- Tytuł:
- Effects of ciliary muscle plasmid electrotransfer of TNF-alpha soluble receptor variants in experimental uveitis.
- Autorzy:
- Źródło:
- Gene therapy [Gene Ther] 2009 Jul; Vol. 16 (7), pp. 862-73. Date of Electronic Publication: 2009 May 14.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Ciliary Body/*metabolism
Genetic Therapy/*methods
Muscle, Smooth/*metabolism
Receptors, Tumor Necrosis Factor, Type I/*biosynthesis
Recombinant Fusion Proteins/*biosynthesis
Tumor Necrosis Factor Decoy Receptors/*biosynthesis
Uveitis/*therapy
Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Electroporation/methods ; Endotoxins/adverse effects ; Eye/metabolism ; Female ; Gene Transfer Techniques ; Genes, Reporter ; Humans ; Immunomodulation ; Interleukin-10/metabolism ; Interleukin-6/metabolism ; Lac Operon/genetics ; Leukocyte Rolling ; Microscopy, Confocal ; Nitric Oxide Synthase Type II/metabolism ; Plasmids ; Rats ; Rats, Inbred Lew ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Recombinant Fusion Proteins/metabolism ; Recombinant Fusion Proteins/pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection/methods ; Tumor Necrosis Factor Decoy Receptors/metabolism ; Tumor Necrosis Factor-alpha/adverse effects ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe