, MB, Canada.
Zhang D; Departments of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.; Neuroscience Research Program, Health Sciences Centre, Winnipeg, MB, Canada.
Mzengeza S; Departments of Radiology, University of Manitoba, Winnipeg, MB, Canada.
Ko JH; Departments of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.; Neuroscience Research Program, Health Sciences Centre, Winnipeg, MB, Canada.
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Źródło :
Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2016 Jul; Vol. 26 (4), pp. 403-5. Date of Electronic Publication: 2016 Apr 15.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Fluorodeoxyglucose F18*
Positron-Emission Tomography*/methods
Adenosine/*physiology
Brain/*diagnostic imaging
Brain/*physiology
Animals ; Brain Mapping ; Glucose ; Glycolysis/physiology ; Humans ; Image Processing, Computer-Assisted ; Male ; Morpholines/pharmacology ; Pyrimidines/pharmacology ; Rats ; Receptor, Adenosine A1/drug effects ; Xanthines/pharmacology
Czasopismo naukowe
Tytuł :
Metabolic resting-state brain networks in health and disease.
Autorzy :
Spetsieris PG; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Ko JH; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Tang CC; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Nazem A; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Sako W; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Peng S; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Ma Y; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Dhawan V; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Eidelberg D; Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Feb 24; Vol. 112 (8), pp. 2563-8. Date of Electronic Publication: 2015 Feb 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Health*
Rest*
Alzheimer Disease/*physiopathology
Brain/*metabolism
Brain/*physiopathology
Nerve Net/*physiopathology
Parkinson Disease/*physiopathology
Alzheimer Disease/metabolism ; Brain Mapping ; Disease ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Activity ; Parkinson Disease/metabolism ; Positron-Emission Tomography ; Principal Component Analysis ; Task Performance and Analysis
Czasopismo naukowe
Tytuł :
Image derived input function for [18F]-FEPPA: application to quantify translocator protein (18 kDa) in the human brain.
Autorzy :
Mabrouk R; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.
Rusjan PM; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.
Mizrahi R; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Jacobs MF; Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.
Koshimori Y; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.
Houle S; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.
Ko JH; Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada.
Strafella AP; Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Canada; Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
PloS one [PLoS One] 2014 Dec 30; Vol. 9 (12), pp. e115768. Date of Electronic Publication: 2014 Dec 30 (Print Publication: 2014).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Positron-Emission Tomography/*methods
Receptors, GABA/*metabolism
Adult ; Aged ; Algorithms ; Female ; Genotype ; Humans ; Kinetics ; Linear Models ; Male ; Middle Aged ; Polymorphism, Genetic ; Principal Component Analysis ; Receptors, GABA/genetics ; Software
Czasopismo naukowe
Tytuł :
Network modulation following sham surgery in Parkinson's disease.
Autorzy :
Ko JH
Feigin A
Mattis PJ
Tang CC
Ma Y
Dhawan V
During MJ
Kaplitt MG
Eidelberg D
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2014 Aug; Vol. 124 (8), pp. 3656-66. Date of Electronic Publication: 2014 Jul 18.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Placebo Effect*
Brain/*metabolism
Brain/*surgery
Parkinson Disease/*metabolism
Parkinson Disease/*surgery
Antiparkinson Agents/therapeutic use ; Brain/diagnostic imaging ; Cerebellum/diagnostic imaging ; Cerebellum/metabolism ; Computer Simulation ; Double-Blind Method ; Female ; Functional Neuroimaging ; Genetic Therapy ; Glutamate Decarboxylase/genetics ; Humans ; Levodopa/therapeutic use ; Limbic System/diagnostic imaging ; Limbic System/metabolism ; Male ; Metabolic Networks and Pathways ; Middle Aged ; Models, Neurological ; Monte Carlo Method ; Parkinson Disease/therapy ; Placebos ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Dopamine-agonists and impulsivity in Parkinson's disease: impulsive choices vs. impulsive actions.
Autorzy :
Antonelli F; Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada.
Ko JH
Miyasaki J
Lang AE
Houle S
Valzania F
Ray NJ
Strafella AP
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Źródło :
Human brain mapping [Hum Brain Mapp] 2014 Jun; Vol. 35 (6), pp. 2499-506. Date of Electronic Publication: 2013 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzothiazoles/*pharmacology
Brain/*drug effects
Choice Behavior/*drug effects
Dopamine Agonists/*pharmacology
Impulsive Behavior/*drug effects
Parkinson Disease/*drug therapy
Brain/diagnostic imaging ; Brain/physiopathology ; Brain Mapping ; Choice Behavior/physiology ; Female ; Humans ; Impulsive Behavior/physiology ; Male ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/physiopathology ; Positron-Emission Tomography ; Pramipexole ; Reward ; Signal Processing, Computer-Assisted ; Task Performance and Analysis
Czasopismo naukowe
Tytuł :
Quantifying significance of topographical similarities of disease-related brain metabolic patterns.
Autorzy :
Ko JH; Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America.
Spetsieris P; Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America.
Ma Y; Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America.
Dhawan V; Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America.
Eidelberg D; Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America.
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Źródło :
PloS one [PLoS One] 2014 Jan 31; Vol. 9 (1), pp. e88119. Date of Electronic Publication: 2014 Jan 31 (Print Publication: 2014).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain*/diagnostic imaging
Brain*/metabolism
Brain Diseases*/diagnostic imaging
Brain Diseases*/metabolism
Computer Simulation*
Magnetic Resonance Imaging*
Female ; Humans ; Male ; Radiography
Czasopismo naukowe
Tytuł :
Evaluation of node-inhomogeneity effects on the functional brain network properties using an anatomy-constrained hierarchical brain parcellation.
Autorzy :
Park B; Department of Nuclear Medicine and Radiology, and Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea ; BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Ko JH
Lee JD
Park HJ
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Źródło :
PloS one [PLoS One] 2013 Sep 18; Vol. 8 (9), pp. e74935. Date of Electronic Publication: 2013 Sep 18 (Print Publication: 2013).
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Brain*/anatomy & histology
Brain*/physiology
Models, Neurological*
Nerve Net*/anatomy & histology
Nerve Net*/physiology
Brain Mapping/*methods
Adult ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Parkinson's disease: increased motor network activity in the absence of movement.
Autorzy :
Ko JH; Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.
Mure H
Tang CC
Ma Y
Dhawan V
Spetsieris P
Eidelberg D
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2013 Mar 06; Vol. 33 (10), pp. 4540-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain Mapping*
Brain/*physiopathology
Deep Brain Stimulation/*methods
Motor Activity/*physiology
Parkinson Disease/*pathology
Parkinson Disease/*physiopathology
Aged ; Antiparkinson Agents/therapeutic use ; Brain/diagnostic imaging ; Brain/drug effects ; Cerebrovascular Circulation ; Cohort Studies ; Deuterium Oxide ; Female ; Humans ; Levodopa/therapeutic use ; Male ; Middle Aged ; Motor Activity/drug effects ; Neural Pathways/drug effects ; Neural Pathways/physiology ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/therapy ; Positron-Emission Tomography ; Subthalamic Nucleus/physiology
Czasopismo naukowe
Tytuł :
Brain stimulation and functional imaging with fMRI and PET.
Autorzy :
Ko JH; Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, NY, USA.
Tang CC
Eidelberg D
Pokaż więcej
Źródło :
Handbook of clinical neurology [Handb Clin Neurol] 2013; Vol. 116, pp. 77-95.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain*/blood supply
Brain*/diagnostic imaging
Brain*/physiology
Deep Brain Stimulation*
Magnetic Resonance Imaging*
Positron-Emission Tomography*
Animals ; Humans
Czasopismo naukowe
Tytuł :
Dopaminergic neurotransmission in the human brain: new lessons from perturbation and imaging.
Autorzy :
Ko JH; PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada.
Strafella AP
Pokaż więcej
Źródło :
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [Neuroscientist] 2012 Apr; Vol. 18 (2), pp. 149-68. Date of Electronic Publication: 2011 May 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neuroimaging*
Brain/*anatomy & histology
Brain/*physiology
Dopamine/*physiology
Synaptic Transmission/*physiology
Animals ; Brain Diseases/pathology ; Brain Diseases/physiopathology ; Cognition/physiology ; Corpus Striatum/anatomy & histology ; Corpus Striatum/metabolism ; Dopamine/analysis ; Dopamine/metabolism ; Humans ; Mental Disorders/pathology ; Mental Disorders/physiopathology ; Nervous System Diseases/pathology ; Nervous System Diseases/physiopathology ; Positron-Emission Tomography ; Transcranial Magnetic Stimulation
Czasopismo naukowe
Tytuł :
Scrub typhus meningo-encephalitis with focal neurologic signs and associated brain MRI abnormal findings: literature review.
Autorzy :
Yum KS; Department of Neurology, Konyang University College of Medicine, 685 Gasuwon-dong, Seo-gu, Daejeon-city 302-718, Republic of Korea.
Na SJ
Lee KO
Ko JH
Pokaż więcej
Źródło :
Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2011 Apr; Vol. 113 (3), pp. 250-3. Date of Electronic Publication: 2010 Dec 03.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Brain/*pathology
Meningoencephalitis/*pathology
Scrub Typhus/*pathology
Adult ; Anti-Bacterial Agents/therapeutic use ; Doxycycline/therapeutic use ; Humans ; Male ; Meningoencephalitis/complications ; Meningoencephalitis/diagnosis ; Nervous System Diseases/etiology ; Neurologic Examination ; Scrub Typhus/complications ; Scrub Typhus/diagnosis
Czasopismo naukowe
    Wyświetlanie 1-18 z 18

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