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Wyświetlanie 1-20 z 43
Tytuł:
Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.
Autorzy:
Rahmani J; Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Montesanto A; Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
Giovannucci E; Departments of Nutrition, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Zand H; National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Barati M; National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Kopchick JJ; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio and Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
Mirisola MG; Department of Surgical, Oncological and Stomatological Disciplines, Università di Palermo, Palermo, Italy.
Lagani V; Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia, USA.; Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology KAUST, Thuwal, Saudi Arabia.
Bawadi H; Human Nutrition Department, College of Health Sciences, QU-Health, Qatar University, Doha, Qatar.
Vardavas R; RAND Corporation, Santa Monica, California, USA.
Laviano A; Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Christensen K; Danish Aging Research Center, University of Southern Denmark, Odense, Denmark.
Passarino G; Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
Longo VD; Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA.; IFOM, FIRC Institute of Molecular Oncology, Milan, Italy.
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Źródło:
Aging cell [Aging Cell] 2022 Feb; Vol. 21 (2), pp. e13540. Date of Electronic Publication: 2022 Jan 20.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin-Like Growth Factor I*
Adult ; Cohort Studies ; Humans ; Proportional Hazards Models ; Prospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging.
Autorzy:
Dixit M; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry New York, New York, NY, USA.
Duran-Ortiz S; Edison Biotechnology Institute and Dept. of Biomedical Sciences, Ohio University, Athens, OH, USA.
Yildirim G; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry New York, New York, NY, USA.
Poudel SB; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry New York, New York, NY, USA.
Louis LD; Department of Biomedical Engineering, City College of New York, New York, NY, USA.
Bartke A; Southern Illinois University School of Medicine, Springfield, IL, USA.
Schaffler MB; Department of Biomedical Engineering, City College of New York, New York, NY, USA.
Kopchick JJ; Edison Biotechnology Institute and Dept. of Biomedical Sciences, Ohio University, Athens, OH, USA.
Yakar S; David B. Kriser Dental Center, Department of Molecular Pathobiology, New York University College of Dentistry New York, New York, NY, USA.
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Źródło:
Aging cell [Aging Cell] 2021 Dec; Vol. 20 (12), pp. e13505. Date of Electronic Publication: 2021 Nov 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Body Composition/*physiology
Bone Diseases, Metabolic/*physiopathology
Growth Hormone/*adverse effects
Spectrum Analysis, Raman/*methods
Aging ; Animals ; Female ; Male ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan.
Autorzy:
Duran-Ortiz S; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.; Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA.
List EO; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
Ikeno Y; Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, USA.
Young J; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Basu R; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
Bell S; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
McHugh T; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA.
Funk K; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
Mathes S; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
Qian Y; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.
Kulkarni P; Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, Ohio, USA.
Yakar S; Department of Molecular Pathobiology, David B. Kriser Dental Center, New York University College of Dentistry, New York, New York, USA.
Berryman DE; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.; Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.; Diabetes Institute, Ohio University, Athens, Ohio, USA.
Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA.; Molecular and Cellular Biology program, Ohio University, Athens, Ohio, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.; Diabetes Institute, Ohio University, Athens, Ohio, USA.
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Źródło:
Aging cell [Aging Cell] 2021 Dec; Vol. 20 (12), pp. e13506. Date of Electronic Publication: 2021 Nov 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin/*metabolism
Receptors, Somatotropin/*genetics
Aging ; Animals ; Female ; Male ; Mice ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of Growth Hormone Receptor Ablation in Corticotropin-Releasing Hormone Cells.
Autorzy:
Dos Santos WO; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
Gusmao DO; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
Wasinski F; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
List EO; Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Kopchick JJ; Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Donato J Jr; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 14; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Corticotropin-Releasing Hormone/*metabolism
Neurons/*metabolism
Receptors, Somatotropin/*metabolism
Animals ; Anxiety/metabolism ; Circadian Rhythm/drug effects ; Energy Metabolism/drug effects ; Feeding Behavior/drug effects ; Female ; Ghrelin/pharmacology ; Glucose/metabolism ; Growth Hormone/pharmacology ; Homeostasis/drug effects ; Mice, Knockout ; Neurons/drug effects ; Paraventricular Hypothalamic Nucleus/metabolism ; Stress, Physiological/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Growth hormone receptor in dopaminergic neurones regulates stress-induced prolactin release in male mice.
Autorzy:
Wasinski F; Departamento de Fisiologia e Biofísica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Chaves FM; Departamento de Fisiologia e Biofísica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Pedroso JAB; Departamento de Fisiologia e Biofísica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Mansano NS; Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Camporez JP; Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil.
Gusmão DO; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
List EO; Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Kopchick JJ; Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Frazão R; Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Szawka RE; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Donato J Jr; Departamento de Fisiologia e Biofísica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
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Źródło:
Journal of neuroendocrinology [J Neuroendocrinol] 2021 Mar; Vol. 33 (3), pp. e12957.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Dopaminergic Neurons/*metabolism
Prolactin/*metabolism
Receptors, Somatotropin/*metabolism
Stress, Psychological/*metabolism
Animals ; Arcuate Nucleus of Hypothalamus/metabolism ; Energy Metabolism/physiology ; Fertility ; Glucose/metabolism ; Human Growth Hormone/analogs & derivatives ; Human Growth Hormone/pharmacology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Rats ; Receptors, Somatotropin/genetics ; Reproduction ; Restraint, Physical ; Stress, Psychological/psychology ; Survival ; Tyrosine 3-Monooxygenase/metabolism ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo.
Autorzy:
Qian Y; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Basu R; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Mathes SC; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Department of Biological Sciences, Ohio University, Athens, OH 45701, USA.
Arnett NA; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Russ College of Engineering, Ohio University, Athens, OH 45701, USA.
Duran-Ortiz S; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Department of Biological Sciences, Ohio University, Athens, OH 45701, USA.; Molecular Cellular Biology Program, Ohio University, Athens, OH 45701, USA.
Funk KR; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Department of Biological Sciences, Ohio University, Athens, OH 45701, USA.; Molecular Cellular Biology Program, Ohio University, Athens, OH 45701, USA.
Brittain AL; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Molecular Cellular Biology Program, Ohio University, Athens, OH 45701, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Kulkarni P; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Department of Biological Sciences, Ohio University, Athens, OH 45701, USA.; Molecular Cellular Biology Program, Ohio University, Athens, OH 45701, USA.
Terry JC; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Department of Biological Sciences, Ohio University, Athens, OH 45701, USA.
Davis E; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Department of Biological Sciences, Ohio University, Athens, OH 45701, USA.; Molecular Cellular Biology Program, Ohio University, Athens, OH 45701, USA.
Singerman JT; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Department of Biological Sciences, Ohio University, Athens, OH 45701, USA.
Henry BE; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
List EO; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Berryman DE; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.; Molecular Cellular Biology Program, Ohio University, Athens, OH 45701, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
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Źródło:
Cancers [Cancers (Basel)] 2020 Dec 04; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 04.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GHR Mice are protected from obesity-related white adipose tissue inflammation.
Autorzy:
Young JA; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Henry BE; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.; School of Applied Health Sciences and Wellness, College of Health Sciences and Professions, Ohio University, Athens, OH, USA.; The Diabetes Institute at Ohio University, Ohio University, Athens, OH, USA.
Benencia F; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Bell S; The Diabetes Institute at Ohio University, Ohio University, Athens, OH, USA.
List EO; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.
Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Berryman DE; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.; The Diabetes Institute at Ohio University, Ohio University, Athens, OH, USA.
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Źródło:
Journal of neuroendocrinology [J Neuroendocrinol] 2020 Nov; Vol. 32 (11), pp. e12854. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adipose Tissue, White/*pathology
Carrier Proteins/*genetics
Inflammation/*genetics
Inflammation/*pathology
Obesity/*genetics
Obesity/*pathology
Abdominal Fat/immunology ; Abdominal Fat/pathology ; Adipose Tissue, White/immunology ; Aging ; Animals ; Body Composition ; Cytokines/blood ; Epididymis/pathology ; Growth Hormone/genetics ; Growth Hormone/metabolism ; Immunity, Cellular/genetics ; Immunity, Cellular/immunology ; Inflammation/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Obesity/immunology ; Organ Size ; T-Lymphocytes/immunology ; T-Lymphocytes, Helper-Inducer/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential gene signature in adipose tissue depots of growth hormone transgenic mice.
Autorzy:
Duran-Ortiz S; Edison Biotechnology Institute, Athens, OH, USA.; Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, OH, USA.
Young JA; Edison Biotechnology Institute, Athens, OH, USA.; Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, OH, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Jara A; Edison Biotechnology Institute, Athens, OH, USA.; Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, OH, USA.
Jensen EA; Edison Biotechnology Institute, Athens, OH, USA.
Basu R; Edison Biotechnology Institute, Athens, OH, USA.
List EO; Edison Biotechnology Institute, Athens, OH, USA.
Qian Y; Edison Biotechnology Institute, Athens, OH, USA.
Kopchick JJ; Edison Biotechnology Institute, Athens, OH, USA.; Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Berryman DE; Edison Biotechnology Institute, Athens, OH, USA.; Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
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Źródło:
Journal of neuroendocrinology [J Neuroendocrinol] 2020 Nov; Vol. 32 (11), pp. e12893. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adipose Tissue/*metabolism
Growth Hormone/*genetics
Growth Hormone/*metabolism
Amino Acids, Branched-Chain/metabolism ; Animals ; Cattle ; Epididymis/metabolism ; Fatty Acids/metabolism ; Gene Expression Regulation/genetics ; Gene Expression Regulation/physiology ; Genotype ; Immune System/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Oxidation-Reduction ; Signal Transduction/genetics ; Subcutaneous Fat/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The acute effects of growth hormone in adipose tissue is associated with suppression of antilipolytic signals.
Autorzy:
Høyer KL; Medical Research Laboratory, Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.; Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark.
Høgild ML; Medical Research Laboratory, Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.; Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark.
List EO; The Edison Biotechnology Institute, Athens, OH, USA.; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Lee KY; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Kissinger E; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Sharma R; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Erik Magnusson N; Medical Research Laboratory, Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.; Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark.
Puri V; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Kopchick JJ; The Edison Biotechnology Institute, Athens, OH, USA.; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Jørgensen JOL; Medical Research Laboratory, Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.; Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark.
Jessen N; Department of Clinical Pharmacology, University of Aarhus, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
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Źródło:
Physiological reports [Physiol Rep] 2020 Feb; Vol. 8 (3), pp. e14373.
Typ publikacji:
Journal Article
MeSH Terms:
Lipolysis*
Adipose Tissue/*metabolism
Human Growth Hormone/*metabolism
3T3 Cells ; Adipose Tissue/drug effects ; Adult ; Animals ; Cyclic Nucleotide Phosphodiesterases, Type 3/metabolism ; Fatty Acids, Nonesterified/blood ; Female ; Human Growth Hormone/pharmacology ; Humans ; Insulin/blood ; Male ; Mice ; Middle Aged ; PTEN Phosphohydrolase/metabolism ; Receptors, Somatotropin/genetics ; Receptors, Somatotropin/metabolism ; STAT5 Transcription Factor/metabolism ; ras Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma.
Autorzy:
Basu R; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .
Kulkarni P; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Molecular and Cellular Biology (MCB) Program, Department of Biological Sciences, Ohio University, Athens, OH 45701, USA. .
Qian Y; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .
Walsh C; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. .
Arora P; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. .
Davis E; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA. .
Duran-Ortiz S; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Molecular and Cellular Biology (MCB) Program, Department of Biological Sciences, Ohio University, Athens, OH 45701, USA. .; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. .
Funk K; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Molecular and Cellular Biology (MCB) Program, Department of Biological Sciences, Ohio University, Athens, OH 45701, USA. .; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. .
Ibarra D; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA. .
Kruse C; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Molecular and Cellular Biology (MCB) Program, Department of Biological Sciences, Ohio University, Athens, OH 45701, USA. .
Mathes S; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .
McHugh T; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .
Brittain A; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Molecular and Cellular Biology (MCB) Program, Department of Biological Sciences, Ohio University, Athens, OH 45701, USA. .; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. .
Berryman DE; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. .; The Diabetes Institute, Ohio University, Athens, OH 45701, USA. .
List EO; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .
Okada S; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; The Diabetes Institute, Ohio University, Athens, OH 45701, USA. .; Department of Pediatrics, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. .
Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. kopchick@ohio.edu.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. kopchick@ohio.edu.
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Źródło:
Cancers [Cancers (Basel)] 2019 Sep 12; Vol. 11 (9). Date of Electronic Publication: 2019 Sep 12.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia.
Autorzy:
Swindell WR; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA. .; Department of Internal Medicine, The Jewish Hospital, Cincinnati, OH, 45236, USA. .
Kruse CPS; Department of Environmental and Plant Biology, Ohio University, Athens, OH, 45701, USA.; Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.
List EO; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.; Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.; The Diabetes Institute, Ohio University, Athens, OH, 45701, USA.
Berryman DE; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.; Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.; The Diabetes Institute, Ohio University, Athens, OH, 45701, USA.
Kopchick JJ; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.; Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.; The Diabetes Institute, Ohio University, Athens, OH, 45701, USA.
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Źródło:
Journal of translational medicine [J Transl Med] 2019 May 22; Vol. 17 (1), pp. 170. Date of Electronic Publication: 2019 May 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling*
Amyotrophic Lateral Sclerosis/*blood
Amyotrophic Lateral Sclerosis/*genetics
Biomarkers/*blood
Hypoxia/*complications
Leukocyte Disorders/*complications
Neutrophils/*pathology
Altitude Sickness/blood ; Altitude Sickness/genetics ; Amyotrophic Lateral Sclerosis/immunology ; Cell Lineage/genetics ; Erythrocytes/metabolism ; Exosomes/metabolism ; Female ; Gene Expression Regulation ; Genetic Loci ; Genetic Predisposition to Disease ; Humans ; Hypoxia/blood ; Hypoxia/genetics ; Leukocyte Disorders/blood ; Leukocyte Disorders/genetics ; Male ; Middle Aged ; Neutrophils/metabolism ; Superoxide Dismutase ; Support Vector Machine ; Survival Analysis ; Transcriptome/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of Growth Hormone Resistance in Experimental and Ulcerative Colitis.
Autorzy:
Soendergaard C; Novo Nordisk A/S, Haemophilia Research, Maaloev 2760, Denmark. .; Department of Gastroenterology, Herlev Hospital, Herlev 2730, Denmark. .
Kvist PH; Novo Nordisk A/S, Haemophilia Research, Maaloev 2760, Denmark. .
Thygesen P; Novo Nordisk A/S, Haemophilia Research, Maaloev 2760, Denmark. .
Reslow M; Novo Nordisk A/S, Haemophilia Research, Maaloev 2760, Denmark. .; Pila Pharma AB, 20512 Malmö, Sweden. .
Nielsen OH; Department of Gastroenterology, Herlev Hospital, Herlev 2730, Denmark. .
Kopchick JJ; Edison Biotechnology Institute & Department of Biomedical Sciences, HCOM, Ohio University, Athens, OH 45701, USA. kopchick@ohio.edu.
Holm TL; Novo Nordisk A/S, Haemophilia Research, Maaloev 2760, Denmark. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2017 Sep 23; Vol. 18 (10). Date of Electronic Publication: 2017 Sep 23.
Typ publikacji:
Journal Article
MeSH Terms:
Colitis, Ulcerative/*metabolism
Growth Hormone/*metabolism
Adult ; Animals ; Biopsy ; Case-Control Studies ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/genetics ; Colonoscopy ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Gene Expression ; Growth Hormone/pharmacology ; Humans ; Immunohistochemistry ; Inflammation Mediators/metabolism ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/pathology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Receptors, Somatotropin/genetics ; Receptors, Somatotropin/metabolism ; Signal Transduction ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass.
Autorzy:
Consitt LA; Department of Biomedical Sciences, Ohio University, 228 Irvine Hall, Athens, Ohio, 45701, USA. .; Ohio Musculoskeletal and Neurological Institute, Ohio University, Athens, Ohio, 45701, USA. .; Diabetes Institute, Ohio University, Athens, Ohio, 45701, USA. .
Saneda A; Department of Biological Sciences, Ohio University, Athens, Ohio, 45701, USA.
Saxena G; Department of Biomedical Sciences, Ohio University, 228 Irvine Hall, Athens, Ohio, 45701, USA.
List EO; Diabetes Institute, Ohio University, Athens, Ohio, 45701, USA.; Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.
Kopchick JJ; Department of Biomedical Sciences, Ohio University, 228 Irvine Hall, Athens, Ohio, 45701, USA.; Diabetes Institute, Ohio University, Athens, Ohio, 45701, USA.; Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.
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Źródło:
Skeletal muscle [Skelet Muscle] 2017 Sep 04; Vol. 7 (1), pp. 17. Date of Electronic Publication: 2017 Sep 04.
Typ publikacji:
Journal Article
MeSH Terms:
Muscle Development*
Growth Hormone/*blood
Muscle Proteins/*metabolism
Muscle, Skeletal/*metabolism
Myostatin/*metabolism
Tripartite Motif Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Activin Receptors, Type II/genetics ; Activin Receptors, Type II/metabolism ; Adaptor Proteins, Signal Transducing ; Animals ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Cycle Proteins ; Eukaryotic Initiation Factors ; Growth Hormone/genetics ; Growth Hormone/metabolism ; Insulin Receptor Substrate Proteins/genetics ; Insulin Receptor Substrate Proteins/metabolism ; MAP Kinase Signaling System ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Proteins/genetics ; Muscle, Skeletal/growth & development ; Myostatin/genetics ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Smad2 Protein/genetics ; Smad2 Protein/metabolism ; Tripartite Motif Proteins/genetics ; Ubiquitin-Protein Ligases/genetics ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.
Autorzy:
Duran-Ortiz S; Edison Biotechnology Institute, Ohio University, Athens, OH USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, OH USA.; Molecular and Cellular Biology Program, Ohio University, Athens, OH USA.
Brittain AL; Edison Biotechnology Institute, Ohio University, Athens, OH USA.; Department of Biological Sciences, College of Arts and Sciences, Ohio University, Athens, OH USA.; Molecular and Cellular Biology Program, Ohio University, Athens, OH USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701 USA.
Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, OH USA.; Molecular and Cellular Biology Program, Ohio University, Athens, OH USA.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701 USA.
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Źródło:
Clinical proteomics [Clin Proteomics] 2017 Jun 29; Vol. 14, pp. 24. Date of Electronic Publication: 2017 Jun 29 (Print Publication: 2017).
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Growth Hormone Resistance-Special Focus on Inflammatory Bowel Disease.
Autorzy:
Soendergaard C; Novo Nordisk A/S, Global Research, Maaloev 2760, Denmark. .
Young JA; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. .; Department of Biological Sciences, Ohio University, Athens, OH 45701, USA. .
Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. kopchick@ohio.edu.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. kopchick@ohio.edu.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2017 May 09; Vol. 18 (5). Date of Electronic Publication: 2017 May 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Inflammatory Bowel Diseases/*metabolism
Laron Syndrome/*metabolism
Receptors, Somatotropin/*genetics
Animals ; Growth Hormone/metabolism ; Humans ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/pathology ; Laron Syndrome/genetics ; Laron Syndrome/pathology ; Receptors, Somatotropin/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice.
Autorzy:
List EO; Edison Biotechnology, Ohio University, Athens, OH, USA; Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; The Diabetes Institute, Ohio University, Athens, OH, USA.
Jensen E; Edison Biotechnology, Ohio University , Athens, OH, USA.
Kowalski J; Edison Biotechnology, Ohio University , Athens, OH, USA.
Buchman M; Edison Biotechnology, Ohio University , Athens, OH, USA.
Berryman DE; Edison Biotechnology, Ohio University, Athens, OH, USA; The Diabetes Institute, Ohio University, Athens, OH, USA; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Kopchick JJ; Edison Biotechnology, Ohio University, Athens, OH, USA; The Diabetes Institute, Ohio University, Athens, OH, USA; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
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Źródło:
Nutrition and healthy aging [Nutr Healthy Aging] 2016 Oct 27; Vol. 4 (1), pp. 95-99. Date of Electronic Publication: 2016 Oct 27.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.
Autorzy:
Visser WE; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Bombardieri CR; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Zevenbergen C; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Barnhoorn S; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Ottaviani A; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.; Institute for Research on Cancer and Aging, Nice (IRCAN), UMR 7284 CNRS U1081 INSERM UNS, 28 avenue de Valombrose Faculté de Médecine, Nice, France.
van der Pluijm I; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Brandt R; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Kaptein E; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
van Heerebeek R; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
van Toor H; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Garinis GA; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Peeters RP; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Medici M; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
van Ham W; Laboratory of Comparative Endocrinology, Biology Department, KULeuven, Leuven, Belgium.
Vermeij WP; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
de Waard MC; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
de Krijger RR; Dept of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.
Boelen A; Dept of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
Kwakkel J; Dept of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands.
Kopchick JJ; Dept of Biomedical Sciences, Edison Biotechnology Institute, Ohio University, Athens, Ohio, United States of America.
List EO; Dept of Biomedical Sciences, Edison Biotechnology Institute, Ohio University, Athens, Ohio, United States of America.
Melis JP; Dept of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands.
Darras VM; Laboratory of Comparative Endocrinology, Biology Department, KULeuven, Leuven, Belgium.
Dollé ME; Centre for Health Protection Research, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
van der Horst GT; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Hoeijmakers JH; MGC Dept of Genetics, Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Visser TJ; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
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Źródło:
PloS one [PLoS One] 2016 Mar 08; Vol. 11 (3), pp. e0149941. Date of Electronic Publication: 2016 Mar 08 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Damage*
Aging/*metabolism
Iodide Peroxidase/*metabolism
Thyroid Hormones/*metabolism
Aging/genetics ; Animals ; Hypothyroidism/genetics ; Hypothyroidism/metabolism ; Iodide Peroxidase/genetics ; Liver/metabolism ; Mice ; Mice, Knockout ; Organ Specificity ; Thyroid Hormones/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland.
Autorzy:
Liu Y; Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Knop E; Ocular Surface Center, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Knop N; Ocular Surface Center, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Sullivan DA; Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
List EO; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Kam WR; Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Ding J; Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
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Źródło:
Journal of ophthalmology [J Ophthalmol] 2016; Vol. 2016, pp. 5728071. Date of Electronic Publication: 2016 Feb 14.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.
Autorzy:
Sadagurski M; Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, USA.
Landeryou T; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
Cady G; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
Kopchick JJ; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.
List EO; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.
Berryman DE; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.
Bartke A; Department of Internal Medicine-Geriatrics Research, Southern Illinois University School of Medicine, Springfield, IL, USA.
Miller RA; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
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Źródło:
Aging cell [Aging Cell] 2015 Dec; Vol. 14 (6), pp. 1045-54. Date of Electronic Publication: 2015 Aug 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Carrier Proteins/*genetics
Dwarfism, Pituitary/*genetics
Growth Hormone/*pharmacology
Insulin/*metabolism
Insulin-Like Growth Factor I/*metabolism
Longevity/*genetics
Agouti-Related Protein/metabolism ; Animals ; Arcuate Nucleus of Hypothalamus/metabolism ; Dwarfism, Pituitary/metabolism ; Growth Hormone/genetics ; Inflammation/pathology ; Leptin/metabolism ; Liver/metabolism ; Male ; Mediodorsal Thalamic Nucleus/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Paraventricular Hypothalamic Nucleus/metabolism ; Pro-Opiomelanocortin/metabolism ; STAT3 Transcription Factor/biosynthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Interventions to Slow Aging in Humans: Are We Ready?
Autorzy:
Longo VD; Davis School of Gerontology and Department of Biological Sciences, Longevity Institute, University of Southern California, Los Angeles, CA, 90089, USA.; IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milano, Italy.
Antebi A; Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50931, Koeln, Germany.
Bartke A; Department of Internal Medicine, Southern Illinois University-School of Medicine, Springfield, IL, 62794, USA.
Barzilai N; Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA.
Brown-Borg HM; Department of Basic Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, 58203, USA.
Caruso C; Immunosenescence Unit, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Palermo, Italy.
Curiel TJ; Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
de Cabo R; Experimental Gerontology Section, TGB, NIA, NIH, 251 Bayview Blvd. Suite 100/Room 9C218, Baltimore, MD, 21224, USA.
Franceschi C; DIMES-Department of Specialty, Diagnostic and Experimental Medicine, Via S. Giacomo, 12, I-40126, Bologna, Italy.
Gems D; Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, The Darwin Building, Gower Street, London, WC1E 6BT, UK.
Ingram DK; Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70809, USA.
Johnson TE; Institute for Behavioral Genetics, University of Colorado at Boulder, Box 447, Boulder, CO, 80309, USA.
Kennedy BK; Buck Institute for Research on Aging, Novato, CA, USA.
Kenyon C; Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, University of California, 600 16th Street, Room S312D, San Francisco, CA, 94158-2517, USA.
Klein S; Center for Human Nutrition, Washington University School of Medicine, Campus Box 8031, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Kopchick JJ; Department of Biomedical Sciences, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.
Lepperdinger G; Institut für Alternsforschung, Universität Innsbruck, Rennweg 10, A-6020, Innsbruck, Austria.
Madeo F; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Humboldtstr. 50, Graz, 8010, Austria.; BioTechMed Graz, Humboldtstr. 50, Graz, 8010, Austria.
Mirisola MG; Dipartimento di Biopatologia e Biotecnologie mediche, Universita' di Palermo, Via Divisi 83, 90133, Palermo, Italy.
Mitchell JR; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, 02115, USA.
Passarino G; Department of Biology, Ecology and Earth Science, University of Calabria, 87036, Rende, Italy.
Rudolph KL; Leibniz Institute for Age Research, Fritz Lipmann Institute, D-07745, Jena, Germany.
Sedivy JM; Laboratories for Molecular Medicine, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship Street, Providence, RI, 02903, USA.
Shadel GS; Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Sinclair DA; Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia.; Australia Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA, Australia.
Spindler SR; Department of Biochemistry, University of California at Riverside, Riverside, CA, USA.
Suh Y; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Vijg J; Department of Genetics, Albert Einstein Medical Center, 1301 Morris Park Avenue, Bronx, NY, USA.
Vinciguerra M; Division of Medicine, University College London (UCL) - Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.
Fontana L; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Clinical and Experimental Sciences, Brescia University, Brescia, Italy.; CEINGE Biotecnologie Avanzate, Napoli, Italy.
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Źródło:
Aging cell [Aging Cell] 2015 Aug; Vol. 14 (4), pp. 497-510. Date of Electronic Publication: 2015 Apr 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Aging/*drug effects
Biological Factors/*therapeutic use
Longevity/*drug effects
Prescription Drugs/*therapeutic use
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Aging/genetics ; Animals ; Caloric Restriction/methods ; Diet ; Enzyme Activation ; Gene Expression Regulation ; Growth Hormone/antagonists & inhibitors ; Growth Hormone/genetics ; Growth Hormone/metabolism ; Humans ; Insulin-Like Growth Factor I/antagonists & inhibitors ; Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/metabolism ; Longevity/genetics ; Mice ; Ribosomal Protein S6 Kinases/antagonists & inhibitors ; Ribosomal Protein S6 Kinases/genetics ; Ribosomal Protein S6 Kinases/metabolism ; Signal Transduction ; Sirtuins/genetics ; Sirtuins/metabolism ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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