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    Wyświetlanie 1-8 z 8
    Tytuł:
    Computational cardiac physiology for new modelers: Origins, foundations, and future.
    Autorzy:
    Koivumäki JT; Faculty of Medicine and Health Technology, and Centre of Excellence in Body-on-Chip Research, Tampere University, Tampere, Finland.
    Hoffman J; Division of Computational Science and Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
    Maleckar MM; Computational Physiology Department, Simula Research Laboratory, Oslo, Norway.
    Einevoll GT; Centre for Integrative Neuroplasticity, University of Oslo, Oslo, Norway.; Department of Physics, University of Oslo, Oslo, Norway.; Department of Physics, Norwegian University of Life Sciences, Ås, Norway.
    Sundnes J; Computational Physiology Department, Simula Research Laboratory, Oslo, Norway.
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    Źródło:
    Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2022 Oct; Vol. 236 (2), pp. e13865. Date of Electronic Publication: 2022 Aug 25.
    Typ publikacji:
    Journal Article; Review; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cardiovascular Physiological Phenomena*
    Models, Theoretical*
    Models, Biological ; Research Design
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Regulation of APD and Force by the Na Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue.
    Autorzy:
    Ismaili D; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Gurr K; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Horváth A; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Yuan L; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
    Lemoine MD; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Schulz C; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Sani J; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Petersen J; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiovascular Surgery, University Heart and Vascular Center, 20246 Hamburg, Germany.
    Reichenspurner H; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiovascular Surgery, University Heart and Vascular Center, 20246 Hamburg, Germany.
    Kirchhof P; Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
    Jespersen T; Department of Cardiovascular Surgery, University Heart and Vascular Center, 20246 Hamburg, Germany.
    Eschenhagen T; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Hansen A; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Koivumäki JT; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
    Christ T; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
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    Źródło:
    Cells [Cells] 2022 Aug 05; Vol. 11 (15). Date of Electronic Publication: 2022 Aug 05.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Induced Pluripotent Stem Cells*/metabolism
    Action Potentials ; Adult ; Animals ; Heart Ventricles/metabolism ; Humans ; Myocytes, Cardiac/metabolism ; Rats ; Sodium-Calcium Exchanger/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A mathematical model of hiPSC cardiomyocytes electromechanics.
    Autorzy:
    Forouzandehmehr M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
    Koivumäki JT; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
    Hyttinen J; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
    Paci M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
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    Źródło:
    Physiological reports [Physiol Rep] 2021 Nov; Vol. 9 (22), pp. e15124.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Action Potentials/*physiology
    Electrophysiological Phenomena/*physiology
    Induced Pluripotent Stem Cells/*physiology
    Myocardial Contraction/*physiology
    Myocytes, Cardiac/*physiology
    3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology ; Action Potentials/drug effects ; Calcium Channel Agonists/pharmacology ; Calcium Channel Blockers/pharmacology ; Computer Simulation ; Electrophysiological Phenomena/drug effects ; Humans ; Models, Theoretical ; Myocardial Contraction/drug effects ; Myocytes, Cardiac/drug effects ; Verapamil/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells.
    Autorzy:
    Shah D; Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University, Tampere 33520, Finland.
    Prajapati C; Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University, Tampere 33520, Finland.
    Penttinen K; Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University, Tampere 33520, Finland.
    Cherian RM; Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University, Tampere 33520, Finland.
    Koivumäki JT; Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University, Tampere 33520, Finland.
    Alexanova A; Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University, Tampere 33520, Finland.
    Hyttinen J; Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University, Tampere 33520, Finland.
    Aalto-Setälä K; Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University, Tampere 33520, Finland.; Heart Hospital, Tampere University Hospital, Tampere 33520, Finland.
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    Źródło:
    Cells [Cells] 2020 May 07; Vol. 9 (5). Date of Electronic Publication: 2020 May 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Models, Biological*
    Induced Pluripotent Stem Cells/*pathology
    Long QT Syndrome/*genetics
    Long QT Syndrome/*pathology
    Mutation/*genetics
    Myocytes, Cardiac/*pathology
    Adult ; Alleles ; Case-Control Studies ; Cell Aggregation ; Female ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Ion Channel Gating ; Male ; Middle Aged ; Myocytes, Cardiac/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (I bk,Ca ).
    Autorzy:
    Horváth A; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, 6721 Szeged, Hungary.
    Christ T; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Koivumäki JT; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
    Prondzynski M; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Zech ATL; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Spohn M; Bioinformatics Core, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
    Saleem U; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Mannhardt I; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Ulmer B; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Girdauskas E; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiovascular Surgery, University Heart Center, 20246 Hamburg, Germany.
    Meyer C; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, 6721 Szeged, Hungary.; Department of Cardiology-Electrophysiology, University Heart Center, 20246 Hamburg, Germany.
    Hansen A; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Eschenhagen T; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
    Lemoine MD; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiology-Electrophysiology, University Heart Center, 20246 Hamburg, Germany.
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    Źródło:
    Cells [Cells] 2020 Jan 20; Vol. 9 (1). Date of Electronic Publication: 2020 Jan 20.
    Typ publikacji:
    Case Reports; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Action Potentials*/physiology
    Artifacts*
    Induced Pluripotent Stem Cells/*metabolism
    Myocytes, Cardiac/*metabolism
    Potassium Channels, Calcium-Activated/*metabolism
    Adult ; Cell Line ; Computer Simulation ; Humans ; Peptides/toxicity ; Tissue Engineering
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Ca(2+) -activated K(+) current is essential for maintaining excitability and gene transcription in early embryonic cardiomyocytes.
    Autorzy:
    Karppinen S; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    Rapila R; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    Naumenko N; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    Tuomainen T; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    Koivumäki JT; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    Hänninen SL; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Institute of Biomedicine, Department of Physiology and Biocenter Oulu, University of Oulu, Oulu, Finland.
    Korhonen T; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    Tavi P; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
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    Źródło:
    Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2016 Jan; Vol. 216 (1), pp. 101-11. Date of Electronic Publication: 2015 Jun 28.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Calcium/*metabolism
    Calcium Signaling/*physiology
    Membrane Potentials/*physiology
    Myocytes, Cardiac/*cytology
    Myocytes, Cardiac/*metabolism
    Potassium/*metabolism
    Sarcoplasmic Reticulum/*metabolism
    Animals ; Apamin/metabolism ; Female ; Mice ; Muscle, Smooth/metabolism ; Pregnancy ; Transcription, Genetic
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    In silico screening of the key cellular remodeling targets in chronic atrial fibrillation.
    Autorzy:
    Koivumäki JT; Simula Research Laboratory, Center for Cardiological Innovation and Center for Biomedical Computing, Oslo, Norway; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    Seemann G; Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany.
    Maleckar MM; Simula Research Laboratory, Center for Cardiological Innovation and Center for Biomedical Computing, Oslo, Norway.
    Tavi P; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2014 May 22; Vol. 10 (5), pp. e1003620. Date of Electronic Publication: 2014 May 22 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Models, Cardiovascular*
    Action Potentials/*physiology
    Atrial Fibrillation/*physiopathology
    Calcium Signaling/*physiology
    Heart Atria/*physiopathology
    Heart Conduction System/*physiopathology
    Myocytes, Cardiac/*physiology
    Atrial Remodeling ; Calcium/metabolism ; Calcium Channels/physiology ; Cells, Cultured ; Computer Simulation ; Heart Atria/pathology ; Heart Conduction System/pathology ; Humans ; Ion Channel Gating/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Impact of sarcoplasmic reticulum calcium release on calcium dynamics and action potential morphology in human atrial myocytes: a computational study.
    Autorzy:
    Koivumäki JT; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    Korhonen T
    Tavi P
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2011 Jan 27; Vol. 7 (1), pp. e1001067. Date of Electronic Publication: 2011 Jan 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Action Potentials*
    Calcium/*metabolism
    Heart Atria/*metabolism
    Sarcoplasmic Reticulum/*metabolism
    Diffusion ; Heart Atria/cytology ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-8 z 8

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