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Tytuł :
The ACE2-binding Interface of SARS-CoV-2 Spike Inherently Deflects Immune Recognition.
Autorzy :
Hattori T; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: .
Koide A; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA; Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Noval MG; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Panchenko T; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.
Romero LA; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Teng KW; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.
Tada T; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Landau NR; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Stapleford KA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Koide S; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: Shohei.Koide@nyulangone.org.
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Feb 05; Vol. 433 (3), pp. 166748. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*immunology
Angiotensin-Converting Enzyme 2/*metabolism
Spike Glycoprotein, Coronavirus/*immunology
Spike Glycoprotein, Coronavirus/*metabolism
A549 Cells ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Binding Sites ; Chlorocebus aethiops ; Epitopes/immunology ; Host-Pathogen Interactions ; Humans ; Immune Sera ; Immunoglobulin G/metabolism ; Mutation ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
An Overlapping Region between the Two Terminal Folding Units of the Outer Surface Protein A (OspA) Controls Its Folding Behavior.
Autorzy :
Makabe K; Graduate School of Science and Engineering, Yamagata University, Jyonan 4-3-16, Yonezawa, Yamagata 992-8510, Japan; Okazaki Institute for Integrative Bioscience and Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan; Department of Functional Molecular Science, SOKENDAI (The Graduate University for Advanced Studies), 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan. Electronic address: .
Nakamura T; Okazaki Institute for Integrative Bioscience and Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan.
Dhar D; Okazaki Institute for Integrative Bioscience and Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan.
Ikura T; Laboratory of Structural Biology, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Koide S; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, and Perlmutter Cancer Center at NYU Langone Health, New York, NY 10016, USA.
Kuwajima K; Okazaki Institute for Integrative Bioscience and Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan; Department of Functional Molecular Science, SOKENDAI (The Graduate University for Advanced Studies), 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan; Department of Physics, School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; School of Computational Sciences, Korea Institute for Advanced Study (KIAS), Dongdaemun-gu, Seoul 130-722, Korea.
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Źródło :
Journal of molecular biology [J Mol Biol] 2018 Jun 08; Vol. 430 (12), pp. 1799-1813. Date of Electronic Publication: 2018 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Surface/*chemistry
Bacterial Outer Membrane Proteins/*chemistry
Bacterial Vaccines/*chemistry
Borrelia burgdorferi/*metabolism
Lipoproteins/*chemistry
Urea/*pharmacology
Antigens, Surface/genetics ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Vaccines/genetics ; Borrelia burgdorferi/chemistry ; Borrelia burgdorferi/genetics ; Circular Dichroism ; Kinetics ; Lipoproteins/genetics ; Models, Molecular ; Protein Domains ; Protein Folding/drug effects ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
Autorzy :
Kükenshöner T; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland.
Schmit NE; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland.
Bouda E; Department of Pharmacological Sciences, Stony Brook University, BST 8-140, Stony Brook, NY 11794-8651, USA.
Sha F; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
Pojer F; Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne, Station 19, 1015 Lausanne, Switzerland.
Koide A; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, 430 East 29th Street, New York, NY 10016, USA; Department of Medicine, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA.
Seeliger M; Department of Pharmacological Sciences, Stony Brook University, BST 8-140, Stony Brook, NY 11794-8651, USA.
Koide S; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, 430 East 29th Street, New York, NY 10016, USA; Department of Medicine, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA. Electronic address: Shohei.Koide@nyumc.org.
Hantschel O; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2017 May 05; Vol. 429 (9), pp. 1364-1380. Date of Electronic Publication: 2017 Mar 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Phosphotyrosine/*immunology
src Homology Domains/*immunology
src-Family Kinases/*antagonists & inhibitors
src-Family Kinases/*immunology
Antibodies, Monoclonal/chemistry ; Crystallography, X-Ray ; Humans ; Kinetics ; Models, Molecular ; Protein Binding ; Protein Conformation ; src-Family Kinases/chemistry
Czasopismo naukowe
Tytuł :
Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Autorzy :
Shao Y; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Huang H; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Qin D; Department of Molecular Genetics and Cell Biology, Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.
Li NS; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Koide A; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Staley JP; Department of Molecular Genetics and Cell Biology, Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.
Koide S; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Kossiakoff AA; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Piccirilli JA; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2016 Oct 09; Vol. 428 (20), pp. 4100-4114. Date of Electronic Publication: 2016 Sep 02.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Immunoglobulin Fab Fragments/*metabolism
Immunologic Factors/*metabolism
RNA/*metabolism
RNA-Binding Proteins/*metabolism
Crystallography, X-Ray ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/genetics ; Immunologic Factors/chemistry ; Immunologic Factors/genetics ; Kinetics ; Models, Molecular ; Nucleic Acid Conformation ; Peptide Library ; Protein Binding ; Protein Conformation ; RNA/chemistry ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
CDR-H3 diversity is not required for antigen recognition by synthetic antibodies.
Autorzy :
Persson H; Banting and Best Department of Medical Research and Department of Molecular Genetics, The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1.
Ye W
Wernimont A
Adams JJ
Koide A
Koide S
Lam R
Sidhu SS
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Źródło :
Journal of molecular biology [J Mol Biol] 2013 Feb 22; Vol. 425 (4), pp. 803-11. Date of Electronic Publication: 2012 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*immunology
Antigens/*immunology
Complementarity Determining Regions/*immunology
Immunoglobulin Heavy Chains/*immunology
Amino Acid Sequence ; Antibodies/chemistry ; Antibodies/genetics ; Complementarity Determining Regions/chemistry ; Complementarity Determining Regions/genetics ; Crystallography, X-Ray ; Genetic Variation/immunology ; Hydrogen Bonding ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/genetics ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Heavy Chains/genetics ; Models, Molecular ; Molecular Sequence Data ; Peptide Library ; Protein Conformation ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Broad ranges of affinity and specificity of anti-histone antibodies revealed by a quantitative peptide immunoprecipitation assay.
Autorzy :
Nishikori S; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Hattori T
Fuchs SM
Yasui N
Wojcik J
Koide A
Strahl BD
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2012 Dec 14; Vol. 424 (5), pp. 391-9. Date of Electronic Publication: 2012 Oct 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibody Affinity*
Antibodies/*immunology
Chromatin Immunoprecipitation/*methods
Histones/*immunology
Antibodies/classification ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold.
Autorzy :
Koide A; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago,IL 60637, USA.
Wojcik J
Gilbreth RN
Hoey RJ
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2012 Jan 13; Vol. 415 (2), pp. 393-405. Date of Electronic Publication: 2011 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Fibronectins/*chemistry
Fibronectins/*metabolism
Amino Acid Sequence ; Crystallography, X-Ray ; Fibronectins/genetics ; Models, Molecular ; Molecular Sequence Data ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Peptide Library ; Protein Binding ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; Sequence Homology
Czasopismo naukowe
Tytuł :
Binding modes of thioflavin-T to the single-layer beta-sheet of the peptide self-assembly mimics.
Autorzy :
Wu C; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.
Biancalana M
Koide S
Shea JE
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Źródło :
Journal of molecular biology [J Mol Biol] 2009 Dec 11; Vol. 394 (4), pp. 627-33. Date of Electronic Publication: 2009 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Thiazoles/*metabolism
Amyloid beta-Peptides/chemistry ; Benzothiazoles ; Binding Sites ; Kinetics ; Models, Molecular ; Protein Binding ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Structural basis for exquisite specificity of affinity clamps, synthetic binding proteins generated through directed domain-interface evolution.
Autorzy :
Huang J; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
Makabe K
Biancalana M
Koide A
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2009 Oct 09; Vol. 392 (5), pp. 1221-31. Date of Electronic Publication: 2009 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Directed Molecular Evolution*
Fibronectins/*chemistry
Fibronectins/*metabolism
PDZ Domains/*genetics
Peptides/*metabolism
Crystallography, X-Ray ; Fibronectins/genetics ; Models, Molecular ; Peptide Library ; Protein Binding ; Protein Engineering/methods ; Protein Structure, Tertiary ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Generation of new protein functions by nonhomologous combinations and rearrangements of domains and modules.
Autorzy :
Koide S; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, United States.
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Źródło :
Current opinion in biotechnology [Curr Opin Biotechnol] 2009 Aug; Vol. 20 (4), pp. 398-404. Date of Electronic Publication: 2009 Aug 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Proteins/*physiology
Protein Folding ; Proteins/chemistry
Czasopismo naukowe
Tytuł :
Molecular mechanism of thioflavin-T binding to the surface of beta-rich peptide self-assemblies.
Autorzy :
Biancalana M; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
Makabe K
Koide A
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2009 Jan 30; Vol. 385 (4), pp. 1052-63. Date of Electronic Publication: 2008 Nov 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Peptides/*chemistry
Peptides/*metabolism
Thiazoles/*metabolism
Benzothiazoles ; Binding Sites ; Crystallography, X-Ray ; Models, Biological ; Models, Molecular ; Protein Structure, Secondary ; Surface Properties ; Thiazoles/chemistry ; Tyrosine/metabolism
Czasopismo naukowe
Tytuł :
Aromatic cross-strand ladders control the structure and stability of beta-rich peptide self-assembly mimics.
Autorzy :
Biancalana M; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Makabe K
Koide A
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2008 Oct 31; Vol. 383 (1), pp. 205-13. Date of Electronic Publication: 2008 Aug 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Peptides/*chemistry
Amino Acids, Aromatic/chemistry ; Crystallography, X-Ray ; Drug Stability ; Models, Molecular ; Molecular Mimicry ; Mutation ; Nuclear Magnetic Resonance, Biomolecular ; Peptides/genetics ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thermodynamics
Czasopismo naukowe
Tytuł :
High-throughput analysis of the protein sequence-stability landscape using a quantitative yeast surface two-hybrid system and fragment reconstitution.
Autorzy :
Dutta S; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Koide A
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2008 Oct 10; Vol. 382 (3), pp. 721-33. Date of Electronic Publication: 2008 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Sequence*
Fibronectins*/chemistry
Fibronectins*/genetics
Fibronectins*/metabolism
Peptide Fragments*/chemistry
Peptide Fragments*/genetics
Peptide Fragments*/metabolism
Protein Conformation*
Two-Hybrid System Techniques*
Directed Molecular Evolution ; Humans ; Molecular Sequence Data ; Mutation ; Peptide Library ; Protein Engineering ; Random Allocation ; Thermodynamics
Czasopismo naukowe
Tytuł :
A dominant conformational role for amino acid diversity in minimalist protein-protein interfaces.
Autorzy :
Gilbreth RN; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
Esaki K
Koide A
Sidhu SS
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2008 Aug 29; Vol. 381 (2), pp. 407-18. Date of Electronic Publication: 2008 Jun 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amino Acids/*chemistry
Carrier Proteins/*chemistry
Fibronectins/*chemistry
Amino Acids/genetics ; Amino Acids/metabolism ; Calorimetry ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Crystallography, X-Ray ; Fibronectins/genetics ; Fibronectins/metabolism ; Kinetics ; Maltose-Binding Proteins ; Models, Molecular ; Mutagenesis ; Protein Binding ; Protein Structure, Secondary ; Serine/chemistry ; Serine/genetics ; Serine/metabolism ; Thermodynamics ; Tyrosine/chemistry ; Tyrosine/genetics ; Tyrosine/metabolism
Czasopismo naukowe
Tytuł :
High-resolution structure of a self-assembly-competent form of a hydrophobic peptide captured in a soluble beta-sheet scaffold.
Autorzy :
Makabe K; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E. 57th Street, Chicago, IL 60637, USA.
Biancalana M
Yan S
Tereshko V
Gawlak G
Miller-Auer H
Meredith SC
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2008 Apr 25; Vol. 378 (2), pp. 459-67. Date of Electronic Publication: 2008 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antigens, Surface/*chemistry
Bacterial Outer Membrane Proteins/*chemistry
Bacterial Vaccines/*chemistry
Isoleucine/*chemistry
Lipoproteins/*chemistry
Oligopeptides/*chemistry
Borrelia ; Circular Dichroism ; Crystallography, X-Ray ; Hydrophobic and Hydrophilic Interactions ; Methods ; Microscopy, Atomic Force ; Models, Molecular ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.
Autorzy :
Fellouse FA; Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Esaki K
Birtalan S
Raptis D
Cancasci VJ
Koide A
Jhurani P
Vasser M
Wiesmann C
Kossiakoff AA
Koide S
Sidhu SS
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Źródło :
Journal of molecular biology [J Mol Biol] 2007 Nov 02; Vol. 373 (4), pp. 924-40. Date of Electronic Publication: 2007 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Peptide Library*
Antibodies/*chemistry
Protein Engineering/*methods
Amino Acid Sequence ; Complementarity Determining Regions/chemistry ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Molecular Sequence Data ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Vascular Endothelial Growth Factor A/chemistry
Czasopismo naukowe
Tytuł :
Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.
Autorzy :
Koide A; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Tereshko V
Uysal S
Margalef K
Kossiakoff AA
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2007 Nov 02; Vol. 373 (4), pp. 941-53. Date of Electronic Publication: 2007 Aug 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies/*chemistry
Carrier Proteins/*chemistry
Amino Acid Sequence ; Antibodies/genetics ; Antibodies/metabolism ; Binding Sites/genetics ; Binding Sites, Antibody/genetics ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Crystallography, X-Ray ; Models, Molecular ; Molecular Sequence Data ; Peptide Library ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary
Czasopismo naukowe
Tytuł :
Hydrophobic surface burial is the major stability determinant of a flat, single-layer beta-sheet.
Autorzy :
Yan S; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Gawlak G
Makabe K
Tereshko V
Koide A
Koide S
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Źródło :
Journal of molecular biology [J Mol Biol] 2007 Apr 20; Vol. 368 (1), pp. 230-43. Date of Electronic Publication: 2007 Feb 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Hydrophobic and Hydrophilic Interactions*
Protein Folding*
Antigens, Surface/*chemistry
Bacterial Outer Membrane Proteins/*chemistry
Bacterial Vaccines/*chemistry
Lipoproteins/*chemistry
Alanine/genetics ; Amino Acid Sequence ; Amino Acid Substitution ; Antigens, Surface/genetics ; Antigens, Surface/metabolism ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/metabolism ; Bacterial Vaccines/genetics ; Bacterial Vaccines/metabolism ; Borrelia burgdorferi ; Crystallography, X-Ray ; Glutamic Acid/genetics ; Lipoproteins/genetics ; Lipoproteins/metabolism ; Lysine/genetics ; Models, Biological ; Models, Molecular ; Molecular Sequence Data ; Mutant Proteins/chemistry ; Protein Denaturation ; Protein Structure, Secondary
Czasopismo naukowe

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