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    Wyświetlanie 1-15 z 15
    Tytuł:
    Autonomous power supply using solar energy in Russian Far East regions
    Autorzy:
    Komarova Nina A.
    Rafikova Yulia Yu.
    Tarasenko Alexey B.
    Kiseleva Sofya V.
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    Temat:
    Engineering (General). Civil engineering (General)
    TA1-2040
    Źródło:
    MATEC Web of Conferences, Vol 112, p 10011 (2017)
    Opis pliku:
    electronic resource
    Relacje:
    https://doaj.org/toc/2261-236X
    Dostęp URL:
    https://doaj.org/article/c14aa6dfe3034b6aa4060ddfc26ed1d9  Link otwiera się w nowym oknie
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling.
    Autorzy:
    Salomatina OV; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., Novosibirsk 630090, Russia.
    Kornienko TE; Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8, Lavrent'ev Ave., Novosibirsk 630090, Russia.
    Zakharenko AL; Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8, Lavrent'ev Ave., Novosibirsk 630090, Russia.
    Komarova NI; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., Novosibirsk 630090, Russia.
    Achara C; School of Pharmacy and Bioengineering, Keele University, Hornbeam Building, Newcastle-under-Lyme, Staffordshire ST5 5BG, UK.
    Reynisson J; School of Pharmacy and Bioengineering, Keele University, Hornbeam Building, Newcastle-under-Lyme, Staffordshire ST5 5BG, UK.
    Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., Novosibirsk 630090, Russia.
    Lavrik OI; Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8, Lavrent'ev Ave., Novosibirsk 630090, Russia.
    Volcho KP; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., Novosibirsk 630090, Russia.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2024 Jan 24; Vol. 29 (3). Date of Electronic Publication: 2024 Jan 24.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Phosphodiesterase Inhibitors*/chemistry
    Phosphoric Diester Hydrolases*/metabolism
    Models, Molecular ; Deoxycholic Acid/pharmacology ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Novel Epoxides of Soloxolone Methyl: An Effect of the Formation of Oxirane Ring and Stereoisomerism on Cytotoxic Profile, Anti-Metastatic and Anti-Inflammatory Activities In Vitro and In Vivo.
    Autorzy:
    Salomatina OV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 8, 630090 Novosibirsk, Russia.; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 9, 630090 Novosibirsk, Russia.
    Sen'kova AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 8, 630090 Novosibirsk, Russia.
    Moralev AD; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 8, 630090 Novosibirsk, Russia.; Faculty of Natural Sciences, Novosibirsk State University, Pirogova Str., 1, 630090 Novosibirsk, Russia.
    Savin IA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 8, 630090 Novosibirsk, Russia.
    Komarova NI; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 9, 630090 Novosibirsk, Russia.
    Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 9, 630090 Novosibirsk, Russia.
    Zenkova MA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 8, 630090 Novosibirsk, Russia.
    Markov AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Avenue, 8, 630090 Novosibirsk, Russia.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2022 Jun 01; Vol. 23 (11). Date of Electronic Publication: 2022 Jun 01.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents*/pharmacology
    Glycyrrhetinic Acid*/pharmacology
    Neoplasms*
    Animals ; Anti-Inflammatory Agents/pharmacology ; Epoxy Compounds/pharmacology ; Ethylene Oxide ; Mice ; Stereoisomerism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 Viruses.
    Autorzy:
    Fomenko VV; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.
    Rudometova NB; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
    Yarovaya OI; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.; Zelman Institute for Medicine and Psychology, Novosibirsk State University, Pirogov Str. 1, 630090 Novosibirsk, Russia.
    Rogachev AD; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.; Zelman Institute for Medicine and Psychology, Novosibirsk State University, Pirogov Str. 1, 630090 Novosibirsk, Russia.
    Fando AA; Zelman Institute for Medicine and Psychology, Novosibirsk State University, Pirogov Str. 1, 630090 Novosibirsk, Russia.
    Zaykovskaya AV; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
    Komarova NI; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.
    Shcherbakov DN; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
    Pyankov OV; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
    Pokrovsky AG; Zelman Institute for Medicine and Psychology, Novosibirsk State University, Pirogov Str. 1, 630090 Novosibirsk, Russia.
    Karpenko LI; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
    Maksyutov RA; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
    Salakhutdinov NF; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia.; Zelman Institute for Medicine and Psychology, Novosibirsk State University, Pirogov Str. 1, 630090 Novosibirsk, Russia.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2022 Jan 04; Vol. 27 (1). Date of Electronic Publication: 2022 Jan 04.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Virus Replication*
    COVID-19 Drug Treatment*
    Antiviral Agents/*pharmacology
    Glycyrrhizic Acid/*chemistry
    HIV Infections/*drug therapy
    HIV-1/*drug effects
    SARS-CoV-2/*drug effects
    Animals ; Antiviral Agents/chemical synthesis ; COVID-19/virology ; Chlorocebus aethiops ; HIV Infections/virology ; HeLa Cells ; Humans ; In Vitro Techniques ; Vero Cells
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2.
    Autorzy:
    Salomatina OV; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
    Dyrkheeva NS; Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
    Popadyuk II; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
    Zakharenko AL; Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
    Ilina ES; Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
    Komarova NI; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
    Reynisson J; School of Pharmacy and Bioengineering, Keele University, Staffordshire ST5 5BG, UK.
    Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
    Lavrik OI; Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
    Volcho KP; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9, Lavrent'ev Ave., 630090 Novosibirsk, Russia.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2021 Dec 23; Vol. 27 (1). Date of Electronic Publication: 2021 Dec 23.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Deoxycholic Acid/*analogs & derivatives
    Deoxycholic Acid/*chemistry
    Phosphodiesterase Inhibitors/*chemistry
    Phosphoric Diester Hydrolases/*chemistry
    Binding Sites ; Cell Line ; Chemical Phenomena ; Chemistry Techniques, Synthetic ; Deoxycholic Acid/pharmacology ; Enzyme Activation/drug effects ; Humans ; Models, Molecular ; Molecular Conformation ; Molecular Structure ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/pharmacology ; Phosphoric Diester Hydrolases/metabolism ; Protein Binding ; Recombinant Proteins/chemistry ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Novel 3'-Substituted-1',2',4'-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O -Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo.
    Autorzy:
    Markov AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
    Sen'kova AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
    Popadyuk II; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 9, 630090 Novosibirsk, Russia.
    Salomatina OV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 9, 630090 Novosibirsk, Russia.
    Logashenko EB; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
    Komarova NI; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 9, 630090 Novosibirsk, Russia.
    Ilyina AA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
    Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 9, 630090 Novosibirsk, Russia.
    Zenkova MA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev ave., 8, 630090 Novosibirsk, Russia.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2020 May 15; Vol. 21 (10). Date of Electronic Publication: 2020 May 15.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anti-Inflammatory Agents/*pharmacology
    Antineoplastic Agents/*pharmacology
    Glycyrrhetinic Acid/*pharmacology
    Oxadiazoles/*chemistry
    Oximes/*chemical synthesis
    Oximes/*pharmacology
    Acylation ; Anti-Inflammatory Agents/chemistry ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Carrageenan ; Caspases/metabolism ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Glycyrrhetinic Acid/chemical synthesis ; Glycyrrhetinic Acid/chemistry ; HeLa Cells ; Humans ; Inflammation/pathology ; Melanoma, Experimental/pathology ; Mitochondria/drug effects ; Mitochondria/metabolism ; Neoplasm Metastasis ; Oximes/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.
    Autorzy:
    Salomatina OV; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, acad. Lavrentjev ave. 9, Novosibirsk 630090, Russia. .
    Popadyuk II; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, acad. Lavrentjev ave. 9, Novosibirsk 630090, Russia. .
    Zakharenko AL; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SB RAS, acad. Lavrentjev ave. 8, Novosibirsk 630090, Russia. .
    Zakharova OD; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SB RAS, acad. Lavrentjev ave. 8, Novosibirsk 630090, Russia. .
    Fadeev DS; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, acad. Lavrentjev ave. 9, Novosibirsk 630090, Russia. .
    Komarova NI; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, acad. Lavrentjev ave. 9, Novosibirsk 630090, Russia. .
    Reynisson J; School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand. .
    Arabshahi HJ; School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand. .
    Chand R; School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand. .
    Volcho KP; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, acad. Lavrentjev ave. 9, Novosibirsk 630090, Russia. .; Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russia. .
    Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, acad. Lavrentjev ave. 9, Novosibirsk 630090, Russia. .; Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russia. .
    Lavrik OI; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, SB RAS, acad. Lavrentjev ave. 8, Novosibirsk 630090, Russia. .; Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russia. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2018 Mar 17; Vol. 23 (3). Date of Electronic Publication: 2018 Mar 17.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Bile Acids and Salts/*chemistry
    Bile Acids and Salts/*pharmacology
    Phosphodiesterase Inhibitors/*pharmacology
    Phosphoric Diester Hydrolases/*metabolism
    Bile Acids and Salts/chemical synthesis ; Binding Sites ; Drug Evaluation, Preclinical ; HCT116 Cells ; Humans ; MCF-7 Cells ; Molecular Docking Simulation ; Niacinamide/analogs & derivatives ; Niacinamide/chemical synthesis ; Niacinamide/chemistry ; Niacinamide/pharmacology ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/chemistry ; Tryptamines/chemical synthesis ; Tryptamines/chemistry ; Tryptamines/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A new approach to the synthesis of the 5'-end substituted oligonucleotides using T4 polynucleotide kinase and gamma-amides of ATP bearing photoreactive groups.
    Autorzy:
    Petrousseva IO; Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Russian Academy of Sciences, pr. Lavrent'eva 8, Novosibirsk, 630090 Russia.
    Safronov IV
    Komarova NI
    Kamynina TP
    Lavrik OI
    Khodyreva SN
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    Źródło:
    Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2003 Mar-Apr; Vol. 389, pp. 114-7.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Adenosine Triphosphate/*metabolism
    Amides/*metabolism
    Oligonucleotides/*biosynthesis
    Oligonucleotides/*chemistry
    Polynucleotide 5'-Hydroxyl-Kinase/*metabolism
    Animals ; Bacteriophage T4/enzymology ; Light ; Models, Molecular ; Phosphorylation ; Photoaffinity Labels ; Photochemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-15 z 15

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