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Tytuł :
Collecting mouse livers for transcriptome analysis of daily rhythms.
Autorzy :
Mortimer T; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Welz PS; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.; Hospital del Mar Medical Research Institute (IMIM), Cancer Research Program, 08003 Barcelona, Spain.
Benitah SA; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.
Koronowski KB; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
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Źródło :
STAR protocols [STAR Protoc] 2021 May 14; Vol. 2 (2), pp. 100539. Date of Electronic Publication: 2021 May 14 (Print Publication: 2021).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Communicating clocks shape circadian homeostasis.
Autorzy :
Koronowski KB; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA. .
Sassone-Corsi P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Feb 12; Vol. 371 (6530).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Homeostasis*
Brain/*physiology
Circadian Clocks/*physiology
Circadian Rhythm/*physiology
Animals ; Astrocytes/physiology ; Cell Communication ; Cues ; Feedback, Physiological ; Gene Expression Regulation ; Humans ; Suprachiasmatic Nucleus Neurons/physiology
Czasopismo naukowe
Tytuł :
S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling.
Autorzy :
Greco CM; Center for Epigenetics and Metabolism; U1233 INSERM; Department of Biological Chemistry, School of Medicine, University of California, Irvine (UCI), Irvine, CA, USA. .
Cervantes M; Center for Epigenetics and Metabolism; U1233 INSERM; Department of Biological Chemistry, School of Medicine, University of California, Irvine (UCI), Irvine, CA, USA.
Fustin JM; Graduate School of Pharmaceutical Sciences, Department of Systems Biology, Kyoto University, Kyoto 606-8501, Japan.
Ito K; Graduate School of Pharmaceutical Sciences, Department of Systems Biology, Kyoto University, Kyoto 606-8501, Japan.
Ceglia N; Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California Irvine (UCI), Irvine, CA, USA.
Samad M; Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California Irvine (UCI), Irvine, CA, USA.
Shi J; Department of Biological Chemistry, School of Medicine, University of California Irvine (UCI), Irvine, CA, USA.; Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Koronowski KB; Center for Epigenetics and Metabolism; U1233 INSERM; Department of Biological Chemistry, School of Medicine, University of California, Irvine (UCI), Irvine, CA, USA.
Forne I; Biomedical Center, Protein Analysis Unit, Faculty of Medicine, Ludwig-Maximilians-Universität München, Großhaderner Strasse 9, 82152 Planegg-Martinsried, Germany.
Ranjit S; Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine (UCI), Irvine, CA, USA.
Gaucher J; Center for Epigenetics and Metabolism; U1233 INSERM; Department of Biological Chemistry, School of Medicine, University of California, Irvine (UCI), Irvine, CA, USA.
Kinouchi K; Center for Epigenetics and Metabolism; U1233 INSERM; Department of Biological Chemistry, School of Medicine, University of California, Irvine (UCI), Irvine, CA, USA.
Kojima R; Graduate School of Pharmaceutical Sciences, Department of Systems Biology, Kyoto University, Kyoto 606-8501, Japan.
Gratton E; Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine (UCI), Irvine, CA, USA.
Li W; Department of Biological Chemistry, School of Medicine, University of California Irvine (UCI), Irvine, CA, USA.; Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Baldi P; Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California Irvine (UCI), Irvine, CA, USA.
Imhof A; Biomedical Center, Protein Analysis Unit, Faculty of Medicine, Ludwig-Maximilians-Universität München, Großhaderner Strasse 9, 82152 Planegg-Martinsried, Germany.
Okamura H; Graduate School of Pharmaceutical Sciences, Department of Systems Biology, Kyoto University, Kyoto 606-8501, Japan.
Sassone-Corsi P; Center for Epigenetics and Metabolism; U1233 INSERM; Department of Biological Chemistry, School of Medicine, University of California, Irvine (UCI), Irvine, CA, USA. .
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Źródło :
Science advances [Sci Adv] 2020 Dec 16; Vol. 6 (51). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Exposure to recurrent hypoglycemia alters hippocampal metabolism in treated streptozotocin-induced diabetic rats.
Autorzy :
Dewan N; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.
Shukla V; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.
Rehni AK; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.
Koronowski KB; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.; Neuroscience Program, University of Miami School of Medicine, Miami, Florida, USA.
Klingbeil KD; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.
Stradecki-Cohan H; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.; Neuroscience Program, University of Miami School of Medicine, Miami, Florida, USA.
Garrett TJ; Southeast Center for Integrated Metabolomics, Clinical and Translational Science Institute, University of Florida, Gainesville, Florida, USA.
Rundek T; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.; Evelyn F. McKnight Brain Institute, University of Miami School of Medicine, Miami, Florida, USA.
Perez-Pinzon MA; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.; Neuroscience Program, University of Miami School of Medicine, Miami, Florida, USA.; Evelyn F. McKnight Brain Institute, University of Miami School of Medicine, Miami, Florida, USA.
Dave KR; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.; Neuroscience Program, University of Miami School of Medicine, Miami, Florida, USA.; Evelyn F. McKnight Brain Institute, University of Miami School of Medicine, Miami, Florida, USA.
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Źródło :
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2020 Jan; Vol. 26 (1), pp. 126-135. Date of Electronic Publication: 2019 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Resveratrol Preconditioning Induces Genomic and Metabolic Adaptations within the Long-Term Window of Cerebral Ischemic Tolerance Leading to Bioenergetic Efficiency.
Autorzy :
Khoury N; Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.; Department of Neurology, University of Miami, Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA.; Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Xu J; Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.; Department of Neurology, University of Miami, Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA.; Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Stegelmann SD; Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.; Department of Neurology, University of Miami, Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA.
Jackson CW; Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.; Department of Neurology, University of Miami, Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA.; Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Koronowski KB; Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.; Department of Neurology, University of Miami, Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA.; Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Dave KR; Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.; Department of Neurology, University of Miami, Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA.; Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Young JI; Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.; John P. Hussman Institute for Human Genomics, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.; Department of Human Genetics, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Perez-Pinzon MA; Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA. .; Department of Neurology, University of Miami, Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA. .; Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2019 Jun; Vol. 56 (6), pp. 4549-4565. Date of Electronic Publication: 2018 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Energy Metabolism*/drug effects
Genome*
Ischemic Preconditioning*
Adaptation, Physiological/*drug effects
Brain Ischemia/*genetics
Brain Ischemia/*physiopathology
Resveratrol/*pharmacology
Acetyl Coenzyme A/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Brain Ischemia/pathology ; Cell Respiration/drug effects ; Coculture Techniques ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Mitochondria/drug effects ; Mitochondria/metabolism ; Models, Biological ; Neurons/drug effects ; Neurons/metabolism ; Rats, Sprague-Dawley ; Time Factors ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Defining the Independence of the Liver Circadian Clock.
Autorzy :
Koronowski KB; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Kinouchi K; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Welz PS; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Smith JG; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Zinna VM; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Shi J; Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Samad M; Institute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.
Chen S; Institute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.
Magnan CN; Institute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.
Kinchen JM; Metabolon, Morrisville, NC 27560, USA.
Li W; Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Baldi P; Institute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.
Benitah SA; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain. Electronic address: .
Sassone-Corsi P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: .
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Źródło :
Cell [Cell] 2019 May 30; Vol. 177 (6), pp. 1448-1462.e14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
ARNTL Transcription Factors/*physiology
Circadian Clocks/*genetics
Liver/*metabolism
ARNTL Transcription Factors/metabolism ; Animals ; CLOCK Proteins/metabolism ; Circadian Clocks/physiology ; Circadian Rhythm/genetics ; Female ; Gene Expression Regulation ; Homeostasis ; Light ; Male ; Mice ; Mice, Knockout ; Models, Animal ; Organ Specificity/physiology ; Photoperiod ; Suprachiasmatic Nucleus/metabolism
Czasopismo naukowe
Tytuł :
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis.
Autorzy :
Welz PS; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain. Electronic address: .
Zinna VM; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Symeonidi A; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Koronowski KB; Center for Epigenetics and Metabolism, University of California, Irvine, CA 92697, USA.
Kinouchi K; Center for Epigenetics and Metabolism, University of California, Irvine, CA 92697, USA.
Smith JG; Center for Epigenetics and Metabolism, University of California, Irvine, CA 92697, USA.
Guillén IM; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Castellanos A; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Furrow S; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Aragón F; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Crainiciuc G; Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.
Prats N; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Caballero JM; PCB-PRBB Animal Facilities, 08028 Barcelona, Spain.
Hidalgo A; Area of Developmental and Cell Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain; Institute for Cardiovascular Prevention, Ludwig-Maximilians University, 80336 Munich, Germany.
Sassone-Corsi P; Center for Epigenetics and Metabolism, University of California, Irvine, CA 92697, USA. Electronic address: .
Benitah SA; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; ICREA, Catalan Institution for Research and Advanced Studies, 08010 Barcelona, Spain. Electronic address: .
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Źródło :
Cell [Cell] 2019 May 30; Vol. 177 (6), pp. 1436-1447.e12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
ARNTL Transcription Factors/*physiology
Circadian Clocks/*genetics
ARNTL Transcription Factors/metabolism ; Animals ; CLOCK Proteins/metabolism ; Circadian Clocks/physiology ; Circadian Rhythm/genetics ; Feeding Behavior/physiology ; Female ; Homeostasis ; Light ; Male ; Mice ; Mice, Knockout ; Models, Animal ; Organ Specificity/physiology ; Photoperiod ; Suprachiasmatic Nucleus/metabolism
Czasopismo naukowe
Tytuł :
The NAD -Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning.
Autorzy :
Khoury N; 1 Department of Neurology; Cerebral Vascular Research Laboratories; and Neuroscience Program, Miller School of Medicine, University of Miami , Miami, Florida.
Koronowski KB; 1 Department of Neurology; Cerebral Vascular Research Laboratories; and Neuroscience Program, Miller School of Medicine, University of Miami , Miami, Florida.
Young JI; 2 Dr. John T. Macdonald Foundation Department of Human Genetics; Hussman Institute for Human Genomics, and Neuroscience Program, Miller School of Medicine, University of Miami , Miami, Florida.
Perez-Pinzon MA; 1 Department of Neurology; Cerebral Vascular Research Laboratories; and Neuroscience Program, Miller School of Medicine, University of Miami , Miami, Florida.
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Źródło :
Antioxidants & redox signaling [Antioxid Redox Signal] 2018 Mar 10; Vol. 28 (8), pp. 691-710. Date of Electronic Publication: 2017 Aug 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Brain/*metabolism
Brain Ischemia/*genetics
Sirtuins/*genetics
Brain/pathology ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Humans ; NAD/metabolism ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain.
Autorzy :
Koronowski KB; Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.; Neuroscience Program, Miller School of Medicine, University of Miami, Miami, FL, United States.; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Khoury N; Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.; Neuroscience Program, Miller School of Medicine, University of Miami, Miami, FL, United States.; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Morris-Blanco KC; Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.; Neuroscience Program, Miller School of Medicine, University of Miami, Miami, FL, United States.; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Stradecki-Cohan HM; Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.; Neuroscience Program, Miller School of Medicine, University of Miami, Miami, FL, United States.; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, United States.
Garrett TJ; Southeast Center for Integrated Metabolomics, Clinical and Translational Science Institute, University of Florida, Gainesville, FL, United States.
Perez-Pinzon MA; Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, FL, United States.; Neuroscience Program, Miller School of Medicine, University of Miami, Miami, FL, United States.; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, United States.
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Źródło :
Frontiers in neuroscience [Front Neurosci] 2018 Jan 30; Vol. 12, pp. 32. Date of Electronic Publication: 2018 Jan 30 (Print Publication: 2018).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Protein kinase C epsilon delays latency until anoxic depolarization through arc expression and GluR2 internalization.
Autorzy :
Cohan CH; 1 Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 2 Evelyn F. McKnight Brain Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 3 Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 4 Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Stradecki-Cohan HM; 1 Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 3 Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 4 Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Morris-Blanco KC; 1 Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 3 Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 4 Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Khoury N; 1 Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 3 Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 4 Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Koronowski KB; 1 Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 3 Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 4 Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Youbi M; 1 Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 3 Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Wright CB; 2 Evelyn F. McKnight Brain Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 3 Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 4 Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Perez-Pinzon MA; 1 Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 2 Evelyn F. McKnight Brain Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 3 Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.; 4 Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2017 Dec; Vol. 37 (12), pp. 3774-3788. Date of Electronic Publication: 2017 Jun 06.
Typ publikacji :
Journal Article
MeSH Terms :
Neuroprotection*
Cytoskeletal Proteins/*metabolism
Hippocampus/*physiology
Nerve Tissue Proteins/*metabolism
Protein Kinase C-epsilon/*metabolism
Receptors, AMPA/*metabolism
Animals ; Brain Ischemia ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Cytoskeletal Proteins/genetics ; Gene Expression ; Hippocampus/cytology ; Hypoxia/genetics ; Hypoxia/metabolism ; Male ; Nerve Tissue Proteins/genetics ; Neurons/cytology ; Neurons/metabolism ; Oxygen/metabolism ; RNA, Messenger/genetics ; Rats, Sprague-Dawley ; Receptor, trkB/metabolism ; Receptors, AMPA/genetics
Czasopismo naukowe
Tytuł :
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Autorzy :
Koronowski KB; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Khoury N; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Saul I; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Loris ZB; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Cohan CH; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Stradecki-Cohan HM; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Dave KR; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Young JI; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL.
Perez-Pinzon MA; From the Cerebral Vascular Disease Research Laboratories (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), Department of Neurology (K.B.K., N.K., I.S., C.H.C., H.M.S.-C., K.R.D., M.A.P.-P.), The Miami Project to Cure Paralysis (Z.B.L.), Department of Neurological Surgery (Z.B.L.), John P. Hussman Institute for Human Genomics (J.I.Y.) and Department of Human Genetics (J.I.Y.), University of Miami Leonard M. Miller School of Medicine, FL. .
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Źródło :
Stroke [Stroke] 2017 Nov; Vol. 48 (11), pp. 3117-3125. Date of Electronic Publication: 2017 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Ischemia/*metabolism
Glycolysis/*drug effects
Neuroprotective Agents/*pharmacology
Sirtuin 1/*metabolism
Stilbenes/*pharmacology
Stroke/*metabolism
Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/genetics ; Disease Models, Animal ; Mice ; Mice, Knockout ; Neurons/metabolism ; Resveratrol ; Sirtuin 1/genetics ; Stroke/genetics ; Stroke/pathology
Czasopismo naukowe
Tytuł :
Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5.
Autorzy :
Morris-Blanco KC; Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Dave KR; Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Saul I; Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Koronowski KB; Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Stradecki HM; Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Perez-Pinzon MA; Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
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Źródło :
Scientific reports [Sci Rep] 2016 Jul 20; Vol. 6, pp. 29790. Date of Electronic Publication: 2016 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia/*metabolism
Mitochondrial Proteins/*metabolism
Protein Kinase C-epsilon/*metabolism
Sirtuins/*metabolism
Animals ; Brain Ischemia/genetics ; Cell Hypoxia ; Cells, Cultured ; Glucose/metabolism ; Mice, 129 Strain ; Mice, Knockout ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Neurons/cytology ; Neurons/metabolism ; Oxygen Consumption/genetics ; Rats, Sprague-Dawley ; Sirtuins/genetics
Czasopismo naukowe
Tytuł :
Long-term window of ischemic tolerance: An evolutionarily conserved form of metabolic plasticity regulated by epigenetic modifications?
Autorzy :
Khoury N; Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Koronowski KB; Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Perez-Pinzon MA; Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, Florida, USA.
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Źródło :
Journal of neurology & neuromedicine [J Neurol Neuromedicine] 2016; Vol. 1 (2), pp. 6-12.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Resveratrol Preconditioning Induces a Novel Extended Window of Ischemic Tolerance in the Mouse Brain.
Autorzy :
Koronowski KB; From the Cerebral Vascular Disease Research Laboratories (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), Department of Neurology (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), and Neuroscience Program (K.B.K., K.R.D., J.I.Y., M.A.P.-P.), Hussman Institute for Human Genetics (V.C., J.I.Y.), University of Miami Miller School of Medicine, Miami, FL.
Dave KR; From the Cerebral Vascular Disease Research Laboratories (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), Department of Neurology (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), and Neuroscience Program (K.B.K., K.R.D., J.I.Y., M.A.P.-P.), Hussman Institute for Human Genetics (V.C., J.I.Y.), University of Miami Miller School of Medicine, Miami, FL.
Saul I; From the Cerebral Vascular Disease Research Laboratories (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), Department of Neurology (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), and Neuroscience Program (K.B.K., K.R.D., J.I.Y., M.A.P.-P.), Hussman Institute for Human Genetics (V.C., J.I.Y.), University of Miami Miller School of Medicine, Miami, FL.
Camarena V; From the Cerebral Vascular Disease Research Laboratories (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), Department of Neurology (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), and Neuroscience Program (K.B.K., K.R.D., J.I.Y., M.A.P.-P.), Hussman Institute for Human Genetics (V.C., J.I.Y.), University of Miami Miller School of Medicine, Miami, FL.
Thompson JW; From the Cerebral Vascular Disease Research Laboratories (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), Department of Neurology (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), and Neuroscience Program (K.B.K., K.R.D., J.I.Y., M.A.P.-P.), Hussman Institute for Human Genetics (V.C., J.I.Y.), University of Miami Miller School of Medicine, Miami, FL.
Neumann JT; From the Cerebral Vascular Disease Research Laboratories (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), Department of Neurology (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), and Neuroscience Program (K.B.K., K.R.D., J.I.Y., M.A.P.-P.), Hussman Institute for Human Genetics (V.C., J.I.Y.), University of Miami Miller School of Medicine, Miami, FL.
Young JI; From the Cerebral Vascular Disease Research Laboratories (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), Department of Neurology (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), and Neuroscience Program (K.B.K., K.R.D., J.I.Y., M.A.P.-P.), Hussman Institute for Human Genetics (V.C., J.I.Y.), University of Miami Miller School of Medicine, Miami, FL.
Perez-Pinzon MA; From the Cerebral Vascular Disease Research Laboratories (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), Department of Neurology (K.B.K., K.R.D., I.S., J.W.T., J.T.N., M.A.P.-P.), and Neuroscience Program (K.B.K., K.R.D., J.I.Y., M.A.P.-P.), Hussman Institute for Human Genetics (V.C., J.I.Y.), University of Miami Miller School of Medicine, Miami, FL. .
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Źródło :
Stroke [Stroke] 2015 Aug; Vol. 46 (8), pp. 2293-8. Date of Electronic Publication: 2015 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*drug effects
Brain Ischemia/*prevention & control
Neuroprotective Agents/*administration & dosage
Stilbenes/*administration & dosage
Animals ; Brain/pathology ; Brain Ischemia/pathology ; Drug Administration Schedule ; Male ; Mice ; Mice, Inbred C57BL ; Resveratrol ; Time Factors
Czasopismo naukowe
Tytuł :
Signaling pathways leading to ischemic mitochondrial neuroprotection.
Autorzy :
Thompson JW; Cerebral Vascular Disease Research Laboratories, Department of Neurology and Neuroscience Program, Miller School of Medicine, University of Miami, P.O. Box 016960, Miami, FL, 33136, USA.
Narayanan SV
Koronowski KB
Morris-Blanco K
Dave KR
Perez-Pinzon MA
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Źródło :
Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 2015 Apr; Vol. 47 (1-2), pp. 101-10. Date of Electronic Publication: 2014 Sep 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Ischemic Preconditioning*
Brain Ischemia/*metabolism
Mitochondria/*metabolism
Animals ; Brain Ischemia/pathology ; Brain Ischemia/prevention & control ; Humans
Czasopismo naukowe
Tytuł :
Increased BDNF protein expression after ischemic or PKC epsilon preconditioning promotes electrophysiologic changes that lead to neuroprotection.
Autorzy :
Neumann JT; 1] Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [2] Evelyn F. McKnight Brain Institute, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [3] Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Thompson JW; 1] Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [2] Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Raval AP; 1] Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [2] Evelyn F. McKnight Brain Institute, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [3] Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Cohan CH; 1] Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [2] Evelyn F. McKnight Brain Institute, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [3] Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [4] Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Koronowski KB; 1] Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [2] Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [3] Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Perez-Pinzon MA; 1] Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [2] Evelyn F. McKnight Brain Institute, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [3] Department of Neurology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA [4] Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2015 Jan; Vol. 35 (1), pp. 121-30. Date of Electronic Publication: 2014 Nov 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Ischemic Preconditioning*
Action Potentials/*physiology
Brain Ischemia/*metabolism
Brain-Derived Neurotrophic Factor/*biosynthesis
Hippocampus/*metabolism
Protein Kinase C-epsilon/*metabolism
Animals ; Blotting, Western ; Brain Ischemia/pathology ; Cell Death ; Coculture Techniques ; Enzyme Activation ; Female ; Hippocampus/pathology ; Humans ; Immunohistochemistry ; In Vitro Techniques ; Male ; Neuroglia/pathology ; Neuroglia/physiology ; Neuronal Plasticity/physiology ; Neurons/pathology ; Neurons/physiology ; Organ Culture Techniques ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Sirt1 in cerebral ischemia.
Autorzy :
Koronowski KB; Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Perez-Pinzon MA; Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Laboratories, Miller School of Medicine, University of Miami, Miami, Florida, USA.
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Źródło :
Brain circulation [Brain Circ] 2015; Vol. 1 (1), pp. 69-78. Date of Electronic Publication: 2015 Sep 30.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons.
Autorzy :
Zhang X; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Urology, The Second Hospital of Shandong University, Jinan, Shandong, PR China. Electronic address: .
Koronowski KB; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Li L; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Freeman BA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Woodcock S; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
de Groat WC; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
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Źródło :
Experimental neurology [Exp Neurol] 2014 Jan; Vol. 251, pp. 12-21. Date of Electronic Publication: 2013 Nov 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Ganglia, Spinal/*cytology
Linoleic Acids/*pharmacology
Neurons/*drug effects
Nitro Compounds/*pharmacology
Nociception/*drug effects
Animals ; Calcium/metabolism ; Capsaicin/pharmacology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Interactions ; Electric Stimulation ; Female ; Isothiocyanates/pharmacology ; Lower Extremity/innervation ; Membrane Potentials/drug effects ; Neurons/metabolism ; Nitriles/pharmacology ; Pain Measurement/drug effects ; Patch-Clamp Techniques ; Pyrethrins/pharmacology ; Rats ; Rats, Sprague-Dawley ; Reaction Time/drug effects ; TRPA1 Cation Channel ; TRPC Cation Channels/agonists ; TRPV Cation Channels/agonists ; Time Factors
Czasopismo naukowe
Tytuł :
Evidence for the role of mast cells in colon-bladder cross organ sensitization.
Autorzy :
Fitzgerald JJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15260, USA. />Ustinova E
Koronowski KB
de Groat WC
Pezzone MA
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Źródło :
Autonomic neuroscience : basic & clinical [Auton Neurosci] 2013 Jan; Vol. 173 (1-2), pp. 6-13. Date of Electronic Publication: 2012 Nov 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Colitis/*immunology
Colon/*immunology
Mast Cells/*immunology
Neurons, Afferent/*immunology
Urinary Bladder/*immunology
Urination Disorders/*immunology
Animals ; Colitis/drug therapy ; Colitis/metabolism ; Colitis/physiopathology ; Colon/drug effects ; Colon/innervation ; Female ; Ketotifen/pharmacology ; Ketotifen/therapeutic use ; Mast Cells/drug effects ; Mast Cells/metabolism ; Membrane Transport Modulators/pharmacology ; Mice ; Mice, Knockout ; Muscle Contraction/drug effects ; Neurons, Afferent/drug effects ; Neurons, Afferent/metabolism ; Oligopeptides/pharmacology ; Permeability/drug effects ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor, PAR-2/agonists ; Receptor, PAR-2/metabolism ; Trinitrobenzenesulfonic Acid ; Urinary Bladder/innervation ; Urinary Bladder/metabolism ; Urinary Bladder/physiopathology ; Urination Disorders/etiology ; Urination Disorders/metabolism ; p-Methoxy-N-methylphenethylamine/pharmacology
Czasopismo naukowe

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