Autor: "Kofler, R." - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The synthetic glucocorticoids prednisolone and dexamethasone regulate the same genes in acute lymphoblastic leukemia cells.
Autorzy:: Bindreither D
Ecker S
Gschirr B
Kofler A
Kofler R
Rainer J; Division of Molecular Pathophysiology, Biocenter, Medical University Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria. .; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2014 Aug 07; Vol. 15, pp. 662. Date of Electronic Publication: 2014 Aug 07.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Dexamethasone/*pharmacology
Genes, Neoplasm/*drug effects
Glucocorticoids/*pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
Prednisolone/*pharmacology
Apoptosis/drug effects ; Child ; Humans ; Jurkat Cells ; Transcription, Genetic/drug effects

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Skocz do pozycji: 2.

Tytuł:: Translational profiling in childhood acute lymphoblastic leukemia: no evidence for glucocorticoid regulation of mRNA translation.
Autorzy:: Aneichyk T; Division of Molecular Pathophysiology, Biocenter, Innsbruck Medical University, Innsbruck 6020, Austria. .
Bindreither D
Mantinger C
Grazio D
Goetsch K
Kofler R
Rainer J; Pokaż więcej
Źródło:: BMC genomics [BMC Genomics] 2013 Dec 01; Vol. 14, pp. 844. Date of Electronic Publication: 2013 Dec 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein Biosynthesis*
Transcriptome*
Glucocorticoids/*physiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
RNA, Messenger/*genetics
Cell Line, Tumor ; Gene Expression Profiling ; Genome, Human ; Humans ; Oligonucleotide Array Sequence Analysis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; RNA, Messenger/metabolism

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Skocz do pozycji: 3.

Tytuł:: The leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression.
Autorzy:: Fuka G; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Kauer M
Kofler R
Haas OA
Panzer-Grümayer R; Pokaż więcej
Źródło:: PloS one [PLoS One] 2011; Vol. 6 (10), pp. e26348. Date of Electronic Publication: 2011 Oct 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Silencing*
Core Binding Factor Alpha 2 Subunit/*deficiency
Core Binding Factor Alpha 2 Subunit/*genetics
Gene Fusion/*genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Proto-Oncogene Proteins c-ets/*deficiency
Proto-Oncogene Proteins c-ets/*genetics
Repressor Proteins/*deficiency
Repressor Proteins/*genetics
Cell Line, Tumor ; Child ; Gene Knockdown Techniques ; Humans ; Oligonucleotide Array Sequence Analysis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; Reproducibility of Results ; Transcriptome/genetics ; ETS Translocation Variant 6 Protein

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Skocz do pozycji: 4.

Tytuł:: Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells.
Autorzy:: Carlet M; Division Molecular Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Janjetovic K
Rainer J
Schmidt S
Panzer-Grümayer R
Mann G
Prelog M
Meister B
Ploner C
Kofler R; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2010 Nov 23; Vol. 10, pp. 638. Date of Electronic Publication: 2010 Nov 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*therapeutic use
Apoptosis/*drug effects
Dexamethasone/*therapeutic use
Glucocorticoids/*therapeutic use
Lymphocytes/*drug effects
Phosphofructokinase-2/*metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Animals ; Apoptosis/genetics ; Cell Survival ; Child ; Doxycycline/pharmacology ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Enzymologic/drug effects ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Jurkat Cells ; Lymphocytes/enzymology ; Lymphocytes/pathology ; Male ; Oligonucleotide Array Sequence Analysis ; Phosphofructokinase-2/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Rats ; Time Factors ; Transfection

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Skocz do pozycji: 5.

Tytuł:: Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis.
Autorzy:: Eberhart K
Renner K
Ritter I
Kastenberger M
Singer K
Hellerbrand C
Kreutz M
Kofler R
Oefner PJ; Pokaż więcej
Źródło:: Leukemia [Leukemia] 2009 Nov; Vol. 23 (11), pp. 2167-70. Date of Electronic Publication: 2009 Aug 06.
Typ publikacji:: Letter
MeSH Terms:: Apoptosis/*drug effects
Deoxyglucose/*pharmacology
Glucocorticoids/*pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
Animals ; Dose-Response Relationship, Drug ; Drug Synergism ; Humans

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Skocz do pozycji: 6.

Tytuł:: Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia.
Autorzy:: Rainer J; Tyrolean Cancer Research Institute, Innsbruck, Austria.
Ploner C
Jesacher S
Ploner A
Eduardoff M
Mansha M
Wasim M
Panzer-Grümayer R
Trajanoski Z
Niederegger H
Kofler R; Pokaż więcej
Źródło:: Leukemia [Leukemia] 2009 Apr; Vol. 23 (4), pp. 746-52. Date of Electronic Publication: 2009 Jan 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Leukemic/*drug effects
Glucocorticoids/*pharmacology
MicroRNAs/*analysis
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Apoptosis ; Cell Line, Tumor ; DNA Polymerase II/genetics ; Gene Expression Profiling ; Glucocorticoids/therapeutic use ; Humans ; MicroRNAs/genetics ; RNA, Messenger

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Skocz do pozycji: 7.

Tytuł:: The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia.
Autorzy:: Ploner C; Division Molecular Pathophysiology, Department Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Rainer J
Niederegger H
Eduardoff M
Villunger A
Geley S
Kofler R; Pokaż więcej
Źródło:: Leukemia [Leukemia] 2008 Feb; Vol. 22 (2), pp. 370-7. Date of Electronic Publication: 2007 Nov 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis/*drug effects
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
Proto-Oncogene Proteins c-bcl-2/*physiology
Adaptor Proteins, Signal Transducing/genetics ; Apoptosis Regulatory Proteins/drug effects ; Apoptosis Regulatory Proteins/genetics ; Bcl-2-Like Protein 11 ; Child ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Humans ; Membrane Proteins/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics

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Skocz do pozycji: 8.

Tytuł:: G1 arrest by p16INK4A uncouples growth from cell cycle progression in leukemia cells with deregulated cyclin E and c-Myc expression.
Autorzy:: Ausserlechner MJ; Molecular Biology Research Laboratory, Department of Pediatrics, Medical University Innsbruck, A-6020 Innsbruck, Austria. />Obexer P
Geley S
Kofler R; Pokaż więcej
Źródło:: Leukemia [Leukemia] 2005 Jun; Vol. 19 (6), pp. 1051-7.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cyclin E/*genetics
Cyclin-Dependent Kinase Inhibitor p16/*genetics
Genes, myc/*physiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*physiopathology
Apoptosis/physiology ; Biomarkers, Tumor ; Cell Differentiation/physiology ; Cell Division/physiology ; Child ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; G1 Phase/physiology ; Gene Expression Regulation, Leukemic ; Humans ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphorylation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Retinoblastoma-Like Protein p107 ; T-Lymphocytes/pathology ; T-Lymphocytes/physiology ; Telomerase/metabolism ; Transcriptional Activation/physiology

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Skocz do pozycji: 9.

Tytuł:: Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts.
Autorzy:: Bernhard D; Tyrolean Cancer Research Institute, Innrain 66, A-6020 Innsbruck, Austria. David_ />Skvortsov S
Tinhofer I
Hübl H
Greil R
Csordas A
Kofler R; Pokaż więcej
Źródło:: Cell death and differentiation [Cell Death Differ] 2001 Oct; Vol. 8 (10), pp. 1014-21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*
Histone Deacetylase Inhibitors*
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
fas Receptor/*physiology
Butyrates/pharmacology ; Caspase 2 ; Caspase 3 ; Caspase 8 ; Caspase 9 ; Caspases/metabolism ; Drug Synergism ; Enzyme Inhibitors/pharmacology ; Fatty Acids/pharmacology ; Humans ; Hydroxamic Acids/pharmacology ; Kinetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology ; Signal Transduction ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/pharmacology

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