Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Korman, Alan"" wg kryterium: Autor


Tytuł :
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients.
Autorzy :
Hodi FS; Department of Adult Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mihm MC
Soiffer RJ
Haluska FG
Butler M
Seiden MV
Davis T
Henry-Spires R
MacRae S
Willman A
Padera R
Jaklitsch MT
Shankar S
Chen TC
Korman A
Allison JP
Dranoff G
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2003 Apr 15; Vol. 100 (8), pp. 4712-7. Date of Electronic Publication: 2003 Apr 07.
Typ publikacji :
Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Immunoconjugates*
Antibodies, Blocking/*therapeutic use
Antigens, Differentiation/*immunology
Cancer Vaccines/*therapeutic use
Melanoma/*immunology
Melanoma/*therapy
Ovarian Neoplasms/*immunology
Ovarian Neoplasms/*therapy
Abatacept ; Adult ; Aged ; Animals ; Antibodies, Monoclonal/therapeutic use ; Antigen Presentation ; Antigens, CD ; CD8-Positive T-Lymphocytes/immunology ; CTLA-4 Antigen ; Female ; Humans ; Male ; Melanoma/pathology ; Melanoma/secondary ; Mice ; Middle Aged ; Necrosis ; Ovarian Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Tumor immunotherapy: preclinical and clinical activity of anti-CTLA4 antibodies.
Autorzy :
Korman A; Medarex Inc, 521 Cottonwood Drive, Milpitas, CA 95035, USA. />Yellin M
Keler T
Pokaż więcej
Źródło :
Current opinion in investigational drugs (London, England : 2000) [Curr Opin Investig Drugs] 2005 Jun; Vol. 6 (6), pp. 582-91.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Antigens, Differentiation/*immunology
Cancer Vaccines/*therapeutic use
Immunotherapy, Active/*methods
Neoplasms/*therapy
Vaccines, Subunit/*therapeutic use
Animals ; Antibodies, Monoclonal/adverse effects ; Antigens, CD ; CTLA-4 Antigen ; Cancer Vaccines/adverse effects ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Humans ; Neoplasms/immunology ; Vaccines, Subunit/adverse effects
Czasopismo naukowe
Tytuł :
Principles and use of anti-CTLA4 antibody in human cancer immunotherapy.
Autorzy :
Peggs KS; Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Quezada SA
Korman AJ
Allison JP
Pokaż więcej
Źródło :
Current opinion in immunology [Curr Opin Immunol] 2006 Apr; Vol. 18 (2), pp. 206-13. Date of Electronic Publication: 2006 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antibodies, Monoclonal*/immunology
Antibodies, Monoclonal*/pharmacology
Antibodies, Monoclonal*/therapeutic use
Antibodies, Neoplasm*/immunology
Antibodies, Neoplasm*/pharmacology
Antibodies, Neoplasm*/therapeutic use
Antigens, Differentiation/*immunology
Antigens, Neoplasm/*immunology
Immunotherapy/*methods
Neoplasms/*therapy
Animals ; Antigen-Antibody Reactions ; Antigens, CD ; Antigens, Differentiation/drug effects ; Antigens, Neoplasm/drug effects ; CTLA-4 Antigen ; Humans ; Models, Immunological ; Neoplasms/immunology
Czasopismo naukowe
Tytuł :
Enhanced protein production by engineered zinc finger proteins.
Autorzy :
Reik A; Sangamo BioSciences, Inc., Point Richmond Tech Center, 501 Canal Boulevard, Richmond, CA 94804, USA.
Zhou Y
Collingwood TN
Warfe L
Bartsevich V
Kong Y
Henning KA
Fallentine BK
Zhang L
Zhong X
Jouvenot Y
Jamieson AC
Rebar EJ
Case CC
Korman A
Li XY
Black A
King DJ
Gregory PD
Pokaż więcej
Źródło :
Biotechnology and bioengineering [Biotechnol Bioeng] 2007 Aug 01; Vol. 97 (5), pp. 1180-9.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Enhancement/*methods
Protein Engineering/*methods
Recombinant Proteins/*biosynthesis
Transcription Factors/*genetics
Zinc Fingers/*genetics
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Promoter Regions, Genetic/genetics
Czasopismo naukowe
Tytuł :
Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs.
Autorzy :
Wong RM; Department of Medicine, University of Southern California, 1441 Eastlake Avenue, Room 6428, Los Angeles, CA 90033, USA.
Scotland RR
Lau RL
Wang C
Korman AJ
Kast WM
Weber JS
Pokaż więcej
Źródło :
International immunology [Int Immunol] 2007 Oct; Vol. 19 (10), pp. 1223-34.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Lymphocyte Activation*
Antigens, Neoplasm/*immunology
Apoptosis Regulatory Proteins/*antagonists & inhibitors
Melanoma/*immunology
Skin Neoplasms/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Antigens, CD/analysis ; Antigens, CD/metabolism ; Apoptosis Regulatory Proteins/analysis ; Apoptosis Regulatory Proteins/metabolism ; Cytokines/metabolism ; Humans ; MART-1 Antigen ; Membrane Glycoproteins/immunology ; Neoplasm Proteins/immunology ; Programmed Cell Death 1 Receptor ; T-Lymphocytes, Cytotoxic/drug effects ; gp100 Melanoma Antigen
Czasopismo naukowe
Tytuł :
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.
Autorzy :
Hodi FS; Department of Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. />Butler M
Oble DA
Seiden MV
Haluska FG
Kruse A
Macrae S
Nelson M
Canning C
Lowy I
Korman A
Lautz D
Russell S
Jaklitsch MT
Ramaiya N
Chen TC
Neuberg D
Allison JP
Mihm MC
Dranoff G
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2008 Feb 26; Vol. 105 (8), pp. 3005-10. Date of Electronic Publication: 2008 Feb 19.
Typ publikacji :
Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Antigens, CD/*immunology
Antigens, Differentiation/*immunology
Carcinoma/*therapy
Immunization, Passive/*methods
Melanoma/*therapy
Ovarian Neoplasms/*therapy
Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/immunology ; CTLA-4 Antigen ; Carcinoma/immunology ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Ipilimumab ; Melanoma/immunology ; Ovarian Neoplasms/immunology ; T-Lymphocytes, Regulatory/immunology
Czasopismo naukowe
Tytuł :
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.
Autorzy :
Rutebemberwa A; Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
Ray SC
Astemborski J
Levine J
Liu L
Dowd KA
Clute S
Wang C
Korman A
Sette A
Sidney J
Pardoll DM
Cox AL
Pokaż więcej
Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2008 Dec 15; Vol. 181 (12), pp. 8215-25.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*metabolism
Apoptosis Regulatory Proteins/*metabolism
Epitopes, T-Lymphocyte/*immunology
Hepacivirus/*immunology
Hepatitis C, Chronic/*immunology
T-Lymphocyte Subsets/*immunology
T-Lymphocyte Subsets/*virology
Virus Latency/*immunology
Acute Disease ; Adult ; Antigens, CD/biosynthesis ; Antigens, CD/genetics ; Antigens, Viral/immunology ; Apoptosis Regulatory Proteins/biosynthesis ; Apoptosis Regulatory Proteins/genetics ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/virology ; Epitopes, T-Lymphocyte/genetics ; Female ; Hepacivirus/genetics ; Hepatitis C, Chronic/virology ; Humans ; Mutation ; Programmed Cell Death 1 Receptor ; Prospective Studies ; RNA, Viral/genetics ; RNA, Viral/metabolism ; T-Lymphocyte Subsets/metabolism ; Viral Load ; Virus Latency/genetics
Czasopismo naukowe
Tytuł :
Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor--secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors.
Autorzy :
Li B; Cell Genesys, Inc., South San Francisco, California 94080, USA.
VanRoey M
Wang C
Chen TH
Korman A
Jooss K
Pokaż więcej
Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2009 Mar 01; Vol. 15 (5), pp. 1623-34. Date of Electronic Publication: 2009 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Immunotherapy*
Antibodies, Monoclonal/*therapeutic use
Apoptosis Regulatory Proteins/*antagonists & inhibitors
Colonic Neoplasms/*therapy
Granulocyte-Macrophage Colony-Stimulating Factor/*physiology
Melanoma, Experimental/*therapy
Animals ; Antibodies, Monoclonal/immunology ; Antigens, CD/immunology ; Antigens, CD/metabolism ; Apoptosis Regulatory Proteins/immunology ; Apoptosis Regulatory Proteins/metabolism ; Cell Proliferation ; Colonic Neoplasms/immunology ; Colonic Neoplasms/metabolism ; Cytokines/metabolism ; Drug Synergism ; Enzyme-Linked Immunosorbent Assay ; Lymphocytes, Tumor-Infiltrating/immunology ; Melanoma, Experimental/immunology ; Melanoma, Experimental/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/immunology ; Neoplasm Proteins/metabolism ; Programmed Cell Death 1 Receptor ; Rats ; Recombinant Fusion Proteins/immunology ; T-Lymphocytes, Cytotoxic/immunology
Czasopismo naukowe
Tytuł :
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Autorzy :
Peggs KS; Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Quezada SA
Chambers CA
Korman AJ
Allison JP
Pokaż więcej
Źródło :
The Journal of experimental medicine [J Exp Med] 2009 Aug 03; Vol. 206 (8), pp. 1717-25. Date of Electronic Publication: 2009 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neoplasm/*therapeutic use
Antigens, CD/*immunology
T-Lymphocyte Subsets/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; Antigens, CD/genetics ; CTLA-4 Antigen ; Cell Line, Tumor ; Humans ; Immunosuppression Therapy ; Immunotherapy ; In Vitro Techniques ; Melanoma, Experimental/immunology ; Melanoma, Experimental/therapy ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology
Czasopismo naukowe
Tytuł :
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells.
Autorzy :
Wang W; Donald A Adam Comprehensive Melanoma Research Center, Department of Immunology and Immunotherapy, Moffitt Cancer Center, 12902 Magnolia Drive, SRB-24324, Tampa, FL 33612, USA. />Lau R
Yu D
Zhu W
Korman A
Weber J
Pokaż więcej
Źródło :
International immunology [Int Immunol] 2009 Sep; Vol. 21 (9), pp. 1065-77. Date of Electronic Publication: 2009 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antigens, CD/*immunology
Apoptosis Regulatory Proteins/*immunology
Melanoma/*immunology
Neoplasm Proteins/*immunology
T-Lymphocytes, Cytotoxic/*immunology
T-Lymphocytes, Regulatory/*immunology
Up-Regulation/*immunology
Antibodies/immunology ; Antibodies/pharmacology ; Apoptosis Regulatory Proteins/antagonists & inhibitors ; B7-H1 Antigen ; CD4 Antigens/immunology ; Humans ; Interleukin-2 Receptor alpha Subunit/immunology ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Staging ; Programmed Cell Death 1 Receptor ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy.
Autorzy :
Mangsbo SM; Uppsala University, Sweden. />Sandin LC
Anger K
Korman AJ
Loskog A
Tötterman TH
Pokaż więcej
Źródło :
Journal of immunotherapy (Hagerstown, Md. : 1997) [J Immunother] 2010 Apr; Vol. 33 (3), pp. 225-35.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*immunology
Antigens, CD/*immunology
Antigens, Surface/*immunology
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Apoptosis Regulatory Proteins/*immunology
Urinary Bladder Neoplasms/*drug therapy
Animals ; Antibodies/administration & dosage ; Antigens, Surface/genetics ; Antigens, Surface/metabolism ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; BCG Vaccine/administration & dosage ; BCG Vaccine/immunology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CTLA-4 Antigen ; Cell Line, Tumor ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic ; Lysosomal-Associated Membrane Protein 1/metabolism ; Mice ; Mice, Inbred C57BL ; Oligodeoxyribonucleotides/administration & dosage ; Programmed Cell Death 1 Receptor ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Treatment Outcome ; Tumor Burden/drug effects ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Autorzy :
Brahmer JR; Johns Hopkins University School of Medicine, and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Drake CG
Wollner I
Powderly JD
Picus J
Sharfman WH
Stankevich E
Pons A
Salay TM
McMiller TL
Gilson MM
Wang C
Selby M
Taube JM
Anders R
Chen L
Korman AJ
Pardoll DM
Lowy I
Topalian SL
Pokaż więcej
Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2010 Jul 01; Vol. 28 (19), pp. 3167-75. Date of Electronic Publication: 2010 Jun 01.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Antigens, CD/*immunology
Apoptosis Regulatory Proteins/*immunology
Neoplasms/*drug therapy
Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/pharmacokinetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/pathology ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Dose-Response Relationship, Drug ; Fatigue/chemically induced ; Female ; Humans ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Lymphopenia/chemically induced ; Male ; Melanoma/drug therapy ; Melanoma/pathology ; Middle Aged ; Neoplasms/pathology ; Nivolumab ; Programmed Cell Death 1 Receptor ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Development of ipilimumab: contribution to a new paradigm for cancer immunotherapy.
Autorzy :
Hoos A; Global Clinical Research, Oncology, Bristol-Myers Squibb Co, Wallingford, CT 06492, USA. />Ibrahim R
Korman A
Abdallah K
Berman D
Shahabi V
Chin K
Canetta R
Humphrey R
Pokaż więcej
Źródło :
Seminars in oncology [Semin Oncol] 2010 Oct; Vol. 37 (5), pp. 533-46.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Antigens, CD/*immunology
Antineoplastic Agents/*therapeutic use
Melanoma/*drug therapy
Skin Neoplasms/*drug therapy
Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/immunology ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/immunology ; Biomarkers ; CTLA-4 Antigen ; Drug Evaluation ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Immune System Diseases/chemically induced ; Immune System Diseases/therapy ; Ipilimumab ; Melanoma/immunology ; Monitoring, Immunologic ; Practice Guidelines as Topic ; Skin Neoplasms/immunology ; Survival Analysis
Czasopismo naukowe
Tytuł :
PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation.
Autorzy :
Norde WJ; Departments of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Maas F
Hobo W
Korman A
Quigley M
Kester MG
Hebeda K
Falkenburg JH
Schaap N
de Witte TM
van der Voort R
Dolstra H
Pokaż więcej
Źródło :
Cancer research [Cancer Res] 2011 Aug 01; Vol. 71 (15), pp. 5111-22. Date of Electronic Publication: 2011 Jun 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Immunologic Memory*
Antigens, CD/*physiology
Apoptosis Regulatory Proteins/*physiology
Leukemia, Myeloid/*immunology
Neoplasm Proteins/*physiology
T-Lymphocyte Subsets/*immunology
Tumor Escape/*physiology
Apoptosis Regulatory Proteins/antagonists & inhibitors ; B7-1 Antigen/biosynthesis ; B7-2 Antigen/biosynthesis ; B7-H1 Antigen ; Coculture Techniques ; Gene Expression Profiling ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Inflammation ; Interferon-gamma/pharmacology ; Leukemia, Myeloid/pathology ; Leukemia, Myeloid/surgery ; Minor Histocompatibility Antigens/immunology ; Neoplasm Proteins/antagonists & inhibitors ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/metabolism ; Programmed Cell Death 1 Receptor ; Receptors, Purinergic P2X5/immunology ; Recurrence ; T-Cell Antigen Receptor Specificity ; Transplantation, Homologous ; Tumor Escape/immunology ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3.
Autorzy :
Bettini M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Szymczak-Workman AL
Forbes K
Castellaw AH
Selby M
Pan X
Drake CG
Korman AJ
Vignali DA
Pokaż więcej
Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2011 Oct 01; Vol. 187 (7), pp. 3493-8. Date of Electronic Publication: 2011 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antigens, CD/*immunology
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Diabetes Mellitus, Type 1/*immunology
Animals ; Cell Separation ; Flow Cytometry ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Autorzy :
Woo SR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Turnis ME
Goldberg MV
Bankoti J
Selby M
Nirschl CJ
Bettini ML
Gravano DM
Vogel P
Liu CL
Tangsombatvisit S
Grosso JF
Netto G
Smeltzer MP
Chaux A
Utz PJ
Workman CJ
Pardoll DM
Korman AJ
Drake CG
Vignali DA
Pokaż więcej
Źródło :
Cancer research [Cancer Res] 2012 Feb 15; Vol. 72 (4), pp. 917-27. Date of Electronic Publication: 2011 Dec 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*physiology
CD4-Positive T-Lymphocytes/*immunology
Neoplasms, Experimental/*immunology
Programmed Cell Death 1 Receptor/*physiology
Tumor Escape/*immunology
Animals ; Antibodies/therapeutic use ; Antigens, CD/immunology ; Cell Line, Tumor ; Drug Synergism ; Immune Tolerance/immunology ; Mice ; Mice, Inbred C57BL ; Neoplasm Transplantation ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/therapy ; Programmed Cell Death 1 Receptor/immunology
Czasopismo naukowe
Tytuł :
Workshop on immunotherapy combinations. Society for Immunotherapy of Cancer annual meeting Bethesda, November 3, 2011.
Autorzy :
Martinez Forero I; Centro de Investigacion Medica Aplicada, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain.
Okada H
Topalian SL
Gajewski TF
Korman AJ
Melero I
Pokaż więcej
Źródło :
Journal of translational medicine [J Transl Med] 2012 May 28; Vol. 10, pp. 108. Date of Electronic Publication: 2012 May 28.
Typ publikacji :
Congress
MeSH Terms :
Societies, Medical*
Immunotherapy/*methods
Neoplasms/*immunology
Neoplasms/*therapy
Animals ; Antibodies, Monoclonal/immunology ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Combined Modality Therapy ; Humans ; Immune System/immunology ; Immune System/pathology ; Mice ; Neoplasms/prevention & control
Tytuł :
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Autorzy :
Topalian SL; Department of Surgery, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA. />Hodi FS
Brahmer JR
Gettinger SN
Smith DC
McDermott DF
Powderly JD
Carvajal RD
Sosman JA
Atkins MB
Leming PD
Spigel DR
Antonia SJ
Horn L
Drake CG
Pardoll DM
Chen L
Sharfman WH
Anders RA
Taube JM
McMiller TL
Xu H
Korman AJ
Jure-Kunkel M
Agrawal S
McDonald D
Kollia GD
Gupta A
Wigginton JM
Sznol M
Pokaż więcej
Źródło :
The New England journal of medicine [N Engl J Med] 2012 Jun 28; Vol. 366 (26), pp. 2443-54. Date of Electronic Publication: 2012 Jun 02.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Antineoplastic Agents/*therapeutic use
Neoplasms/*drug therapy
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Adult ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/pharmacology ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Renal Cell/drug therapy ; Colorectal Neoplasms/drug therapy ; Dose-Response Relationship, Drug ; Female ; Humans ; Ligands ; Male ; Melanoma/drug therapy ; Neoplasms/metabolism ; Nivolumab ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Prostatic Neoplasms/drug therapy
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies