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Wyszukujesz frazę ""Kostic M"" wg kryterium: Autor


Tytuł:
Exploring Targeted Degradation Strategy for Oncogenic KRAS .
Autorzy:
Zeng M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Xiong Y; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Safaee N; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Nowak RP; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Yuan CJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Nabet B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Gero TW; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Feru F; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Li L; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Gondi S; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Ombelets LJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Quan C; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Jänne PA; Lowe Center for Thoracic Oncology and the Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Kostic M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Scott DA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Westover KD; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. Electronic address: .
Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: eric_.
Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: nathanael_.
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Źródło:
Cell chemical biology [Cell Chem Biol] 2020 Jan 16; Vol. 27 (1), pp. 19-31.e6. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Proteolysis/*drug effects
Proto-Oncogene Proteins p21(ras)/*antagonists & inhibitors
Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Drug Design ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism
Czasopismo naukowe
Tytuł:
Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation.
Autorzy:
Zhang T; Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.
Hatcher JM; Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.
Teng M; Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.
Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address: nathanael_.
Kostic M; Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: milka_kostic@dfci.harvard.edu.
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Źródło:
Cell chemical biology [Cell Chem Biol] 2019 Nov 21; Vol. 26 (11), pp. 1486-1500. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Ligands*
Cyclin-Dependent Kinases/*metabolism
Protein Kinase Inhibitors/*metabolism
Cyclin-Dependent Kinases/antagonists & inhibitors ; Humans ; Lysine/chemistry ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/chemistry ; Pyrimidines/metabolism ; Tyrosine/chemistry
Czasopismo naukowe
Tytuł:
YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex.
Autorzy:
Kostic M; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Paridaen JTML; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Long KR; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Kalebic N; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Langen B; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Grübling N; Technische Universität Dresden, Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Fetscherstraße 74, 01307 Dresden, Germany.
Wimberger P; Technische Universität Dresden, Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Fetscherstraße 74, 01307 Dresden, Germany.
Kawasaki H; Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, Ishikawa 920-8640, Japan.
Namba T; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. Electronic address: .
Huttner WB; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2019 Apr 23; Vol. 27 (4), pp. 1103-1118.e6.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adaptor Proteins, Signal Transducing/*physiology
Cell Cycle Proteins/*physiology
Neocortex/*cytology
Stem Cells/*cytology
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Biological Evolution ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Proliferation ; Ferrets ; Humans ; Mammals ; Mice ; Neocortex/growth & development ; Neocortex/metabolism ; Signal Transduction ; YAP-Signaling Proteins
Czasopismo naukowe
Tytuł:
Allosteric Regulation of NCLX by Mitochondrial Membrane Potential Links the Metabolic State and Ca Signaling in Mitochondria.
Autorzy:
Kostic M; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Katoshevski T; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Sekler I; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2018 Dec 18; Vol. 25 (12), pp. 3465-3475.e4.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Signaling*/drug effects
Membrane Potential, Mitochondrial*/drug effects
Mitochondria/*metabolism
Mitochondrial Proteins/*metabolism
Sodium-Calcium Exchanger/*metabolism
Allosteric Regulation/drug effects ; Calcium/metabolism ; Cell Line ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Enzyme Activation/drug effects ; Glucose/pharmacology ; Humans ; Mitochondria/drug effects ; Mitochondrial Proteins/chemistry ; Models, Biological ; Phosphorylation/drug effects ; Protein Domains ; Sodium-Calcium Exchanger/chemistry ; Uncoupling Protein 1/metabolism
Czasopismo naukowe
Tytuł:
Chemical Biology as a Driver of Innovation in Cancer Research and Drug Discovery.
Autorzy:
Kostic M
Arkin M
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Źródło:
Cell chemical biology [Cell Chem Biol] 2017 Sep 21; Vol. 24 (9), pp. 1057.
Typ publikacji:
Editorial; Introductory Journal Article
MeSH Terms:
Biomedical Research*
Drug Discovery*
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*therapeutic use
Neoplasms/*chemistry
Neoplasms/*drug therapy
Humans ; Neoplasms/pathology
Czasopismo naukowe
Tytuł:
From Glioblastoma to Hepatitis C: It's a Metabolism Thing.
Autorzy:
Kostic M
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Źródło:
Cell chemical biology [Cell Chem Biol] 2016 Nov 17; Vol. 23 (11), pp. 1315-1316.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms/*metabolism
Glioblastoma/*metabolism
Hepacivirus/*metabolism
Hepatitis C/*metabolism
Brain Neoplasms/complications ; Brain Neoplasms/virology ; Cholesterol/metabolism ; Glioblastoma/complications ; Glioblastoma/virology ; Hepatitis C/complications ; Hepatitis C/virology ; Humans ; Receptors, Cytoplasmic and Nuclear/metabolism
Czasopismo naukowe
Czasopismo naukowe
Tytuł:
PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons.
Autorzy:
Kostic M; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Ludtmann MH; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Bading H; Department of Neurobiology, University of Heidelberg, Heidelberg 69120, Germany, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Hershfinkel M; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Steer E; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Chu CT; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Abramov AY; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: .
Sekler I; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2015 Oct 13; Vol. 13 (2), pp. 376-86. Date of Electronic Publication: 2015 Oct 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Membrane Potential, Mitochondrial*
Calcium/*metabolism
Cyclic AMP-Dependent Protein Kinases/*metabolism
Dopaminergic Neurons/*metabolism
Protein Kinases/*metabolism
Sodium-Calcium Exchanger/*metabolism
Animals ; Calcium/toxicity ; Cell Line, Tumor ; HEK293 Cells ; Humans ; Mice ; Mitochondria/metabolism ; Phosphorylation ; Protein Kinases/genetics ; Sodium-Calcium Exchanger/genetics
Czasopismo naukowe

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