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Wyszukujesz frazę ""Kooistra, AJ"" wg kryterium: Autor

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    Wyświetlanie 1-5 z 5
    Tytuł:
    Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks.
    Autorzy:
    Kanev GK; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Neurosurgery, Amsterdam University Medical Centers, Cancer Center Amsterdam, Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.
    Zhang Y; Department of Neurosurgery, Amsterdam University Medical Centers, Cancer Center Amsterdam, Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.
    Kooistra AJ; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
    Bender A; Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
    Leurs R; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
    Bailey D; The WINDOW consortium, www.window-consortium.org.; IOTA Pharmaceuticals Ltd, St Johns Innovation Centre, Cambridge, United Kingdom.
    Würdinger T; Department of Neurosurgery, Amsterdam University Medical Centers, Cancer Center Amsterdam, Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.; The WINDOW consortium, www.window-consortium.org.
    de Graaf C; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
    de Esch IJP; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
    Westerman BA; Department of Neurosurgery, Amsterdam University Medical Centers, Cancer Center Amsterdam, Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.; The WINDOW consortium, www.window-consortium.org.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2023 Sep 05; Vol. 19 (9), pp. e1011301. Date of Electronic Publication: 2023 Sep 05 (Print Publication: 2023).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Delivery Systems*
    Machine Learning*
    Neural Networks, Computer ; Protein Kinase Inhibitors/pharmacology ; Workflow
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Covalent Inhibition of the Histamine H 3 Receptor.
    Autorzy:
    Wágner G; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    Mocking TAM; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    Kooistra AJ; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    Slynko I; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    Ábrányi-Balogh P; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.
    Keserű GM; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.
    Wijtmans M; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    Vischer HF; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    de Esch IJP; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    Leurs R; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Dec 11; Vol. 24 (24). Date of Electronic Publication: 2019 Dec 11.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Isothiocyanates/*chemical synthesis
    Receptors, Histamine H3/*metabolism
    Small Molecule Libraries/*chemical synthesis
    Drug Inverse Agonism ; HEK293 Cells ; Histamine Agonists/chemical synthesis ; Histamine Agonists/chemistry ; Histamine Agonists/pharmacology ; Histamine Antagonists/chemical synthesis ; Histamine Antagonists/chemistry ; Histamine Antagonists/pharmacology ; Humans ; Isothiocyanates/chemistry ; Isothiocyanates/pharmacology ; Ligands ; Receptors, Histamine H3/chemistry ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Function-specific virtual screening for GPCR ligands using a combined scoring method.
    Autorzy:
    Kooistra AJ; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    Vischer HF; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    McNaught-Flores D; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    Leurs R; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    de Esch IJ; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
    de Graaf C; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
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    Źródło:
    Scientific reports [Sci Rep] 2016 Jun 24; Vol. 6, pp. 28288. Date of Electronic Publication: 2016 Jun 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    User-Computer Interface*
    Drug Evaluation, Preclinical/*methods
    Receptors, G-Protein-Coupled/*metabolism
    Adrenergic beta-Agonists/chemistry ; Adrenergic beta-Agonists/pharmacology ; Adrenergic beta-Antagonists/chemistry ; Adrenergic beta-Antagonists/pharmacology ; Binding Sites ; Computer Simulation ; Crystallography, X-Ray ; Drug Discovery ; HEK293 Cells ; Histamine Agonists/chemistry ; Histamine Agonists/pharmacology ; Histamine H1 Antagonists/chemistry ; Histamine H1 Antagonists/pharmacology ; Humans ; Ligands ; Models, Molecular ; Molecular Docking Simulation ; Protein Binding ; Radioligand Assay ; Receptors, Adrenergic, beta/chemistry ; Receptors, Adrenergic, beta/genetics ; Receptors, Adrenergic, beta/metabolism ; Receptors, Histamine H1/chemistry ; Receptors, Histamine H1/genetics ; Receptors, Histamine H1/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.
    Autorzy:
    de Munnik SM; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
    Kooistra AJ; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
    van Offenbeek J; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
    Nijmeijer S; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
    de Graaf C; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
    Smit MJ; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
    Leurs R; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
    Vischer HF; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
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    Źródło:
    PloS one [PLoS One] 2015 Apr 20; Vol. 10 (4), pp. e0124486. Date of Electronic Publication: 2015 Apr 20 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Endocytosis*
    Arrestins/*metabolism
    Chemokine CXCL1/*metabolism
    Chemokine CXCL10/*metabolism
    Interleukin-8/*metabolism
    Receptors, Chemokine/*metabolism
    Receptors, G-Protein-Coupled/*metabolism
    Viral Proteins/*metabolism
    Amino Acid Sequence ; Cell Proliferation ; DNA, Complementary/metabolism ; Enzyme-Linked Immunosorbent Assay ; HEK293 Cells ; Humans ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Protein Structure, Secondary ; Sequence Homology, Amino Acid ; Serine/chemistry ; Signal Transduction ; Threonine/chemistry ; Type C Phospholipases/metabolism ; beta-Arrestins
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.
    Autorzy:
    Kooistra AJ; Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems, VU University Amsterdam, The Netherlands.
    Kuhne S
    de Esch IJ
    Leurs R
    de Graaf C
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    Źródło:
    British journal of pharmacology [Br J Pharmacol] 2013 Sep; Vol. 170 (1), pp. 101-26.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    Receptors, G-Protein-Coupled/*metabolism
    Receptors, Histamine/*metabolism
    Amino Acid Sequence ; Binding Sites ; Crystallization ; Humans ; Ligands ; Mutagenesis, Site-Directed ; Protein Binding ; Protein Conformation ; Receptors, G-Protein-Coupled/chemistry ; Receptors, Histamine/chemistry ; Sequence Analysis, Protein ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-5 z 5

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